Q9D9Q0
PR
Gene name |
Lrrc69 |
Protein name |
Leucine-rich repeat-containing protein 69 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73314 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D9Q0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D9Q0-F1 | Predicted | AlphaFoldDB |
22 variants for Q9D9Q0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411599556 | 13 | G>D | No | EVA | |
| rs255698365 | 14 | K>R | No | EVA | |
| rs27741852 | 58 | T>I | No | EVA | |
| rs3388673395 | 80 | K>N | No | EVA | |
| rs246208897 | 87 | N>S | No | EVA | |
| rs3388667216 | 99 | A>V | No | EVA | |
| rs27741891 | 103 | F>L | No | EVA | |
| rs245424243 | 104 | N>D | No | EVA | |
| rs3388668787 | 123 | P>H | No | EVA | |
| rs240764215 | 153 | E>D | No | EVA | |
| rs3388663151 | 181 | L>F | No | EVA | |
| rs238642774 | 224 | T>R | No | EVA | |
| rs256453236 | 240 | F>L | No | EVA | |
| rs27757400 | 253 | I>T | No | EVA | |
| rs27757402 | 272 | V>A | No | EVA | |
| rs27757404 | 293 | R>S | No | EVA | |
| rs27757405 | 298 | T>S | No | EVA | |
| rs3388669127 | 306 | F>Y | No | EVA | |
| rs3388673397 | 330 | S>F | No | EVA | |
| rs254355637 | 332 | Q>R | No | EVA | |
| rs3388678556 | 340 | D>G | No | EVA | |
| rs3388673744 | 344 | I>N | No | EVA |
No associated diseases with Q9D9Q0
11 regional properties for Q9D9Q0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 15 - 82 | IPR001611-1 |
| repeat | Leucine-rich repeat | 84 - 152 | IPR001611-2 |
| repeat | Leucine-rich repeat | 177 - 233 | IPR001611-3 |
| repeat | Leucine-rich repeat, typical subtype | 36 - 58 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 59 - 81 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 82 - 105 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 106 - 128 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 129 - 151 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 152 - 174 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 175 - 197 | IPR003591-7 |
| repeat | Leucine-rich repeat, typical subtype | 198 - 220 | IPR003591-8 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAERLLVTAL | KGGKNTKILT | LNGKRITKMP | STLEKLPNLK | TLDLQNNSIS | KVCPELRTLT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLTLLNLGNN | HLQEVPEEIK | YLTSLKNLHL | FGNRICRIAP | GVFNGLHRLI | MLNLNDNRLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLPQEIGRLR | SLTYLSLNRN | NLTVIPKELC | SLEHLSELHL | NYNQIVYIPE | EIKFLKNLQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFLVRNNIEE | LPEEICHLEK | LRVLDIAGNV | IQIFPAGFQN | LRLTEFYCEG | NPLFLKRPFF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVQPKDLWTL | REIAARFVLS | LLEENDPLIM | NVIESYPEVK | DKLSKAKKCS | ICRKPFLTEW |
| 310 | 320 | 330 | 340 | ||
| LECVYFVAPS | KNWKISRNLK | LIPVQTSVCS | YQCFDQRDPD | VFGIAQE |