Q9CAI7
PR
Gene name |
TIF4A-3 (RH23, At1g72730, F28P22.8) |
Protein name |
Eukaryotic initiation factor 4A-3 |
Names |
eIF-4A-3, ATP-dependent RNA helicase eIF4A-3, DEAD-box ATP-dependent RNA helicase 23 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G72730 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CAI7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CAI7-F1 | Predicted | AlphaFoldDB |
14 variants for Q9CAI7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_27379589_G_A | 2 | A>V | No | 1000Genomes | |
| tmp_1_27379526_A_G | 23 | I>T | No | 1000Genomes | |
| ENSVATH14474055 | 31 | T>I | No | 1000Genomes | |
| tmp_1_27379422_G_T | 32 | F>L | No | 1000Genomes | |
| ENSVATH05134076 | 36 | Y>S | No | 1000Genomes | |
| ENSVATH14474041 | 101 | Q>L | No | 1000Genomes | |
| tmp_1_27379059_T_A | 106 | S>C | No | 1000Genomes | |
| tmp_1_27378912_C_G | 155 | V>L | No | 1000Genomes | |
| tmp_1_27378899_C_T | 159 | G>D | No | 1000Genomes | |
| ENSVATH05134073 | 162 | V>I | No | 1000Genomes | |
| ENSVATH05134069 | 237 | N>S | No | 1000Genomes | |
| tmp_1_27378500_T_C | 262 | D>G | No | 1000Genomes | |
| tmp_1_27378393_C_T | 298 | D>N | No | 1000Genomes | |
| ENSVATH13798551 | 309 | A>S | No | 1000Genomes |
No associated diseases with Q9CAI7
5 regional properties for Q9CAI7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 188 - 196 | IPR000629 |
| domain | Helicase, C-terminal | 253 - 414 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 66 - 227 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 60 - 257 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 41 - 69 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| Q41741 | Eukaryotic initiation factor 4A | Zea mays (Maize) | PR | |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| P27639 | inf-1 | Eukaryotic initiation factor 4A | Caenorhabditis elegans | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SA27 | RH36 | DEAD-box ATP-dependent RNA helicase 36 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FVV4 | RH55 | DEAD-box ATP-dependent RNA helicase 55 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80792 | RH33 | Putative DEAD-box ATP-dependent RNA helicase 33 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22907 | RH24 | DEAD-box ATP-dependent RNA helicase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIH9 | RH51 | DEAD-box ATP-dependent RNA helicase 51 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY84 | RH10 | DEAD-box ATP-dependent RNA helicase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FFQ1 | RH31 | DEAD-box ATP-dependent RNA helicase 31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SB89 | RH27 | DEAD-box ATP-dependent RNA helicase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84TG1 | RH57 | DEAD-box ATP-dependent RNA helicase 57 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H0U8 | RH42 | DEAD-box ATP-dependent RNA helicase 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGMASDGTQ | YDPRQFDTKM | NAILGEEGEE | TFYTNYDEVC | DSFDAMELQP | DLLRGIYAYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEKPSAIQQR | GIIPFCKGLD | VIQQAQSGTG | KTATFCSGVL | QQLDISLVQC | QALVLAPTRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAQQIEKVMR | ALGDYLGVKA | QACVGGTSVR | EDQRVLQSGV | HVVVGTPGRV | FDLLRRQSLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADAIKMFVLD | EADEMLSRGF | KDQIYDIFQL | LPSKVQVGVF | SATMPPEALE | ITRKFMNKPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RILVKRDELT | LEGIKQFYVN | VDKEEWKLET | LCDLYETLAI | TQSVIFVNTR | RKVDWLTDKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RSRDHTVSAT | HGDMDQNTRD | IIMREFRSGS | SRVLITTDLL | ARGIDVQQVS | LVINFDLPTQ |
| 370 | 380 | 390 | 400 | 410 | |
| PENYLHRIGR | SGRFGRKGVA | INFMTSEDER | MMADIQRFYN | VVVEELPSNV | ADLL |