Q9D5U8
PR
Gene name |
Cnbd2 (Cris) |
Protein name |
Cyclic nucleotide-binding domain-containing protein 2 |
Names |
Cyclic nucleotide receptor involved in sperm function |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70873 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D5U8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D5U8-F1 | Predicted | AlphaFoldDB |
47 variants for Q9D5U8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs27355685 | 2 | N>D | No | EVA | |
| rs219554213 | 5 | A>S | No | EVA | |
| rs3392503696 | 8 | E>D | No | EVA | |
| rs240158541 | 22 | K>T | No | EVA | |
| rs3392269391 | 32 | K>E | No | EVA | |
| rs3392471513 | 33 | D>V | No | EVA | |
| rs3388602615 | 38 | R>S | No | EVA | |
| rs3388606700 | 43 | P>Q | No | EVA | |
| rs222730562 | 44 | A>T | No | EVA | |
| rs3388598139 | 79 | T>I | No | EVA | |
| rs240144276 | 98 | I>M | No | EVA | |
| rs230168706 | 108 | K>R | No | EVA | |
| rs3388608298 | 121 | R>* | No | EVA | |
| rs3388606100 | 126 | F>I | No | EVA | |
| rs3388606113 | 142 | V>F | No | EVA | |
| rs250675575 | 148 | D>A | No | EVA | |
| rs3388598098 | 168 | A>P | No | EVA | |
| rs241637217 | 170 | Q>E | No | EVA | |
| rs262188183 | 185 | K>N | No | EVA | |
| rs3388600119 | 191 | H>L | No | EVA | |
| rs243226025 | 240 | G>S | No | EVA | |
| rs3388596689 | 243 | F>C | No | EVA | |
| rs3413133873 | 253 | I>L | No | EVA | |
| rs3388608253 | 260 | S>N | No | EVA | |
| rs3392430877 | 274 | G>D | No | EVA | |
| rs3388598105 | 330 | N>I | No | EVA | |
| rs3388607017 | 384 | V>A | No | EVA | |
| rs3388604720 | 388 | D>N | No | EVA | |
| rs216788076 | 390 | S>R | No | EVA | |
| rs3388606159 | 392 | Y>F | No | EVA | |
| rs3388590475 | 392 | Y>N | No | EVA | |
| rs230799299 | 410 | I>V | No | EVA | |
| rs3388590560 | 415 | I>L | No | EVA | |
| rs3388602101 | 453 | F>L | No | EVA | |
| rs47783332 | 476 | F>Y | No | EVA | |
| rs27336883 | 479 | L>P | No | EVA | |
| rs3392137284 | 486 | N>I | No | EVA | |
| rs3388604731 | 503 | K>N | No | EVA | |
| rs3388609109 | 523 | I>T | No | EVA | |
| rs3388604664 | 528 | R>L | No | EVA | |
| rs222842547 | 532 | L>V | No | EVA | |
| rs220683170 | 556 | R>K | No | EVA | |
| rs3388607248 | 569 | D>N | No | EVA | |
| rs27336855 | 591 | R>Q | No | EVA | |
| rs221004653 | 600 | S>P | No | EVA | |
| rs3388607031 | 619 | F>L | No | EVA | |
| rs3388600101 | 626 | E>D | No | EVA |
No associated diseases with Q9D5U8
5 regional properties for Q9D5U8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 383 - 391 | IPR000629 |
| domain | Helicase, C-terminal | 448 - 639 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 256 - 425 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 250 - 452 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 231 - 259 | IPR014014 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00514 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| P00515 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| P31322 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Bos taurus (Bovine) | EV |
| Q5ZM91 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Gallus gallus (Chicken) | SS |
| P81900 | Pka-R2 | cAMP-dependent protein kinase type II regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| P16905 | Pka-R1 | cAMP-dependent protein kinase type I regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| P13861 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Homo sapiens (Human) | PR |
| P31323 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Homo sapiens (Human) | PR |
| P10644 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Homo sapiens (Human) | EV |
| P31321 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | Homo sapiens (Human) | EV |
| Q96M20 | CNBD2 | Cyclic nucleotide-binding domain-containing protein 2 | Homo sapiens (Human) | PR |
| P12849 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Mus musculus (Mouse) | PR |
| P12367 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Mus musculus (Mouse) | PR |
| P31324 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Mus musculus (Mouse) | PR |
| Q9DBC7 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed] | Mus musculus (Mouse) | SS |
| P05207 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P07802 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P12369 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P12368 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Rattus norvegicus (Rat) | PR |
| P81377 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P09456 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit | Rattus norvegicus (Rat) | SS |
| P30625 | kin-2 | cAMP-dependent protein kinase regulatory subunit | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRSANPEAA | SSTSHVKFDL | GKSVDISSTD | TKDGGTARSP | LEPADKSDTT | ESKSESGSDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSEEDKESPA | SIKEIKAETP | QPKDRPGVQI | KLSWSQKIKS | WTAKKKRKLY | QLVIDIIMMN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVCKMFRQGL | RGFREYQIIE | PVHKKHPDFS | FWDKKKQGRI | SFVTEDFAAQ | EGHFPPRAIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ITQKKPSWRT | HQEIQDLCNI | LQALDCYRSY | TESLQLLLAK | VIRFERFGRR | RVIVKKGQMG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NSFYFIYLGT | VAITEDEDGS | SAFLDPHPTL | LHRGGSFGEM | GLLSTTVRSA | TVVCMEETEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVVDREDFVA | NKLGDEVQKE | TQYRYNFFRN | LDIFQSWSEE | KLWKLVALGR | IERFSYGQMV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SKDFMNSAFI | TFICQGNCEI | LRLVALGDCS | AYYKWVWQQL | ELLDHKPLRI | HDNEISPKER |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FKELQIKSYP | LQDFTYLKLL | RLQKAREQQG | IDFHGKINKV | ENTLPKLLGP | KIKSRFGHLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KCSMVNTKFG | ELPKEAIVGV | YMKIHKTEEG | EIVGLHQAFV | PEIQRDCRPF | ILLSLGSELI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QVRKEKFYDM | VDEETRAKII | KMDVDYPSDE | DLCQSFLKEN | DYIVFRKDLL | RLLVEPLNKS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFIPVQTKKK | EIYNHKSLFL | DLCSLEKKVK | QHYPIFLAPQ | KYLPPLRVVQ | AISAPRHKIQ |
| 670 | |||||
| ELLPQYKNAG | VLI |