Q9D666
Gene name |
Sun1 (Unc84a) |
Protein name |
SUN domain-containing protein 1 |
Names |
Protein unc-84 homolog A , Sad1/unc-84 protein-like 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77053 |
EC number |
|
Protein Class |
SAD1/UNC-84-LIKE PROTEIN-RELATED (PTHR12911) |
Descriptions
SUN proteins are the core components of LINC complexes that span across the nuclear envelope for nuclear positioning and migration. Autoinhibition of SUN1 involves an autoinhibitory domain (AID) preceding the SUN domain that forms a three-helix bundle. This bundle interacts with the SUN domain, locking it in an autoinhibited state, preventing binding to the KASH peptide.
Autoinhibitory domains (AIDs)
Target domain |
738-913 (SUN domain) |
Relief mechanism |
Partner binding |
Assay |
Deletion assay, Mutagenesis experiment, Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9D666
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5YWZ | X-ray | 220 A | A | 672-913 | PDB |
| AF-Q9D666-F1 | Predicted | AlphaFoldDB |
36 variants for Q9D666
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388808102 | 6 | L>P | No | EVA | |
| rs3388811294 | 13 | Q>* | No | EVA | |
| rs3388797867 | 41 | K>N | No | EVA | |
| rs13473689 | 77 | S>T | No | EVA | |
| rs3388805636 | 85 | K>Q | No | EVA | |
| rs3388785748 | 88 | E>V | No | EVA | |
| rs3388805659 | 130 | V>M | No | EVA | |
| rs3388808064 | 183 | Y>H | No | EVA | |
| rs3388804475 | 204 | I>N | No | EVA | |
| rs252367472 | 299 | S>A | No | EVA | |
| rs3396047850 | 304 | E>K | No | EVA | |
| rs3388804487 | 360 | S>F | No | EVA | |
| rs3396134459 | 408 | R>W | No | EVA | |
| rs3543927352 | 411 | R>P | No | EVA | |
| rs264505827 | 421 | L>I | No | EVA | |
| rs3388797876 | 436 | Q>H | No | EVA | |
| rs3388803165 | 437 | G>R | No | EVA | |
| rs3388797896 | 442 | L>V | No | EVA | |
| rs3388795391 | 466 | P>H | No | EVA | |
| rs216905497 | 473 | P>A | No | EVA | |
| rs226474483 | 494 | V>I | No | EVA | |
| rs37554647 | 509 | A>S | No | EVA | |
| rs3388811282 | 517 | K>T | No | EVA | |
| rs3388805347 | 538 | N>I | No | EVA | |
| rs3388811263 | 549 | T>S | No | EVA | |
| rs3388800539 | 577 | L>P | No | EVA | |
| rs3543864183 | 625 | L>V | No | EVA | |
| rs3395905134 | 628 | W>C | No | EVA | |
| rs3388792156 | 664 | E>K | No | EVA | |
| rs3396344224 | 680 | L>* | No | EVA | |
| rs3388804527 | 684 | E>V | No | EVA | |
| rs3388789184 | 700 | Q>L | No | EVA | |
| rs3543869959 | 773 | F>C | No | EVA | |
| rs3388804513 | 790 | P>A | No | EVA | |
| rs218266685 | 860 | R>Q | No | EVA | |
| rs227930475 | 876 | L>P | No | EVA |
No associated diseases with Q9D666
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR12911 | SAD1/UNC-84-LIKE PROTEIN-RELATED |
| PANTHER Subfamily | PTHR12911:SF23 | SUN DOMAIN-CONTAINING PROTEIN 1 |
| PANTHER Protein Class |
cytoskeletal protein
non-motor microtubule binding protein |
|
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| meiotic nuclear membrane microtubule tethering complex | A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| outer acrosomal membrane | The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytoskeleton-nuclear membrane anchor activity | The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. |
| identical protein binding | Binding to an identical protein or proteins. |
| lamin binding | Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. |
| protein-membrane adaptor activity | The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| centrosome localization | Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. |
| homologous chromosome pairing at meiosis | The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. |
| meiotic attachment of telomere to nuclear envelope | The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation. |
| nuclear envelope organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. |
| nuclear matrix anchoring at nuclear membrane | The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane. |
| nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration | The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration. |
| ossification | The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| response to mechanical stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P47069 | MPS3 | Spindle pole body assembly component MPS3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9UH99 | SUN2 | SUN domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q8TC36 | SUN5 | SUN domain-containing protein 5 | Homo sapiens (Human) | PR |
| O94901 | SUN1 | SUN domain-containing protein 1 | Homo sapiens (Human) | SS |
| Q9DA32 | Sun5 | SUN domain-containing protein 5 | Mus musculus (Mouse) | PR |
| Q8BJS4 | Sun2 | SUN domain-containing protein 2 | Mus musculus (Mouse) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFSRLHTYT | PPQCVPENTG | YTYALSSSYS | SDALDFETEH | KLEPVFDSPR | MSRRSLRLVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TASYSSGDSQ | AIDSHISTSR | ATPAKGRETR | TVKQRRSASK | PAFSINHLSG | KGLSSSTSHD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSCSLRSATV | LRHPVLDESL | IREQTKVDHF | WGLDDDGDLK | GGNKAATQGN | GELAAEVASS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NGYTCRDCRM | LSARTDALTA | HSAIHGTTSR | VYSRDRTLKP | RGVSFYLDRT | LWLAKSTSSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FASFIVQLFQ | VVLMKLNFET | YKLKGYESRA | YESQSYETKS | HESEAHLGHC | GRMTAGELSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDGESLCDDC | KGKKHLEIHT | ATHSQLPQPH | RVAGAMGRLC | IYTGDLLVQA | LRRTRAAGWS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAEAVWSVLW | LAVSAPGKAA | SGTFWWLGSG | WYQFVTLISW | LNVFLLTRCL | RNICKVFVLL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPLLLLLGAG | VSLWGQGNFF | SLLPVLNWTA | MQPTQRVDDS | KGMHRPGPLP | PSPPPKVDHK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASQWPQESDM | GQKVASLSAQ | CHNHDERLAE | LTVLLQKLQI | RVDQVDDGRE | GLSLWVKNVV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GQHLQEMGTI | EPPDAKTDFM | TFHHDHEVRL | SNLEDVLRKL | TEKSEAIQKE | LEETKLKAGS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RDEEQPLLDR | VQHLELELNL | LKSQLSDWQH | LKTSCEQAGA | RIQETVQLMF | SEDQQGGSLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WLLEKLSSRF | VSKDELQVLL | HDLELKLLQN | ITHHITVTGQ | APTSEAIVSA | VNQAGISGIT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EAQAHIIVNN | ALKLYSQDKT | GMVDFALESG | GGSILSTRCS | ETYETKTALL | SLFGVPLWYF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SQSPRVVIQP | DIYPGNCWAF | KGSQGYLVVR | LSMKIYPTTF | TMEHIPKTLS | PTGNISSAPK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DFAVYGLETE | YQEEGQPLGR | FTYDQEGDSL | QMFHTLERPD | QAFQIVELRV | LSNWGHPEYT |
| 910 | |||||
| CLYRFRVHGE | PIQ |