AiPD: Autoinhibited Protein Database

Q9BZL6

Gene name	PRKD2 (PKD2, HSPC187)
Protein name	Serine/threonine-protein kinase D2
Names	nPKC-D2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:25865
EC number	2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

Protein kinase D (PKD) is a member of Ser/Thr kinases and plays a major role in Golgi function and organization. The PH domain within the PKD may autoinhibit the function of the PKD.

Autoinhibitory domains (AIDs)

397-509 (PH domain) SS

Target domain	589-845 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

397-509 (PH domain)

Target domain

589-845 (Protein kinase domain)

Relief mechanism

PTM (Phosphorylation at Tyr-463 by Abl)

Assay

Accessory elements

694-716 (Activation loop from InterPro)

Target domain	551-807 (Protein kinase domain)
Relief mechanism
Assay

References

Storz P et al. (2003) "Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation", The Journal of biological chemistry, 278, 17969-76

Autoinhibited structure

Activated structure

5 structures for Q9BZL6

Entry ID	Method	Resolution	Chain	Position	Source
2COA	NMR	-	A	398-509	PDB
3BGM	X-ray	160 A	C	526-534	PDB
4NNX	X-ray	210 A	C	526-534	PDB
4NNY	X-ray	190 A	C	526-534	PDB
AF-Q9BZL6-F1	Predicted				AlphaFoldDB

521 variants for Q9BZL6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1459489245 CA406470779	2	A>S		No	ClinGen gnomAD
rs1599847447 CA406470774	3	T>P		No	ClinGen Ensembl
CA9531258 rs780606637	5	P>S		No	ClinGen ExAC gnomAD
CA406470753 rs1158283095	6	S>F		No	ClinGen gnomAD
CA9531257 rs754611092	8	P>L		No	ClinGen ExAC gnomAD
CA406470739 rs1197005723	9	A>T		No	ClinGen gnomAD
rs758265254 CA9531254	14	S>F		No	ClinGen ExAC gnomAD
rs765247412 CA9531252	17	P>S		No	ClinGen ExAC gnomAD
rs752789164 CA9531250	18	G>V		No	ClinGen ExAC TOPMed gnomAD
rs759742456 CA9531249	21	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759742456 CA9531248	21	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA406470613 rs1568741809	21	P>S		No	ClinGen Ensembl
CA9531247 rs774438856	22	P>A		No	ClinGen ExAC gnomAD
CA406470597 rs1330793119	22	P>L		No	ClinGen gnomAD
rs1330793119 CA406470599	22	P>R		No	ClinGen gnomAD
rs774438856 CA309070636	22	P>S		No	ClinGen ExAC gnomAD
rs895194317 CA309070616	23	P>S		No	ClinGen TOPMed gnomAD
CA406470575 rs1276566248	24	G>D		No	ClinGen gnomAD
CA9531245 rs376804861	25	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1175980848 CA406470570	25	G>R		No	ClinGen TOPMed
CA9531244 rs773614119	27	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1599847348 CA406470551	27	E>Q		No	ClinGen Ensembl
rs770253505 CA9531243	29	Q>P		No	ClinGen ExAC gnomAD
CA406470504 rs1345174993	30	S>L		No	ClinGen TOPMed
CA406470492 rs1465313123	31	P>L		No	ClinGen gnomAD
CA9531241 rs776148897	32	P>S		No	ClinGen ExAC gnomAD
rs771902315 CA9531237	36	P>L		No	ClinGen ExAC gnomAD
rs779561959 CA9531238	36	P>S		No	ClinGen ExAC gnomAD
rs577377407 CA9531236	38	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA9531235 rs778885396	40	A>T		No	ClinGen ExAC gnomAD
CA406470378 rs1458435913	42	G>S		No	ClinGen gnomAD
rs753727761 CA9531233	44	G>R		No	ClinGen ExAC gnomAD
CA406470261 rs1568741687	50	Q>H		No	ClinGen Ensembl
CA9531232 rs781263890	51	I>F		No	ClinGen ExAC gnomAD
rs200962415 CA406470242	51	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1367289117 CA406470216	53	L>P		No	ClinGen gnomAD
CA406493862 rs1225294414	56	E>K		No	ClinGen TOPMed
CA406493826 rs1174094432	61	P>S		No	ClinGen gnomAD
rs146804334 CA9531225	62	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777001291 CA9531224	63	A>T		No	ClinGen ExAC gnomAD
CA406493798 rs1450740440	66	L>M		No	ClinGen gnomAD
CA406493781 rs1599847212	68	H>Q		No	ClinGen Ensembl
rs911566004 CA309114822	68	H>Y		No	ClinGen TOPMed gnomAD
rs1442222205 CA406493750	73	A>D		No	ClinGen TOPMed gnomAD
rs1442222205 CA406493748	73	A>V		No	ClinGen TOPMed gnomAD
rs1226379710 CA406493675	81	F>L		No	ClinGen gnomAD
CA406493663 rs1411343007	83	E>D		No	ClinGen gnomAD
CA9531208 rs750649124	83	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9531209 rs750649124	83	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA406493652 rs1414355523	85	G>C		No	ClinGen TOPMed
CA406493637 rs1405428090	87	Y>C		No	ClinGen gnomAD
rs1226177313 CA406493624	89	L>F		No	ClinGen gnomAD
CA406493617 rs1342751346	90	Y>S		No	ClinGen TOPMed
rs764480251 CA9531204	91	D>H		No	ClinGen ExAC TOPMed gnomAD
CA9531203 rs761279629	92	K>E		No	ClinGen ExAC gnomAD
rs1202715828 CA406493539	101	T>K		No	ClinGen TOPMed
CA309113382 rs866313306	103	A>T		No	ClinGen Ensembl
CA9531200 rs759189553	105	L>F		No	ClinGen ExAC gnomAD
rs1376459417 CA406493496	108	L>P		No	ClinGen gnomAD
CA9531198 rs770763595	110	R>C		No	ClinGen ExAC TOPMed gnomAD
CA406493486 rs1328358048	110	R>H		No	ClinGen gnomAD
rs1263515553 CA406493473	112	S>C		No	ClinGen TOPMed
COSM3766383 rs769577782 CA9531195	116	Q>E	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1360459560 CA406493436	117	E>D		No	ClinGen gnomAD
rs748139278 CA9531194	120	L>V		No	ClinGen ExAC gnomAD
rs1599845460 CA406493407	122	E>G		No	ClinGen Ensembl
rs1599845454 CA406493400	123	V>G		No	ClinGen Ensembl
CA406493386 rs1167253874	126	S>P		No	ClinGen gnomAD
rs780042850 CA9531193	126	S>W		No	ClinGen ExAC gnomAD
rs938146133 CA309110834	128	S>L		No	ClinGen gnomAD
rs768631871 CA9531173	129	A>V		No	ClinGen ExAC TOPMed gnomAD
CA309110805 rs927087756	130	T>I		No	ClinGen gnomAD
CA406492601 rs1299020297	131	F>I		No	ClinGen gnomAD
rs1216877513 CA406492587	131	F>L		No	ClinGen TOPMed gnomAD
CA9531170 rs553302740	135	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
CA406492498 rs1449191589	137	R>C		No	ClinGen gnomAD
rs1377511257 CA406492488	138	P>T		No	ClinGen gnomAD
CA309110721 rs868644975	140	A>S		No	ClinGen TOPMed
CA406492457 rs868644975	140	A>T		No	ClinGen TOPMed
CA406492390 rs1599842960	144	H>L		No	ClinGen Ensembl
CA406492337 rs1476027505	148	A>S		No	ClinGen gnomAD
CA406492315 rs1483165783	150	A>T		No	ClinGen gnomAD
rs1252596198 CA406492305	150	A>V		No	ClinGen gnomAD
CA9531164 rs755581255	151	F>L		No	ClinGen ExAC TOPMed gnomAD
rs768112939 CA9531165	151	F>Y		No	ClinGen ExAC gnomAD
CA309110673 rs974412159	154	H>Y		No	ClinGen TOPMed
CA406492229 rs1312559136	155	C>Y		No	ClinGen gnomAD
CA309110668 rs866401102	156	G>W		No	ClinGen Ensembl
CA406492202 rs1357709078	157	E>K		No	ClinGen gnomAD
CA406492136 rs143631618	160	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA406492133 rs1300031426	161	G>R		No	ClinGen gnomAD
rs764857604 CA9531159	163	V>G		No	ClinGen ExAC gnomAD
CA9531158 rs761575561	164	R>C		No	ClinGen ExAC gnomAD
rs1462839119 CA406492080	165	Q>*		No	ClinGen gnomAD
CA406492078 rs1409544522	165	Q>R		No	ClinGen gnomAD
rs1181150074 CA406492044	167	L>P		No	ClinGen gnomAD
CA309110634 rs867399842	168	K>N		No	ClinGen Ensembl
CA406492015 rs1188963196	169	C>*		No	ClinGen gnomAD
rs1252211147 CA406492020	169	C>Y		No	ClinGen gnomAD
CA309110633 rs752231529	170	D>E		No	ClinGen gnomAD
CA406492011 rs768543948	170	D>N		No	ClinGen ExAC gnomAD
rs768543948 CA9531156	170	D>Y		No	ClinGen ExAC gnomAD
rs763806947 CA9531114	175	N>H		No	ClinGen ExAC
rs1182630223 CA406490109	176	Y>H		No	ClinGen gnomAD
CA9531112 rs371737313	184	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA406489922 rs1599836697	186	N>H		No	ClinGen Ensembl
rs773291492 CA9531109	186	N>S		No	ClinGen ExAC gnomAD
rs1279702203 CA406489842	189	S>T		No	ClinGen gnomAD
CA406489815 rs1443778046	190	G>E		No	ClinGen TOPMed gnomAD
rs144404837 CA406489802	191	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776989283 CA9531106	191	A>S		No	ClinGen ExAC gnomAD
rs776989283 CA406489811	191	A>T		No	ClinGen ExAC gnomAD
rs144404837 CA9531105	191	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406489790 rs1329803436	192	R>C		No	ClinGen TOPMed
rs867808245 CA309105501	192	R>H		No	ClinGen gnomAD
CA406489760 rs1433688868	194	R>G		No	ClinGen TOPMed
rs962788073 CA309105500 COSM439844	195	R>C	endometrium breast [Cosmic]	No	ClinGen cosmic curated TOPMed
CA309105497 rs1016024133	196	L>P		No	ClinGen Ensembl
rs775746699 CA9531103	199	T>M		No	ClinGen ExAC TOPMed gnomAD
CA406489590 rs1159314940	205	H>L		No	ClinGen TOPMed gnomAD
rs1471268301 CA406489587	205	H>Q		No	ClinGen gnomAD
CA406489561 rs1599836553	207	V>G		No	ClinGen Ensembl
CA9531101 rs746372258	207	V>M		No	ClinGen ExAC TOPMed gnomAD
rs150056935 CA9531100	208	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA309105475 rs1026645138	208	R>H		No	ClinGen Ensembl
CA9531099 rs756752090	210	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1465303410 CA406489522	211	T>I		No	ClinGen Ensembl
rs199909805 CA309105470	212	S>F		No	ClinGen TOPMed gnomAD
CA406489493 rs1165302976	216	P>T		No	ClinGen TOPMed
rs376158404 CA9531095	217	C>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA406489484 rs1342394755	217	C>Y		No	ClinGen gnomAD
rs767240469 CA9531094	218	T>M		No	ClinGen ExAC gnomAD
CA406489466 rs1328472390	220	E>A		No	ClinGen gnomAD
CA406489467 rs1281174377	220	E>K		No	ClinGen Ensembl
CA9531069 rs370465589	224	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs752855161 CA9531068	224	R>H		No	ClinGen ExAC gnomAD
rs759802222 CA9531066	225	S>C		No	ClinGen ExAC gnomAD
rs1599836273 CA406489397	226	T>P		No	ClinGen Ensembl
rs139391523 CA9531065	227	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406489390 rs1599836261	227	T>P		No	ClinGen Ensembl
CA9531063 rs763476816	228	E>K		No	ClinGen ExAC gnomAD
CA9531062 rs769193163	229	L>F		No	ClinGen ExAC TOPMed gnomAD
CA406489370 rs769193163	229	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1599836232 CA406489367	229	L>P		No	ClinGen Ensembl
rs769193163 CA9531061	229	L>V		No	ClinGen ExAC TOPMed gnomAD
CA406489346 rs1416947929	232	R>C		No	ClinGen gnomAD
rs780694769 CA9531059	233	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746759244 CA9531057	233	R>H		No	ClinGen ExAC TOPMed gnomAD
rs746759244 CA9531058	233	R>L		No	ClinGen ExAC TOPMed gnomAD
CA309105348 rs909950029	234	P>S		No	ClinGen Ensembl
CA9531055 rs758351115	235	P>L		No	ClinGen ExAC gnomAD
rs1202454227 CA406489322	235	P>S		No	ClinGen TOPMed
CA406489301 rs1233988221	237	S>F		No	ClinGen gnomAD
rs1273019175 CA406489262	241	S>F		No	ClinGen gnomAD
rs1273019175 CA406489264	241	S>Y		No	ClinGen gnomAD
CA406489242 rs1187714085	243	A>V		No	ClinGen gnomAD
CA9531050 rs767608222	245	S>L		No	ClinGen ExAC TOPMed gnomAD
CA406489202 rs1299939093	247	T>A		No	ClinGen gnomAD
CA9531047 rs143170215	247	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs950595996 CA309105326	248	G>A		No	ClinGen Ensembl
CA9531045 rs773706136	249	R>C		No	ClinGen ExAC gnomAD
COSM191148 rs1026152619 CA309105319	249	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA309105313 rs976363809	251	I>T		No	ClinGen TOPMed gnomAD
CA9531044 rs770391326	251	I>V		No	ClinGen ExAC
rs776236498 CA9531042	252	E>K		No	ClinGen ExAC gnomAD
CA309105303 rs965969111	254	D>E		No	ClinGen gnomAD
CA9531039 rs145571238	259	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145571238 CA309105297	259	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA309105284 rs868447537	262	K>N		No	ClinGen Ensembl
rs1259313946 CA406489016 COSM1287398	264	P>L	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated gnomAD
rs967592855 CA309105283	266	T>S		No	ClinGen TOPMed
CA9531036 rs778689797	270	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs143238059 CA9531037	270	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA309105275 rs903560915	271	S>N		No	ClinGen TOPMed gnomAD
CA406488962 rs903560915	271	S>T		No	ClinGen TOPMed gnomAD
CA406488943 COSM566759 rs1326449512	274	R>Q	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA406488928 rs1442859263	277	V>I		No	ClinGen TOPMed gnomAD
rs1386246308 CA406488889	282	K>R		No	ClinGen gnomAD
CA406488834 rs1346579465	290	R>Q		No	ClinGen gnomAD
CA9531031 rs751786745	296	K>R		No	ClinGen ExAC gnomAD
rs1227922216 CA406488752	300	F>L		No	ClinGen gnomAD
CA9531003 rs775176492	303	H>Q		No	ClinGen ExAC gnomAD
rs765898055 CA309103542	305	R>C		No	ClinGen TOPMed gnomAD
rs142714532 CA309103537	305	R>H		No	ClinGen ESP TOPMed
CA9531001 rs759288903	307	A>T		No	ClinGen ExAC TOPMed gnomAD
rs369442988 CA9531000	309	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA9530999 rs202009599	309	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs369442988 CA406488691	309	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA9530997 rs773190037	310	V>I		No	ClinGen ExAC gnomAD
rs1462923300 CA406488677	311	P>L		No	ClinGen gnomAD
rs1375183247 CA406488671	312	N>S		No	ClinGen gnomAD
rs1163218107 CA406488664	313	D>G		No	ClinGen gnomAD
CA406488663 rs1163218107	313	D>V		No	ClinGen gnomAD
rs1258415298 CA406488630	318	A>D		No	ClinGen gnomAD
rs747061893 CA9530995	321	N>Y		No	ClinGen ExAC gnomAD
VAR_042330 rs45455991 CA9530984	324	V>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs371760202 CA9530983	325	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167303043 CA406488567	326	M>T		No	ClinGen gnomAD
CA406488562 rs1468770997	327	E>*		No	ClinGen gnomAD
CA9530980 rs772921569	329	A>P		No	ClinGen ExAC
CA309103367 rs915919073	330	T>I		No	ClinGen Ensembl
CA9530976 rs775481750 COSM998471	331	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs775481750 CA9530977	331	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA9530975 rs561186732	332	F>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1468714265 CA406488517	333	S>R		No	ClinGen gnomAD
rs745991981 CA9530974	334	E>K		No	ClinGen ExAC gnomAD
rs779171577 CA9530973	337	K>E		No	ClinGen ExAC TOPMed gnomAD
rs779171577 CA406488494	337	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA9530971 rs749621217	338	S>G		No	ClinGen ExAC gnomAD
CA309103304 rs780980915	338	S>N		No	ClinGen gnomAD
rs10402397 CA9530969	339	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA309103279 rs756838548	340	L>F		No	ClinGen TOPMed
CA9530967 rs781782443	341	M>T		No	ClinGen ExAC TOPMed gnomAD
CA406488459 rs1325939449	342	D>G		No	ClinGen gnomAD
rs1164008849 CA406488444	344	S>L		No	ClinGen TOPMed
CA406488423 rs1384456428	347	S>A		No	ClinGen gnomAD
rs374895780 CA9530964	348	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA9530965 rs751082013	348	G>S		No	ClinGen ExAC TOPMed gnomAD
CA309103257 rs374895780	348	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1446075654 CA406488367	356	E>D		No	ClinGen gnomAD
rs761661352 CA309103243	356	E>K		No	ClinGen ExAC TOPMed gnomAD
rs761661352 CA9530960	356	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA9530959 rs769274317	358	A>V		No	ClinGen ExAC TOPMed gnomAD
CA406488349 rs1278962843	359	L>F		No	ClinGen gnomAD
rs759626748 CA9530957	359	L>P		No	ClinGen ExAC gnomAD
CA406488344 rs1372348261	360	H>Y		No	ClinGen gnomAD
rs199584064 CA406488334	361	A>P		No	ClinGen ExAC TOPMed gnomAD
rs199584064 CA9530955 COSM1222066	361	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs140335932 CA9530954	363	E>V		No	ClinGen ESP ExAC gnomAD
rs376747447 CA9530951	367	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173082921 CA406488253	368	E>K		No	ClinGen TOPMed gnomAD
rs1427103439 CA406488226	370	G>D		No	ClinGen gnomAD
rs781759427 CA9530948	370	G>S		No	ClinGen ExAC TOPMed gnomAD
CA406488193 rs1474936936	373	Q>R		No	ClinGen gnomAD
CA309101677 rs941157980	376	L>R		No	ClinGen TOPMed
rs200312083 CA309101673	377	G>V		No	ClinGen 1000Genomes
CA9530925 rs745430394	378	Y>H		No	ClinGen ExAC gnomAD
CA406487382 rs1410294659	389	R>P		No	ClinGen gnomAD
CA9530921 rs763806572	391	T>M		No	ClinGen ExAC gnomAD
CA9530919 rs201153892	393	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9530918 rs767550862	394	K>T		No	ClinGen ExAC TOPMed gnomAD
CA406487278 rs1568728189	397	T>N		No	ClinGen Ensembl
rs866422417 CA309101637	398	T>M		No	ClinGen TOPMed gnomAD
CA406486743 rs1222637788	399	L>P		No	ClinGen gnomAD
CA406486732 rs1323724325	400	R>L		No	ClinGen TOPMed gnomAD
CA406486736 rs1323724325	400	R>Q		No	ClinGen TOPMed gnomAD
CA406486722 rs1304978090	401	E>A		No	ClinGen gnomAD
rs765515951 CA9530915	401	E>D		No	ClinGen ExAC TOPMed gnomAD
CA9530914 rs762149643	404	V>L		No	ClinGen ExAC TOPMed gnomAD
CA406486687 rs762149643	404	V>M		No	ClinGen ExAC TOPMed gnomAD
CA406486645 rs1311305182	407	Y>H		No	ClinGen gnomAD
rs776997966 COSM998467 CA9530913	408	S>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1393513366 CA406486619	409	N>H		No	ClinGen gnomAD
rs768896657 CA9530912	409	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9530910 rs775838431	410	K>R		No	ClinGen ExAC gnomAD
CA406486425 rs747857891	418	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA9530885 rs747857891	418	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA406486397 rs1170175592	420	R>C		No	ClinGen TOPMed gnomAD
CA9530882 rs751548679	425	C>Y		No	ClinGen ExAC
rs944355588 CA309101210	426	I>V		No	ClinGen TOPMed
rs141249700 CA309101208	427	T>K		No	ClinGen ESP
rs757388004 CA9530880	429	F>C		No	ClinGen ExAC gnomAD
CA9530877 rs760970123	430	Q>H		No	ClinGen ExAC gnomAD
CA9530878 rs151039989	430	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9530879 rs151039989	430	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1193381782 CA406486242	432	N>S		No	ClinGen TOPMed
CA9530876 rs752943052	433	T>M		No	ClinGen ExAC gnomAD
CA9530875 rs767870846	435	N>K		No	ClinGen ExAC gnomAD
CA9530874 rs759956923	437	Y>C		No	ClinGen ExAC gnomAD
CA406486141 rs1291008144	439	K>T		No	ClinGen gnomAD
CA9530854 rs766836075	442	P>A		No	ClinGen ExAC gnomAD
CA9530853 rs763539356	442	P>L		No	ClinGen ExAC gnomAD
CA406485638 rs766836075	442	P>S		No	ClinGen ExAC gnomAD
CA406485621 rs1162012004	445	E>G		No	ClinGen TOPMed
CA9530850 rs761298497	445	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA9530848 rs768462170	448	T>M		No	ClinGen ExAC TOPMed gnomAD
CA406485580 rs1445769377	451	S>F		No	ClinGen TOPMed
rs536434220 CA406485578	452	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9530845 rs536434220	452	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406485568 rs1159210222	453	Q>H		No	ClinGen TOPMed gnomAD
CA406485559 rs1202874784	454	N>K		No	ClinGen TOPMed gnomAD
CA406485552 rs1286065697	455	F>L		No	ClinGen gnomAD
CA406485554 rs1349389725	455	F>S		No	ClinGen gnomAD
CA309099306 rs866307826	458	V>A		No	ClinGen Ensembl
rs778780083 CA9530843	459	P>L		No	ClinGen ExAC gnomAD
CA9530844 rs745819170	459	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9530841 rs187308910	460	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9530840 rs527595835	462	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406485457 rs1172573215	463	N>S		No	ClinGen gnomAD
rs1478553121 CA406485444	464	P>S		No	ClinGen gnomAD
CA406485411 rs1245519029	466	C>F		No	ClinGen TOPMed
CA406485377 rs1179631507	468	E>D		No	ClinGen TOPMed
CA406485390 rs1472074362	468	E>K		No	ClinGen TOPMed
CA9530836 rs758766629	470	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1190626310 CA406485351	471	T>A		No	ClinGen gnomAD
rs765711862 CA9530834	473	N>D		No	ClinGen ExAC gnomAD
rs902275668 CA309099277	473	N>S		No	ClinGen TOPMed gnomAD
CA309099275 rs1051056547	474	A>T		No	ClinGen gnomAD
rs761353253 CA9530833	475	T>I		No	ClinGen ExAC gnomAD
rs1276971441 CA406485254	478	V>M		No	ClinGen gnomAD
CA9530830 COSM1161280 rs760413562	480	E>K	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9530829 rs775354542	481	M>T		No	ClinGen ExAC gnomAD
CA9530827 rs759304190	484	G>R		No	ClinGen ExAC TOPMed gnomAD
rs770816078 CA9530825	485	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1414936404 CA406485146	486	P>A		No	ClinGen gnomAD
rs144835599 CA9530824	486	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768809577 CA9530822	487	G>D		No	ClinGen ExAC gnomAD
rs1423810249 CA406485099	490	S>T		No	ClinGen gnomAD
CA9530821 RCV000962733 rs80021620	493	G>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs80021620 CA406485061	493	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9530820 rs140899472	494	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9530819 rs758778443	496	A>P		No	ClinGen ExAC TOPMed gnomAD
VAR_042331 CA9530818 rs55716765	496	A>V		No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
CA406485022 rs1213111699	497	A>T		No	ClinGen gnomAD
rs1317555367 CA406485013	497	A>V		No	ClinGen gnomAD
CA9530816 rs757860622	498	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs779434479 CA9530817	498	R>W		No	ClinGen ExAC TOPMed gnomAD
CA309099241 rs977555608	499	G>S		No	ClinGen Ensembl
CA9530815 rs753340735	504	I>V		No	ClinGen ExAC gnomAD
CA406484920 rs1448737424	505	R>C		No	ClinGen gnomAD
rs201530743 CA9530814	505	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA309099235 rs201530743	505	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1326610553 CA406484887	507	A>V		No	ClinGen gnomAD
CA9530813 rs760325391	509	M>T		No	ClinGen ExAC gnomAD
rs199530973 CA9530811	511	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA309099221 rs958934940	515	D>G		No	ClinGen Ensembl
rs774048512 CA406484773	516	A>S		No	ClinGen ExAC TOPMed gnomAD
rs774048512 CA9530809	516	A>T		No	ClinGen ExAC TOPMed gnomAD
CA406484742 rs1181879099	518	S>R		No	ClinGen TOPMed gnomAD
rs1473416821 CA406484738	519	A>S		No	ClinGen TOPMed gnomAD
rs1473416821 CA406484734	519	A>T		No	ClinGen TOPMed gnomAD
CA406484691 rs1457641247	522	H>R		No	ClinGen gnomAD
rs1197173926 CA406484695	522	H>Y		No	ClinGen gnomAD
rs776626136 CA9530806	523	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9530805 rs77539002	523	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406484660 rs1599824962	524	P>L		No	ClinGen Ensembl
CA309099203 rs371981872	526	R>G		No	ClinGen ESP TOPMed gnomAD
CA9530785 rs202076996	526	R>K		No	ClinGen ExAC TOPMed gnomAD
CA9530784 rs772278023	528	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1381798248 CA406483813	530	L>P		No	ClinGen TOPMed
CA9530783 rs138428419	531	S>R		No	ClinGen ESP ExAC TOPMed
CA406483760 rs1287892831	532	I>V		No	ClinGen TOPMed
rs1293807364 CA406483576	538	Q>H		No	ClinGen gnomAD
CA406483530 rs1438134662	540	Q>H		No	ClinGen gnomAD
CA309098640 rs1016054137	541	E>Q		No	ClinGen Ensembl
CA406483493 rs1342991374	542	N>K		No	ClinGen gnomAD
rs1388281106 CA406483489	543	V>M		No	ClinGen TOPMed
CA406483317 rs1201146902	545	I>V		No	ClinGen TOPMed
rs1315711171 CA406482986	559	S>A		No	ClinGen gnomAD
rs1256451401 CA406482875	565	V>F		No	ClinGen TOPMed
rs1341876942 CA406482851	566	Y>F		No	ClinGen TOPMed gnomAD
rs928925940 CA309097962	568	G>A		No	ClinGen Ensembl
rs1248881267 CA406482316	570	H>R		No	ClinGen gnomAD
rs1173012563 CA406482286	572	K>N		No	ClinGen gnomAD
CA406482251 rs1447925115	575	R>Q		No	ClinGen TOPMed gnomAD
CA309097953 rs897509792	575	R>W		No	ClinGen gnomAD
CA406482238 rs56144729	576	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406482244 rs1337774015	576	D>H		No	ClinGen gnomAD
rs766572176 CA9530726 COSM998461	578	A>E	endometrium prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA406482187 rs1391627261	581	V>I		No	ClinGen TOPMed gnomAD
CA9530725 rs572801854	585	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs750665196 CA9530724 COSM439841	586	R>H	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1197811373 CA406481909 COSM566762	592	E>D	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1413386361 CA406481899	593	S>N		No	ClinGen TOPMed gnomAD
CA406481819 rs1312702342	596	R>Q		No	ClinGen TOPMed
rs1213734409 COSM302992 CA406481821	596	R>W	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
CA406481646 rs1182473898	603	Q>H		No	ClinGen gnomAD
rs34325043 VAR_042332 CA9530702	604	S>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA406481446 rs1568721720	604	S>N		No	ClinGen Ensembl
CA9530700 rs761081110	606	R>Q		No	ClinGen ExAC gnomAD
rs200536563 CA9530701	606	R>W		No	ClinGen ExAC TOPMed gnomAD
CA309097414 rs994152284	607	H>Q		No	ClinGen TOPMed gnomAD
CA9530694 rs748977120	617	F>V		No	ClinGen ExAC TOPMed gnomAD
CA406481132 rs1423792152	618	E>K		No	ClinGen gnomAD
rs1476677646 CA406481104	619	T>M		No	ClinGen gnomAD
rs1463074692 CA406481100	620	P>T		No	ClinGen gnomAD
CA406480992 rs1320599219	625	V>M		No	ClinGen TOPMed
CA406480905 rs1317458016	630	L>M		No	ClinGen gnomAD
CA9530686 rs757345373	641	S>G		No	ClinGen ExAC gnomAD
CA9530685 rs754074032	644	G>V		No	ClinGen ExAC gnomAD
rs756439784 CA9530683	645	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9530684 rs764267606	645	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9530682 rs34795467	649	R>C		No	ClinGen ExAC gnomAD
CA9530681 rs767961173	649	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1255333611 CA406479831	651	T>A		No	ClinGen TOPMed
rs984151744 CA309097337	651	T>I		No	ClinGen TOPMed gnomAD
rs1163254483 CA406479707	656	T>N		No	ClinGen gnomAD
CA406479715 rs1599820578	656	T>P		No	ClinGen Ensembl
rs1431664735 CA406478244	662	L>S		No	ClinGen gnomAD
CA9530652 rs775462183	663	R>G		No	ClinGen ExAC gnomAD
CA406478224 rs1481482324	664	H>Y		No	ClinGen gnomAD
rs1209844347 CA406478131	671	V>A		No	ClinGen Ensembl
CA406478018 rs1263015374	682	L>M		No	ClinGen gnomAD
rs1311268655 CA406477965	688	F>I		No	ClinGen TOPMed gnomAD
rs748368507 CA9530647	690	Q>R		No	ClinGen ExAC gnomAD
rs758876482 CA9530624	700	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1237138259 CA406476966	700	R>H		No	ClinGen gnomAD
CA309086043 rs926442685	701	I>M		No	ClinGen Ensembl
rs779609817 CA9530622	703	G>S		No	ClinGen ExAC gnomAD
CA406476897 rs756792184	704	E>*		No	ClinGen ExAC TOPMed gnomAD
rs756792184 CA9530621	704	E>K		No	ClinGen ExAC TOPMed gnomAD
rs763752080 CA9530619	706	S>L		No	ClinGen ExAC gnomAD
rs1218479922 CA406476810	708	R>C		No	ClinGen TOPMed
rs1387904543 CA406476791	709	R>C		No	ClinGen TOPMed gnomAD
rs1387904543 CA406476794	709	R>G		No	ClinGen TOPMed gnomAD
COSM712233 CA9530616 rs767210044	709	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA406476756 rs1328477526	711	V>L		No	ClinGen gnomAD
CA406476707 rs1392181290	714	T>M		No	ClinGen gnomAD
CA9530613 rs766343388	715	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1568712890 CA406476639	720	P>S		No	ClinGen Ensembl
rs768869479 CA9530610	725	N>D		No	ClinGen ExAC gnomAD
CA309085985 rs754211889	731	S>L		No	ClinGen Ensembl
CA406476503 rs1208685921	731	S>T		No	ClinGen TOPMed gnomAD
CA406476459 rs1225323516	734	M>T		No	ClinGen gnomAD
rs1240051755 CA406476369	741	M>L		No	ClinGen TOPMed gnomAD
rs1240051755 CA406476367	741	M>V		No	ClinGen TOPMed gnomAD
CA9530605 rs779519593	747	G>S		No	ClinGen ExAC TOPMed gnomAD
CA406476212 rs1304923175	752	N>S		No	ClinGen gnomAD
rs866307765 CA309085946	753	E>K		No	ClinGen Ensembl
rs755714612 CA9530601	757	I>V		No	ClinGen ExAC gnomAD
CA9530600 rs752280760	758	N>S		No	ClinGen ExAC gnomAD
rs1375518183 CA406476109	759	D>H		No	ClinGen gnomAD
CA9530597 rs766259352	763	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1270405405 CA406476075	763	N>S		No	ClinGen gnomAD
rs764079163 COSM267262 CA9530593	765	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs370149673 CA406476052	767	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370149673 CA9530592	767	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1353138979 CA406476041	768	Y>S		No	ClinGen gnomAD
rs775542092 CA406476032	769	P>L		No	ClinGen ExAC gnomAD
rs775542092 CA9530591	769	P>Q		No	ClinGen ExAC gnomAD
rs1346305592 CA406476031	770	A>P		No	ClinGen gnomAD
CA406476022 rs1398074050	771	S>N		No	ClinGen gnomAD
CA406476019 rs774867853	771	S>R		No	ClinGen ExAC TOPMed gnomAD
rs774867853 CA9530589	771	S>R		No	ClinGen ExAC TOPMed gnomAD
rs55933311 CA9530586	773	W>G		No	ClinGen ExAC gnomAD
rs55933311 CA309085892 VAR_042333	773	W>R		No	ClinGen UniProt ExAC dbSNP gnomAD
rs201225333 CA9530585	775	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747736186 CA9530583	776	I>N		No	ClinGen ExAC gnomAD
CA9530582 rs780669827	779	G>E		No	ClinGen ExAC gnomAD
CA406475291 rs1469763918	781	I>V		No	ClinGen gnomAD
CA406475264 rs1482366933	782	D>E		No	ClinGen gnomAD
rs1206670046 COSM1304817 CA406475271	782	D>G	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1244929696 CA406475259	783	L>F		No	ClinGen TOPMed
rs1555825242 CA9530552	785	N>S		No	ClinGen Ensembl
CA406475141 rs1196779403	791	K>N		No	ClinGen TOPMed gnomAD
rs755165428 CA9530549	792	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1341681749 CA406475118	792	M>R		No	ClinGen TOPMed gnomAD
CA309084025 rs906595714	792	M>V		No	ClinGen Ensembl
CA406475112 rs1361412854	793	R>C		No	ClinGen gnomAD
CA406475099 rs1306793696	795	R>C		No	ClinGen gnomAD
rs751808641 CA9530548	795	R>H		No	ClinGen ExAC gnomAD
rs373418059 CA309083988	797	S>N		No	ClinGen ESP TOPMed
rs1025031662 CA309083973	798	V>M		No	ClinGen Ensembl
CA406475074 rs1280804997	799	D>N		No	ClinGen TOPMed gnomAD
CA406475056 rs1433738565	801	S>C		No	ClinGen gnomAD
CA406475051 rs1410968801	802	L>F		No	ClinGen TOPMed
CA406475046 rs1244118550	803	S>G		No	ClinGen gnomAD
rs766749822 CA9530547	805	P>H		No	ClinGen ExAC
CA406475020 rs1367861336	806	W>*		No	ClinGen gnomAD
rs1425826712 CA406475023	806	W>*		No	ClinGen gnomAD
rs1185826348 CA406474987	809	E>A		No	ClinGen gnomAD
CA9530529 rs758661830	812	T>M		No	ClinGen ExAC gnomAD
rs1224764339 CA406474937	816	L>F		No	ClinGen gnomAD
rs1305237784 CA406474936	816	L>H		No	ClinGen gnomAD
CA9530526 rs762146805	817	R>L		No	ClinGen ExAC gnomAD
CA406474931 rs762146805	817	R>Q		No	ClinGen ExAC gnomAD
rs373208619 CA9530525	819	L>M		No	ClinGen ESP ExAC gnomAD
CA309083637 rs780442730	820	E>Q		No	ClinGen gnomAD
CA9530523 rs760124538	821	G>E		No	ClinGen ExAC TOPMed gnomAD
CA9530522 rs774992717	824	G>R		No	ClinGen ExAC gnomAD
rs771555628 CA9530521	826	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA406474858 rs1417875543	828	I>M		No	ClinGen TOPMed gnomAD
CA309083589 rs774846613	828	I>N		No	ClinGen Ensembl
rs1322375437 CA406474850	830	H>D		No	ClinGen TOPMed
rs1322375437 CA406474851	830	H>Y		No	ClinGen TOPMed
CA406474832 rs1428986114	832	S>N		No	ClinGen gnomAD
CA9530519 rs770736873	833	D>E		No	ClinGen ExAC TOPMed gnomAD
rs749135021 CA9530517	834	D>N		No	ClinGen ExAC TOPMed gnomAD
CA309083577 rs536277467	834	D>V		No	ClinGen 1000Genomes
rs314665 CA406474812	835	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747734223 CA9530515	835	A>T		No	ClinGen ExAC TOPMed gnomAD
CA309083573 rs314665 VAR_061531	835	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs201625972 CA9530512	836	R>C		No	ClinGen ExAC TOPMed gnomAD
rs750647595 CA9530511	836	R>H		No	ClinGen ExAC gnomAD
CA9530510 rs779057757	837	W>R		No	ClinGen ExAC TOPMed gnomAD
rs757614240 CA9530509	839	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA406474776 rs1337715827	840	F>L		No	ClinGen gnomAD
CA406474782 rs1382455501	840	F>L		No	ClinGen gnomAD
CA406474765 rs1051465175	842	A>G		No	ClinGen TOPMed
CA309083544 rs1051465175	842	A>V		No	ClinGen TOPMed
rs754220558 CA9530507	843	E>Q		No	ClinGen ExAC gnomAD
rs761172786 CA9530505	844	H>R		No	ClinGen ExAC gnomAD
CA9530504 rs753267078	845	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1443824341 CA406474738	847	P>S		No	ClinGen gnomAD
rs527870015 CA9530501	848	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9530500 rs770521796	851	L>M		No	ClinGen ExAC gnomAD
rs1195832363 CA406474713	852	P>T		No	ClinGen TOPMed gnomAD
rs1277444596 CA406474704	853	T>M		No	ClinGen TOPMed gnomAD
CA406474705 rs1481260229	853	T>S		No	ClinGen gnomAD
CA9530499 rs763388384	854	D>E		No	ClinGen ExAC gnomAD
CA406474671 rs1334162268	858	G>C		No	ClinGen TOPMed gnomAD
CA406474673 rs1334162268	858	G>S		No	ClinGen TOPMed gnomAD
CA406474651 rs1452817692	861	C>F		No	ClinGen TOPMed
rs921682772 CA309083475	862	P>S		No	ClinGen gnomAD
rs769789721 CA9530497	863	P>Q		No	ClinGen ExAC gnomAD
CA406474640 rs1392087671	863	P>S		No	ClinGen gnomAD
rs1301293182 CA406474637	864	Q>K		No	ClinGen gnomAD
CA406474617 rs1365976163	866	H>R		No	ClinGen gnomAD
rs772173802 CA9530494	867	D>E		No	ClinGen ExAC gnomAD
rs745979602 CA9530493	868	M>L		No	ClinGen ExAC gnomAD
CA9530492 rs779143456	869	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA406474597 rs779143456	869	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA406474585 rs1351154579	871	L>M		No	ClinGen TOPMed
rs757479531 CA9530491	872	A>V		No	ClinGen ExAC gnomAD
CA9530489 rs61731796	873	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756527845 CA9530488	874	R>C		No	ClinGen ExAC TOPMed gnomAD
rs753177508 CA9530487	874	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1211951851 CA406474549	876	S>I		No	ClinGen gnomAD
rs1211951851 CA406474552	876	S>N		No	ClinGen gnomAD
CA9530486 rs373787185	877	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs759045702 CA9530485	879	L>R		No	ClinGen ExAC gnomAD

No associated diseases with Q9BZL6

8 regional properties for Q9BZL6

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	551 - 807	IPR000719
domain	Pleckstrin homology domain	397 - 511	IPR001849
active_site	Serine/threonine-protein kinase, active site	670 - 682	IPR008271
binding_site	Protein kinase, ATP binding site	557 - 580	IPR017441
domain	Diacylglycerol/phorbol-ester binding	136 - 150	IPR020454-1
domain	Diacylglycerol/phorbol-ester binding	152 - 161	IPR020454-2
domain	Diacylglycerol/phorbol-ester binding	291 - 302	IPR020454-3
domain	Diacylglycerol/phorbol-ester binding	303 - 315	IPR020454-4

Functions

		Description
EC Number	2.7.11.13	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cell membrane Nucleus Golgi apparatus, trans-Golgi network	Translocation to the cell membrane is required for kinase activation Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

9 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity	Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
metal ion binding	Binding to a metal ion.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase C activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
protein kinase C binding	Binding to protein kinase C.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

36 GO annotations of biological process

Name	Definition
adaptive immune response	An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell death	Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
cellular response to vascular endothelial growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
endothelial tube morphogenesis	The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of blood vessel endothelial cell migration	Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
positive regulation of cell adhesion	Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of CREB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
positive regulation of DNA biosynthetic process	Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
positive regulation of DNA-binding transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of endothelial cell chemotaxis	Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of fibroblast growth factor receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
positive regulation of histone deacetylase activity	Any process that activates or increases the frequency, rate or extent of histone deacetylase activity.
positive regulation of interleukin-2 production	Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of interleukin-8 production	Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
positive regulation of intracellular signal transduction	Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of peptidyl-serine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
positive regulation of T cell receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of vascular endothelial growth factor receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein kinase D signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
sphingolipid biosynthetic process	The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
T cell receptor signaling pathway	The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
vascular endothelial growth factor receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O94806	PRKD3	Serine/threonine-protein kinase D3	Homo sapiens (Human)	SS
Q15139	PRKD1	Serine/threonine-protein kinase D1	Homo sapiens (Human)	EV
Q8K1Y2	Prkd3	Serine/threonine-protein kinase D3	Mus musculus (Mouse)	SS
Q62101	Prkd1	Serine/threonine-protein kinase D1	Mus musculus (Mouse)	SS
Q8BZ03	Prkd2	Serine/threonine-protein kinase D2	Mus musculus (Mouse)	SS
Q9WTQ1	Prkd1	Serine/threonine-protein kinase D1	Rattus norvegicus (Rat)	SS
Q5XIS9	Prkd2	Serine/threonine-protein kinase D2	Rattus norvegicus (Rat)	SS
O45818	dkf-2	Serine/threonine-protein kinase dkf-2	Caenorhabditis elegans	SS

10	20	30	40	50	60
MATAPSYPAG	LPGSPGPGSP	PPPGGLELQS	PPPLLPQIPA	PGSGVSFHIQ	IGLTREFVLL
70	80	90	100	110	120
PAASELAHVK	QLACSIVDQK	FPECGFYGLY	DKILLFKHDP	TSANLLQLVR	SSGDIQEGDL
130	140	150	160	170	180
VEVVLSASAT	FEDFQIRPHA	LTVHSYRAPA	FCDHCGEMLF	GLVRQGLKCD	GCGLNYHKRC
190	200	210	220	230	240
AFSIPNNCSG	ARKRRLSSTS	LASGHSVRLG	TSESLPCTAE	ELSRSTTELL	PRRPPSSSSS
250	260	270	280	290	300
SSASSYTGRP	IELDKMLLSK	VKVPHTFLIH	SYTRPTVCQA	CKKLLKGLFR	QGLQCKDCKF
310	320	330	340	350	360
NCHKRCATRV	PNDCLGEALI	NGDVPMEEAT	DFSEADKSAL	MDESEDSGVI	PGSHSENALH
370	380	390	400	410	420
ASEEEEGEGG	KAQSSLGYIP	LMRVVQSVRH	TTRKSSTTLR	EGWVVHYSNK	DTLRKRHYWR
430	440	450	460	470	480
LDCKCITLFQ	NNTTNRYYKE	IPLSEILTVE	SAQNFSLVPP	GTNPHCFEIV	TANATYFVGE
490	500	510	520	530	540
MPGGTPGGPS	GQGAEAARGW	ETAIRQALMP	VILQDAPSAP	GHAPHRQASL	SISVSNSQIQ
550	560	570	580	590	600
ENVDIATVYQ	IFPDEVLGSG	QFGVVYGGKH	RKTGRDVAVK	VIDKLRFPTK	QESQLRNEVA
610	620	630	640	650	660
ILQSLRHPGI	VNLECMFETP	EKVFVVMEKL	HGDMLEMILS	SEKGRLPERL	TKFLITQILV
670	680	690	700	710	720
ALRHLHFKNI	VHCDLKPENV	LLASADPFPQ	VKLCDFGFAR	IIGEKSFRRS	VVGTPAYLAP
730	740	750	760	770	780
EVLLNQGYNR	SLDMWSVGVI	MYVSLSGTFP	FNEDEDINDQ	IQNAAFMYPA	SPWSHISAGA
790	800	810	820	830	840
IDLINNLLQV	KMRKRYSVDK	SLSHPWLQEY	QTWLDLRELE	GKMGERYITH	ESDDARWEQF
850	860	870
AAEHPLPGSG	LPTDRDLGGA	CPPQDHDMQG	LAERISVL