Q9C8G9

PR
Gene name
ABCC1 (EST1, MRP1, At1g30400, T4K22.12)
Protein name
ABC transporter C family member 1
Names
ABC transporter ABCC.1, AtABCC1, ATP-energized glutathione S-conjugate pump 1, Glutathione S-conjugate-transporting ATPase 1, Multidrug resistance-associated protein 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G30400
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

826-895 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C8G9

Entry ID Method Resolution Chain Position Source
AF-Q9C8G9-F1 Predicted AlphaFoldDB

56 variants for Q9C8G9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04675522 41 I>N No 1000Genomes
tmp_1_10728269_T_C 44 L>P No 1000Genomes
tmp_1_10728321_C_A 61 H>Q No 1000Genomes
ENSVATH04675524 63 V>M No 1000Genomes
tmp_1_10728395_C_G 86 A>G No 1000Genomes
tmp_1_10728421_A_G 95 R>G No 1000Genomes
tmp_1_10728562_C_T 111 A>V No 1000Genomes
ENSVATH14009695 134 T>K No 1000Genomes
tmp_1_10728642_G_A 138 E>K No 1000Genomes
ENSVATH04675531 200 Y>F No 1000Genomes
tmp_1_10729107_C_T 219 L>F No 1000Genomes
tmp_1_10729658_G_A 263 D>N No 1000Genomes
ENSVATH14009700 270 T>I No 1000Genomes
tmp_1_10729781_G_T 276 Q>H No 1000Genomes
ENSVATH04675538 278 S>Y No 1000Genomes
tmp_1_10731321_C_T 407 A>V No 1000Genomes
tmp_1_10732267_A_G 517 K>R No 1000Genomes
tmp_1_10733308_C_T 661 A>V No 1000Genomes
tmp_1_10733576_G_A 695 R>H No 1000Genomes
ENSVATH04675572 710 E>K No 1000Genomes
tmp_1_10734269_G_C 798 Q>H No 1000Genomes
ENSVATH12385548 822 Y>H No 1000Genomes
ENSVATH04675577 849 N>S No 1000Genomes
tmp_1_10734444_A_G 857 T>A No 1000Genomes
tmp_1_10734468_G_A 865 G>R No 1000Genomes
ENSVATH12385550 875 I>T No 1000Genomes
ENSVATH12385551 878 K>N No 1000Genomes
ENSVATH01129570 883 G>A No 1000Genomes
tmp_1_10734531_G_A 886 V>I No 1000Genomes
tmp_1_10734549_G_A 892 E>K No 1000Genomes
ENSVATH12385552 904 E>K No 1000Genomes
tmp_1_10735334_G_A 998 A>T No 1000Genomes
ENSVATH01129574 1038 A>T No 1000Genomes
tmp_1_10735554_A_T 1071 Y>F No 1000Genomes
ENSVATH14009762 1111 D>E No 1000Genomes
ENSVATH04675588 1131 N>Y No 1000Genomes
tmp_1_10736131_C_T 1219 P>S No 1000Genomes
tmp_1_10736153_G_A 1226 R>H No 1000Genomes
tmp_1_10736188_A_C 1238 K>Q No 1000Genomes
tmp_1_10736266_A_G 1264 M>V No 1000Genomes
tmp_1_10736376_C_G 1300 C>W No 1000Genomes
ENSVATH04675591 1310 L>V No 1000Genomes
tmp_1_10736603_C_T 1341 A>V No 1000Genomes
ENSVATH12385624 1366 E>D No 1000Genomes
ENSVATH12385705 1387 A>P No 1000Genomes
ENSVATH04675601 1454 S>L No 1000Genomes
ENSVATH12385706 1490 R>C No 1000Genomes
ENSVATH04675602 1496 G>D No 1000Genomes
ENSVATH04675603 1509 Q>R No 1000Genomes
tmp_1_10737355_G_A 1540 D>N No 1000Genomes
ENSVATH12385708 1556 R>G No 1000Genomes
ENSVATH12385709 1557 S>N No 1000Genomes
tmp_1_10737436_A_G 1567 I>V No 1000Genomes
tmp_1_10737602_C_T 1592 L>F No 1000Genomes
tmp_1_10737630_A_G 1601 N>S No 1000Genomes
tmp_1_10737654_A_G 1609 N>S No 1000Genomes

No associated diseases with Q9C8G9

2 regional properties for Q9C8G9

Type Name Position InterPro Accession
domain SOCS box domain 175 - 228 IPR001496
domain Small GTP-binding protein domain 16 - 156 IPR005225

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
  • Tonoplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

7 GO annotations of molecular function

Name Definition
(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other.
ABC-type phytochelatin transporter activity Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes.
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled arsenite transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out).
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

4 GO annotations of biological process

Name Definition
(+)-abscisic acid D-glucopyranosyl ester transmembrane transport The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane.
arsenite transport The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to arsenic-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38735 VMR1 ABC transporter ATP-binding protein/permease VMR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0CE68 NFT1 ABC transporter NFT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
Q6UR05 ABCC1 Multidrug resistance-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGFEPLDWYC KPVPNGVWTK TVDYAFGAYT PCAIDSFVLG ISHLVLLILC LYRLWLITKD
70 80 90 100 110 120
HKVDKFCLRS KWFSYFLALL AAYATAEPLF RLVMRISVLD LDGAGFPPYE AFMLVLEAFA
130 140 150 160 170 180
WGSALVMTVV ETKTYIHELR WYVRFAVIYA LVGDMVLLNL VLSVKEYYGS FKLYLYISEV
190 200 210 220 230 240
AVQVAFGTLL FVYFPNLDPY PGYTPVGTEN SEDYEYEELP GGENICPERH ANLFDSIFFS
250 260 270 280 290 300
WLNPLMTLGS KRPLTEKDVW HLDTWDKTET LMRSFQKSWD KELEKPKPWL LRALNNSLGG
310 320 330 340 350 360
RFWWGGFWKI GNDCSQFVGP LLLNELLKSM QLNEPAWIGY IYAISIFVGV VLGVLCEAQY
370 380 390 400 410 420
FQNVMRVGYR LRSALIAAVF RKSLRLTNEG RKKFQTGKIT NLMTTDAESL QQICQSLHTM
430 440 450 460 470 480
WSAPFRIIVA LVLLYQQLGV ASIIGALFLV LMFPIQTVII SKTQKLTKEG LQRTDKRIGL
490 500 510 520 530 540
MNEVLAAMDT VKCYAWENSF QSKVQTVRDD ELSWFRKAQL LSAFNMFILN SIPVLVTVVS
550 560 570 580 590 600
FGVFSLLGGD LTPARAFTSL SLFSVLRFPL FMLPNIITQM VNANVSLNRL EEVLSTEERV
610 620 630 640 650 660
LLPNPPIEPG QPAISIRNGY FSWDSKADRP TLSNINLDIP LGSLVAVVGS TGEGKTSLIS
670 680 690 700 710 720
AMLGELPARS DATVTLRGSV AYVPQVSWIF NATVRDNILF GAPFDQEKYE RVIDVTALQH
730 740 750 760 770 780
DLELLPGGDL TEIGERGVNI SGGQKQRVSM ARAVYSNSDV CILDDPLSAL DAHVGQQVFE
790 800 810 820 830 840
KCIKRELGQT TRVLVTNQLH FLSQVDKILL VHEGTVKEEG TYEELCHSGP LFQRLMENAG
850 860 870 880 890 900
KVEDYSEENG EAEVDQTSVK PVENGNANNL QKDGIETKNS KEGNSVLVKR EERETGVVSW
910 920 930 940 950 960
KVLERYQNAL GGAWVVMMLV ICYVLTQVFR VSSSTWLSEW TDSGTPKTHG PLFYNIVYAL
970 980 990 1000 1010 1020
LSFGQVSVTL INSYWLIMSS LYAAKKMHDA MLGSILRAPM VFFQTNPLGR IINRFAKDMG
1030 1040 1050 1060 1070 1080
DIDRTVAVFV NMFMGSIAQL LSTVILIGIV STLSLWAIMP LLVVFYGAYL YYQNTSREIK
1090 1100 1110 1120 1130 1140
RMDSTTRSPV YAQFGEALNG LSSIRAYKAY DRMAEINGRS MDNNIRFTLV NMAANRWLGI
1150 1160 1170 1180 1190 1200
RLEVLGGLMV WLTASLAVMQ NGKAANQQAY ASTMGLLLSY ALSITSSLTA VLRLASLAEN
1210 1220 1230 1240 1250 1260
SLNSVERVGN YIEIPSEAPL VIENNRPPPG WPSSGSIKFE DVVLRYRPEL PPVLHGVSFL
1270 1280 1290 1300 1310 1320
ISPMDKVGIV GRTGAGKSSL LNALFRIVEL EKGRILIDEC DIGRFGLMDL RKVLGIIPQA
1330 1340 1350 1360 1370 1380
PVLFSGTVRF NLDPFSEHND ADLWESLERA HLKDTIRRNP LGLDAEVTEA GENFSVGQRQ
1390 1400 1410 1420 1430 1440
LLSLARALLR RSKILVLDEA TAAVDVRTDV LIQKTIREEF KSCTMLIIAH RLNTIIDCDK
1450 1460 1470 1480 1490 1500
VLVLDSGKVQ EFSSPENLLS NGESSFSKMV QSTGTANAEY LRSITLENKR TREANGDDSQ
1510 1520 1530 1540 1550 1560
PLEGQRKWQA SSRWAAAAQF ALAVSLTSSH NDLQSLEIED DNSILKKTKD AVVTLRSVLE
1570 1580 1590 1600 1610 1620
GKHDKEIEDS LNQSDISRER WWPSLYKMVE GLAVMSRLAR NRMQHPDYNL EGKSFDWDNV
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