Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

150-173 (Activation loop from InterPro)

Target domain

11-291 (Protein kinase domain)

Relief mechanism

Assay

Autoinhibited structure

Activated structure

1 structures for Q9C9U2

Entry ID Method Resolution Chain Position Source
AF-Q9C9U2-F1 Predicted AlphaFoldDB

24 variants for Q9C9U2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05140559 13 K>R No 1000Genomes
tmp_1_27715203_A_G 31 T>A No 1000Genomes
ENSVATH05140560 31 T>I No 1000Genomes
ENSVATH05140561 32 K>M No 1000Genomes
tmp_1_27715525_C_A 44 L>I No 1000Genomes
ENSVATH14477210 51 V>M No 1000Genomes
tmp_1_27715602_T_A 69 H>Q No 1000Genomes
tmp_1_27715628_C_G 78 P>R No 1000Genomes
ENSVATH01532644 101 R>C No 1000Genomes
ENSVATH05140580 101 R>P No 1000Genomes
ENSVATH05140583 126 G>D No 1000Genomes
ENSVATH05140589 144 N>S No 1000Genomes
tmp_1_27715938_G_T 150 A>S No 1000Genomes
tmp_1_27716188_C_T 205 R>C No 1000Genomes
ENSVATH05140598 215 I>L No 1000Genomes
ENSVATH05140599 254 R>H No 1000Genomes
tmp_1_27716431_T_A 260 V>D No 1000Genomes
tmp_1_27716485_C_G 278 S>C No 1000Genomes
tmp_1_27716515_A_G 288 H>R No 1000Genomes
ENSVATH05140605 292 T>K No 1000Genomes
ENSVATH01532646 300 P>T No 1000Genomes
ENSVATH05140606 313 K>T No 1000Genomes
tmp_1_27716772_G_T 347 D>Y No 1000Genomes
ENSVATH00141609 348 Q>H No 1000Genomes

No associated diseases with Q9C9U2

3 regional properties for Q9C9U2

Type Name Position InterPro Accession
domain Protein kinase domain 11 - 291 IPR000719
active_site Serine/threonine-protein kinase, active site 129 - 141 IPR008271
binding_site Protein kinase, ATP binding site 17 - 41 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZL9 CDK20 Cyclin-dependent kinase 20 Homo sapiens (Human) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
P29620 CDKD-1 Cyclin-dependent kinase D-1 Oryza sativa subsp japonica (Rice) PR
Q9LMT0 CDKD-3 Cyclin-dependent kinase D-3 Arabidopsis thaliana (Mouse-ear cress) PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVM9 At1g54610 Probable serine/threonine-protein kinase At1g54610 Arabidopsis thaliana (Mouse-ear cress) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEQPKKVADR YLKREVLGQG TYGVVFKATD TKNGETVAIK KIRLGKEKEG VNVTALREIK
70 80 90 100 110 120
LLKELKHPHI IELIDAFPHK ENLHIVFEFM ETDLEAVIRD RNLYLSPGDV KSYLQMILKG
130 140 150 160 170 180
LEYCHGKWVL HRDMKPNNLL IGPNGQLKLA DFGLARIFGS PGRKFTHQVF ARWYRAPELL
190 200 210 220 230 240
FGAKQYDGAV DVWAAGCIFA ELLLRRPFLQ GNSDIDQLSK IFAAFGTPKA DQWPDMICLP
250 260 270 280 290 300
DYVEYQFVPA PSLRSLLPTV SEDALDLLSK MFTYDPKSRI SIQQALKHRY FTSAPSPTDP
310 320 330 340 350 360
LKLPRPVSKQ DAKSSDSKLE AIKVLSPAHK FRRVMPDRGK SGNGFKDQSV DVMRQASHDG
370 380 390
QAPMSLDFTI LAERPPNRPT ITSADRSHLK RKLDLEFL