Q9C8H0

PR
Gene name
ABCC12 (MRP12, MRP13, At1g30410, T4K22.13)
Protein name
ABC transporter C family member 12
Names
ABC transporter ABCC.12, AtABCC12, ATP-energized glutathione S-conjugate pump 13, Glutathione S-conjugate-transporting ATPase 13, Multidrug resistance-associated protein 13
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G30410
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

824-908 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C8H0

Entry ID Method Resolution Chain Position Source
AF-Q9C8H0-F1 Predicted AlphaFoldDB

105 variants for Q9C8H0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_10739394_T_C 13 V>A No 1000Genomes
ENSVATH00051993 21 A>E No 1000Genomes
ENSVATH00051994 23 D>V No 1000Genomes
tmp_1_10739514_G_A 53 R>Q No 1000Genomes
tmp_1_10739522_A_G 56 I>V No 1000Genomes
tmp_1_10739535_A_C 60 N>T No 1000Genomes
ENSVATH12385924 61 T>A No 1000Genomes
tmp_1_10739570_T_A 72 Y>N No 1000Genomes
ENSVATH12386075 79 L>S No 1000Genomes
ENSVATH14009830 98 L>F No 1000Genomes
ENSVATH04675637 101 M>V No 1000Genomes
ENSVATH12386078 122 W>C No 1000Genomes
tmp_1_10739865_C_G 126 L>V No 1000Genomes
ENSVATH00051996 135 Q>K No 1000Genomes
tmp_1_10739920_T_C 144 V>A No 1000Genomes
ENSVATH04675641 147 G>S No 1000Genomes
tmp_1_10739978_G_C 163 L>F No 1000Genomes
tmp_1_10739976_T_G 163 L>V No 1000Genomes
ENSVATH04675648 198 L>M No 1000Genomes
ENSVATH00051997 209 N>D No 1000Genomes
ENSVATH01129603 214 N>S No 1000Genomes
ENSVATH14009833 230 R>L No 1000Genomes
ENSVATH14009833 230 R>Q No 1000Genomes
tmp_1_10740650_A_G 238 I>V No 1000Genomes
tmp_1_10740695_A_C 253 K>Q No 1000Genomes
ENSVATH07534620 261 W>* No 1000Genomes
tmp_1_10740759_A_G 274 K>R No 1000Genomes
tmp_1_10740894_C_T 285 R>W No 1000Genomes
tmp_1_10740930_A_G 297 N>D No 1000Genomes
tmp_1_10741058_T_C 303 F>S No 1000Genomes
tmp_1_10741282_C_T 326 H>Y No 1000Genomes
tmp_1_10741628_T_G 335 D>E No 1000Genomes
tmp_1_10741636_G_T 338 W>L No 1000Genomes
ENSVATH12386084 338 W>R No 1000Genomes
ENSVATH04675665 391 A>G No 1000Genomes
tmp_1_10742016_C_G 392 R>G No 1000Genomes
tmp_1_10742044_C_A 401 T>K No 1000Genomes
tmp_1_10742201_G_T 427 R>L No 1000Genomes
tmp_1_10742249_C_T 443 S>L No 1000Genomes
ENSVATH12386229 444 L>P No 1000Genomes
ENSVATH12386232 480 G>S No 1000Genomes
ENSVATH12386308 550 G>E No 1000Genomes
ENSVATH12386309 551 D>E No 1000Genomes
ENSVATH12386311 581 V>I No 1000Genomes
ENSVATH14009850 592 E>G No 1000Genomes
ENSVATH12386312 598 E>D No 1000Genomes
ENSVATH04675677 607 P>S No 1000Genomes
tmp_1_10743168_G_C 611 G>A No 1000Genomes
tmp_1_10743171_C_T 612 T>I No 1000Genomes
ENSVATH04675678 619 N>D No 1000Genomes
ENSVATH04675678 619 N>Y No 1000Genomes
tmp_1_10743343_C_T 631 P>L No 1000Genomes
ENSVATH04675679 641 P>S No 1000Genomes
ENSVATH12386375 644 T>S No 1000Genomes
ENSVATH04675680 660 I>L No 1000Genomes
ENSVATH00052004 680 S>A No 1000Genomes
tmp_1_10743490_C_T 680 S>F No 1000Genomes
tmp_1_10743522_T_G 691 F>V No 1000Genomes
tmp_1_10743698_T_G 704 D>E No 1000Genomes
tmp_1_10743733_C_T 716 A>V No 1000Genomes
tmp_1_10743762_C_T 726 L>F No 1000Genomes
ENSVATH04675687 769 S>N No 1000Genomes
ENSVATH01129616 787 E>G No 1000Genomes
ENSVATH14009907 817 I>V No 1000Genomes
ENSVATH01129617 829 S>C No 1000Genomes
tmp_1_10744344_G_T 834 K>N No 1000Genomes
ENSVATH14009908 838 E>A No 1000Genomes
ENSVATH14009909 842 K>Q No 1000Genomes
ENSVATH01129618 853 D>Y No 1000Genomes
ENSVATH01129619 857 L>M No 1000Genomes
ENSVATH00052006 859 L>P No 1000Genomes
ENSVATH04675692 862 T>I No 1000Genomes
ENSVATH04675692 862 T>S No 1000Genomes
tmp_1_10744433_C_T 864 T>M No 1000Genomes
ENSVATH14009912 866 D>N No 1000Genomes
ENSVATH12386382 877 Q>* No 1000Genomes
ENSVATH00052007 886 I>V No 1000Genomes
tmp_1_10744502_A_T 887 K>M No 1000Genomes
tmp_1_10744539_T_G 899 N>K No 1000Genomes
ENSVATH04675695 922 L>V No 1000Genomes
ENSVATH04675696 927 L>F No 1000Genomes
tmp_1_10745021_C_T 977 S>L No 1000Genomes
ENSVATH14009914 981 A>S No 1000Genomes
ENSVATH14009935 1027 L>I No 1000Genomes
tmp_1_10745509_A_T 1108 Y>F No 1000Genomes
ENSVATH12386579 1109 D>G No 1000Genomes
tmp_1_10745514_C_T 1110 R>W No 1000Genomes
tmp_1_10745748_G_A 1188 G>S No 1000Genomes
ENSVATH04675704 1208 N>S No 1000Genomes
ENSVATH12386580 1218 D>N No 1000Genomes
ENSVATH14009939 1241 H>Y No 1000Genomes
ENSVATH01129627 1243 R>H No 1000Genomes
tmp_1_10746052_A_G 1289 E>G No 1000Genomes
ENSVATH12386581 1292 R>T No 1000Genomes
tmp_1_10746066_A_T 1294 M>L No 1000Genomes
tmp_1_10746103_C_A 1306 T>K No 1000Genomes
ENSVATH12386582 1308 V>L No 1000Genomes
tmp_1_10746260_T_C 1330 I>T No 1000Genomes
tmp_1_10746285_T_A 1338 D>E No 1000Genomes
ENSVATH01129629 1340 G>D No 1000Genomes
tmp_1_10746289_G_C 1340 G>R No 1000Genomes
ENSVATH04675712 1419 K>N No 1000Genomes
tmp_1_10746743_T_G 1444 S>A No 1000Genomes
ENSVATH04675717 1465 F>Y No 1000Genomes
ENSVATH04675720 1492 S>N No 1000Genomes

No associated diseases with Q9C8H0

10 regional properties for Q9C8H0

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 615 - 839 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1235 - 1469 IPR003439-2
domain AAA+ ATPase domain 642 - 823 IPR003593-1
domain AAA+ ATPase domain 1261 - 1454 IPR003593-2
domain ABC transporter type 1, transmembrane domain 304 - 583 IPR011527-1
domain ABC transporter type 1, transmembrane domain 915 - 1198 IPR011527-2
conserved_site ABC transporter-like, conserved site 741 - 755 IPR017871-1
conserved_site ABC transporter-like, conserved site 1372 - 1386 IPR017871-2
domain ABC transporter C family, six-transmembrane helical domain 2 914 - 1210 IPR044726
domain ABC transporter C family, six-transmembrane helical domain 1 305 - 591 IPR044746

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

1 GO annotations of biological process

Name Definition
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38735 VMR1 ABC transporter ATP-binding protein/permease VMR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0CE68 NFT1 ABC transporter NFT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
Q6UR05 ABCC1 Multidrug resistance-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGFEALNWYC KPVADGFWEK AVDGAFGAYT PCAIDSLVML VSHFVLLGLC FYRIWIIFHN
70 80 90 100 110 120
TKAQIYVLRK KYYNCVLGLL ACYCVVEPVL RLVMGISLFD MDEETDFPPF EVASLMVEAF
130 140 150 160 170 180
AWFSMLVLIG LETKQYVKEF RWYVRFGVLY VLVADAVLLD LVLPLKNSIN RTALYLFISS
190 200 210 220 230 240
RCSQALFGIL LLIYIPELDP YPGYHIVNNE PLDNVEYDAL RGGEHICPER HASIFSRIYF
250 260 270 280 290 300
GWITPLMQLG YRKPITEKDV WQLDKWDQTE TLIKRFQRCW TEESRRPKPW LLRALNNSLG
310 320 330 340 350 360
GRFWLAGIFK IGNDLSQFVG PVILSHLLRS MQEGDPAWVG YVYAFIIFVG VTLGVLCEAQ
370 380 390 400 410 420
YFQNVWRVGF RLRSTLVAAI FHKSLRLTHE ARKNFASGKV TNMITTDANA LQQISQQLHG
430 440 450 460 470 480
LWSAPFRIIV SMILLYQQLG VASLFGSLIL FLLIPLQTLI ISKMRKLTKE GLQWTDKRVG
490 500 510 520 530 540
ITNEILSSMD TVKCYAWEKS FESRIQGIRN EELSWFRKAQ LLSAFNSFIL NSIPVVVTVV
550 560 570 580 590 600
SFGVFVLLGG DLTPARAFTS LSLFAVLRFP LNMLPNLLSQ VVNANVSLQR IEELLLSEER
610 620 630 640 650 660
ILAQNPPLQP GTPAISIKNG YFSWDSKTTK PTLSDINLEI PVGTLVAIVG GTGEGKTSLI
670 680 690 700 710 720
SAMLGELSHA ETTSVVIRGS VAYVPQVSWI FNATVRENIL FGSDFESERY WRAIDATALQ
730 740 750 760 770 780
HDLDLLPGRD LTEIGERGVN ISGGQKQRVS MARAVYSNSD VYIFDDPLSA LDAHVAHQVF
790 800 810 820 830 840
DSCMKDELRG KTRVLVTNQL HFLPLMDKII LVSEGMIKEE GTFVELSKSG ILFKKLMENA
850 860 870 880 890 900
GKMDATQEVN TNDENILKLG PTVTVDVSER NLGSTKQGKR RRSVLIKQEE RETGIISWNV
910 920 930 940 950 960
LMRYKEAVGG LWVVMILLAC YLATEVLRVS SSTWLSIWTD QSTSKNYSPG FYIVVYALLG
970 980 990 1000 1010 1020
FGQVAVTFTN SFWLITSSLH AARRLHDAML SSILRAPMLF FHTNPTGRVI NRFSKDIGDI
1030 1040 1050 1060 1070 1080
DRNVANLMNM FMNQLWQLLS TFALIGTVST ISLWAIMPLL ILFYAAYLYY QSTSREVRRL
1090 1100 1110 1120 1130 1140
DSVTRSPIYA QFGEALNGLS SIRAYKAYDR MAKINGKSMD NNIRFTLANT SSNRWLTIRL
1150 1160 1170 1180 1190 1200
ETLGGVMIWL TATFAVLQNG NTNNQAGFAS TMGLLLSYTL NITSLLSGVL RQASRAENSL
1210 1220 1230 1240 1250 1260
NSVERVGNYI DLPSEATDII ENNRPVCGWP SGGSIKFEDV HLRYRPGLPP VLHGLTFFVS
1270 1280 1290 1300 1310 1320
PSEKVGVVGR TGAGKSSMLN ALFRIVEVEK GRIMIDDCDV AKFGLTDVRR VLSIIPQSPV
1330 1340 1350 1360 1370 1380
LFSGTVRFNI DPFSEHNDAG LWEALHRAHI KDVISRNPFG LDAEVCEGGE NFSVGQRQLL
1390 1400 1410 1420 1430 1440
SLARALLRRS KILVLDEATA SVDVRTDSLI QRTIREEFKS CTMLVIAHRL NTIIDCDKIL
1450 1460 1470 1480 1490
VLSSGQVLEY DSPQELLSRD TSAFFRMVHS TGPANAQYLS NLVFERRENG MSVGG