Q9D300
Gene name |
Rasgef1c |
Protein name |
Ras-GEF domain-containing family member 1C |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74563 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D300
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D300-F1 | Predicted | AlphaFoldDB |
17 variants for Q9D300
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs258935740 | 15 | S>N | No | EVA | |
| rs3389125021 | 18 | P>S | No | EVA | |
| rs3389128909 | 19 | P>H | No | EVA | |
| rs217454052 | 25 | E>G | No | EVA | |
| rs3389140173 | 39 | S>T | No | EVA | |
| rs3389156285 | 75 | E>D | No | EVA | |
| rs3389125053 | 84 | C>F | No | EVA | |
| rs3389160128 | 149 | G>V | No | EVA | |
| rs220473822 | 150 | S>N | No | EVA | |
| rs216644446 | 152 | V>I | No | EVA | |
| rs3389155046 | 166 | L>F | No | EVA | |
| rs229290041 | 240 | R>C | No | EVA | |
| rs3389156248 | 381 | C>S | No | EVA | |
| rs3413126640 | 408 | W>* | No | EVA | |
| rs3389128952 | 410 | Q>L | No | EVA | |
| rs3389125039 | 419 | P>Q | No | EVA | |
| rs3389152650 | 463 | L>M | No | EVA |
No associated diseases with Q9D300
9 regional properties for Q9D300
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 215 - 284 | IPR001452 |
| domain | PDZ domain | 130 - 209 | IPR001478 |
| domain | L27 domain | 1 - 110 | IPR004172 |
| domain | Guanylate kinase-like domain | 338 - 525 | IPR008144 |
| domain | Guanylate kinase/L-type calcium channel beta subunit | 337 - 528 | IPR008145 |
| domain | L27 domain, C-terminal | 1 - 53 | IPR014775-1 |
| domain | L27 domain, C-terminal | 58 - 108 | IPR014775-2 |
| conserved_site | Guanylate kinase, conserved site | 373 - 390 | IPR020590 |
| domain | MPP6, SH3 domain | 219 - 279 | IPR035603 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N9B8 | RASGEF1A | Ras-GEF domain-containing family member 1A | Homo sapiens (Human) | PR |
| Q8N431 | RASGEF1C | Ras-GEF domain-containing family member 1C | Homo sapiens (Human) | PR |
| Q02384 | Sos2 | Son of sevenless homolog 2 | Mus musculus (Mouse) | SS |
| Q62245 | Sos1 | Son of sevenless homolog 1 | Mus musculus (Mouse) | SS |
| Q8VCC8 | Rapgef3 | Rap guanine nucleotide exchange factor 3 | Mus musculus (Mouse) | SS |
| Q9EQZ6 | Rapgef4 | Rap guanine nucleotide exchange factor 4 | Mus musculus (Mouse) | EV |
| Q03385 | Ralgds | Ral guanine nucleotide dissociation stimulator | Mus musculus (Mouse) | PR |
| Q9Z1S3 | Rasgrp1 | RAS guanyl-releasing protein 1 | Mus musculus (Mouse) | SS |
| Q8BTM9 | Rasgrp4 | RAS guanyl-releasing protein 4 | Mus musculus (Mouse) | SS |
| Q9QUG9 | Rasgrp2 | RAS guanyl-releasing protein 2 | Mus musculus (Mouse) | SS |
| Q9ERD6 | Ralgps2 | Ras-specific guanine nucleotide-releasing factor RalGPS2 | Mus musculus (Mouse) | PR |
| A2AR50 | Ralgps1 | Ras-specific guanine nucleotide-releasing factor RalGPS1 | Mus musculus (Mouse) | PR |
| Q28EC1 | rasgef1b | Ras-GEF domain-containing family member 1B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A0JM95 | rasgef1a | Ras-GEF domain-containing family member 1A | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRTLTASDM | VTPGSLSPPP | TESTEGEQAG | QPLLDGAPSS | ASLDTLIQHL | VPTADYYPEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AYIFTFLLSS | RLFIEPRELL | ARVCHLCIEQ | QQLDKPVLDK | ARVRKFGAKL | LQLLAEWTET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FPRDFEEEST | IGHLTDVVGR | ISPCDETYGS | RVHQLLQTLH | QKLASLGQGP | ESLVGADKPI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYRTKPPASI | HRELLGVCSD | PYTLAQQLTH | VELERLRHIG | PEEFVQAFVN | KDPLAGTKPR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSDKTNNVEA | YVKWFNRLCY | LVATEICMPA | KKKQRAQVIE | FFIDVARECF | NIGNFNSLMA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IISGMNMSPV | SRLKKTWAKV | KTAKFFILEH | QMDPTGNFCN | YRTALRGAAH | RSLTAHSSRE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KIVIPFFSLL | IKDIYFLNEG | CANRLPNGHV | NFEKFLELAK | QVGEFITWKQ | VECPFEQDPS |
| 430 | 440 | 450 | 460 | ||
| ITHYLYTAPI | FSEDGLYLAS | YESESPESQT | EKERWKSLRS | SILGKT |