Q9D1T0
PR
Gene name |
Lingo1 (Lern1, Lrrn6a) |
Protein name |
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 |
Names |
Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:235402 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D1T0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D1T0-F1 | Predicted | AlphaFoldDB |
41 variants for Q9D1T0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389027324 | 50 | L>F | No | EVA | |
| rs3389050726 | 58 | A>T | No | EVA | |
| rs3389048881 | 74 | K>Q | No | EVA | |
| rs13465411 | 95 | E>Q | No | EVA | |
| rs3389048659 | 101 | V>M | No | EVA | |
| rs3389048814 | 102 | S>R | No | EVA | |
| rs3389053151 | 111 | N>K | No | EVA | |
| rs3400188216 | 135 | G>D | No | EVA | |
| rs3389034525 | 138 | N>I | No | EVA | |
| rs13465410 | 145 | S>R | No | EVA | |
| rs3389021613 | 157 | F>L | No | EVA | |
| rs3389044452 | 179 | R>Q | No | EVA | |
| rs3389048697 | 242 | H>L | No | EVA | |
| rs3389040677 | 246 | L>M | No | EVA | |
| rs3389055236 | 256 | G>R | No | EVA | |
| rs13465418 | 303 | E>D | No | EVA | |
| rs3389050706 | 304 | L>P | No | EVA | |
| rs3389044449 | 337 | S>T | No | EVA | |
| rs3389055230 | 359 | I>F | No | EVA | |
| rs3389048276 | 369 | C>S | No | EVA | |
| rs3389048804 | 370 | R>Q | No | EVA | |
| rs3400201128 | 418 | A>S | No | EVA | |
| rs3400201067 | 419 | H>Q | No | EVA | |
| rs3400426839 | 419 | H>R | No | EVA | |
| rs3400426829 | 420 | I>M | No | EVA | |
| rs3400002550 | 421 | R>W | No | EVA | |
| rs3400201097 | 422 | D>A | No | EVA | |
| rs3389021608 | 456 | R>P | No | EVA | |
| rs3400171741 | 458 | H>L | No | EVA | |
| rs3399646691 | 462 | A>G | No | EVA | |
| rs3389044674 | 468 | L>H | No | EVA | |
| rs3389050725 | 477 | E>* | No | EVA | |
| rs3389040658 | 498 | G>D | No | EVA | |
| rs13465414 | 514 | D>Y | No | EVA | |
| rs13465413 | 527 | S>Y | No | EVA | |
| rs3389044736 | 538 | T>I | No | EVA | |
| rs3389048855 | 556 | T>S | No | EVA | |
| rs3389044530 | 575 | L>P | No | EVA | |
| rs3389048899 | 583 | T>I | No | EVA | |
| rs3389053156 | 602 | S>* | No | EVA | |
| rs3389034567 | 606 | P>A | No | EVA |
No associated diseases with Q9D1T0
18 regional properties for Q9D1T0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Leucine-rich repeat N-terminal domain | 35 - 69 | IPR000372 |
| repeat | Leucine-rich repeat | 89 - 149 | IPR001611-1 |
| repeat | Leucine-rich repeat | 282 - 303 | IPR001611-2 |
| repeat | Leucine-rich repeat | 306 - 365 | IPR001611-3 |
| repeat | Leucine-rich repeat, typical subtype | 88 - 111 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 112 - 135 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 136 - 159 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 160 - 183 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 184 - 207 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 208 - 231 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 280 - 303 | IPR003591-7 |
| repeat | Leucine-rich repeat, typical subtype | 304 - 327 | IPR003591-8 |
| repeat | Leucine-rich repeat, typical subtype | 328 - 351 | IPR003591-9 |
| domain | Immunoglobulin subtype 2 | 431 - 498 | IPR003598 |
| domain | Immunoglobulin subtype | 425 - 509 | IPR003599 |
| domain | Immunoglobulin-like domain | 405 - 507 | IPR007110 |
| domain | Immunoglobulin I-set | 423 - 508 | IPR013098 |
| repeat | BspA type Leucine rich repeat region | 154 - 272 | IPR026906 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| epidermal growth factor receptor binding | Binding to an epidermal growth factor receptor. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| central nervous system neuron development | The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. |
| negative regulation of oligodendrocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| oligodendrocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. |
| protein kinase B signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| Q8VCH9 | Lrrc3b | Leucine-rich repeat-containing protein 3B | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLAGGMRSMP | SPLLACWQPI | LLLVLGSVLS | GSATGCPPRC | ECSAQDRAVL | CHRKRFVAVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EGIPTETRLL | DLGKNRIKTL | NQDEFASFPH | LEELELNENI | VSAVEPGAFN | NLFNLRTLGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSNRLKLIPL | GVFTGLSNLT | KLDISENKIV | ILLDYMFQDL | YNLKSLEVGD | NDLVYISHRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FSGLNSLEQL | TLEKCNLTSI | PTEALSHLHG | LIVLRLRHLN | INAIRDYSFK | RLYRLKVLEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SHWPYLDTMT | PNCLYGLNLT | SLSITHCNLT | AVPYLAVRHL | VYLRFLNLSY | NPIGTIEGSM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LHELLRLQEI | QLVGGQLAVV | EPYAFRGLNY | LRVLNVSGNQ | LTTLEESAFH | SVGNLETLIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DSNPLACDCR | LLWVFRRRWR | LNFNRQQPTC | ATPEFVQGKE | FKDFPDVLLP | NYFTCRRAHI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RDRKAQQVFV | DEGHTVQFVC | RADGDPPPAI | LWLSPRKHLV | SAKSNGRLTV | FPDGTLEVRY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AQVQDNGTYL | CIAANAGGND | SMPAHLHVRS | YSPDWPHQPN | KTFAFISNQP | GEGEANSTRA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TVPFPFDIKT | LIIATTMGFI | SFLGVVLFCL | VLLFLWSRGK | GNTKHNIEIE | YVPRKSDAGI |
| 610 | |||||
| SSADAPRKFN | MKMI |