Q9C646

PR
Gene name
RXW24L (At1g58410, F9K23.6, X7J.10)
Protein name
Probable disease resistance protein RXW24L
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G58410
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

102-184 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C646

Entry ID Method Resolution Chain Position Source
AF-Q9C646-F1 Predicted AlphaFoldDB

223 variants for Q9C646

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_21704239_A_C 6 F>C No 1000Genomes
ENSVATH01395095 6 F>L No 1000Genomes
ENSVATH04994732 13 D>N No 1000Genomes
ENSVATH13633292 19 Y>H No 1000Genomes
ENSVATH01395092 20 D>E No 1000Genomes
ENSVATH13633291 22 F>S No 1000Genomes
ENSVATH01395091 23 K>N No 1000Genomes
tmp_1_21704150_G_C 36 L>V No 1000Genomes
tmp_1_21704124_T_G 44 K>N No 1000Genomes
ENSVATH04994729 46 A>T No 1000Genomes
ENSVATH04994728 52 I>V No 1000Genomes
ENSVATH04994725 54 E>K No 1000Genomes
ENSVATH01395085 61 E>V No 1000Genomes
ENSVATH01395084 65 D>E No 1000Genomes
ENSVATH13633286 78 I>L No 1000Genomes
ENSVATH13633285 79 L>H No 1000Genomes
ENSVATH04994722 85 M>I No 1000Genomes
ENSVATH04994723 85 M>K No 1000Genomes
ENSVATH04994721 95 R>* No 1000Genomes
ENSVATH00104848 101 M>V No 1000Genomes
ENSVATH04994720 104 R>M No 1000Genomes
ENSVATH01395077 110 I>T No 1000Genomes
ENSVATH04994719 111 G>E No 1000Genomes
ENSVATH04994718 114 S>R No 1000Genomes
ENSVATH04994716 120 V>G No 1000Genomes
ENSVATH14350974 126 S>I No 1000Genomes
tmp_1_21703855_G_C 134 T>S No 1000Genomes
ENSVATH04994714 158 S>Y No 1000Genomes
tmp_1_21703780_T_A 159 E>V No 1000Genomes
ENSVATH04994712 165 M>I No 1000Genomes
ENSVATH01395074 165 M>L No 1000Genomes
tmp_1_21703762_A_G 165 M>T No 1000Genomes
ENSVATH01395072 171 K>I No 1000Genomes
tmp_1_21703735_C_T 174 G>E No 1000Genomes
ENSVATH01395070 177 V>L No 1000Genomes
ENSVATH01395069 178 E>G No 1000Genomes
ENSVATH13633257 185 V>F No 1000Genomes
tmp_1_21703691_C_G 189 G>R No 1000Genomes
tmp_1_21703681_C_G 192 G>A No 1000Genomes
ENSVATH01395062 198 L>V No 1000Genomes
tmp_1_21703640_C_T 206 D>N No 1000Genomes
ENSVATH13633254 220 V>I No 1000Genomes
ENSVATH04994705 228 S>L No 1000Genomes
ENSVATH04994706 228 S>P No 1000Genomes
ENSVATH13633252 238 T>I No 1000Genomes
ENSVATH04994704 244 D>E No 1000Genomes
ENSVATH04994703 247 Q>H No 1000Genomes
ENSVATH00104843 251 E>K No 1000Genomes
ENSVATH04994702 252 A>G No 1000Genomes
ENSVATH01395057 252 A>S No 1000Genomes
ENSVATH04994701 267 T>S No 1000Genomes
ENSVATH13633249 274 I>M No 1000Genomes
ENSVATH04994698 276 K>N No 1000Genomes
ENSVATH01395054 277 E>K No 1000Genomes
ENSVATH01395053 282 L>V No 1000Genomes
ENSVATH13633248 289 P>A No 1000Genomes
ENSVATH01395052 290 K>E No 1000Genomes
ENSVATH04994697 291 K>N No 1000Genomes
ENSVATH04994695 305 A>P No 1000Genomes
tmp_1_21703233_C_T 308 G>E No 1000Genomes
tmp_1_21703228_T_C 310 T>A No 1000Genomes
ENSVATH13633234 317 P>R No 1000Genomes
tmp_1_21703203_T_C 318 K>R No 1000Genomes
ENSVATH13633233 330 Q>* No 1000Genomes
ENSVATH13633232 330 Q>R No 1000Genomes
tmp_1_21703162_T_C 332 I>V No 1000Genomes
tmp_1_21703159_C_T 333 A>T No 1000Genomes
ENSVATH01395035 342 F>Y No 1000Genomes
ENSVATH13633214 346 E>K No 1000Genomes
ENSVATH01395034 350 N>D No 1000Genomes
ENSVATH09345361 350 N>K No 1000Genomes
ENSVATH01395033 351 M>L No 1000Genomes
tmp_1_21702929_T_G 353 K>Q No 1000Genomes
ENSVATH13633213 354 K>E No 1000Genomes
ENSVATH13633211 355 M>I No 1000Genomes
ENSVATH01395029 363 S>P No 1000Genomes
ENSVATH13633209 378 T>K No 1000Genomes
ENSVATH04994687 378 T>S No 1000Genomes
ENSVATH01395022 389 I>S No 1000Genomes
ENSVATH04994683 390 G>R No 1000Genomes
ENSVATH01395021 395 E>K No 1000Genomes
ENSVATH00104842 396 R>T No 1000Genomes
tmp_1_21702786_G_T 400 N>K No 1000Genomes
tmp_1_21702787_T_G 400 N>T No 1000Genomes
tmp_1_21702780_A_C 402 S>R No 1000Genomes
ENSVATH13633206 405 D>G No 1000Genomes
ENSVATH01395020 410 V>M No 1000Genomes
ENSVATH04994682 412 F>V No 1000Genomes
tmp_1_21702710_G_A 426 L>F No 1000Genomes
tmp_1_21702695_C_T 431 E>K No 1000Genomes
ENSVATH01395018 448 G>E No 1000Genomes
tmp_1_21702629_T_A 453 R>W No 1000Genomes
ENSVATH00104839 454 R>H No 1000Genomes
ENSVATH04994678 455 Y>* No 1000Genomes
ENSVATH04994679 455 Y>N No 1000Genomes
ENSVATH13633183 456 D>N No 1000Genomes
tmp_1_21702617_C_T 457 G>R No 1000Genomes
ENSVATH14350969 460 I>S No 1000Genomes
ENSVATH00104838 463 T>I No 1000Genomes
ENSVATH00104837 468 I>L No 1000Genomes
tmp_1_21702581_C_T 469 E>K No 1000Genomes
ENSVATH00104836 470 E>D No 1000Genomes
ENSVATH04994674 481 R>W No 1000Genomes
tmp_1_21702534_C_A 484 M>I No 1000Genomes
ENSVATH00104835 484 M>L No 1000Genomes
ENSVATH00104834 489 E>K No 1000Genomes
ENSVATH01395015 492 R>C No 1000Genomes
ENSVATH04994673 494 H>L No 1000Genomes
tmp_1_21702506_G_A 494 H>Y No 1000Genomes
tmp_1_21702498_C_T 496 M>I No 1000Genomes
ENSVATH04994672 503 F>L No 1000Genomes
tmp_1_21702478_A_G 503 F>S No 1000Genomes
ENSVATH01395014 504 K>I No 1000Genomes
tmp_1_21702476_T_G 504 K>Q No 1000Genomes
ENSVATH01395014 504 K>R No 1000Genomes
ENSVATH04994671 508 E>D No 1000Genomes
ENSVATH01395013 512 Q>H No 1000Genomes
ENSVATH04994670 513 I>T No 1000Genomes
ENSVATH13633182 517 H>D No 1000Genomes
ENSVATH01395012 519 P>T No 1000Genomes
ENSVATH00104832 523 P>A No 1000Genomes
ENSVATH13633181 531 R>* No 1000Genomes
tmp_1_21702363_A_T 541 H>Q No 1000Genomes
ENSVATH01395010 543 E>D No 1000Genomes
ENSVATH01395011 543 E>Q No 1000Genomes
tmp_1_21702351_A_C 545 Y>* No 1000Genomes
ENSVATH01395009 549 P>L No 1000Genomes
ENSVATH13633180 552 R>* No 1000Genomes
ENSVATH13633179 554 L>V No 1000Genomes
ENSVATH00104831 558 Y>S No 1000Genomes
tmp_1_21702299_T_C 563 N>D No 1000Genomes
tmp_1_21702297_A_T 563 N>K No 1000Genomes
ENSVATH01395008 576 V>L No 1000Genomes
ENSVATH01395003 585 V>I No 1000Genomes
ENSVATH14350966 587 A>G No 1000Genomes
tmp_1_21702222_C_A,G 588 K>N No 1000Genomes
ENSVATH01395002 589 F>L No 1000Genomes
ENSVATH01395001 591 G>E No 1000Genomes
ENSVATH13633176 597 D>Y No 1000Genomes
tmp_1_21702164_T_G 608 S>R No 1000Genomes
ENSVATH04994665 612 A>D No 1000Genomes
ENSVATH01394994 619 S>Y No 1000Genomes
ENSVATH04994663 624 L>I No 1000Genomes
tmp_1_21702097_A_T 630 L>* No 1000Genomes
ENSVATH14350965 631 D>Y No 1000Genomes
tmp_1_21702092_T_A 632 I>L No 1000Genomes
ENSVATH13633163 633 R>H No 1000Genomes
ENSVATH04994661 635 D>N No 1000Genomes
ENSVATH13633162 636 F>C No 1000Genomes
ENSVATH13633160 639 I>R No 1000Genomes
ENSVATH04994659 642 P>L No 1000Genomes
ENSVATH13633157 647 G>R No 1000Genomes
ENSVATH14350944 649 R>K No 1000Genomes
ENSVATH04994657 660 M>I No 1000Genomes
ENSVATH04994656 661 H>Y No 1000Genomes
tmp_1_21701987_C_G 667 E>Q No 1000Genomes
tmp_1_21701982_C_A 668 L>F No 1000Genomes
tmp_1_21701972_C_G 672 E>Q No 1000Genomes
tmp_1_21701941_G_T 682 T>K No 1000Genomes
ENSVATH13633155 684 S>N No 1000Genomes
ENSVATH13633154 686 S>I No 1000Genomes
ENSVATH13633153 688 E>D No 1000Genomes
tmp_1_21701870_C_T 706 G>R No 1000Genomes
ENSVATH13633147 708 S>T No 1000Genomes
ENSVATH00104827 712 L>R No 1000Genomes
ENSVATH14350942 713 S>F No 1000Genomes
tmp_1_21701849_A_T 713 S>T No 1000Genomes
ENSVATH13633146 714 A>T No 1000Genomes
ENSVATH01394985 717 C>R No 1000Genomes
tmp_1_21701821_A_T 722 L>* No 1000Genomes
ENSVATH01394984 723 E>K No 1000Genomes
ENSVATH01394983 724 N>I No 1000Genomes
ENSVATH01394982 725 F>L No 1000Genomes
ENSVATH04994653 727 I>T No 1000Genomes
tmp_1_21701802_C_T 728 M>I No 1000Genomes
ENSVATH13633134 731 A>T No 1000Genomes
ENSVATH13633133 731 A>V No 1000Genomes
ENSVATH04994652 735 R>K No 1000Genomes
ENSVATH04994651 738 E>K No 1000Genomes
tmp_1_21701737_T_A 750 K>M No 1000Genomes
tmp_1_21701731_G_C 752 T>S No 1000Genomes
ENSVATH04994650 754 S>R No 1000Genomes
ENSVATH04994649 759 R>M No 1000Genomes
tmp_1_21701705_G_A 761 P>S No 1000Genomes
tmp_1_21701679_G_T 769 H>Q No 1000Genomes
ENSVATH04994646 794 L>S No 1000Genomes
tmp_1_21701602_T_G 795 K>T No 1000Genomes
ENSVATH04994645 801 Y>D No 1000Genomes
tmp_1_21701578_G_A 803 S>F No 1000Genomes
tmp_1_21701569_C_G 806 G>A No 1000Genomes
ENSVATH13633127 806 G>R No 1000Genomes
ENSVATH13633126 812 S>T No 1000Genomes
ENSVATH13633125 813 A>P No 1000Genomes
ENSVATH13633114 813 A>V No 1000Genomes
ENSVATH04994644 817 P>H No 1000Genomes
tmp_1_21701537_G_A 817 P>S No 1000Genomes
ENSVATH04994643 820 R>L No 1000Genomes
ENSVATH04994643 820 R>P No 1000Genomes
ENSVATH04994642 823 A>D No 1000Genomes
ENSVATH04994642 823 A>V No 1000Genomes
ENSVATH14350941 826 E>K No 1000Genomes
ENSVATH01394976 829 E>V No 1000Genomes
tmp_1_21701488_C_A 833 W>L No 1000Genomes
ENSVATH01394975 837 E>K No 1000Genomes
ENSVATH13633105 838 G>C No 1000Genomes
ENSVATH01394974 841 S>P No 1000Genomes
tmp_1_21701461_C_A 842 R>L No 1000Genomes
tmp_1_21701440_C_T 849 W>* No 1000Genomes
ENSVATH01394972 857 P>H No 1000Genomes
ENSVATH04994640 861 R>Q No 1000Genomes
tmp_1_21701396_A_T 864 Y>N No 1000Genomes
tmp_1_21701395_T_G 864 Y>S No 1000Genomes
ENSVATH04994639 866 L>I No 1000Genomes
ENSVATH13633101 877 E>D No 1000Genomes
ENSVATH13633102 877 E>K No 1000Genomes
ENSVATH00104826 881 E>K No 1000Genomes
tmp_1_21701333_C_T 885 E>K No 1000Genomes
ENSVATH04994637 887 Y>D No 1000Genomes
ENSVATH01394969 890 Q>K No 1000Genomes
tmp_1_21701314_T_C 891 N>S No 1000Genomes
ENSVATH01394967 894 F>S No 1000Genomes
ENSVATH01394966 899 S>F No 1000Genomes
tmp_1_21701287_T_G 900 S>S No 1000Genomes

No associated diseases with Q9C646

3 regional properties for Q9C646

Type Name Position InterPro Accession
domain NB-ARC 166 - 413 IPR002182
domain Virus X resistance protein-like, coiled-coil domain 4 - 121 IPR038005
domain Rx, N-terminal 3 - 82 IPR041118

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
response to other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MHT9 NLRC4 NLR family CARD domain-containing protein 4 Bos taurus (Bovine) SS
O14727 APAF1 Apoptotic protease-activating factor 1 Homo sapiens (Human) EV
Q9NPP4 NLRC4 NLR family CARD domain-containing protein 4 Homo sapiens (Human) SS
Q3UP24 Nlrc4 NLR family CARD domain-containing protein 4 Mus musculus (Mouse) EV
F1M649 Nlrc4 NLR family CARD domain-containing protein 4 Rattus norvegicus (Rat) SS
O22727 At1g61190 Probable disease resistance protein At1g61190 Arabidopsis thaliana (Mouse-ear cress) PR
O64790 At1g61300 Probable disease resistance protein At1g61300 Arabidopsis thaliana (Mouse-ear cress) PR
O64973 RPS5 Disease resistance protein RPS5 Arabidopsis thaliana (Mouse-ear cress) PR
P0C8S1 RPP8L2 Probable disease resistance RPP8-like protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
P60838 SUMM2 Disease resistance protein SUMM2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38834 RPP13L4 Disease resistance RPP13-like protein 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q39214 RPM1 Disease resistance protein RPM1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W3K3 At1g58400 Putative disease resistance protein At1g58400 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJB5 RPP8L3 Disease resistance RPP8-like protein 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR4 RPPL1 Putative disease resistance RPP13-like protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9T048 At4g27190 Disease resistance protein At4g27190 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIF0 At1g59780 Putative disease resistance protein At1g59780 Arabidopsis thaliana (Mouse-ear cress) PR
O64789 At1g61310 Probable disease resistance protein At1g61310 Arabidopsis thaliana (Mouse-ear cress) PR
Q940K0 UNI Disease resistance protein UNI Arabidopsis thaliana (Mouse-ear cress) PR
Q9I9H8 apaf1 Apoptotic protease-activating factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MELVSFGVEK LWDRLSQEYD QFKGVEDQVT ELKSNLNLLK SFLKDADAKK HISEMVRHCV
70 80 90 100 110 120
EEIKDIVYDT EDIIETFILK EKVEMKRGIM KRIKRFASTI MDRRELASDI GGISKRISKV
130 140 150 160 170 180
IQDMQSFGVQ QIITDGSRSS HPLQERQREM RHTFSRDSEN DFVGMEANVK KLVGYLVEKD
190 200 210 220 230 240
DYQIVSLTGM GGLGKTTLAR QVFNHDVVKD RFDGFAWVSV SQEFTRISVW QTILQNLTSK
250 260 270 280 290 300
ERKDEIQNMK EADLHDDLFR LLESSKTLIV LDDIWKEEDW DLIKPIFPPK KGWKVLLTSR
310 320 330 340 350 360
TESIAMRGDT TYISFKPKCL SIPDSWTLFQ SIAMPRKDTS EFKVDEEMEN MGKKMIKHCG
370 380 390 400 410 420
GLSLAVKVLG GLLAAKYTLH DWKRLSENIG SHIVERTSGN NSSIDHVLSV SFEELPNYLK
430 440 450 460 470 480
HCFLYLAHFP EDHEIDVEKL HYYWAAEGIS ERRRYDGETI RDTGDSYIEE LVRRNMVISE
490 500 510 520 530 540
RDVMTSRFET CRLHDMMREI CLFKAKEENF LQIVSNHSPT SNPQTLGASR RFVLHNPTTL
550 560 570 580 590 600
HVERYKNNPK LRSLVVVYDD IGNRRWMLSG SIFTRVKLLR VLDLVQAKFK GGKLPSDIGK
610 620 630 640 650 660
LIHLRYLSLK DAKVSHLPSS LRNLVLLIYL DIRTDFTDIF VPNVFMGMRE LRYLELPRFM
670 680 690 700 710 720
HEKTKLELSN LEKLEALENF STKSSSLEDL RGMVRLRTLV IILSEGTSLQ TLSASVCGLR
730 740 750 760 770 780
HLENFKIMEN AGVNRMGEER MVLDFTYLKK LTLSIEMPRL PKIQHLPSHL TVLDLSYCCL
790 800 810 820 830 840
EEDPMPILEK LLELKDLSLD YLSFSGRKMV CSAGGFPQLR KLALDEQEEW EEWIVEEGSM
850 860 870 880 890
SRLHTLSIWS STLKELPDGL RFIYSLKNLI MGKSWMERLS ERGEEFYKVQ NIPFIKFSS