AiPD: Autoinhibited Protein Database

Q9BZG1

Gene name	RAB34 (RAB39, RAH)
Protein name	Ras-related protein Rab-34
Names	Ras-related protein Rab-39, Ras-related protein Rah
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83871
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-71 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9BZG1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BZG1-F1	Predicted				AlphaFoldDB

216 variants for Q9BZG1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA289130528 rs1026261316	3	I>T		No	ClinGen Ensembl
CA289130553 rs988185296	3	I>V		No	ClinGen TOPMed gnomAD
CA398401170 rs1361744966	5	A>V		No	ClinGen gnomAD
rs958360393 CA289130526	6	P>S		No	ClinGen TOPMed
CA398401161 rs1567738176	7	V>M		No	ClinGen Ensembl
CA8466215 rs778569401	9	R>G		No	ClinGen ExAC gnomAD
rs755004460 CA8466214	10	D>N		No	ClinGen ExAC gnomAD
CA8466213 rs749161318	11	R>S		No	ClinGen ExAC gnomAD
CA8466212 rs779659664	12	V>I		No	ClinGen ExAC gnomAD
rs780822468 CA8466208	15	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	15	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8466207 rs756895497	16	L>P		No	ClinGen ExAC gnomAD
CA398401027 rs1429527379	17	P>L		No	ClinGen TOPMed gnomAD
CA289130494 rs1023223196	18	Q>P		No	ClinGen TOPMed
TCGA novel	19	C>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8466178 rs141216782	19	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs762657234 CA398400891	23	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762657234 CA8466175	23	E>K		No	ClinGen ExAC gnomAD
rs1434119142 CA398400821	27	H>R		No	ClinGen TOPMed
CA398400811 rs1236653446	28	G>R		No	ClinGen gnomAD
rs745779703 CA8466172	29	H>Y		No	ClinGen ExAC gnomAD
CA8466170 rs151293243	30	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA398400770 rs1437184305	30	K>R		No	ClinGen TOPMed
rs1218608862 CA398400698	34	P>R		No	ClinGen gnomAD
CA8466169 rs746477626	35	R>C		No	ClinGen ExAC gnomAD
CA8466168 rs777305504	35	R>H		No	ClinGen ExAC TOPMed gnomAD
CA289130255 rs999262267	38	C>F		No	ClinGen Ensembl
rs936693635 CA289130258	38	C>R		No	ClinGen TOPMed
TCGA novel	40	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398400618 rs1375687733	41	Q>*		No	ClinGen gnomAD
CA398400599 rs1328921718	42	E>K		No	ClinGen gnomAD
CA398400558 rs1422674741	44	R>Q		No	ClinGen gnomAD
rs1360129104 CA398400547	45	T>R		No	ClinGen gnomAD
rs1413269502 CA398400519	47	T>I		No	ClinGen gnomAD
rs780553281 CA8466165	49	G>A		No	ClinGen ExAC TOPMed gnomAD
CA398400322 rs1181062242	50	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA398400304 rs1203151879	51	K>N		No	ClinGen TOPMed
CA398400269 rs1471709541	53	S>F		No	ClinGen gnomAD
CA289129773 rs11545697	54	K>E		No	ClinGen Ensembl
rs756581417 CA8466143	56	I>T		No	ClinGen ExAC TOPMed gnomAD
rs746190667 CA8466142	57	V>A		No	ClinGen ExAC gnomAD
CA398400190 rs1483990202	59	G>R		No	ClinGen TOPMed
TCGA novel	59	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398400170 rs1567733851	60	D>G		No	ClinGen Ensembl
CA8466141 rs781568212	60	D>H		No	ClinGen ExAC gnomAD
rs757773764 CA8466140	62	S>L	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1171075006 CA398400119	64	G>R		No	ClinGen TOPMed
CA398400103 rs1597768843	65	K>E		No	ClinGen Ensembl
rs1340345184 CA398400078	66	T>I		No	ClinGen gnomAD
rs758656765 CA8466137	67	C>S		No	ClinGen ExAC
rs778888217 CA8466136	69	I>L		No	ClinGen ExAC TOPMed gnomAD
rs778888217 CA289129730	69	I>V		No	ClinGen ExAC TOPMed gnomAD
rs765393450 CA8466135	70	N>D		No	ClinGen ExAC gnomAD
rs368248729 CA8466117	71	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	75	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398399933 rs1387401094	75	D>N		No	ClinGen TOPMed gnomAD
CA398399930 rs1387401094	75	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1242105472 CA398399795	81	Y>F		No	ClinGen TOPMed
CA8466113 rs760571428	83	A>S		No	ClinGen ExAC gnomAD
CA398399737 rs1171107490	84	T>I		No	ClinGen gnomAD
CA8466112 rs750408092	85	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1567732776 CA398399608	90	E>Q		No	ClinGen Ensembl
CA398399542 rs1178170449	92	E>A		No	ClinGen gnomAD
rs1597766523 CA398399527	92	E>D		No	ClinGen Ensembl
rs375545338 CA8466109	93	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs375545338 CA8466110	93	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA398399512 rs1266060351	93	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs768476656 CA8466108	94	F>I		No	ClinGen ExAC gnomAD
rs1238483473 CA398399420	97	L>M		No	ClinGen TOPMed gnomAD
rs776896962 CA8466106	100	P>A		No	ClinGen ExAC gnomAD
CA8466104 rs747285865	103	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1415079014 CA398399281	104	Q>*		No	ClinGen TOPMed
CA289129537 rs200692938	105	L>P		No	ClinGen 1000Genomes
CA398399155 rs1473732725	106	W>*		No	ClinGen TOPMed
CA8466079 rs773445329	109	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs988904564 CA289129424	110	G>W		No	ClinGen TOPMed
rs1597764082 CA398399072	111	Q>*		No	ClinGen Ensembl
CA398398967 rs1311047739	113	R>K		No	ClinGen gnomAD
CA398398972 rs1311047739	113	R>T		No	ClinGen gnomAD
rs748632564 CA8466076	117	I>F		No	ClinGen ExAC TOPMed gnomAD
CA398398857 rs1436587241	119	S>L		No	ClinGen TOPMed
CA398398849 rs1282012964	120	T>S		No	ClinGen TOPMed
CA398398796 rs1188671420	122	Y>H		No	ClinGen gnomAD
CA398398772 rs1254632246	123	R>*		No	ClinGen gnomAD
CA289129399 rs993800392	123	R>K		No	ClinGen TOPMed
CA398398767 rs993800392	123	R>T		No	ClinGen TOPMed
rs368931578 CA8466073	125	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398398712 rs1203706370	125	A>V		No	ClinGen TOPMed
CA398398542 rs1344446595	130	I>T		No	ClinGen TOPMed
CA289129302 rs886491758	130	I>V		No	ClinGen TOPMed
CA8466049 rs746043124	133	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1189869733 CA398398441	136	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8466048 rs781521789	136	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1466509029 CA398398424	137	V>E		No	ClinGen gnomAD
CA398398431 rs1173272376	137	V>M		No	ClinGen gnomAD
CA398398393 rs1423512589	139	S>C		No	ClinGen gnomAD
TCGA novel	141	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1166688570 CA398398336	142	H>R		No	ClinGen gnomAD
rs375689752 CA8466045	143	T>N		No	ClinGen ESP
CA398397320 rs1452536252	144	K>N		No	ClinGen TOPMed gnomAD
rs372354441 CA8466044	144	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398397305 rs1356111075	145	Q>L		No	ClinGen Ensembl
rs746859387 CA8466025	147	L>P		No	ClinGen ExAC gnomAD
rs746859387 CA8466026	147	L>Q		No	ClinGen ExAC gnomAD
CA8466024 rs777706860	148	A>G		No	ClinGen ExAC gnomAD
CA398397247 rs1334137584	148	A>T		No	ClinGen gnomAD
CA398397232 rs777706860	148	A>V		No	ClinGen ExAC gnomAD
CA8466022 rs748013391	149	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA289129164 rs1029150984	150	A>T		No	ClinGen TOPMed gnomAD
CA398397054 rs1271222432	154	N>K		No	ClinGen gnomAD
CA8466019 rs754475362	155	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA289129121 rs370732433	157	S>C		No	ClinGen ESP TOPMed
rs370732433 CA289129114	157	S>F		No	ClinGen ESP TOPMed
CA8466017 rs779691660	158	S>R		No	ClinGen ExAC TOPMed
rs373902000 CA8466016	158	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398396935 rs1340564657	160	L>F		No	ClinGen gnomAD
rs1352517542 CA398396915	161	L>V		No	ClinGen gnomAD
CA289129078 rs971932267	163	L>P		No	ClinGen Ensembl
CA8466015 rs751983240	164	V>I		No	ClinGen ExAC TOPMed
rs548063948 CA8466014	165	G>C		No	ClinGen 1000Genomes ExAC gnomAD
CA8466013 rs763332667	165	G>V		No	ClinGen ExAC gnomAD
rs1479942630 CA398396811	166	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1173794406 CA398396783	168	K>T		No	ClinGen TOPMed
rs367763029 CA8466012	169	D>Y		No	ClinGen ESP ExAC gnomAD
CA398396740 rs1391340927	170	L>M		No	ClinGen TOPMed
CA289129049 rs529926528	171	S>N		No	ClinGen 1000Genomes
rs1288823771 CA398396733	171	S>R		No	ClinGen TOPMed
CA8465991 rs201771822	172	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201771822 CA8465992	172	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8465990 rs755538638	173	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8465989 rs755538638	173	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8465988 rs754011850	175	Q>P		No	ClinGen ExAC gnomAD
CA8465987 rs766545423	177	A>V		No	ClinGen ExAC TOPMed gnomAD
rs760787696 CA8465986	179	M>V		No	ClinGen ExAC gnomAD
CA289128932 rs762515620	180	E>G		No	ClinGen gnomAD
rs773335418 CA8465985	180	E>K		No	ClinGen ExAC TOPMed gnomAD
rs767710164 CA8465984 COSM1222927 COSM1222926	181	K>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8465982 rs149679668	182	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8465983 rs761523637	182	D>V		No	ClinGen ExAC gnomAD
rs769328864 CA398396428	183	A>D		No	ClinGen ExAC gnomAD
COSM284430 CA8465979 rs769328864	183	A>G	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA8465980 rs376355510	183	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8465978 rs769328864	183	A>V		No	ClinGen ExAC gnomAD
CA289128910 rs895698835	185	Q>P		No	ClinGen TOPMed
CA398396374 rs1425653812	186	V>A		No	ClinGen gnomAD
rs1171324772 CA398396368	187	A>S		No	ClinGen TOPMed gnomAD
rs1171324772 CA398396361	187	A>T		No	ClinGen TOPMed gnomAD
rs925622590 CA289128885	188	Q>R		No	ClinGen TOPMed gnomAD
rs1042758045 CA289128881	193	E>K		No	ClinGen TOPMed
CA398396189 rs1292361580	194	Y>N		No	ClinGen TOPMed
rs780723414 CA8465976	195	W>R		No	ClinGen ExAC gnomAD
CA398396130 rs1488600743	196	A>T		No	ClinGen gnomAD
CA289128867 rs12125 VAR_015097	197	V>L		No	ClinGen UniProt Ensembl dbSNP
rs769408506 CA289128859	198	S>L		No	ClinGen TOPMed gnomAD
CA8465975 rs756922447	198	S>T		No	ClinGen ExAC TOPMed gnomAD
rs377221783 CA8465973	199	S>T		No	ClinGen ESP ExAC gnomAD
rs4429342 CA289128829	200	L>F		No	ClinGen Ensembl
rs1248926597 CA398396042	200	L>P		No	ClinGen TOPMed
rs4429342 CA289128832	200	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs370068278 CA8465960	202	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs894000336 CA289128768 COSM1381742	203	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA398395885 rs1567727240	204	N>K		No	ClinGen Ensembl
CA8465959 rs139219728	206	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs745430836 CA8465958	206	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1023011912 COSM1381741 CA289128764	207	E>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA398395818 rs776203692	208	F>I		No	ClinGen ExAC TOPMed gnomAD
rs776203692 CA8465957	208	F>V		No	ClinGen ExAC TOPMed gnomAD
CA398395772 rs1371065836 COSM560077	209	F>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA289128749 rs373753688	211	R>C		No	ClinGen gnomAD
CA289128746 rs910197266	211	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs910197266 CA398395707	211	R>P		No	ClinGen TOPMed gnomAD
CA8465954 rs377233779	213	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1240501614 CA398395670	214	A>T		No	ClinGen gnomAD
CA398395620 rs1362084572	216	T>N		No	ClinGen TOPMed
CA398395562 rs1181491295	219	A>S		No	ClinGen gnomAD
CA398395554 rs1258809203	220	N>Y		No	ClinGen gnomAD
rs1182982992 CA398395534	221	V>M		No	ClinGen gnomAD
CA8465952 rs755425112	223	A>T		No	ClinGen ExAC gnomAD
rs780718448 CA8465950	224	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8465951 rs749597197	224	E>Q		No	ClinGen ExAC gnomAD
CA398395455 rs1237999268	225	L>V		No	ClinGen gnomAD
CA398395430 rs1597753527	226	E>G		No	ClinGen Ensembl
CA398395441 rs1325155991	226	E>K		No	ClinGen TOPMed
CA8465949 rs376343488	228	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	230	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8465946 rs757465924	231	R>*		No	ClinGen ExAC TOPMed gnomAD
CA8465947 rs757465924	231	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8465945 rs751842603	231	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA8465944 rs139525649	232	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs762752582 CA8465943	232	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8465941 rs765227633	233	I>T		No	ClinGen ExAC gnomAD
CA8465942 rs371761055	233	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA398395330 rs1567726289	234	G>W		No	ClinGen Ensembl
rs1157655480 CA398395318	235	D>H		No	ClinGen gnomAD
CA8465940 rs759487638	236	V>I		No	ClinGen ExAC TOPMed gnomAD
CA398395267 rs1480920063	237	V>A		No	ClinGen TOPMed
rs776055012 CA8465939	238	R>C		No	ClinGen ExAC TOPMed gnomAD
CA398395109 rs1225775440	243	D>Y		No	ClinGen TOPMed
rs766161767 CA289128599	244	S>C		No	ClinGen ExAC TOPMed gnomAD
rs766161767 CA8465921	244	S>G		No	ClinGen ExAC TOPMed gnomAD
rs760245441 CA8465919	244	S>N		No	ClinGen ExAC gnomAD
rs766161767 CA8465920	244	S>R		No	ClinGen ExAC TOPMed gnomAD
rs150552930 CA8465918	245	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs761523967 CA8465916	248	L>R		No	ClinGen ExAC gnomAD
TCGA novel	249	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs535052273 CA8465915	249	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1339404958 CA398395033	249	T>S		No	ClinGen TOPMed gnomAD
CA8465914 rs535052273	249	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1021035418 CA398395016	251	S>G		No	ClinGen TOPMed gnomAD
CA289128584 rs1021035418	251	S>R		No	ClinGen TOPMed gnomAD
CA398394981 rs1224692481	253	K>E		No	ClinGen gnomAD
CA8465913 rs746156114	253	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8465911 rs771331213	254	K>N		No	ClinGen ExAC gnomAD
rs566631717 CA8465912	254	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA289128581 rs377289155	255	P>L		No	ClinGen ESP
CA8465910 rs747162136	258	C>*		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q9BZG1

1 regional properties for Q9BZG1

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	52 - 208	IPR005225

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Golgi apparatus Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole	Recruited to phagosomes containing S aureus or M tuberculosis (PubMed:21255211)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cisterna	Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.
Golgi stack	The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

4 GO annotations of molecular function

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTP-dependent protein binding	Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
small GTPase binding	Binding to a small monomeric GTPase.

10 GO annotations of biological process

Name	Definition
antigen processing and presentation	The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
cell projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Golgi to plasma membrane protein transport	The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
lysosome localization	Any process in which a lysosome is transported to, and/or maintained in, a specific location.
phagosome maturation	A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
phagosome-lysosome fusion	The creation of a phagolysosome from a phagosome and a lysosome.
positive regulation of smoothened signaling pathway	Any process that activates or increases the frequency, rate or extent of smoothened signaling.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QR46	RAB6B	Ras-related protein Rab-6B	Bos taurus (Bovine)	PR
Q1KME6	RAB6A	Ras-related protein Rab-6A	Gallus gallus (Chicken)	PR
O18334	Rab6	Ras-related protein Rab6	Drosophila melanogaster (Fruit fly)	PR
Q5JT25	RAB41	Ras-related protein Rab-41	Homo sapiens (Human)	PR
Q9NRW1	RAB6B	Ras-related protein Rab-6B	Homo sapiens (Human)	PR
P20340	RAB6A	Ras-related protein Rab-6A	Homo sapiens (Human)	PR
Q15771	RAB30	Ras-related protein Rab-30	Homo sapiens (Human)	PR
O00194	RAB27B	Ras-related protein Rab-27B	Homo sapiens (Human)	PR
P51159	RAB27A	Ras-related protein Rab-27A	Homo sapiens (Human)	PR
O95755	RAB36	Ras-related protein Rab-36	Homo sapiens (Human)	PR
P35279	Rab6a	Ras-related protein Rab-6A	Mus musculus (Mouse)	PR
P61294	Rab6b	Ras-related protein Rab-6B	Mus musculus (Mouse)	PR
Q8CAM5	Rab36	Ras-related protein Rab-36	Mus musculus (Mouse)	PR
Q9WVB1	Rab6a	Ras-related protein Rab-6A	Rattus norvegicus (Rat)	PR
P34213	rab-6.1	Ras-related protein rab-6.1	Caenorhabditis elegans	PR
Q22782	rab-6.2	Ras-related protein rab-6.2	Caenorhabditis elegans	PR
O80501	RABH1B	Ras-related protein RABH1b	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SMR4	RABH1C	Ras-related protein RABH1c	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LFT9	RABH1E	Ras-related protein RABH1e	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LV79	RABH1A	Ras-related protein RABH1a	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MNILAPVRRD	RVLAELPQCL	RKEAALHGHK	DFHPRVTCAC	QEHRTGTVGF	KISKVIVVGD
70	80	90	100	110	120
LSVGKTCLIN	RFCKDTFDKN	YKATIGVDFE	MERFEVLGIP	FSLQLWDTAG	QERFKCIAST
130	140	150	160	170	180
YYRGAQAIII	VFNLNDVASL	EHTKQWLADA	LKENDPSSVL	LFLVGSKKDL	STPAQYALME
190	200	210	220	230	240
KDALQVAQEM	KAEYWAVSSL	TGENVREFFF	RVAALTFEAN	VLAELEKSGA	RRIGDVVRIN
250
SDDSNLYLTA	SKKKPTCCP