Q9CZK6

PR
Gene name
Anks3 (Kiaa1977)
Protein name
Ankyrin repeat and SAM domain-containing protein 3
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72615
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

332-407 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CZK6

Entry ID Method Resolution Chain Position Source
AF-Q9CZK6-F1 Predicted AlphaFoldDB

41 variants for Q9CZK6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs864301071 50 V>E No EVA
rs3389392275 69 G>S No EVA
rs3389388439 76 A>G No EVA
rs3389348187 95 V>L No EVA
rs3389313840 118 A>S No EVA
rs215634086 134 H>Q No EVA
rs3406677243 166 P>S No EVA
rs3389404025 170 Y>F No EVA
rs3389395095 187 Y>* No EVA
rs211813471 212 F>C No EVA
rs211813471 212 F>Y No EVA
rs3406023977 273 A>T No EVA
rs3389358632 325 D>* No EVA
rs3389412646 327 E>G No EVA
rs3389395168 386 R>W No EVA
rs3389404073 405 S>N No EVA
rs247465746 406 T>I No EVA
rs231501481 408 P>A No EVA
rs231501481 408 P>T No EVA
rs51450294 411 I>T No EVA
rs3389395565 433 L>M No EVA
rs3389392317 442 L>M No EVA
rs3389404070 453 R>C No EVA
rs864268343 453 R>H No EVA
rs3412749418 508 Q>H No EVA
rs3389367188 533 E>* No EVA
rs3389412624 534 L>W No EVA
rs3389391156 580 L>Q No EVA
rs3389412660 582 A>P No EVA
rs3389391191 584 L>W No EVA
rs233571835 596 N>I No EVA
rs3389392355 602 A>S No EVA
rs3406543073 634 L>F No EVA
rs3404964340 638 T>I No EVA
rs3406925566 638 T>S No EVA
rs3404964334 641 L>M No EVA
rs3389392281 642 E>G No EVA
rs4231052 643 K>R No EVA
rs4231053 646 M>V No EVA
rs4231054 650 K>E No EVA
rs4231055 650 K>N No EVA

No associated diseases with Q9CZK6

6 regional properties for Q9CZK6

Type Name Position InterPro Accession
repeat Leucine-rich repeat 48 - 69 IPR001611
repeat WD40 repeat 309 - 361 IPR001680-1
repeat WD40 repeat 417 - 458 IPR001680-2
repeat WD40 repeat 468 - 507 IPR001680-3
repeat WD40 repeat 582 - 623 IPR001680-4
conserved_site WD40 repeat, conserved site 444 - 458 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04861 NFKB1 Nuclear factor NF-kappa-B p105 subunit Gallus gallus (Chicken) SS
P98150 NFKB2 Nuclear factor NF-kappa-B p100 subunit Gallus gallus (Chicken) SS
Q94527 Rel Nuclear factor NF-kappa-B p110 subunit Drosophila melanogaster (Fruit fly) EV
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens (Human) SS
Q99549 MPHOSPH8 M-phase phosphoprotein 8 Homo sapiens (Human) PR
Q00653 NFKB2 Nuclear factor NF-kappa-B p100 subunit Homo sapiens (Human) SS
Q8N9B4 ANKRD42 Ankyrin repeat domain-containing protein 42 Homo sapiens (Human) PR
Q6ZVZ8 ASB18 Ankyrin repeat and SOCS box protein 18 Homo sapiens (Human) PR
P25799 Nfkb1 Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] Mus musculus (Mouse) EV
Q8VHA6 Asb18 Ankyrin repeat and SOCS box protein 18 Mus musculus (Mouse) PR
Q9WTK5 Nfkb2 Nuclear factor NF-kappa-B p100 subunit [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] Mus musculus (Mouse) EV
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
O22265 CAO Signal recognition particle 43 kDa protein, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZI3 NPR2 Regulatory protein NPR2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSELSDEASE PELLKRSLSM WHGLGAQGSP EELDVPLDLH TAASIGQHEV VKECVQRGEL
70 80 90 100 110 120
DLNKKNGGGW TALMYASYIG HDTIVHLLLE AGVSVNVPTP EGQTPLMLAS SCGNESIAYF
130 140 150 160 170 180
LLQQGAELEM KDIHGWTALF HCTSAGHQQM VKFLLESGAN ANVREPVYGY TPLMEAAASG
190 200 210 220 230 240
HEIIVQYFLN HGVKVDTRDH SGATACMLAR QFGHMKIVAL METHSPVLPK SLYRSPEKYE
250 260 270 280 290 300
DLSSSDESWP VPQRQRPCRK KGLSIHEGPR ALAKITAIGL GGKTQTTYEQ VPPRGYVTFT
310 320 330 340 350 360
SSDENTMESE GLCYRDVTSP INEQDVESSS SSSREEPTFC ASLGPVWRSS SSDGLARAQG
370 380 390 400 410 420
LSSEASIESN EDSDHARKSS VRKQTRSYLK NKSRHGNSDG HWPSSTGPAS IPGSEPQTEK
430 440 450 460 470 480
SPYSGPQDLA TLLEQIGCLK YLQVFEEQDI DLRIFLTLTE SDLKEIGITL FGPKRKMTSA
490 500 510 520 530 540
IARWHSSARP PSDALELAYA DRLETEMQEL AIQLHKCCEE AEALRGQVSQ EQELRAVVES
550 560 570 580 590 600
CLLEQDSARK DIHAQLQEAQ TLAQDAALVL DQLRACQAEL SARLRQHHSP REGTPNPHFL
610 620 630 640 650
SADSKGWPIP LQALSLPELS GALEDRVHEM GQALCSVTQS LEKLQMLNAK KWREP