Q9CZJ2

PR
Gene name
Hspa12b
Protein name
Heat shock 70 kDa protein 12B
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72630
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CZJ2

Entry ID Method Resolution Chain Position Source
AF-Q9CZJ2-F1 Predicted AlphaFoldDB

33 variants for Q9CZJ2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3410608141 25 S>R No EVA
rs3388592986 36 C>S No EVA
rs3388592981 140 F>I No EVA
rs3388589623 175 H>P No EVA
rs3388596800 208 P>S No EVA
rs3388591834 220 R>K No EVA
rs3388587101 230 S>P No EVA
rs3392210440 259 M>T No EVA
rs3392239803 261 L>Q No EVA
rs3388596808 265 T>I No EVA
rs3388594121 270 R>C No EVA
rs33099956 301 A>S No EVA
rs3388589650 378 R>S No EVA
rs3388589630 431 R>H No EVA
rs3388594124 447 R>W No EVA
rs3392245997 458 Q>H No EVA
rs3392084041 461 V>D No EVA
rs3392281137 462 S>R No EVA
rs3392282113 464 I>F No EVA
rs3392213653 464 I>M No EVA
rs3392139896 465 I>N No EVA
rs232761650 499 V>M No EVA
rs3392251196 524 A>V No EVA
rs3392246019 553 P>R No EVA
rs3388595070 574 F>S No EVA
rs3388596821 587 G>* No EVA
rs3388596757 588 E>D No EVA
rs3388589295 606 I>V No EVA
rs3388592923 625 R>H No EVA
rs242707440 646 S>P No EVA
rs3388594794 650 R>C No EVA
rs3388589293 677 R>W No EVA
rs3388587055 682 F>C No EVA

No associated diseases with Q9CZJ2

5 regional properties for Q9CZJ2

Type Name Position InterPro Accession
domain C2 domain 58 - 183 IPR000008
domain HECT domain 530 - 886 IPR000569
domain WW domain 249 - 282 IPR001202-1
domain WW domain 405 - 438 IPR001202-2
domain WW domain 460 - 493 IPR001202-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

52 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19120 HSPA8 Heat shock cognate 71 kDa protein Bos taurus (Bovine) SS
Q27975 HSPA1A Heat shock 70 kDa protein 1A Bos taurus (Bovine) SS
Q2YDD0 HSPA14 Heat shock 70 kDa protein 14 Bos taurus (Bovine) SS
P0CB32 HSPA1L Heat shock 70 kDa protein 1-like Bos taurus (Bovine) SS
O73885 HSPA8 Heat shock cognate 71 kDa protein Gallus gallus (Chicken) SS
E1C2P3 HSPA14 Heat shock 70 kDa protein 14 Gallus gallus (Chicken) SS
P08106 Heat shock 70 kDa protein Gallus gallus (Chicken) SS
P29843 Hsc70-1 Heat shock 70 kDa protein cognate 1 Drosophila melanogaster (Fruit fly) SS
P02825 Hsp70Ab Major heat shock 70 kDa protein Ab Drosophila melanogaster (Fruit fly) SS
P82910 Hsp70Aa Major heat shock 70 kDa protein Aa Drosophila melanogaster (Fruit fly) SS
Q9VG58 Hsp70Bbb Major heat shock 70 kDa protein Bbb Drosophila melanogaster (Fruit fly) SS
Q9BIR7 Hsp70Bc Major heat shock 70 kDa protein Bc Drosophila melanogaster (Fruit fly) SS
Q8INI8 Hsp70Ba Major heat shock 70 kDa protein Ba Drosophila melanogaster (Fruit fly) SS
Q9BIS2 Hsp70Bb Major heat shock 70 kDa protein Bb Drosophila melanogaster (Fruit fly) SS
P11146 Hsc70-2 Heat shock 70 kDa protein cognate 2 Drosophila melanogaster (Fruit fly) SS
P11147 Hsc70-4 Heat shock 70 kDa protein cognate 4 Drosophila melanogaster (Fruit fly) SS
O97125 Hsp68 Heat shock protein 68 Drosophila melanogaster (Fruit fly) SS
P17066 HSPA6 Heat shock 70 kDa protein 6 Homo sapiens (Human) SS
P0DMV9 HSPA1B Heat shock 70 kDa protein 1B Homo sapiens (Human) SS
P0DMV8 HSPA1A Heat shock 70 kDa protein 1A Homo sapiens (Human) SS
P34931 HSPA1L Heat shock 70 kDa protein 1-like Homo sapiens (Human) SS
Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 Homo sapiens (Human) SS
P54652 HSPA2 Heat shock-related 70 kDa protein 2 Homo sapiens (Human) SS
P11142 HSPA8 Heat shock cognate 71 kDa protein Homo sapiens (Human) EV
O43301 HSPA12A Heat shock 70 kDa protein 12A Homo sapiens (Human) PR
Q96MM6 HSPA12B Heat shock 70 kDa protein 12B Homo sapiens (Human) PR
P11143 HSP70 Heat shock 70 kDa protein Zea mays (Maize) SS
P16627 Hspa1l Heat shock 70 kDa protein 1-like Mus musculus (Mouse) SS
P63017 Hspa8 Heat shock cognate 71 kDa protein Mus musculus (Mouse) SS
Q99M31 Hspa14 Heat shock 70 kDa protein 14 Mus musculus (Mouse) SS
P17156 Hspa2 Heat shock-related 70 kDa protein 2 Mus musculus (Mouse) SS
Q61696 Hspa1a Heat shock 70 kDa protein 1A Mus musculus (Mouse) SS
P17879 Hspa1b Heat shock 70 kDa protein 1B Mus musculus (Mouse) SS
Q8K0U4 Hspa12a Heat shock 70 kDa protein 12A Mus musculus (Mouse) PR
Q6S4N2 HSPA1B Heat shock 70 kDa protein 1B Sus scrofa (Pig) SS
P14659 Hspa2 Heat shock-related 70 kDa protein 2 Rattus norvegicus (Rat) SS
P0DMW1 Hspa1b Heat shock 70 kDa protein 1B Rattus norvegicus (Rat) SS
P0DMW0 Hspa1a Heat shock 70 kDa protein 1A Rattus norvegicus (Rat) SS
P63018 Hspa8 Heat shock cognate 71 kDa protein Rattus norvegicus (Rat) SS
P55063 Hspa1l Heat shock 70 kDa protein 1-like Rattus norvegicus (Rat) SS
P09446 hsp-1 Heat shock protein hsp-1 Caenorhabditis elegans SS
P26413 HSP70 Heat shock 70 kDa protein Glycine max (Soybean) (Glycine hispida) SS
Q9S9N1 HSP70-5 Heat shock 70 kDa protein 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C7X7 HSP70-18 Heat shock 70 kDa protein 18 Arabidopsis thaliana (Mouse-ear cress) SS
O65719 HSP70-3 Heat shock 70 kDa protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LHA8 HSP70-4 Heat shock 70 kDa protein 4 Arabidopsis thaliana (Mouse-ear cress) SS
P22954 HSP70-2 Heat shock 70 kDa protein 2 Arabidopsis thaliana (Mouse-ear cress) SS
P22953 HSP70-1 Heat shock 70 kDa protein 1 Arabidopsis thaliana (Mouse-ear cress) SS
P24629 HSC-I Heat shock cognate 70 kDa protein 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
P27322 HSC-2 Heat shock cognate 70 kDa protein 2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
Q5RGE6 hspa14 Heat shock 70 kDa protein 14 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90473 hspa8 Heat shock cognate 71 kDa protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLTVPEMGLQ GLYISSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE ARALQQASFS
70 80 90 100 110 120
VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH QKTPTCLLLT PEGIFHSFGY
130 140 150 160 170 180
TARDYYHDLD PEEARDWLYF EKFKMKIHSA TDLTLKTQLE AVNGKKMLAL EVFAHALRFF
190 200 210 220 230 240
KEHALQELRE QSECMLEKGA VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS REDAEKLLIA
250 260 270 280 290 300
LEPEAASVYC RKLRLHQLMD LSSRTAGRGR LGERRSIDSS FRHAREQLRR SRHSRTFLVE
310 320 330 340 350 360
AGVGELWAEM QEGDRYMVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP YGAVGVDLAF
370 380 390 400 410 420
EQLLCRIFGE DFIAKFKRQR PAAWVDLTIA FEARKRTAGP HRAGALNISL PFSFIDFYRK
430 440 450 460 470 480
QRGHNVETAL RRSSVNLVKW SSQGMLRMSC EAMNELFQPT VSGIIQHIEM LLAKPEVQGV
490 500 510 520 530 540
KLLFLVGGFA ESAVLQHAVQ EALGTRGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP
550 560 570 580 590 600
LTYGVGVLNR FVPGHHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG
610 620 630 640 650 660
QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPEGCP ENTGTSPSRR EIRAAMQFGD
670 680
TEIKVTAVDV STNRSVRAAI DFLSN