Q9DDA9

SS
Gene name
pacsin2
Protein name
Protein kinase C and casein kinase substrate in neurons protein 2
Names
x-PACSIN2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398138
EC number
Protein Class

Descriptions

PACSINs plays a central role in synaptic vesicle recycling and receptor-mediated endocytosis and controlling the cell surface expression of transmembrane proteins. The C-terminal SH3 of human homologous PACSIN2 (Q9UNF0) is an autoinhibitory domain affecting activation of the F-BAR domain. The competing binding of protein ligands to the SH3 or linker domain or posttranslational modifications of PACSIN2 permits activation of the F-BAR domain.

Autoinhibitory domains (AIDs)

417-477 (SH3 domain) SS

Target domain

11-282 (F-BAR domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DDA9

Entry ID Method Resolution Chain Position Source
AF-Q9DDA9-F1 Predicted AlphaFoldDB

No variants for Q9DDA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9DDA9

No associated diseases with Q9DDA9

5 regional properties for Q9DDA9

Type Name Position InterPro Accession
domain FCH domain 16 - 104 IPR001060
domain SH3 domain 417 - 477 IPR001452
domain F-BAR domain 11 - 282 IPR031160
domain PACSIN1/PACSIN2, SH3 domain 420 - 475 IPR035743
domain PACSIN2, F-BAR domain 18 - 275 IPR037453

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Cytoplasmic vesicle
  • Cell projection, ruffle membrane
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Early endosome
  • Recycling endosome membrane
  • Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cell projection
  • Membrane, caveola
  • Detected at the neck of flask-shaped caveolae
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

1 GO annotations of molecular function

Name Definition
phosphatidic acid binding Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

4 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
caveola assembly The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
plasma membrane tubulation A membrane tubulation process occurring in a plasma membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCND LMNCIHERAR IEKVYAQQLT
70 80 90 100 110 120
EWAKRWKQLV ERGPQYGTVE KAWHNLMTEA EKVSELHLEV KNALMNEDFE KIKNWQKEAF
130 140 150 160 170 180
HKQMMGGFKE TKEADDGFRK AQKPWAKKLK EVEAAKKSYH AACKEEKLAT SRETNSKADP
190 200 210 220 230 240
AMNPEQLKKL QDKVEKSKQD SQKTKEKYEK SLKDLDGTTP QYMENMEQVF EQCQQFEDKR
250 260 270 280 290 300
LSFFREVLLE VEKHLDLSNV ESYASIYREL EYAIKSADAM EDLKWFRNNH GPGMSMNWPQ
310 320 330 340 350 360
FEDWSADLNR TLSRREKKKP TDGVTLTGIS QSGEQSSIQN QHSSHLSVQS AQSTNNPFED
370 380 390 400 410 420
EEETVSINET ENKKIENVGS YEKTHPAEWS DDESNNPFNP SDTNGDNNPF DEDALTTLEV
430 440 450 460 470
RVRALYDYDG QELDELSFKA GEELTKIEDE DEQGWCKGRL EGGQVGLYPA NYVESVQ