Q9C9U2
Gene name |
CDKD-1 (At1g73690, F25P22.11) |
Protein name |
Cyclin-dependent kinase D-1 |
Names |
CDKD1, CDK-activating kinase 3-At, CAK3-At |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G73690 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
150-173 (Activation loop from InterPro)
Target domain |
11-291 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for Q9C9U2
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q9C9U2-F1 | Predicted | AlphaFoldDB |
24 variants for Q9C9U2
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
ENSVATH05140559 | 13 | K>R | No | 1000Genomes | |
tmp_1_27715203_A_G | 31 | T>A | No | 1000Genomes | |
ENSVATH05140560 | 31 | T>I | No | 1000Genomes | |
ENSVATH05140561 | 32 | K>M | No | 1000Genomes | |
tmp_1_27715525_C_A | 44 | L>I | No | 1000Genomes | |
ENSVATH14477210 | 51 | V>M | No | 1000Genomes | |
tmp_1_27715602_T_A | 69 | H>Q | No | 1000Genomes | |
tmp_1_27715628_C_G | 78 | P>R | No | 1000Genomes | |
ENSVATH01532644 | 101 | R>C | No | 1000Genomes | |
ENSVATH05140580 | 101 | R>P | No | 1000Genomes | |
ENSVATH05140583 | 126 | G>D | No | 1000Genomes | |
ENSVATH05140589 | 144 | N>S | No | 1000Genomes | |
tmp_1_27715938_G_T | 150 | A>S | No | 1000Genomes | |
tmp_1_27716188_C_T | 205 | R>C | No | 1000Genomes | |
ENSVATH05140598 | 215 | I>L | No | 1000Genomes | |
ENSVATH05140599 | 254 | R>H | No | 1000Genomes | |
tmp_1_27716431_T_A | 260 | V>D | No | 1000Genomes | |
tmp_1_27716485_C_G | 278 | S>C | No | 1000Genomes | |
tmp_1_27716515_A_G | 288 | H>R | No | 1000Genomes | |
ENSVATH05140605 | 292 | T>K | No | 1000Genomes | |
ENSVATH01532646 | 300 | P>T | No | 1000Genomes | |
ENSVATH05140606 | 313 | K>T | No | 1000Genomes | |
tmp_1_27716772_G_T | 347 | D>Y | No | 1000Genomes | |
ENSVATH00141609 | 348 | Q>H | No | 1000Genomes |
No associated diseases with Q9C9U2
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
3 GO annotations of cellular component
Name | Definition |
---|---|
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
transcription factor TFIIK complex | A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. |
4 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. |
4 GO annotations of biological process
Name | Definition |
---|---|
cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
9 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q8IZL9 | CDK20 | Cyclin-dependent kinase 20 | Homo sapiens (Human) | PR |
Q9JHU3 | Cdk20 | Cyclin-dependent kinase 20 | Mus musculus (Mouse) | PR |
Q4KM34 | Cdk20 | Cyclin-dependent kinase 20 | Rattus norvegicus (Rat) | PR |
P29620 | CDKD-1 | Cyclin-dependent kinase D-1 | Oryza sativa subsp japonica (Rice) | PR |
Q9LMT0 | CDKD-3 | Cyclin-dependent kinase D-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
F4I114 | At1g09600 | Probable serine/threonine-protein kinase At1g09600 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q9FGW5 | CDKG1 | Cyclin-dependent kinase G1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q9ZVM9 | At1g54610 | Probable serine/threonine-protein kinase At1g54610 | Arabidopsis thaliana (Mouse-ear cress) | PR |
A8WIP6 | cdk20 | Cyclin-dependent kinase 20 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MEQPKKVADR | YLKREVLGQG | TYGVVFKATD | TKNGETVAIK | KIRLGKEKEG | VNVTALREIK |
70 | 80 | 90 | 100 | 110 | 120 |
LLKELKHPHI | IELIDAFPHK | ENLHIVFEFM | ETDLEAVIRD | RNLYLSPGDV | KSYLQMILKG |
130 | 140 | 150 | 160 | 170 | 180 |
LEYCHGKWVL | HRDMKPNNLL | IGPNGQLKLA | DFGLARIFGS | PGRKFTHQVF | ARWYRAPELL |
190 | 200 | 210 | 220 | 230 | 240 |
FGAKQYDGAV | DVWAAGCIFA | ELLLRRPFLQ | GNSDIDQLSK | IFAAFGTPKA | DQWPDMICLP |
250 | 260 | 270 | 280 | 290 | 300 |
DYVEYQFVPA | PSLRSLLPTV | SEDALDLLSK | MFTYDPKSRI | SIQQALKHRY | FTSAPSPTDP |
310 | 320 | 330 | 340 | 350 | 360 |
LKLPRPVSKQ | DAKSSDSKLE | AIKVLSPAHK | FRRVMPDRGK | SGNGFKDQSV | DVMRQASHDG |
370 | 380 | 390 | |||
QAPMSLDFTI | LAERPPNRPT | ITSADRSHLK | RKLDLEFL |