Q9C7S1

PR
Gene name
FH12 (At1g42980, F13A11.4)
Protein name
Formin-like protein 12
Names
AtFH12
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G42980
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

161-235 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C7S1

Entry ID Method Resolution Chain Position Source
AF-Q9C7S1-F1 Predicted AlphaFoldDB

93 variants for Q9C7S1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_16133440_G_A 3 S>N No 1000Genomes
ENSVATH13282033 3 S>R No 1000Genomes
ENSVATH00076721 7 K>I No 1000Genomes
ENSVATH00076721 7 K>T No 1000Genomes
ENSVATH01262206 10 S>G No 1000Genomes
ENSVATH01262206 10 S>R No 1000Genomes
ENSVATH04830541 32 I>L No 1000Genomes
ENSVATH04830542 49 M>K No 1000Genomes
tmp_1_16133714_G_T 50 D>Y No 1000Genomes
tmp_1_16133821_G_C 57 G>A No 1000Genomes
ENSVATH00076723 57 G>R No 1000Genomes
ENSVATH00076723 57 G>S No 1000Genomes
ENSVATH01262223 61 E>D No 1000Genomes
ENSVATH04830547 62 V>L No 1000Genomes
tmp_1_16133838_C_T 63 L>F No 1000Genomes
ENSVATH01262224 74 M>I No 1000Genomes
tmp_1_16133984_G_A 85 V>M No 1000Genomes
tmp_1_16133990_G_A 87 A>T No 1000Genomes
tmp_1_16133991_C_T 87 A>V No 1000Genomes
ENSVATH01262225 90 V>I No 1000Genomes
tmp_1_16134002_G_T 91 E>* No 1000Genomes
ENSVATH04830554 93 P>S No 1000Genomes
tmp_1_16134012_C_T 94 S>F No 1000Genomes
tmp_1_16134015_G_T 95 R>M No 1000Genomes
tmp_1_16134024_A_T 98 D>V No 1000Genomes
ENSVATH14186463 100 K>R No 1000Genomes
ENSVATH14186464 101 M>L No 1000Genomes
ENSVATH14186485 101 M>R No 1000Genomes
ENSVATH04830555 103 M>T No 1000Genomes
ENSVATH04830556 105 T>K No 1000Genomes
ENSVATH04830556 105 T>M No 1000Genomes
ENSVATH04830556 105 T>R No 1000Genomes
tmp_1_16134048_T_C 106 I>T No 1000Genomes
tmp_1_16134047_A_G 106 I>V No 1000Genomes
ENSVATH04830558 108 A>D No 1000Genomes
ENSVATH04830557 108 A>T No 1000Genomes
tmp_1_16134056_G_A 109 A>T No 1000Genomes
tmp_1_16134365_C_T 114 T>M No 1000Genomes
tmp_1_16134374_T_C 117 V>A No 1000Genomes
ENSVATH00076729 117 V>M No 1000Genomes
ENSVATH04830592 118 K>R No 1000Genomes
ENSVATH00076730 120 F>Y No 1000Genomes
ENSVATH04830593 121 R>P No 1000Genomes
ENSVATH04830594 122 I>F No 1000Genomes
ENSVATH13282102 128 T>R No 1000Genomes
tmp_1_16134422_G_A 133 R>K No 1000Genomes
ENSVATH14186488 135 S>A No 1000Genomes
ENSVATH04830598 136 N>I No 1000Genomes
ENSVATH04830598 136 N>T No 1000Genomes
tmp_1_16134537_T_C 137 V>A No 1000Genomes
tmp_1_16134540_A_T 138 E>V No 1000Genomes
tmp_1_16134555_G_C 143 S>T No 1000Genomes
ENSVATH01262263 152 Y>D No 1000Genomes
ENSVATH04830599 156 D>H No 1000Genomes
tmp_1_16134602_A_G 159 K>E No 1000Genomes
ENSVATH00076734 172 A>P No 1000Genomes
tmp_1_16134758_C_T 174 S>L No 1000Genomes
tmp_1_16134850_G_T 177 E>* No 1000Genomes
tmp_1_16134862_A_G 181 I>V No 1000Genomes
ENSVATH04830612 191 I>M No 1000Genomes
tmp_1_16134895_G_A 192 E>K No 1000Genomes
tmp_1_16134907_A_C 196 N>H No 1000Genomes
ENSVATH13282127 196 N>T No 1000Genomes
ENSVATH04830613 197 D>N No 1000Genomes
ENSVATH01262269 201 A>T No 1000Genomes
tmp_1_16134923_C_T 201 A>V No 1000Genomes
tmp_1_16134932_A_T 204 N>I No 1000Genomes
ENSVATH00076740 208 N>Y No 1000Genomes
ENSVATH00076741 211 G>S No 1000Genomes
ENSVATH14186491 216 V>L No 1000Genomes
ENSVATH14186491 216 V>M No 1000Genomes
tmp_1_16135056_A_G 222 T>A No 1000Genomes
tmp_1_16135057_C_T 222 T>M No 1000Genomes
tmp_1_16135065_G_A 225 G>S No 1000Genomes
ENSVATH13282129 233 L>V No 1000Genomes
ENSVATH01262274 234 Y>F No 1000Genomes
ENSVATH00076743 237 V>A No 1000Genomes
ENSVATH00076744 240 L>V No 1000Genomes
tmp_1_16135226_G_A 252 V>I No 1000Genomes
ENSVATH00076748 257 A>V No 1000Genomes
ENSVATH13282159 260 I>F No 1000Genomes
tmp_1_16135343_C_T 263 R>C No 1000Genomes
ENSVATH04830621 272 R>P No 1000Genomes
ENSVATH13282160 273 E>K No 1000Genomes
ENSVATH14186545 281 A>T No 1000Genomes
ENSVATH13282161 282 E>A No 1000Genomes
tmp_1_16135403_A_G 283 K>E No 1000Genomes
ENSVATH04830622 284 E>K No 1000Genomes
ENSVATH01262279 287 E>Q No 1000Genomes
ENSVATH00076749 289 R>G No 1000Genomes
tmp_1_16135429_G_A 291 M>I No 1000Genomes
ENSVATH04830624 298 N>K No 1000Genomes
tmp_1_16135451_C_T 299 L>F No 1000Genomes

No associated diseases with Q9C7S1

3 regional properties for Q9C7S1

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 260 IPR000719
active_site Serine/threonine-protein kinase, active site 119 - 131 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A0A1D5P556 DAAM2 Disheveled-associated activator of morphogenesis 2 Gallus gallus (Chicken) SS
O95466 FMNL1 Formin-like protein 1 Homo sapiens (Human) SS
Q27J81 INF2 Inverted formin-2 Homo sapiens (Human) EV
Q9Y4D1 DAAM1 Disheveled-associated activator of morphogenesis 1 Homo sapiens (Human) EV
Q86T65 DAAM2 Disheveled-associated activator of morphogenesis 2 Homo sapiens (Human) SS
Q80U19 Daam2 Disheveled-associated activator of morphogenesis 2 Mus musculus (Mouse) SS
Q8BPM0 Daam1 Disheveled-associated activator of morphogenesis 1 Mus musculus (Mouse) PR
Q0GNC1 Inf2 Inverted formin-2 Mus musculus (Mouse) SS
Q0QWG9 Grid2ip Delphilin Mus musculus (Mouse) PR
Q9LH02 FH17 Formin-like protein 17 Arabidopsis thaliana (Mouse-ear cress) PR
P0C5K4 FH21A Putative formin-like protein 21a Arabidopsis thaliana (Mouse-ear cress) PR
Q9FF14 FH19 Formin-like protein 19 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASNCEKMLS KIKIPLPDML NAVLDLDSSA VIIDQIKNLI KICWSKEEMD RLRNSAGGDK
70 80 90 100 110 120
EVLGKCEEIF GELMMVPRIE PKLRVFAFKV EYPSRVSDLK MWMHTIIAAT KEITGSVKLF
130 140 150 160 170 180
RIMQTSLTMQ VLRGSNVECG LDSLVKLCDN VYLMHDFCKL LDFGNDLVHL EAASRIELET
190 200 210 220 230 240
ITNKMQELFD IEEEVNDEFL ASENDGANFV GYRNVVHDFL CTIDGDKQLL NILYAEVGGL
250 260 270 280 290
VNSYIAEYPS GVRFKEATNI LTRFVETFYK SREEIERQAE AEKEILEKRK MNIKQNGNL