AiPD: Autoinhibited Protein Database

Gene name	Ddx28
Protein name	Probable ATP-dependent RNA helicase DDX28
Names	Mitochondrial DEAD box protein 28
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71986
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

23-100 (Predicted disordered autoinhibitory region) PR

23-100 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9CWT6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389012499	11	A>E	No	EVA
rs3389009579	14	V>L	No	EVA
rs3389004857	17	L>F	No	EVA
rs3389009614	59	P>S	No	EVA
rs3389013349	94	S>F	No	EVA
rs3389000490	122	L>I	No	EVA
rs3389008610	148	V>G	No	EVA
rs3388958604	149	V>L	No	EVA
rs3388958604	149	V>M	No	EVA
rs211773321	153	S>A	No	EVA
rs3399595405	159	I>T	No	EVA
rs3389006160	199	R>C	No	EVA
rs30927572	201	F>S	No	EVA
rs3388983556	202	T>M	No	EVA
rs3389005067	216	A>T	No	EVA
rs3389013387	233	Q>*	No	EVA
rs3388958638	314	A>V	No	EVA
rs3389006144	316	L>I	No	EVA
rs3389009567	343	K>R	No	EVA
rs215719866	389	D>G	No	EVA
rs30927569	392	S>N	No	EVA
rs3389004850	422	I>F	No	EVA
rs3389012452	422	I>T	No	EVA
rs3389005082	439	I>F	No	EVA
rs3389001097	463	S>C	No	EVA
rs3389005025	488	V>SDG*	No	EVA
rs3389004897	490	R>S	No	EVA
rs3388995467	493	S>N	No	EVA
rs3389013356	504	T>I	No	EVA
rs3388989485	508	D>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	377 - 536	IPR001650
domain	DEAD/DEAH box helicase domain	152 - 337	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	147 - 365	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	126 - 156	IPR014014

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus Mitochondrion Mitochondrion matrix, mitochondrion nucleoid Mitochondrion matrix	Transported between these two compartments Nuclear localization depends on active RNA polymerase II transcription Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial nucleoid	The region of a mitochondrion to which the DNA is confined.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
ribonucleoprotein granule	A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.
rRNA binding	Binding to a ribosomal RNA.

Name	Definition
mitochondrial large ribosomal subunit assembly	The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q29S22	DDX47	Probable ATP-dependent RNA helicase DDX47	Bos taurus (Bovine)	PR
Q9H0S4	DDX47	Probable ATP-dependent RNA helicase DDX47	Homo sapiens (Human)	PR
Q9NUL7	DDX28	Probable ATP-dependent RNA helicase DDX28	Homo sapiens (Human)	PR
Q9CWX9	Ddx47	Probable ATP-dependent RNA helicase DDX47	Mus musculus (Mouse)	PR
Q8K363	Ddx18	ATP-dependent RNA helicase DDX18	Mus musculus (Mouse)	PR
Q4FZF3	Ddx49	Probable ATP-dependent RNA helicase DDX49	Mus musculus (Mouse)	PR
Q8K4L0	Ddx54	ATP-dependent RNA helicase DDX54	Mus musculus (Mouse)	PR
Q91VR5	Ddx1	ATP-dependent RNA helicase DDX1	Mus musculus (Mouse)	PR
Q6ZPL9	Ddx55	ATP-dependent RNA helicase DDX55	Mus musculus (Mouse)	PR
Q9ESV0	Ddx24	ATP-dependent RNA helicase DDX24	Mus musculus (Mouse)	PR
P60843	Eif4a1	Eukaryotic initiation factor 4A-I	Mus musculus (Mouse)	PR
P10630	Eif4a2	Eukaryotic initiation factor 4A-II	Mus musculus (Mouse)	PR
Q569Z5	Ddx46	Probable ATP-dependent RNA helicase DDX46	Mus musculus (Mouse)	PR
Q7Y183	RH10	DEAD-box ATP-dependent RNA helicase 10	Oryza sativa subsp japonica (Rice)	PR
P34580	T26G10.1	Putative ATP-dependent RNA helicase T26G10.1	Caenorhabditis elegans	PR
Q8GY84	RH10	DEAD-box ATP-dependent RNA helicase 10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q56X76	RH39	DEAD-box ATP-dependent RNA helicase 39	Arabidopsis thaliana (Mouse-ear cress)	PR