Q9C7X7

SS
Gene name
HSP70-18 (HSP70T-1, At1g56410, F13N6.9)
Protein name
Heat shock 70 kDa protein 18
Names
Heat shock protein 70-18 , AtHsp70-18 , Heat-shock protein 70T-1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G56410
EC number
Protein Class

Descriptions

HSPA8 (or hsc70) is a heat shock cognate protein involved in many cellular processes. During recovery from stress, HSPA8, initially accumulating in the nucleoplasm for folding/refolding of proteins, transiently concentrates in nucleoli for nucleolar morphology and function restoration. The inhibitory region is positioned at one of the three domains of HSPA8 protein, which is the N-terminal ATPase domain, specifically in residues 263-287 of domain IIB. Under normal growth conditions, the constitutive nucleolar targeting function that is provided by residues 225-262 is diminished by the autoinhibitory element located in residues 263-287. When cells recover from stress, the autoinhibitory element is inactivated, and the constitutive nucleolar targeting function restores.

Autoinhibitory domains (AIDs)

269-293 (Autoinhibitory region) SS

Target domain

231-268 (Nucleolar targeting region)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C7X7

Entry ID Method Resolution Chain Position Source
AF-Q9C7X7-F1 Predicted AlphaFoldDB

95 variants for Q9C7X7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14332118 3 G>C No 1000Genomes
ENSVATH13596358 4 K>N No 1000Genomes
ENSVATH04977629 7 G>A No 1000Genomes
ENSVATH04977631 35 D>N No 1000Genomes
ENSVATH13596365 41 T>R No 1000Genomes
ENSVATH04977632 49 D>E No 1000Genomes
tmp_1_21117305_G_T 53 L>F No 1000Genomes
tmp_1_21117330_G_C 62 V>L No 1000Genomes
ENSVATH13596387 86 V>F No 1000Genomes
ENSVATH14332124 100 G>R No 1000Genomes
ENSVATH14332145 101 Q>K No 1000Genomes
ENSVATH00101032 102 A>V No 1000Genomes
ENSVATH01379463 108 F>L No 1000Genomes
ENSVATH04977648 115 E>* No 1000Genomes
ENSVATH04977648 115 E>K No 1000Genomes
ENSVATH13596388 120 A>S No 1000Genomes
ENSVATH13596388 120 A>T No 1000Genomes
ENSVATH13596389 124 S>Y No 1000Genomes
ENSVATH00101033 129 I>T No 1000Genomes
tmp_1_21117776_A_C 130 K>T No 1000Genomes
ENSVATH04977650 140 G>C No 1000Genomes
ENSVATH04977650 140 G>R No 1000Genomes
ENSVATH14332146 152 A>S No 1000Genomes
ENSVATH13596391 167 V>M No 1000Genomes
ENSVATH04977651 176 I>F No 1000Genomes
ENSVATH00101035 194 T>S No 1000Genomes
tmp_1_21118048_G_C 221 G>R No 1000Genomes
ENSVATH04977656 234 L>P No 1000Genomes
tmp_1_21118130_T_C,A 248 V>A No 1000Genomes
tmp_1_21118130_T_C,A 248 V>D No 1000Genomes
tmp_1_21118172_A_C 262 D>A No 1000Genomes
ENSVATH04977660 263 A>T No 1000Genomes
tmp_1_21118178_G_A 264 R>K No 1000Genomes
ENSVATH13596405 265 A>S No 1000Genomes
ENSVATH13596406 265 A>V No 1000Genomes
ENSVATH14332149 284 A>T No 1000Genomes
tmp_1_21118240_C_A 285 Q>K No 1000Genomes
tmp_1_21118273_G_A 296 G>R No 1000Genomes
ENSVATH14332151 299 F>L No 1000Genomes
ENSVATH04977662 311 M>I No 1000Genomes
ENSVATH01379467 317 R>K No 1000Genomes
tmp_1_21118342_T_A 319 C>S No 1000Genomes
tmp_1_21118347_G_A 320 M>I No 1000Genomes
ENSVATH04977665 328 R>C No 1000Genomes
tmp_1_21118374_C_A 329 D>E No 1000Genomes
tmp_1_21118382_T_A 332 M>K No 1000Genomes
tmp_1_21118408_G_T 341 V>F No 1000Genomes
tmp_1_21118417_G_T 344 G>C No 1000Genomes
tmp_1_21118424_C_A 346 S>Y No 1000Genomes
ENSVATH00101038 348 R>H No 1000Genomes
tmp_1_21118440_A_T 351 K>N No 1000Genomes
ENSVATH14332153 355 L>F No 1000Genomes
ENSVATH00101039 363 K>Q No 1000Genomes
ENSVATH01379468 365 L>P No 1000Genomes
ENSVATH04977668 368 S>F No 1000Genomes
tmp_1_21118505_A_C 373 E>A No 1000Genomes
ENSVATH14332154 377 Y>C No 1000Genomes
ENSVATH13596410 382 Q>E No 1000Genomes
tmp_1_21118555_G_T 390 G>W No 1000Genomes
ENSVATH04977669 395 Q>* No 1000Genomes
tmp_1_21118573_G_A 396 D>N No 1000Genomes
tmp_1_21118597_C_G 404 P>A No 1000Genomes
ENSVATH13596411 406 S>T No 1000Genomes
tmp_1_21118630_GT_AT,G 415 V>I No 1000Genomes
ENSVATH01379469 422 R>K No 1000Genomes
tmp_1_21118711_C_T 442 P>S No 1000Genomes
ENSVATH13596412 455 R>K No 1000Genomes
ENSVATH00101040 460 N>S No 1000Genomes
ENSVATH04977675 468 S>Y No 1000Genomes
ENSVATH14332196 477 I>T No 1000Genomes
tmp_1_21118842_C_A 485 D>E No 1000Genomes
ENSVATH01379470 492 L>I No 1000Genomes
tmp_1_21118868_T_G 494 V>G No 1000Genomes
tmp_1_21118879_G_A 498 D>N No 1000Genomes
ENSVATH04977676 515 R>C No 1000Genomes
tmp_1_21118944_C_G 519 D>E No 1000Genomes
tmp_1_21118942_G_A 519 D>N No 1000Genomes
ENSVATH13596417 530 K>E No 1000Genomes
tmp_1_21118993_G_A,T 536 E>* No 1000Genomes
tmp_1_21118993_G_A,T 536 E>K No 1000Genomes
ENSVATH04977677 553 Y>* No 1000Genomes
tmp_1_21119074_G_A 563 G>S No 1000Genomes
ENSVATH04977678 563 G>V No 1000Genomes
ENSVATH04977679 564 E>K No 1000Genomes
tmp_1_21119096_A_G 570 D>G No 1000Genomes
ENSVATH13596418 578 I>N No 1000Genomes
ENSVATH13596419 580 E>K No 1000Genomes
ENSVATH04977680 585 L>I No 1000Genomes
tmp_1_21119147_A_G 587 D>G No 1000Genomes
ENSVATH04977681 595 E>V No 1000Genomes
ENSVATH13596421 600 M>L No 1000Genomes
ENSVATH04977682 605 S>N No 1000Genomes
ENSVATH04977683 615 Y>F No 1000Genomes
tmp_1_21119233_C_T 616 Q>* No 1000Genomes
ENSVATH04977684 616 Q>P No 1000Genomes

No associated diseases with Q9C7X7

3 regional properties for Q9C7X7

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 12 - 19 IPR018181-1
conserved_site Heat shock protein 70, conserved site 203 - 216 IPR018181-2
conserved_site Heat shock protein 70, conserved site 340 - 354 IPR018181-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

61 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P11484 SSB1 Ribosome-associated molecular chaperone SSB1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P40150 SSB2 Ribosome-associated molecular chaperone SSB2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P22202 SSA4 Heat shock protein SSA4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P09435 SSA3 Heat shock protein SSA3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P10592 SSA2 Heat shock protein SSA2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P10591 SSA1 Heat shock protein SSA1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q2YDD0 HSPA14 Heat shock 70 kDa protein 14 Bos taurus (Bovine) SS
P0CB32 HSPA1L Heat shock 70 kDa protein 1-like Bos taurus (Bovine) SS
P19120 HSPA8 Heat shock cognate 71 kDa protein Bos taurus (Bovine) SS
Q27975 HSPA1A Heat shock 70 kDa protein 1A Bos taurus (Bovine) SS
E1C2P3 HSPA14 Heat shock 70 kDa protein 14 Gallus gallus (Chicken) SS
O73885 HSPA8 Heat shock cognate 71 kDa protein Gallus gallus (Chicken) SS
P08106 Heat shock 70 kDa protein Gallus gallus (Chicken) SS
P77319 hscC Chaperone protein HscC Escherichia coli (strain K12) PR
P0A6Y8 dnaK Chaperone protein DnaK Escherichia coli (strain K12) SS
P02825 Hsp70Ab Major heat shock 70 kDa protein Ab Drosophila melanogaster (Fruit fly) SS
P82910 Hsp70Aa Major heat shock 70 kDa protein Aa Drosophila melanogaster (Fruit fly) SS
Q9VG58 Hsp70Bbb Major heat shock 70 kDa protein Bbb Drosophila melanogaster (Fruit fly) SS
Q9BIR7 Hsp70Bc Major heat shock 70 kDa protein Bc Drosophila melanogaster (Fruit fly) SS
Q8INI8 Hsp70Ba Major heat shock 70 kDa protein Ba Drosophila melanogaster (Fruit fly) SS
Q9BIS2 Hsp70Bb Major heat shock 70 kDa protein Bb Drosophila melanogaster (Fruit fly) SS
P11146 Hsc70-2 Heat shock 70 kDa protein cognate 2 Drosophila melanogaster (Fruit fly) SS
O97125 Hsp68 Heat shock protein 68 Drosophila melanogaster (Fruit fly) SS
P11147 Hsc70-4 Heat shock 70 kDa protein cognate 4 Drosophila melanogaster (Fruit fly) SS
P29843 Hsc70-1 Heat shock 70 kDa protein cognate 1 Drosophila melanogaster (Fruit fly) SS
A2Q0Z1 HSPA8 Heat shock cognate 71 kDa protein Equus caballus (Horse) SS
Q96MM6 HSPA12B Heat shock 70 kDa protein 12B Homo sapiens (Human) PR
O43301 HSPA12A Heat shock 70 kDa protein 12A Homo sapiens (Human) PR
Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 Homo sapiens (Human) SS
P0DMV9 HSPA1B Heat shock 70 kDa protein 1B Homo sapiens (Human) SS
P0DMV8 HSPA1A Heat shock 70 kDa protein 1A Homo sapiens (Human) SS
P17066 HSPA6 Heat shock 70 kDa protein 6 Homo sapiens (Human) SS
P34931 HSPA1L Heat shock 70 kDa protein 1-like Homo sapiens (Human) SS
P54652 HSPA2 Heat shock-related 70 kDa protein 2 Homo sapiens (Human) SS
P11142 HSPA8 Heat shock cognate 71 kDa protein Homo sapiens (Human) EV
P11143 HSP70 Heat shock 70 kDa protein Zea mays (Maize) SS
Q99M31 Hspa14 Heat shock 70 kDa protein 14 Mus musculus (Mouse) SS
Q8K0U4 Hspa12a Heat shock 70 kDa protein 12A Mus musculus (Mouse) PR
Q9CZJ2 Hspa12b Heat shock 70 kDa protein 12B Mus musculus (Mouse) PR
P16627 Hspa1l Heat shock 70 kDa protein 1-like Mus musculus (Mouse) SS
P17156 Hspa2 Heat shock-related 70 kDa protein 2 Mus musculus (Mouse) SS
P17879 Hspa1b Heat shock 70 kDa protein 1B Mus musculus (Mouse) SS
P63017 Hspa8 Heat shock cognate 71 kDa protein Mus musculus (Mouse) SS
Q61696 Hspa1a Heat shock 70 kDa protein 1A Mus musculus (Mouse) SS
Q6S4N2 HSPA1B Heat shock 70 kDa protein 1B Sus scrofa (Pig) SS
P0DMW0 Hspa1a Heat shock 70 kDa protein 1A Rattus norvegicus (Rat) SS
P0DMW1 Hspa1b Heat shock 70 kDa protein 1B Rattus norvegicus (Rat) SS
P14659 Hspa2 Heat shock-related 70 kDa protein 2 Rattus norvegicus (Rat) SS
P55063 Hspa1l Heat shock 70 kDa protein 1-like Rattus norvegicus (Rat) SS
P63018 Hspa8 Heat shock cognate 71 kDa protein Rattus norvegicus (Rat) SS
P09446 hsp-1 Heat shock protein hsp-1 Caenorhabditis elegans SS
P26413 HSP70 Heat shock 70 kDa protein Glycine max (Soybean) (Glycine hispida) SS
O65719 HSP70-3 Heat shock 70 kDa protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
P22954 HSP70-2 Heat shock 70 kDa protein 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LHA8 HSP70-4 Heat shock 70 kDa protein 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q9S9N1 HSP70-5 Heat shock 70 kDa protein 5 Arabidopsis thaliana (Mouse-ear cress) SS
P22953 HSP70-1 Heat shock 70 kDa protein 1 Arabidopsis thaliana (Mouse-ear cress) SS
P24629 HSC-I Heat shock cognate 70 kDa protein 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
P27322 HSC-2 Heat shock cognate 70 kDa protein 2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
Q5RGE6 hspa14 Heat shock 70 kDa protein 14 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90473 hspa8 Heat shock cognate 71 kDa protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS ERLIGDAAKN
70 80 90 100 110 120
QVAMNPVNTV FDAKRLIGRR FSDASVQSDM KFWPFKVTPG QADKPMIFVN YKGEEKQFAA
130 140 150 160 170 180
EEISSMVLIK MREIAEAYLG SSIKNAVVTV PAYFNDSQRQ ATKDAGVIAG LNVLRIINEP
190 200 210 220 230 240
TAAAIAYGLD KKATSVGIKN VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD
250 260 270 280 290 300
NRMVNHFVQE FKRKNKKDIS GDARALRRLR TACERAKRTL SSTAQTTVEV DSLFEGIDFY
310 320 330 340 350 360
SPITRAKFEE MNMDLFRKCM EPVMKCLRDS KMDKSMVHDV VLVGGSTRIP KVQQLLQDFF
370 380 390 400 410 420
NGKELCKSIN PDEAVAYGAA VQAAILSGEG NEKVQDLLLL DVTPLSLGIE TIGGVMTTLI
430 440 450 460 470 480
QRNTTIPAKK EQEFTTTVDN QPDVLIQVYE GERARTIDNN ILGQFVLSGI PPAPRGIPQF
490 500 510 520 530 540
TVCFDIDSNG ILNVSAEDKA TGKKNKITIT NDKGRLSKDD IEKMVQEAEK YKSEDEEHKK
550 560 570 580 590 600
KVEAKNGLEN YAYNVGNTLR DMGEKLPAAD KKKFEDSIEE VIQWLDDNQL AEADEFEHKM
610
KELESVWSTI ITKMYQG