AiPD: Autoinhibited Protein Database

Gene name	CDKD-1 (At1g73690, F25P22.11)
Protein name	Cyclin-dependent kinase D-1
Names	CDKD1, CDK-activating kinase 3-At, CAK3-At
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G73690
EC number	2.7.11.22: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

286-398 (Predicted disordered autoinhibitory region) PR

286-398 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9C9U2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH05140559	13	K>R	No	1000Genomes
tmp_1_27715203_A_G	31	T>A	No	1000Genomes
ENSVATH05140560	31	T>I	No	1000Genomes
ENSVATH05140561	32	K>M	No	1000Genomes
tmp_1_27715525_C_A	44	L>I	No	1000Genomes
ENSVATH14477210	51	V>M	No	1000Genomes
tmp_1_27715602_T_A	69	H>Q	No	1000Genomes
tmp_1_27715628_C_G	78	P>R	No	1000Genomes
ENSVATH01532644	101	R>C	No	1000Genomes
ENSVATH05140580	101	R>P	No	1000Genomes
ENSVATH05140583	126	G>D	No	1000Genomes
ENSVATH05140589	144	N>S	No	1000Genomes
tmp_1_27715938_G_T	150	A>S	No	1000Genomes
tmp_1_27716188_C_T	205	R>C	No	1000Genomes
ENSVATH05140598	215	I>L	No	1000Genomes
ENSVATH05140599	254	R>H	No	1000Genomes
tmp_1_27716431_T_A	260	V>D	No	1000Genomes
tmp_1_27716485_C_G	278	S>C	No	1000Genomes
tmp_1_27716515_A_G	288	H>R	No	1000Genomes
ENSVATH05140605	292	T>K	No	1000Genomes
ENSVATH01532646	300	P>T	No	1000Genomes
ENSVATH05140606	313	K>T	No	1000Genomes
tmp_1_27716772_G_T	347	D>Y	No	1000Genomes
ENSVATH00141609	348	Q>H	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	11 - 291	IPR000719
active_site	Serine/threonine-protein kinase, active site	129 - 141	IPR008271
binding_site	Protein kinase, ATP binding site	17 - 41	IPR017441

		Description
EC Number	2.7.11.22	Protein-serine/threonine kinases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIK complex	A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity	Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IZL9	CDK20	Cyclin-dependent kinase 20	Homo sapiens (Human)	PR
Q9JHU3	Cdk20	Cyclin-dependent kinase 20	Mus musculus (Mouse)	PR
Q4KM34	Cdk20	Cyclin-dependent kinase 20	Rattus norvegicus (Rat)	PR
P29620	CDKD-1	Cyclin-dependent kinase D-1	Oryza sativa subsp japonica (Rice)	PR
Q9LMT0	CDKD-3	Cyclin-dependent kinase D-3	Arabidopsis thaliana (Mouse-ear cress)	PR
F4I114	At1g09600	Probable serine/threonine-protein kinase At1g09600	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FGW5	CDKG1	Cyclin-dependent kinase G1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZVM9	At1g54610	Probable serine/threonine-protein kinase At1g54610	Arabidopsis thaliana (Mouse-ear cress)	PR
A8WIP6	cdk20	Cyclin-dependent kinase 20	Danio rerio (Zebrafish) (Brachydanio rerio)	PR