Q9C6C3
PR
Gene name |
AGD2 (At1g60860, F23C21.2, T7P1.1) |
Protein name |
ADP-ribosylation factor GTPase-activating protein AGD2 |
Names |
ARF GAP AGD2, Protein ARF-GAP DOMAIN 2, AtAGD2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G60860 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9C6C3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9C6C3-F1 | Predicted | AlphaFoldDB |
102 variants for Q9C6C3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_22407604_C_A | 12 | M>I | No | 1000Genomes | |
| tmp_1_22407480_C_A | 25 | D>Y | No | 1000Genomes | |
| ENSVATH13674010 | 33 | K>T | No | 1000Genomes | |
| tmp_1_22407449_T_C | 35 | Y>C | No | 1000Genomes | |
| tmp_1_22407450_A_G | 35 | Y>H | No | 1000Genomes | |
| ENSVATH13674002 | 50 | T>N | No | 1000Genomes | |
| tmp_1_22407053_G_C | 64 | A>G | No | 1000Genomes | |
| tmp_1_22407046_A_T | 66 | H>Q | No | 1000Genomes | |
| tmp_1_22406427_T_C | 85 | T>A | No | 1000Genomes | |
| tmp_1_22406409_A_G | 91 | S>P | No | 1000Genomes | |
| ENSVATH05014563 | 93 | K>N | No | 1000Genomes | |
| tmp_1_22406385_G_C | 99 | Q>E | No | 1000Genomes | |
| ENSVATH05014559 | 109 | T>I | No | 1000Genomes | |
| ENSVATH05014558 | 110 | N>K | No | 1000Genomes | |
| tmp_1_22406120_A_T | 115 | D>E | No | 1000Genomes | |
| tmp_1_22406122_C_T | 115 | D>N | No | 1000Genomes | |
| tmp_1_22405749_G_A | 124 | R>C | No | 1000Genomes | |
| tmp_1_22405724_G_A | 132 | S>F | No | 1000Genomes | |
| ENSVATH05014539 | 141 | V>A | No | 1000Genomes | |
| ENSVATH05014537 | 144 | K>R | No | 1000Genomes | |
| tmp_1_22405318_C_T | 148 | R>K | No | 1000Genomes | |
| ENSVATH05014536 | 149 | G>V | No | 1000Genomes | |
| ENSVATH13673980 | 152 | V>I | No | 1000Genomes | |
| ENSVATH13673977 | 182 | A>S | No | 1000Genomes | |
| tmp_1_22404968_A_C | 188 | F>C | No | 1000Genomes | |
| tmp_1_22404948_T_C | 195 | I>V | No | 1000Genomes | |
| tmp_1_22404791_C_A | 211 | S>I | No | 1000Genomes | |
| tmp_1_22404780_G_T,C | 215 | P>A | No | 1000Genomes | |
| tmp_1_22404780_G_T,C | 215 | P>T | No | 1000Genomes | |
| tmp_1_22404771_G_A | 218 | H>Y | No | 1000Genomes | |
| ENSVATH13673963 | 224 | A>V | No | 1000Genomes | |
| tmp_1_22404387_A_T | 231 | S>T | No | 1000Genomes | |
| tmp_1_22404368_C_A | 237 | R>L | No | 1000Genomes | |
| ENSVATH01414768 | 239 | A>E | No | 1000Genomes | |
| ENSVATH01414767 | 248 | Q>H | No | 1000Genomes | |
| ENSVATH05014519 | 253 | S>N | No | 1000Genomes | |
| tmp_1_22404311_G_A | 256 | A>V | No | 1000Genomes | |
| tmp_1_22404299_G_T | 260 | A>E | No | 1000Genomes | |
| tmp_1_22404293_G_A | 262 | P>L | No | 1000Genomes | |
| ENSVATH00108814 | 266 | G>D | No | 1000Genomes | |
| ENSVATH00108813 | 284 | V>L | No | 1000Genomes | |
| ENSVATH05014518 | 285 | S>L | No | 1000Genomes | |
| ENSVATH13673962 | 287 | A>V | No | 1000Genomes | |
| ENSVATH05014510 | 292 | T>N | No | 1000Genomes | |
| tmp_1_22403735_G_A | 300 | R>* | No | 1000Genomes | |
| ENSVATH14369497 | 300 | R>L | No | 1000Genomes | |
| tmp_1_22403653_G_A | 327 | T>I | No | 1000Genomes | |
| ENSVATH05014508 | 329 | N>D | No | 1000Genomes | |
| ENSVATH00108807 | 329 | N>K | No | 1000Genomes | |
| tmp_1_22403643_T_G | 330 | K>N | No | 1000Genomes | |
| tmp_1_22403639_C_A | 332 | A>S | No | 1000Genomes | |
| tmp_1_22403376_T_A | 333 | K>* | No | 1000Genomes | |
| ENSVATH05014504 | 344 | H>N | No | 1000Genomes | |
| tmp_1_22403342_T_G | 344 | H>P | No | 1000Genomes | |
| ENSVATH00108804 | 344 | H>Q | No | 1000Genomes | |
| tmp_1_22403319_A_C | 352 | F>V | No | 1000Genomes | |
| ENSVATH01414759 | 353 | R>H | No | 1000Genomes | |
| tmp_1_22403199_T_C | 392 | I>V | No | 1000Genomes | |
| ENSVATH05014501 | 396 | Q>L | No | 1000Genomes | |
| tmp_1_22403040_G_A | 417 | T>I | No | 1000Genomes | |
| ENSVATH01414758 | 422 | I>T | No | 1000Genomes | |
| tmp_1_22402887_T_A | 440 | K>M | No | 1000Genomes | |
| ENSVATH05014495 | 440 | K>N | No | 1000Genomes | |
| ENSVATH01414755 | 442 | T>S | No | 1000Genomes | |
| tmp_1_22402831_A_T | 459 | Y>N | No | 1000Genomes | |
| tmp_1_22402818_A_C | 463 | L>R | No | 1000Genomes | |
| ENSVATH05014494 | 480 | N>K | No | 1000Genomes | |
| tmp_1_22402747_C_A | 487 | A>S | No | 1000Genomes | |
| tmp_1_22402711_C_T | 499 | V>I | No | 1000Genomes | |
| ENSVATH00108799 | 543 | G>A | No | 1000Genomes | |
| ENSVATH14369481 | 543 | G>R | No | 1000Genomes | |
| ENSVATH05014488 | 553 | L>F | No | 1000Genomes | |
| tmp_1_22402326_A_T | 553 | L>H | No | 1000Genomes | |
| ENSVATH05014487 | 555 | H>Q | No | 1000Genomes | |
| ENSVATH05014486 | 556 | L>P | No | 1000Genomes | |
| tmp_1_22402088_G_A | 568 | L>F | No | 1000Genomes | |
| tmp_1_22402075_G_A | 572 | S>L | No | 1000Genomes | |
| ENSVATH00108797 | 601 | E>Q | No | 1000Genomes | |
| ENSVATH01414746 | 604 | A>V | No | 1000Genomes | |
| tmp_1_22401836_A_G | 606 | S>P | No | 1000Genomes | |
| ENSVATH14369476 | 610 | S>N | No | 1000Genomes | |
| ENSVATH14369475 | 619 | R>K | No | 1000Genomes | |
| ENSVATH05014479 | 626 | R>Q | No | 1000Genomes | |
| ENSVATH05014478 | 627 | L>F | No | 1000Genomes | |
| tmp_1_22401769_A_G | 628 | I>T | No | 1000Genomes | |
| tmp_1_22401762_T_G | 630 | K>N | No | 1000Genomes | |
| ENSVATH14369464 | 631 | A>T | No | 1000Genomes | |
| tmp_1_22401734_A_T | 640 | F>I | No | 1000Genomes | |
| ENSVATH00108796 | 648 | V>A | No | 1000Genomes | |
| ENSVATH05014477 | 649 | Y>H | No | 1000Genomes | |
| ENSVATH05014477 | 649 | Y>N | No | 1000Genomes | |
| tmp_1_22401694_T_C | 653 | H>R | No | 1000Genomes | |
| ENSVATH05014475 | 677 | E>K | No | 1000Genomes | |
| tmp_1_22401616_C_T | 679 | R>K | No | 1000Genomes | |
| tmp_1_22401569_C_T | 695 | G>S | No | 1000Genomes | |
| tmp_1_22401544_A_T | 703 | L>Q | No | 1000Genomes | |
| tmp_1_22401541_A_T | 704 | L>* | No | 1000Genomes | |
| tmp_1_22401529_G_A | 708 | A>V | No | 1000Genomes | |
| tmp_1_22401503_C_T | 717 | G>R | No | 1000Genomes | |
| ENSVATH13673940 | 726 | A>G | No | 1000Genomes | |
| ENSVATH13673941 | 726 | A>T | No | 1000Genomes | |
| ENSVATH05014469 | 762 | A>D | No | 1000Genomes |
No associated diseases with Q9C6C3
5 regional properties for Q9C6C3
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PK26 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A1Z7A6 | Asap | ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein | Drosophila melanogaster (Fruit fly) | SS |
| O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q7SIG6 | Asap2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | SS |
| Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q8K2H4 | Acap1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q6ZQK5 | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
| Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q9SMX5 | AGD4 | ADP-ribosylation factor GTPase-activating protein AGD4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGFINLEDS | PMFQKQVFSL | EGTSDELKDR | CQKLYKGVKK | FMGALGEAST | GVSAFADSLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFGAGHDDPV | SVSIGGPVIS | KFINTLRELS | SYKEFLRSQV | EHVLLERLTN | FMTVDLQEAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESRRRFDKAV | HSYDQAREKF | VSLKKNTRGD | IVAELEEDLE | NSKSAFEKSR | FNLVNSLMTI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAKKKYEFLE | SISAIMDSHF | KYFKLGYDLL | SQLEPYIHQV | LTYAQQSKEQ | SKIEQDRFAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIQEFRTQSE | LDSQQASAKA | DPSDVGGNHV | YRAIPRKNVE | ANSVSTADKE | VTKQGYLLKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SASLRADWKR | RFFVLDNHGS | LYYYRNTGNK | SAKSQHYYSG | LGEHSSGVFG | RFRTRHNRSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQGSLDCNMI | DLRTSLIKLD | AEDTDLRLCF | RIISPQKTYT | LQAENGADRM | DWVNKITAAI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIRLNSHFLQ | QSPARYLDKK | NTSSGPATEN | LTLNQKEDYN | QRLNVGDDVL | TILREIPGNN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TCAECNAPDP | DWASLNLGVL | MCIECSGVHR | NLGVHISKVR | SLTLDVKVWE | PTILDLFRNL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GNGYCNSVWE | ELLHHLDDDS | EKGSTDTLAS | VSKPSSEDWF | TLKEKYINGK | YLEKALVVKD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EREANSTASS | RIWEAVQSRN | IRDIYRLIVK | ADANIINTKF | DDITDLDVYH | HHHVDAPDEV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KKRHDPNACQ | RIKNSNEARN | CLQGCSLLHV | ACQSGDPILL | ELLLQFGADI | NMRDYHGRTP |
| 730 | 740 | 750 | 760 | 770 | |
| LHHCIASGNN | AFAKVLLRRG | ARPSIEDGGG | LSVLERAMEM | GAITDEELFL | LLAECQ |