Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CUL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CUL5-F1 | Predicted | AlphaFoldDB |
46 variants for Q9CUL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388486668 | 3 | N>I | No | EVA | |
| rs3388487691 | 10 | W>R | No | EVA | |
| rs3388487742 | 38 | V>F | No | EVA | |
| rs3388487767 | 51 | Q>L | No | EVA | |
| rs3388490116 | 57 | E>V | No | EVA | |
| rs3388486931 | 58 | N>I | No | EVA | |
| rs3388490050 | 74 | K>M | No | EVA | |
| rs3388486661 | 87 | K>M | No | EVA | |
| rs3388487389 | 92 | E>G | No | EVA | |
| rs3388487489 | 120 | P>L | No | EVA | |
| rs3388487390 | 123 | F>V | No | EVA | |
| rs3390228594 | 138 | L>R | No | EVA | |
| rs221262141 | 140 | R>Q | No | EVA | |
| rs3390310416 | 186 | I>S | No | EVA | |
| rs235183888 | 201 | H>Q | No | EVA | |
| rs3388486948 | 235 | V>I | No | EVA | |
| rs3390276470 | 281 | K>RP* | No | EVA | |
| rs3410771089 | 283 | D>V | No | EVA | |
| rs3388486183 | 329 | F>L | No | EVA | |
| rs3388486806 | 336 | Q>* | No | EVA | |
| rs227913634 | 339 | G>E | No | EVA | |
| rs212555369 | 362 | N>K | No | EVA | |
| rs227224298 | 414 | I>M | No | EVA | |
| rs3388487721 | 434 | K>* | No | EVA | |
| rs3388486766 | 465 | N>K | No | EVA | |
| rs240707708 | 483 | I>L | No | EVA | |
| rs30344151 | 508 | I>M | No | EVA | |
| rs238546218 | 528 | K>E | No | EVA | |
| rs3388486322 | 542 | Y>F | No | EVA | |
| rs3388488034 | 576 | I>F | No | EVA | |
| rs3388486801 | 579 | L>M | No | EVA | |
| rs3388486660 | 616 | G>R | No | EVA | |
| rs257819084 | 650 | Q>H | No | EVA | |
| rs3388486992 | 661 | T>S | No | EVA | |
| rs3388486765 | 667 | K>R | No | EVA | |
| rs3390294801 | 700 | I>V | No | EVA | |
| rs3390316149 | 702 | G>W | No | EVA | |
| rs3390297295 | 703 | T>S | No | EVA | |
| rs3390303442 | 716 | C>* | No | EVA | |
| rs3388487439 | 721 | K>R | No | EVA | |
| rs3388486130 | 748 | R>G | No | EVA | |
| rs245244241 | 752 | K>E | No | EVA | |
| rs3388486663 | 822 | Y>N | No | EVA | |
| rs3388486954 | 824 | K>* | No | EVA | |
| rs3388487387 | 830 | K>R | No | EVA | |
| rs3388490056 | 835 | L>P | No | EVA |
No associated diseases with Q9CUL5
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNLMYNKMW | HQTQEALNSL | LDKEFQKMSE | PQANKVLVFQ | MLATFYINYV | QIFRNMENVY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQIVHPQKRM | LIRKVLDGVM | GRILELKNEM | VELEMTEFHY | FDDILQDLKL | SPQQLDVPIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RYFLKERLEV | IKGREKILAR | ILTECGLNLP | VKYAAKSIAL | EEAVKLIQIA | ERARQGRLRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFMKQIFLQE | CRAKEMKLLG | HRLLDTKLAA | LQIQKVWRGF | HQCKKTVKER | EEEMVFLGMK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSPLFNEVSD | AIVQSKQVTN | LRDEVQLKHE | QDYQEALVNI | KEDLKMLEGP | DIKEHLQDQI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RQWFIECRNL | TGTFPDYPNE | EDGGSALIFS | NKTPEQVMGD | IIATQEEEEK | LKKKKKKEDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ENKGKKGKKE | KKEKKEKKVS | LKEKAMKDED | EEWKMSPSLF | LQLMEEGNSL | YKDIWLNKDE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SWNFPQDYDP | ELIKEEKRKE | LEMEIRVQVD | ELMRQELKNL | KLAVNREMEI | PPRQKKGKKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QTIVFPREVF | GNPRVALVSL | HIRALWGISY | LSFNNGTIES | LYQELVEKGL | LIQALKVNLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DYIGEYSYLG | TTLRQVAIEP | MPSLLDVRQL | ITLYGILPLG | SAEVHERAPL | VKSLLLAGPS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GVGKKMLVHA | ICTETGANLF | NLSALNIAGK | YPGKTGLQMM | IHLVFKVARQ | LQPSVVWIQD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TEKTFYKKVP | QAEKRFEPKR | LKRYLPKLLK | LLKPDDRILI | VGTTHRPFDA | ELQPFCRVYQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KIILVPRPDY | ASRYGKFHEV | LWKEIILRNG | GKLTNSLNIS | CLSKVTDGFT | QGQIVQVIKD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VLTERRLRQQ | AHKPLTAIEF | ITMMTNMNPV | YREEEESFKN | WYAKTPLGKK | RVLSLTVGNK |
| 850 | |||||
| EKEKDKGKKG | KRGKKKK |