Q9C5C0

SS
Gene name
MPK18 (At1g53510, F22G10.12, T3F20.17)
Protein name
Mitogen-activated protein kinase 18
Names
AtMPK18 , MAP kinase 18 , EC 2.7.11.24
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G53510
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.

Autoinhibitory domains (AIDs)

74-153 (Autoinhibitory region) SS

Target domain

25-316 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

168-194 (Activation loop from InterPro)

Target domain

25-316 (Protein kinase domain)

Relief mechanism

Assay

168-194 (Activation loop from InterPro)

Target domain

25-316 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9C5C0

Entry ID Method Resolution Chain Position Source
AF-Q9C5C0-F1 Predicted AlphaFoldDB

32 variants for Q9C5C0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_19974146_G_C 5 Q>E No 1000Genomes
tmp_1_19973145_T_C 207 K>R No 1000Genomes
ENSVATH04954212 252 S>L No 1000Genomes
ENSVATH04954208 274 N>Y No 1000Genomes
tmp_1_19972498_T_A 281 K>N No 1000Genomes
ENSVATH01365728 291 R>H No 1000Genomes
ENSVATH01365728 291 R>L No 1000Genomes
ENSVATH13557241 295 R>K No 1000Genomes
tmp_1_19972261_T_A 321 K>* No 1000Genomes
ENSVATH14308706 341 R>L No 1000Genomes
ENSVATH04954196 421 V>L No 1000Genomes
tmp_1_19971618_C_A 422 V>F No 1000Genomes
tmp_1_19971605_G_A 426 S>L No 1000Genomes
ENSVATH04954195 435 S>G No 1000Genomes
ENSVATH04954194 437 R>C No 1000Genomes
tmp_1_19971572_C_A 437 R>L No 1000Genomes
ENSVATH01365721 458 Y>C No 1000Genomes
tmp_1_19971504_T_G 460 T>P No 1000Genomes
ENSVATH00096242 463 I>V Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 4 wks at 5c and 8hrs daylight] Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 2 wks at 5c and 8hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] No 1000Genomes
tmp_1_19971492_C_T 464 G>R No 1000Genomes
tmp_1_19971473_G_T 470 P>Q No 1000Genomes
tmp_1_19971371_C_T 480 E>K No 1000Genomes
ENSVATH13557229 499 A>G No 1000Genomes
tmp_1_19971311_C_G 500 V>L No 1000Genomes
ENSVATH13557228 507 F>S No 1000Genomes
tmp_1_19971179_C_T 544 A>T No 1000Genomes
tmp_1_19971175_G_A 545 T>I No 1000Genomes
tmp_1_19971106_G_A 568 T>I No 1000Genomes
tmp_1_19971080_T_C 577 M>V No 1000Genomes
tmp_1_19971050_G_C 587 Q>E No 1000Genomes
ENSVATH00096240 613 A>T No 1000Genomes
tmp_1_19970969_C_A 614 A>S No 1000Genomes

No associated diseases with Q9C5C0

3 regional properties for Q9C5C0

Type Name Position InterPro Accession
domain Protein kinase domain 25 - 316 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 60 - 163 IPR003527
binding_site Protein kinase, ATP binding site 31 - 55 IPR017441

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction
protein serine kinase activity Catalysis of the reactions

2 GO annotations of biological process

Name Definition
cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

89 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41808 SMK1 Sporulation-specific mitogen-activated protein kinase SMK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q00772 SLT2 Mitogen-activated protein kinase SLT2/MPK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3T0N5 MAPK13 Mitogen-activated protein kinase 13 Bos taurus (Bovine) SS
A5PKJ4 MAPK7 Mitogen-activated protein kinase 7 Bos taurus (Bovine) SS
P46196 MAPK1 Mitogen-activated protein kinase 1 Bos taurus (Bovine) SS
Q5F3W3 MAPK6 Mitogen-activated protein kinase 6 Gallus gallus (Chicken) SS
Q95NE7 MAPK14 Mitogen-activated protein kinase 14 Pan troglodytes (Chimpanzee) SS
Q9N272 MAPK13 Mitogen-activated protein kinase 13 Pan troglodytes (Chimpanzee) SS
Q9W354 Erk7 Extracellular signal-regulated kinase 7 Drosophila melanogaster (Fruit fly) SS
O61443 p38b Mitogen-activated protein kinase p38b Drosophila melanogaster (Fruit fly) SS
O62618 p38a Mitogen-activated protein kinase p38a Drosophila melanogaster (Fruit fly) SS
P83100 p38c Putative mitogen-activated protein kinase 14C Drosophila melanogaster (Fruit fly) SS
P40417 rl Mitogen-activated protein kinase ERK-A Drosophila melanogaster (Fruit fly) SS
O15264 MAPK13 Mitogen-activated protein kinase 13 Homo sapiens (Human) SS
P53778 MAPK12 Mitogen-activated protein kinase 12 Homo sapiens (Human) SS
Q16539 MAPK14 Mitogen-activated protein kinase 14 Homo sapiens (Human) SS
Q16659 MAPK6 Mitogen-activated protein kinase 6 Homo sapiens (Human) SS
Q15759 MAPK11 Mitogen-activated protein kinase 11 Homo sapiens (Human) SS
Q8TD08 MAPK15 Mitogen-activated protein kinase 15 Homo sapiens (Human) SS
P31152 MAPK4 Mitogen-activated protein kinase 4 Homo sapiens (Human) SS
P27361 MAPK3 Mitogen-activated protein kinase 3 Homo sapiens (Human) SS
P28482 MAPK1 Mitogen-activated protein kinase 1 Homo sapiens (Human) EV
Q9UBE8 NLK Serine/threonine-protein kinase NLK Homo sapiens (Human) SS
Q13164 MAPK7 Mitogen-activated protein kinase 7 Homo sapiens (Human) SS
Q9Z1B7 Mapk13 Mitogen-activated protein kinase 13 Mus musculus (Mouse) SS
P47811 Mapk14 Mitogen-activated protein kinase 14 Mus musculus (Mouse) SS
Q61532 Mapk6 Mitogen-activated protein kinase 6 Mus musculus (Mouse) SS
Q9WUI1 Mapk11 Mitogen-activated protein kinase 11 Mus musculus (Mouse) SS
O08911 Mapk12 Mitogen-activated protein kinase 12 Mus musculus (Mouse) SS
Q80Y86 Mapk15 Mitogen-activated protein kinase 15 Mus musculus (Mouse) SS
Q6P5G0 Mapk4 Mitogen-activated protein kinase 4 Mus musculus (Mouse) SS
P63085 Mapk1 Mitogen-activated protein kinase 1 Mus musculus (Mouse) SS
Q63844 Mapk3 Mitogen-activated protein kinase 3 Mus musculus (Mouse) SS
Q9WVS8 Mapk7 Mitogen-activated protein kinase 7 Mus musculus (Mouse) SS
P70618 Mapk14 Mitogen-activated protein kinase 14 Rattus norvegicus (Rat) SS
Q9WTY9 Mapk13 Mitogen-activated protein kinase 13 Rattus norvegicus (Rat) SS
Q9Z2A6 Mapk15 Mitogen-activated protein kinase 15 Rattus norvegicus (Rat) SS
P27704 Mapk6 Mitogen-activated protein kinase 6 Rattus norvegicus (Rat) SS
Q63538 Mapk12 Mitogen-activated protein kinase 12 Rattus norvegicus (Rat) SS
Q63454 Mapk4 Mitogen-activated protein kinase 4 Rattus norvegicus (Rat) SS
P21708 Mapk3 Mitogen-activated protein kinase 3 Rattus norvegicus (Rat) SS
P63086 Mapk1 Mitogen-activated protein kinase 1 Rattus norvegicus (Rat) SS
P0C865 Mapk7 Mitogen-activated protein kinase 7 Rattus norvegicus (Rat) SS
Q5VP69 MPK16 Mitogen-activated protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q0E459 MPK13 Mitogen-activated protein kinase 13 Oryza sativa subsp. japonica (Rice) SS
Q6Z437 MPK3 Mitogen-activated protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q10N20 MPK5 Mitogen-activated protein kinase 5 Oryza sativa subsp. japonica (Rice) SS
Q75KK8 MPK14 Mitogen-activated protein kinase 14 Oryza sativa subsp. japonica (Rice) SS
Q6L5F7 MPK17 Mitogen-activated protein kinase 17 Oryza sativa subsp. japonica (Rice) SS
Q84UI5 MPK1 Mitogen-activated protein kinase 1 Oryza sativa subsp. japonica (Rice) SS
Q5Z859 MPK4 Mitogen-activated protein kinase 4 Oryza sativa subsp. japonica (Rice) SS
Q5Z9J0 MPK12 Mitogen-activated protein kinase 12 Oryza sativa subsp. japonica (Rice) SS
Q5J4W4 MPK2 Mitogen-activated protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q336X9 MPK6 Mitogen-activated protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
Q53N72 MPK15 Mitogen-activated protein kinase 15 Oryza sativa subsp. japonica (Rice) SS
Q5ZCI1 MPK10 Mitogen-activated protein kinase 10 Oryza sativa subsp. japonica (Rice) SS
Q5VN19 MPK11 Mitogen-activated protein kinase 11 Oryza sativa subsp. japonica (Rice) SS
Q5SN53 MPK8 Mitogen-activated protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q67C40 MPK7 Mitogen-activated protein kinase 7 Oryza sativa subsp. japonica (Rice) SS
Q6L5D4 MPK9 Mitogen-activated protein kinase 9 Oryza sativa subsp japonica (Rice) PR
Q17446 pmk-1 Mitogen-activated protein kinase pmk-1 Caenorhabditis elegans SS
Q11179 mapk-15 Mitogen-activated protein kinase 15 Caenorhabditis elegans SS
Q8MXI4 pmk-2 Mitogen-activated protein kinase pmk-2 Caenorhabditis elegans SS
P39745 mpk-1 Mitogen-activated protein kinase mpk-1 Caenorhabditis elegans SS
O44514 pmk-3 Mitogen-activated protein kinase pmk-3 Caenorhabditis elegans PR
G5EBT1 sma-5 Mitogen-activated protein kinase sma-5 Caenorhabditis elegans SS
O23236 MPK14 Mitogen-activated protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) SS
Q39021 MPK1 Mitogen-activated protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q39022 MPK2 Mitogen-activated protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q39023 MPK3 Mitogen-activated protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q39024 MPK4 Mitogen-activated protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q39025 MPK5 Mitogen-activated protein kinase 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q39026 MPK6 Mitogen-activated protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q39027 MPK7 Mitogen-activated protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q84M93 MPK17 Mitogen-activated protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) SS
Q8W4J2 MPK16 Mitogen-activated protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LM33 MPK8 Mitogen-activated protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LUC3 MPK19 Mitogen-activated protein kinase 19 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M1Z5 MPK10 Mitogen-activated protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJG9 MPK20 Mitogen-activated protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GYQ5 MPK12 Mitogen-activated protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV37 MPK9 Mitogen-activated protein kinase 9 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C9U4 MPK15 Mitogen-activated protein kinase 15 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LMM5 MPK11 Mitogen-activated protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LQQ9 MPK13 Mitogen-activated protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) SS
P43294 MHK Serine/threonine-protein kinase MHK Arabidopsis thaliana (Mouse-ear cress) PR
O42376 mapk12 Mitogen-activated protein kinase 12 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE1 mapk14b Mitogen-activated protein kinase 14B Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE2 mapk14a Mitogen-activated protein kinase 14A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MQQNQVKKGT KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTHTGEK VAIKKINDVF
70 80 90 100 110 120
EHISDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK DIYVVFELME SDLHQVIKAN
130 140 150 160 170 180
DDLTREHHQF FLYQMLRALK FMHTANVYHR DLKPKNILAN ANCKLKVCDF GLARVAFNDT
190 200 210 220 230 240
PTTVFWTDYV ATRWYRAPEL CGSFFSKYTP AIDVWSIGCI FAEVLTGKPL FPGKSVVHQL
250 260 270 280 290 300
ELITDLLGTP KSETISGVRN DKARKYLTEM RKKNPVTFSQ KFSKADPLAL RLLQRLLAFD
310 320 330 340 350 360
PKDRPTPAEA LADPYFKGLS KIEREPSSQQ ISKMEFEFER RRLTKDDIRE LIYREILEYH
370 380 390 400 410 420
PQLLKDYMSG SEGSNFVYPS AIGHLRQQFT YLEENSSRNG PVIPLERKHA SLPRSTVHST
430 440 450 460 470 480
VVHSTSQPNL GATDSRRVSF EPSKNGASSA GHPSTSAYPT KSIGPPPRVP PSGRPGRVVE
490 500 510 520 530 540
SSVSYENGRN LKEAYFRSAV SSPHCYFRPN TMTNPENRNI EASSFPPKPQ NPVHQFSPTE
550 560 570 580 590 600
PPAATTNQAD VETMNHPNPY FQPQLPKTDQ LNNNTHMAID AKLLQAQSQF GPAGAAAVAV
610
AAHRNIGTIS YSAAS