Q9DA32

PR
Gene name
Sun5 (Spag4l)
Protein name
SUN domain-containing protein 5
Names
Sperm-associated antigen 4-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76407
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DA32

Entry ID Method Resolution Chain Position Source
AF-Q9DA32-F1 Predicted AlphaFoldDB

No variants for Q9DA32

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9DA32

No associated diseases with Q9DA32

1 regional properties for Q9DA32

Type Name Position InterPro Accession
domain SUN domain 203 - 362 IPR012919

Functions

Description
EC Number
Subcellular Localization
  • Nucleus inner membrane ; Single-pass membrane protein
  • Golgi apparatus
  • During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling apparatus of the sperm during sperm head elongation and differentiation
  • In mature spermatozoa, is localized to the coupling apparatus of the sperm head and tail in the implementation fossa
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of nuclear inner membrane The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
meiotic nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
sperm connecting piece The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum.

1 GO annotations of molecular function

Name Definition
protein-membrane adaptor activity The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.

3 GO annotations of biological process

Name Definition
nuclear envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47069 MPS3 Spindle pole body assembly component MPS3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O94901 SUN1 SUN domain-containing protein 1 Homo sapiens (Human) SS
Q9UH99 SUN2 SUN domain-containing protein 2 Homo sapiens (Human) SS
Q8TC36 SUN5 SUN domain-containing protein 5 Homo sapiens (Human) PR
Q8BJS4 Sun2 SUN domain-containing protein 2 Mus musculus (Mouse) EV
Q9D666 Sun1 SUN domain-containing protein 1 Mus musculus (Mouse) EV
10 20 30 40 50 60
MPRTRNIGAL CTLPEDTTHS GRPRRGVQRS YISRMAEPAP ANMNDPLLLP LRMNTPGLSL
70 80 90 100 110 120
VQILLGYMSW LTYLACFLRT QTQQVFLNTC RCKLFCQKVM EKMGLLVLCV FGFWMFSMHL
130 140 150 160 170 180
PSKVEVWQDD SINGPLQSLR MYQEKVRHHT GEIQDLRGSM NQLIAKLQKM EAISDEQKMA
190 200 210 220 230 240
QKIMKMIQGD YIEKPDFALK SIGASIDFEH TSATYNHDKA RSYWNWIRLW NYAQPPDVIL
250 260 270 280 290 300
EPNVTPGNCW AFASDRGQVT IRLAQKVYLS NITLQHIPKT ISLSGSPDTA PKDIVIYGLE
310 320 330 340 350 360
SLPREEVFLG AFQFQPENVI QMFQLQNLPP RSFAAVKVKI SSNWGNPRFT CMYRVRVHGS
370
VTPPKDSHLE PLS