AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

32-251 (Predicted disordered autoinhibitory region) PR

32-251 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D5D8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389012029	16	R>S	No	EVA
rs3389015178	60	L>*	No	EVA
rs3388964324	82	R>C	No	EVA
rs3389014574	92	R>W	No	EVA
rs3389015244	96	P>A	No	EVA
rs3389007855	100	K>I	No	EVA
rs3388984374	109	V>I	No	EVA
rs241012459	114	S>P	No	EVA
rs3389014320	118	K>N	No	EVA
rs3388995396	119	G>R	No	EVA
rs3389019825	120	S>E	No	EVA
rs251683313	163	D>E	No	EVA
rs3389001582	232	R>SE*	No	EVA
rs3389014360	234	R>G	No	EVA
rs3389019857	253	K>N	No	EVA
rs3399697624	256	G>C	No	EVA
rs3389001543	265	Q>R	No	EVA
rs3388995395	273	T>I	No	EVA
rs3389012195	287	A>T	No	EVA
rs3389019812	300	V>M	No	EVA
rs3389006651	302	S>N	No	EVA
rs3389019862	330	E>D	No	EVA
rs3388995313	338	A>S	No	EVA
rs3388984350	378	T>I	No	EVA
rs3389012227	442	V>M	No	EVA
rs3389015186	452	V>*	No	EVA
rs3389006608	454	E>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Chromo/chromo shadow domain	6 - 67	IPR000953
conserved_site	Chromo domain, conserved site	25 - 45	IPR023779
domain	Chromo domain	7 - 56	IPR023780

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99549	MPHOSPH8	M-phase phosphoprotein 8	Homo sapiens (Human)	PR
P83916	CBX1	Chromobox protein homolog 1	Homo sapiens (Human)	PR
Q9Y232	CDYL	Chromodomain Y-like protein	Homo sapiens (Human)	PR
Q8N8U2	CDYL2	Chromodomain Y-like protein 2	Homo sapiens (Human)	PR
P83917	Cbx1	Chromobox protein homolog 1	Mus musculus (Mouse)	PR
Q9WTK2	Cdyl	Chromodomain Y-like protein	Mus musculus (Mouse)	PR
Q6AYK9	Cdyl	Chromodomain Y-like protein	Rattus norvegicus (Rat)	PR