AiPD: Autoinhibited Protein Database

Q9BYP7

Gene name	WNK3
Protein name	Serine/threonine-protein kinase WNK3
Names	Protein kinase lysine-deficient 3, Protein kinase with no lysine 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:65267
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

WNK family protein kinases are large enzymes that contain the catalytic lysine in a unique position compared with all other protein kinases. Rat WNK1 (Q9JIH7) contains an autoinhibitory region C-terminal to the catalytic kinase domain.

Autoinhibitory domains (AIDs)

440-463 (Autoinhibitory region) SS

Target domain	147-405 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

440-463 (Autoinhibitory region)

Target domain

147-405 (Protein kinase domain)

Relief mechanism

PTM (Autophosphorylation at Ser-382 within WNK activation loop and phosphorylation at Ser-378)

Assay

Accessory elements

293-314 (Activation loop from InterPro)

Target domain	147-405 (Protein kinase domain)
Relief mechanism
Assay

References

Xu BE et al. (2002) "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation", The Journal of biological chemistry, 277, 48456-62

Autoinhibited structure

Activated structure

9 structures for Q9BYP7

Entry ID	Method	Resolution	Chain	Position	Source
5NKP	X-ray	280 A	C/D	537-547	PDB
5O1V	X-ray	172 A	A/B	132-414	PDB
5O21	X-ray	206 A	A/B	132-414	PDB
5O23	X-ray	225 A	A/B	132-414	PDB
5O26	X-ray	238 A	A/B	133-414	PDB
5O2B	X-ray	204 A	A/B	132-414	PDB
5O2C	X-ray	240 A	A	123-500	PDB
8EDH	X-ray	311 A	A/C	1-1800	PDB
AF-Q9BYP7-F1	Predicted				AlphaFoldDB

703 variants for Q9BYP7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10424753 rs782739360	8	P>L		No	ClinGen ExAC gnomAD
CA10424752 rs782511442	9	A>V		No	ClinGen ExAC TOPMed gnomAD
CA10424751 rs782507903	10	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413353314 rs1569539176	13	D>E		No	ClinGen Ensembl
rs1449103220 CA413353074	23	E>V		No	ClinGen TOPMed
CA329043222 rs146463327	26	V>A		No	ClinGen ESP
CA10424750 rs782794204	26	V>I		No	ClinGen ExAC gnomAD
rs972461261 CA329043220	28	Q>R		No	ClinGen TOPMed gnomAD
CA10424749 rs782163611	30	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1557174790 CA413352785	34	T>A		No	ClinGen gnomAD
rs781785725 CA10424748	36	E>K		No	ClinGen ExAC gnomAD
CA413352721 rs1410645440	37	A>T		No	ClinGen TOPMed
CA413352623 rs1569539173	41	E>K		No	ClinGen Ensembl
CA10424747 COSM613405 rs782264239	44	S>G	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA413352544 rs782264239	44	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA413352492 rs1333566428	46	F>L		No	ClinGen TOPMed
rs939905882 CA329043201	47	S>C		No	ClinGen TOPMed gnomAD
rs939905882 CA413352473	47	S>F		No	ClinGen TOPMed gnomAD
rs782073797 CA10424746	49	S>C		No	ClinGen ExAC gnomAD
CA10424745 rs781963077	53	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1557174762 CA413352244	56	K>N		No	ClinGen TOPMed
CA10424744 rs782394558	57	R>K		No	ClinGen ExAC gnomAD
rs1557174756 CA413352208	57	R>S		No	ClinGen gnomAD
rs1557174755 CA413352123	60	R>Q		No	ClinGen gnomAD
rs782667504 CA10424743	63	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782042256 CA10424742	66	T>M		No	ClinGen ExAC TOPMed gnomAD
CA413351966 rs1557174745	67	E>Q		No	ClinGen gnomAD
CA10424741 rs371151681	68	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs782203222 CA10424740	69	D>E		No	ClinGen ExAC gnomAD
rs1268086714 CA413351897	70	K>R		No	ClinGen TOPMed
rs187828471 CA10424738	73	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10424737 rs140257369	75	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1557174730 CA413351769	76	P>T		No	ClinGen gnomAD
rs1557174727 CA413351751	77	K>E		No	ClinGen gnomAD
rs782657393 CA10424736	77	K>R		No	ClinGen ExAC gnomAD
CA413351677 rs1322041081	80	R>S		No	ClinGen TOPMed
CA413351626 rs201541598	83	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424735 rs201541598	83	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs781899650 CA10424734	85	M>I		No	ClinGen ExAC gnomAD
CA10424733 rs202201697	86	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA10424732 rs782448948	88	P>Q		No	ClinGen ExAC
CA413351487 rs1244154071	90	V>G		No	ClinGen TOPMed
rs200098628 CA10424731	93	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA413351425 rs1464698205	94	P>S		No	ClinGen TOPMed
CA10424729 rs146653146	98	L>F		No	ClinGen ESP ExAC gnomAD
rs149686278 CA10424730	98	L>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781893776 CA10424728	99	R>G		No	ClinGen ExAC gnomAD
CA413351323 rs1557174689	99	R>K		No	ClinGen gnomAD
CA10424727 rs782820361	100	G>R		No	ClinGen ExAC gnomAD
rs1557174684 CA413351160	106	Y>C		No	ClinGen gnomAD
rs781835029 CA10424726 COSM3965379	107	E>Q	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA413351041 rs1475857124	111	K>E		No	ClinGen TOPMed
rs1603400058 CA413351029	111	K>N		No	ClinGen Ensembl
CA329043019 rs966190906	112	S>P		No	ClinGen Ensembl
CA10424723 rs144511829	113	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557174656 CA413350979	114	S>L		No	ClinGen gnomAD
rs1557174646 CA413350833	121	F>L		No	ClinGen gnomAD
rs1557174641 CA413350746	125	N>D		No	ClinGen TOPMed
CA10424721 rs782383532	129	M>I		No	ClinGen ExAC TOPMed gnomAD
CA413350329 rs1557174633	138	V>I		No	ClinGen gnomAD
rs374080880 CA10424719	142	P>A		No	ClinGen ESP ExAC gnomAD
rs374080880 CA10424718	142	P>S		No	ClinGen ESP ExAC gnomAD
CA10424716 rs782597295	151	I>L		No	ClinGen ExAC TOPMed gnomAD
rs111850805 CA329042947	155	R>G		No	ClinGen Ensembl
rs1315940370 CA413348284	162	Y>C		No	ClinGen TOPMed gnomAD
rs781852077 CA10424714	167	T>S		No	ClinGen ExAC gnomAD
CA10424704 rs782818873	186	A>G		No	ClinGen ExAC gnomAD
CA10424701 rs782334275 COSM1558630	204	P>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA413353745 rs1445548658	216	I>V		No	ClinGen TOPMed
rs1557169598 CA413353670	222	C>Y		No	ClinGen gnomAD
CA10424698 rs782411346 COSM457776	237	T>M	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA413353080 rs1569538596	244	V>F		No	ClinGen Ensembl
CA413352933 rs1467996657	249	V>A		No	ClinGen TOPMed
rs782055967 CA329027979	252	S>N		No	ClinGen Ensembl
rs782075036 CA10424685	262	Q>H		No	ClinGen ExAC gnomAD
rs1557169251 CA413352383	271	I>V		No	ClinGen gnomAD
CA413351713 rs781938886	302	R>C		No	ClinGen TOPMed
CA329027961 rs200575360	302	R>H		No	ClinGen TOPMed gnomAD
CA329027965 rs781938886	302	R>S		No	ClinGen TOPMed
CA10424681 rs782042709	303	T>A		No	ClinGen ExAC gnomAD
rs1557169229 CA413351619	306	A>V		No	ClinGen gnomAD
CA413351314 rs1347192309	317	A>T		No	ClinGen TOPMed
CA10424670 rs782453350	329	V>I		No	ClinGen ExAC gnomAD
CA413348145 rs1557167532	365	I>V		No	ClinGen gnomAD
CA413347869 rs1603393453	373	V>F		No	ClinGen Ensembl
CA413347846 rs1557167529	374	T>A		No	ClinGen TOPMed
rs1569538392 CA413347664	383	E>V		No	ClinGen Ensembl
rs782598590 CA10424653	387	R>C		No	ClinGen ExAC
CA10424652 rs782355785	387	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1603392660 COSM1270491 CA413347363	401	N>K	oesophagus [Cosmic]	No	ClinGen cosmic curated Ensembl
CA10424638 rs781931476	412	R>K		No	ClinGen ExAC gnomAD
rs1557166756 CA413347198	419	D>G		No	ClinGen gnomAD
rs1337828270 CA413347205	419	D>N		No	ClinGen TOPMed gnomAD
rs1428931184 CA413347185	420	D>V		No	ClinGen TOPMed
rs1557166752 CA413347177	421	C>R		No	ClinGen gnomAD
CA329026190 rs111262520	442	H>R		No	ClinGen Ensembl
rs1276514127 CA413346897	445	N>D		No	ClinGen TOPMed
rs1321367633 CA413346893	445	N>S		No	ClinGen TOPMed
rs1557166723 CA413346665	458	T>I		No	ClinGen gnomAD
CA10424630 rs782326412	464	Y>H		No	ClinGen ExAC gnomAD
rs782756233 CA10424619	467	V>I		No	ClinGen ExAC gnomAD
CA10424618 rs782126477	475	S>G		No	ClinGen ExAC gnomAD
CA413345786 rs1381062505	484	I>V		No	ClinGen TOPMed
rs1424113106 CA413345743	485	R>S		No	ClinGen TOPMed
CA413345686 rs1161469441	488	V>M		No	ClinGen TOPMed gnomAD
COSM116663 rs373983548 CA10424617	489	T>M	ovary upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs782070721 CA10424615	490	P>A		No	ClinGen ExAC gnomAD
rs1406972167 CA413345595	491	I>V		No	ClinGen TOPMed
CA10424614 rs781954947	495	R>K		No	ClinGen ExAC TOPMed
rs781954947 CA413345485	495	R>T		No	ClinGen ExAC TOPMed
rs782370150 CA10424613	497	K>Q		No	ClinGen ExAC gnomAD
CA413345400 rs1375842626	498	K>Q		No	ClinGen TOPMed
CA413345364 rs1444193522	499	P>H		No	ClinGen TOPMed
CA10424612 rs782003416	500	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs782407317 CA10424611	500	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA413345308 rs1311012318	501	G>V		No	ClinGen TOPMed
CA10424609 rs782298211	506	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782571046 CA10424608 COSM3701872	506	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA413345193 rs782571046	506	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1315609 rs149832313 CA10424607 RCV000904930	507	R>S	urinary_tract [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10424606 rs782206706	510	Q>R		No	ClinGen ExAC gnomAD
CA10424605 rs782608495	511	C>F		No	ClinGen ExAC TOPMed gnomAD
CA10424604 rs782511258	514	M>V		No	ClinGen ExAC gnomAD
rs1257895581 CA413344959	516	N>S		No	ClinGen TOPMed
rs1557165881 CA413344857	520	Q>H		No	ClinGen gnomAD
rs781863997 CA413344801	525	T>A		No	ClinGen ExAC TOPMed gnomAD
rs781863997 CA10424603	525	T>P		No	ClinGen ExAC TOPMed gnomAD
rs782320716 CA10424600	531	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782320716 CA10424601	531	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371957284 CA329025562	535	G>R		No	ClinGen ESP TOPMed gnomAD
CA329025558 rs371957284	535	G>W		No	ClinGen ESP TOPMed gnomAD
rs1163772057 CA413344402	543	V>A		No	ClinGen TOPMed
rs782772231 CA10424596	546	H>R		No	ClinGen ExAC TOPMed gnomAD
CA10424597 rs781992551	546	H>Y		No	ClinGen ExAC gnomAD
rs1557165851 CA413344278	548	R>K		No	ClinGen gnomAD
CA10424594 rs782313288	550	Q>H		No	ClinGen ExAC gnomAD
CA10424595 rs782151856	550	Q>L		No	ClinGen ExAC gnomAD
rs1557165841 CA413344199	551	L>R		No	ClinGen gnomAD
CA10424591 rs781945634	556	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1557165818 CA413344094	557	Q>*		No	ClinGen gnomAD
rs782356886 CA10424590	561	S>F		No	ClinGen ExAC TOPMed gnomAD
CA413343967 rs1395067678	562	S>C		No	ClinGen TOPMed
CA413343637 rs1557165573	570	E>G		No	ClinGen gnomAD
CA329025366 rs781902102	571	A>T		No	ClinGen Ensembl
CA10424576 COSM3845106 rs782728825	572	G>E	breast [Cosmic]	No	ClinGen cosmic curated ExAC
rs782098232 CA10424575	573	A>V		No	ClinGen ExAC TOPMed
rs781986184 CA10424574	574	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10424571 rs782024634	577	I>L		No	ClinGen ExAC gnomAD
rs1172296528 CA413343469	577	I>M		No	ClinGen TOPMed
CA10424572 rs782024634	577	I>V		No	ClinGen ExAC gnomAD
rs1557165549 CA413343451	578	H>R		No	ClinGen gnomAD
rs1557165553 CA413343458	578	H>Y		No	ClinGen gnomAD
CA329025350 rs201568341	583	S>G		No	ClinGen Ensembl
CA413343236 rs1416355178	586	S>R		No	ClinGen TOPMed gnomAD
CA413343231 rs1174398203 COSM1468660	587	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1557165537 CA413343199	588	A>T		No	ClinGen Ensembl
rs782309322 CA10424570	594	T>M		No	ClinGen ExAC TOPMed
CA413343006 rs1557165527	596	G>S		No	ClinGen gnomAD
CA10424568 rs147282819	602	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424567 rs782382951	603	I>M		No	ClinGen ExAC TOPMed gnomAD
rs377713590 CA10424566	604	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424564 rs782544068	606	A>T		No	ClinGen ExAC gnomAD
rs143891385 CA10424563	607	E>K		No	ClinGen ESP ExAC TOPMed
CA413342679 rs1557165504	610	V>L		No	ClinGen gnomAD
CA329025311 rs969124118	611	P>R		No	ClinGen Ensembl
CA413342557 rs1557165499	615	Y>S		No	ClinGen gnomAD
rs1236011730 CA413342429	620	L>P		No	ClinGen TOPMed gnomAD
CA10424560 rs781839567	621	V>E		No	ClinGen ExAC gnomAD
CA329025303 rs991829539	623	H>R		No	ClinGen Ensembl
CA10424559 rs782763536	626	Q>K		No	ClinGen ExAC
rs782132872 CA10424558	628	S>L		No	ClinGen ExAC gnomAD
rs1557165435 CA413342090	632	K>N		No	ClinGen gnomAD
rs782011608 CA10424547	633	H>D		No	ClinGen ExAC gnomAD
rs782413999 CA10424546	635	K>E		No	ClinGen ExAC gnomAD
rs782413999 CA413342037	635	K>Q		No	ClinGen ExAC gnomAD
CA10424545 rs782291840	638	Q>E		No	ClinGen ExAC gnomAD
CA413341967 rs1379847450	638	Q>H		No	ClinGen TOPMed
CA10424543 rs782328561	639	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781920437 CA10424544	639	P>S		No	ClinGen ExAC gnomAD
rs782621772 CA10424541	640	Q>*		No	ClinGen ExAC
rs1401186386 CA413341880	643	P>R		No	ClinGen TOPMed
rs782501795 CA10424540	643	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1322706736 CA413341835	646	Q>E		No	ClinGen TOPMed gnomAD
CA413341809 rs1557165384	647	G>S		No	ClinGen gnomAD
CA10424539 rs782262225	654	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10424538 rs139873078	659	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs781784064 CA10424536	666	Q>R		No	ClinGen ExAC gnomAD
rs1237347688 CA413341325	667	V>A		No	ClinGen TOPMed
CA413341332 rs199655322	667	V>F		No	ClinGen 1000Genomes TOPMed gnomAD
CA413341337 COSM3668749 rs199655322	667	V>I	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes TOPMed gnomAD
rs996420520 CA413341240	671	T>I		No	ClinGen TOPMed
rs996420520 CA329025250	671	T>S		No	ClinGen TOPMed
rs782700460 CA10424535	672	V>I		No	ClinGen ExAC gnomAD
CA10424534 rs782477216	678	I>V		No	ClinGen ExAC gnomAD
rs1329526588 CA413356291	682	S>F		No	ClinGen TOPMed gnomAD
rs983775071 CA329015409	684	P>T		No	ClinGen Ensembl
rs1447919909 CA413356274	685	V>D		No	ClinGen TOPMed
CA413356262 rs1377545107	687	A>D		No	ClinGen TOPMed gnomAD
rs1377545107 CA413356263	687	A>G		No	ClinGen TOPMed gnomAD
rs201840392 CA10424524	687	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs199587694 CA10424522	692	A>T		No	ClinGen ExAC TOPMed gnomAD
CA10424521 rs200859828	692	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1018275791 CA329015399	700	R>P		No	ClinGen Ensembl
rs1557156205 CA413356170	701	S>N		No	ClinGen gnomAD
CA413356147 rs1557155423	702	L>W		No	ClinGen gnomAD
rs957187991 CA329014283	703	N>K		No	ClinGen Ensembl
CA413356135 COSM265930 rs1557155418	704	Q>E	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA10424511 RCV000882848 rs56077971 VAR_041323	704	Q>H		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1398509697 CA413356114	707	A>T		No	ClinGen TOPMed
CA10424509 rs141367442	708	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424510 rs141367442	708	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424508 rs782417608	709	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413356098 rs1557155386	710	K>E		No	ClinGen gnomAD
CA413356083 rs1557155382	712	N>D		No	ClinGen gnomAD
CA10424505 rs782304144	713	V>I		No	ClinGen ExAC gnomAD
CA413356069 rs1557155373	714	S>G		No	ClinGen gnomAD
rs781943674 CA10424503	720	S>R		No	ClinGen ExAC gnomAD
rs782263059 CA10424501	725	Q>E		No	ClinGen ExAC gnomAD
rs1286563870 CA413355976	726	D>E		No	ClinGen TOPMed
rs1557155355 COSM362691 CA413355973	727	R>Q	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1447824802 CA413355928	733	A>V		No	ClinGen TOPMed
CA10424500 rs372464064	736	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA413355913 rs372464064	736	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA413355875 rs782185007	742	T>A		No	ClinGen ExAC gnomAD
rs782185007 CA10424498	742	T>P		No	ClinGen ExAC gnomAD
CA10424497 rs782586809	744	F>Y		No	ClinGen ExAC gnomAD
rs781843108 CA10424495	748	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1160919797 CA413355803	751	V>L		No	ClinGen TOPMed gnomAD
CA10424483 rs782166679	753	T>A		No	ClinGen ExAC TOPMed gnomAD
CA413355775 rs1603382708	756	D>N		No	ClinGen Ensembl
rs781926556 CA10424482	760	E>D		No	ClinGen ExAC gnomAD
CA413355682 rs1439911047	768	N>S		No	ClinGen TOPMed gnomAD
CA10424480 rs782217542	777	V>I		No	ClinGen ExAC
rs372610914 CA10424479	781	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424477 rs782261658	783	E>Q		No	ClinGen ExAC gnomAD
rs782656145 CA10424476	784	D>G		No	ClinGen ExAC gnomAD
rs1557154956 CA413355550	787	D>H		No	ClinGen gnomAD
rs782462658 CA10424472	795	V>M		No	ClinGen ExAC TOPMed gnomAD
rs138016185 CA10424470	798	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA413355455 rs1603382133	798	S>T		No	ClinGen Ensembl
rs782559176 CA413355426	802	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs904531563 CA329013058	802	K>N		No	ClinGen TOPMed gnomAD
rs782559176 CA10424469	802	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA329013057 rs376341338	804	V>I		No	ClinGen ESP
rs145358981 CA10424468	805	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424467 rs369362535	806	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413355388 rs1255762334	807	L>F		No	ClinGen TOPMed
rs370235367 CA329013015	809	A>T		No	ClinGen Ensembl
rs1603382097 CA413355338	815	Q>*		No	ClinGen Ensembl
CA10424466 rs201281405	815	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782763124 CA10424464	818	L>F		No	ClinGen ExAC gnomAD
rs782405935 CA10424461	821	H>Q		No	ClinGen ExAC gnomAD
rs782001482 CA10424462	821	H>R		No	ClinGen ExAC gnomAD
rs782295588 CA10424460	823	A>D		No	ClinGen ExAC gnomAD
rs1557154252 CA413355277	824	T>I		No	ClinGen gnomAD
CA10424459 rs781918743	826	R>G		No	ClinGen ExAC gnomAD
CA10424458 rs782314090	827	A>D		No	ClinGen ExAC gnomAD
CA413355254 rs1557154243	828	T>A		No	ClinGen gnomAD
CA413355248 rs1557154235	829	G>R		No	ClinGen gnomAD
rs982508228 CA329012983	830	V>G		No	ClinGen Ensembl
CA10424457 rs140263470	833	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10424456 rs371759302	834	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10424455 rs782499802	838	N>S		No	ClinGen ExAC TOPMed gnomAD
rs782505998 CA329012956	839	S>N		No	ClinGen Ensembl
rs1391524112 CA413355173	840	S>R		No	ClinGen TOPMed
CA10424454 rs782284763	841	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs781899848 CA10424444	842	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782060150 CA10424443	843	G>E		No	ClinGen ExAC gnomAD
rs146672116 CA329012914	848	V>I		No	ClinGen ESP TOPMed gnomAD
rs1557154175 CA413355082	852	S>C		No	ClinGen gnomAD
rs782356624 CA10424441	853	T>A		No	ClinGen ExAC gnomAD
rs1207463417 CA413355076	853	T>I		No	ClinGen TOPMed
CA10424440 rs782238282	854	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1557154167 CA413355069	855	T>A		No	ClinGen gnomAD
CA10424439 rs781999100	857	T>A		No	ClinGen ExAC gnomAD
rs1475463200 CA413355048	858	S>N		No	ClinGen TOPMed
CA10424432 rs371385907	859	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA413354972 rs1220446857	868	V>I		No	ClinGen TOPMed
rs1557153813 CA413354921	874	C>R		No	ClinGen gnomAD
CA329012525 rs959075562	878	T>M		No	ClinGen TOPMed
rs1557153808 CA413354851	880	R>K		No	ClinGen gnomAD
rs782432728 CA10424429	882	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10424427 rs781802911	882	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs781802911 CA10424428	882	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs150096945 CA10424426	883	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs782243482 CA10424425	886	S>C		No	ClinGen ExAC gnomAD
rs782243482 CA413354790	886	S>F		No	ClinGen ExAC gnomAD
CA10424424 rs782767979	889	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1183182850 CA413354694	896	A>T		No	ClinGen TOPMed
rs201969750 CA10424423	896	A>V		No	ClinGen ExAC TOPMed gnomAD
CA10424422 rs781922477	898	P>R		No	ClinGen ExAC gnomAD
CA413354664 rs1557153780	899	G>C		No	ClinGen gnomAD
rs1603381689 CA413354655 RCV000995923	900	R>Q		No	ClinGen ClinVar Ensembl dbSNP
rs782085509 CA10424420	902	P>A		No	ClinGen ExAC TOPMed
CA10424419 rs782730940	904	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA10424418 rs782730940	904	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs782652815 CA10424417	905	S>G		No	ClinGen ExAC TOPMed gnomAD
rs782747415 CA10424401	906	P>R		No	ClinGen ExAC TOPMed gnomAD
CA10424400 rs782124950	910	S>T		No	ClinGen ExAC gnomAD
CA10424399 rs781964103	913	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA10424397 rs782257900	914	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1557153672 CA413353202	915	S>P		No	ClinGen gnomAD
rs111417684 CA10424396	916	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1557153668 CA413353132	918	T>S		No	ClinGen gnomAD
CA10424395 rs782318683	921	T>A		No	ClinGen ExAC gnomAD
CA329012374 rs151337939	921	T>I		No	ClinGen ESP
rs782200825 CA10424394	929	R>C		No	ClinGen ExAC gnomAD
rs147109461 CA10424393	929	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413352664 rs1557153651	938	H>Y		No	ClinGen gnomAD
CA10424390 rs782662006	939	K>R		No	ClinGen ExAC gnomAD
rs946662676 CA329012361	940	D>G		No	ClinGen gnomAD
rs782435149 CA10424389 COSM1715018	940	D>N	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10424388 rs190471786	944	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10424387 RCV000884228 rs149437976	946	I>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs782574568 CA329012341	947	S>F		No	ClinGen 1000Genomes
CA10424386 rs782496912	948	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10424385 rs781866335	950	A>T		No	ClinGen ExAC gnomAD
rs1427024503 CA413352311	951	S>I		No	ClinGen TOPMed
CA10424384 rs782786256	956	Q>H		No	ClinGen ExAC gnomAD
rs1470882013 CA413352198	956	Q>L		No	ClinGen TOPMed
CA329012319 rs960592190	958	A>V		No	ClinGen Ensembl
rs1557153596 CA413352023	964	E>K		No	ClinGen gnomAD
CA329012311 rs782471132	968	Q>H		No	ClinGen gnomAD
CA413351893 rs1603381525	969	I>T		No	ClinGen Ensembl
CA413351808 rs1337315985	974	T>I		No	ClinGen TOPMed
CA413351757 rs782542794	977	S>C		No	ClinGen ExAC TOPMed gnomAD
rs782542794 CA10424383	977	S>F		No	ClinGen ExAC TOPMed gnomAD
CA10424380 rs140928847	980	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs928677313 CA413351694	981	T>A		No	ClinGen TOPMed gnomAD
CA10424379 rs147706876	981	T>S		No	ClinGen ESP ExAC TOPMed
rs928677313 CA329012265	981	T>S		No	ClinGen TOPMed gnomAD
rs1569536622 CA413351679	982	T>A		No	ClinGen Ensembl
CA10424378 rs782731290	985	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10424377 rs200979535	985	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413351578 rs1321876571	988	P>T		No	ClinGen TOPMed
rs782406134 CA10424375	992	E>G		No	ClinGen ExAC gnomAD
rs549618930 CA329012236	993	G>E		No	ClinGen Ensembl
CA413351460 rs1264342536	995	T>I		No	ClinGen TOPMed
rs145468986 CA10424374	998	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_041325 CA329012235 rs56404148	998	A>T		No	ClinGen UniProt Ensembl dbSNP
CA10424373 rs781937568	999	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1243387786 CA413351324	1002	I>T		No	ClinGen TOPMed gnomAD
CA10424372 rs370590119	1003	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs782226120 CA10424371	1004	V>L		No	ClinGen ExAC gnomAD
rs1557153523 CA413351282	1005	Y>H		No	ClinGen gnomAD
rs1198255823 CA413351258	1006	P>L		No	ClinGen TOPMed
CA10424370 rs782643827	1007	C>R		No	ClinGen ExAC gnomAD
CA413351195 rs1557153510	1009	Q>R		No	ClinGen gnomAD
CA413351153 rs1557153503	1011	A>V		No	ClinGen gnomAD
CA413351147 rs1603381466	1012	S>G		No	ClinGen Ensembl
rs782637003 CA10424369	1012	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA329012193 rs781891866 COSM3092692	1023	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA413350864 rs1557153484	1025	T>P		No	ClinGen gnomAD
rs782431389 CA10424366	1032	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1398919624 CA413350683	1034	T>P		No	ClinGen TOPMed gnomAD
CA413350645 rs1157003590	1036	A>T		No	ClinGen TOPMed
rs1347093544 CA413350623	1036	A>V		No	ClinGen TOPMed
CA10424365 rs781800081	1038	D>G		No	ClinGen ExAC gnomAD
rs782505507 CA329012178	1042	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1557153454 CA413350474	1042	Q>P		No	ClinGen gnomAD
rs1557153449 CA413350452	1043	T>A		No	ClinGen gnomAD
CA10424362 rs781852931	1045	S>P		No	ClinGen ExAC TOPMed gnomAD
CA413350236 rs1302788593	1049	P>Q		No	ClinGen TOPMed
rs1603381422 CA413350153	1052	D>E		No	ClinGen Ensembl
CA10424361 rs782791620	1053	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1407174103 CA413350083	1056	I>T		No	ClinGen TOPMed
rs1603381413 CA413350015	1060	G>E		No	ClinGen Ensembl
CA329012160 rs375928678	1071	P>R		No	ClinGen ESP gnomAD
CA413349850 rs1373207932	1071	P>S		No	ClinGen TOPMed gnomAD
rs782146970 CA10424360	1073	T>A		No	ClinGen ExAC gnomAD
CA10424358 rs782716330	1074	V>F		No	ClinGen ExAC gnomAD
rs781894959 CA329012113	1075	I>V		No	ClinGen 1000Genomes
rs1557153424 CA413349785	1076	P>R		No	ClinGen gnomAD
rs782022800 CA10424353	1080	P>S		No	ClinGen ExAC gnomAD
rs1316992545 CA413349680	1085	T>A		No	ClinGen TOPMed
CA413349609 rs1289170230	1091	T>A		No	ClinGen TOPMed gnomAD
rs782337614 CA10424349	1096	D>V		No	ClinGen ExAC gnomAD
CA10424348 rs782437240	1100	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA413349407 rs1557153385	1106	A>V		No	ClinGen gnomAD
CA10424347 rs782635253	1108	N>T		No	ClinGen ExAC TOPMed gnomAD
COSM278141 CA413349369 rs1557153381	1109	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs782512030 CA10424346	1115	E>G		No	ClinGen ExAC gnomAD
CA413349158 rs1557153375	1126	S>N		No	ClinGen gnomAD
rs139937497 CA10424345	1132	P>T		No	ClinGen ESP ExAC gnomAD
CA413349066 rs1557153361	1133	E>K		No	ClinGen gnomAD
CA10424343 rs147480156	1138	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA413348984 rs147480156	1138	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557153347 CA413348977	1139	Q>E		No	ClinGen gnomAD
rs781824909 CA10424342	1143	S>A		No	ClinGen ExAC gnomAD
CA413348915 rs1557153333	1144	P>T		No	ClinGen gnomAD
rs1163122285 CA413348851	1149	A>T		No	ClinGen TOPMed
rs1363923361 CA413348808	1152	T>A		No	ClinGen TOPMed
CA10424339 rs781871276	1152	T>N		No	ClinGen ExAC TOPMed gnomAD
RCV001092788 rs1557153313	1154	S>F		No	ClinVar dbSNP
CA413348789 rs1557153313	1154	S>Y		No	ClinGen gnomAD
CA413348784 rs1557153310	1155	C>Y		No	ClinGen gnomAD
rs1304128290 CA413348773	1157	V>M		No	ClinGen TOPMed gnomAD
rs782813200 CA10424338	1163	I>V		No	ClinGen ExAC gnomAD
CA413348637 rs1557153300	1167	G>A		No	ClinGen gnomAD
CA329012052 rs891306470	1168	I>F		No	ClinGen Ensembl
CA329012045 VAR_041326 rs55903619	1169	K>E		No	ClinGen UniProt TOPMed dbSNP gnomAD
rs782166941 CA10424337	1172	P>L		No	ClinGen ExAC gnomAD
CA413348533 rs1281811477	1175	S>P		No	ClinGen TOPMed gnomAD
CA10424335 rs782321162	1175	S>Y		No	ClinGen ExAC gnomAD
rs782079629 CA413348521	1176	P>H		No	ClinGen ExAC TOPMed gnomAD
rs782079629 CA10424334	1176	P>R		No	ClinGen ExAC TOPMed gnomAD
rs370142696 CA10424333	1177	N>S		No	ClinGen ESP ExAC gnomAD
rs1244568984 CA413348403	1181	T>S		No	ClinGen TOPMed gnomAD
CA413348376 rs1557153236	1183	S>P		No	ClinGen gnomAD
CA413348305 rs1312325148	1188	N>H		No	ClinGen TOPMed gnomAD
rs782656518 CA10424330	1188	N>S		No	ClinGen ExAC TOPMed gnomAD
CA413348248 rs1222840274	1192	S>G		No	ClinGen TOPMed
CA329011991 rs201972022	1196	N>S		No	ClinGen 1000Genomes gnomAD
rs1271947866 CA413348152	1197	I>M		No	ClinGen TOPMed gnomAD
CA329011980 rs200210498 COSM1468653	1201	K>R	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1557153215 CA413348034	1202	R>K		No	ClinGen gnomAD
rs782173132 CA10424328	1207	I>V		No	ClinGen ExAC TOPMed gnomAD
CA10424325 rs3747286	1213	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557153197 CA413347736	1216	L>S		No	ClinGen gnomAD
CA413347726 rs373458497	1217	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424323 rs373458497	1217	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557150958 CA413346848	1218	E>*		No	ClinGen gnomAD
rs1557150958 CA413346851	1218	E>Q		No	ClinGen gnomAD
rs782158806 CA10424305	1222	D>A		No	ClinGen ExAC TOPMed gnomAD
CA413346742 rs1224328258	1223	A>V		No	ClinGen TOPMed
rs1293055363 CA413346705	1226	P>T		No	ClinGen TOPMed gnomAD
rs782319888 CA10424303	1235	A>G		No	ClinGen ExAC gnomAD
rs782394062 CA10424300	1239	G>D		No	ClinGen ExAC
CA413346434 rs1557150940	1239	G>S		No	ClinGen gnomAD
rs1557150928 CA413346305	1246	T>R		No	ClinGen gnomAD
rs1557150923 CA413346301	1247	G>R		No	ClinGen gnomAD
CA413346188 rs1470236873	1254	S>N		No	ClinGen TOPMed
rs1557150915 CA413346184	1254	S>R		No	ClinGen gnomAD
rs1557150908 CA413346044	1260	L>F		No	ClinGen gnomAD
CA329009165 rs942589187	1261	K>R		No	ClinGen Ensembl
rs373588742 CA10424297	1263	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA413345943 rs1411251742	1264	I>L		No	ClinGen TOPMed
CA329009139 rs912484193	1269	W>*		No	ClinGen Ensembl
rs1425327305 CA413345748	1271	R>C		No	ClinGen TOPMed gnomAD
CA413345740 rs868955784	1271	R>H		No	ClinGen TOPMed
CA10424296 rs138028142	1277	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1306216232 CA413345608	1277	A>V		No	ClinGen TOPMed
rs782475066 CA10424294	1281	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM3092667 rs377088498 CA10424295	1281	R>W	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1569536313 CA413345506	1282	Q>*		No	ClinGen Ensembl
rs1302481742 CA413345499	1282	Q>R		No	ClinGen TOPMed
CA413345448 rs1377254030	1285	S>G		No	ClinGen TOPMed
CA413345300 rs1557150870	1292	V>A		No	ClinGen gnomAD
CA413345293 COSM1715016 rs1230331380	1293	R>C	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs200080539 CA10424293 COSM1165480	1293	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA10424283 rs781929534	1295	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10424282 rs782779614	1297	T>A		No	ClinGen ExAC gnomAD
rs782127828 CA10424281	1297	T>I		No	ClinGen ExAC TOPMed gnomAD
rs782428652 CA10424279	1298	E>D		No	ClinGen ExAC gnomAD
rs782021146 CA10424280	1298	E>K		No	ClinGen ExAC gnomAD
CA10424278 rs372554629	1300	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557150743 CA413344989	1303	A>T		No	ClinGen gnomAD
rs1039306862 CA329008867	1305	A>V		No	ClinGen gnomAD
CA10424277 rs781942753	1310	P>L		No	ClinGen ExAC gnomAD
CA329008850 rs942389403	1312	T>S		No	ClinGen Ensembl
rs368509222 CA329008826	1313	R>Q		No	ClinGen ESP TOPMed gnomAD
rs782307597 CA10424276	1313	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10424275 rs782221000	1321	A>P		No	ClinGen ExAC gnomAD
CA10424274 rs782621895	1321	A>V		No	ClinGen ExAC gnomAD
rs200922004 CA10424273	1323	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA329008801 rs376813688	1324	R>S		No	ClinGen ESP
rs782274374 CA10424272	1327	A>V		No	ClinGen ExAC TOPMed gnomAD
rs781803806 CA10424269	1334	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10424270 COSM1123350 rs201834658	1334	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1557150700 CA413344298	1336	R>Q		No	ClinGen gnomAD
CA413344087 rs1200963538	1340	I>V		No	ClinGen TOPMed gnomAD
rs782374181 CA10424259	1342	I>V		No	ClinGen ExAC gnomAD
rs1557150537 CA413343980	1344	Q>R		No	ClinGen gnomAD
CA10424258 rs782119691	1347	S>P		No	ClinGen ExAC gnomAD
CA10424257 rs782010947	1350	M>L		No	ClinGen ExAC gnomAD
CA329008457 rs782305717	1355	I>T		No	ClinGen gnomAD
CA413343758 rs1603379015	1356	E>K		No	ClinGen Ensembl
CA413343727 rs1429482337	1357	H>Y		No	ClinGen TOPMed
CA413343711 rs1156555298	1358	I>L		No	ClinGen TOPMed
CA413343713 rs1156555298	1358	I>V		No	ClinGen TOPMed
rs782181966 CA10424255	1361	F>L		No	ClinGen ExAC gnomAD
CA10424256 rs782414538	1361	F>S		No	ClinGen ExAC gnomAD
CA329008413 rs782358138	1363	E>K		No	ClinGen Ensembl
rs781974747 CA10424254	1365	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1557150510 CA413343498	1368	S>G		No	ClinGen gnomAD
rs200980554 CA10424253	1368	S>N		No	ClinGen ExAC TOPMed gnomAD
rs200980554 CA413343491	1368	S>T		No	ClinGen ExAC TOPMed gnomAD
rs183721653 CA10424252	1371	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA10424251 rs782642108	1374	K>R		No	ClinGen ExAC TOPMed gnomAD
CA329008397 VAR_041327 rs55879434	1375	T>I		No	ClinGen UniProt dbSNP gnomAD
rs1403125302 CA413343212	1379	Q>P		No	ClinGen TOPMed gnomAD
CA10424250 rs145423484	1381	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs781904194 CA10424248	1384	E>*		No	ClinGen ExAC
rs782583912 CA10424247	1384	E>D		No	ClinGen ExAC gnomAD
rs868969709 CA413343056	1386	A>S		No	ClinGen TOPMed
rs868969709 CA413343061	1386	A>T		No	ClinGen TOPMed
rs1557150463 CA413343041	1387	T>S		No	ClinGen gnomAD
CA10424246 rs782461541	1390	P>R		No	ClinGen ExAC TOPMed gnomAD
rs374273753 CA329008357	1392	T>A		No	ClinGen ESP TOPMed gnomAD
rs781830908 COSM1123346 CA10424245	1393	S>L	endometrium skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA413342905 rs1557150451	1395	S>P		No	ClinGen gnomAD
rs1490006571 CA413342864	1397	E>K		No	ClinGen TOPMed
CA413342847 rs1557150446	1398	K>E		No	ClinGen gnomAD
CA413342715 rs1268940996	1403	Q>P		No	ClinGen TOPMed gnomAD
CA413342709 rs1557150435	1404	E>Q		No	ClinGen gnomAD
CA10424242 rs781864619	1407	K>E		No	ClinGen ExAC gnomAD
CA413342649 rs781864619	1407	K>Q		No	ClinGen ExAC gnomAD
CA10424241 rs782782407	1407	K>R		No	ClinGen ExAC TOPMed gnomAD
rs782155575 CA10424240	1411	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10424239 rs781916557	1412	V>I		No	ClinGen ExAC TOPMed gnomAD
rs782563888 CA10424237	1414	K>E		No	ClinGen 1000Genomes ExAC
CA413342432 rs1419385386	1415	Q>R		No	ClinGen TOPMed gnomAD
CA413342360 rs1557150411	1418	N>T		No	ClinGen gnomAD
CA16608956 RCV000425408 rs1057524673	1423	S>R		No	ClinGen ClinVar dbSNP gnomAD
rs781995218 CA10424235	1424	A>T		No	ClinGen ExAC TOPMed gnomAD
CA413342179 rs1426504599	1426	C>S		No	ClinGen TOPMed
CA10424233 rs782692764	1428	T>I		No	ClinGen ExAC gnomAD
rs1303725191 CA413342108	1429	D>G		No	ClinGen TOPMed
rs782308944 CA10424232	1430	V>A		No	ClinGen ExAC gnomAD
rs782198665 CA10424231	1431	S>P		No	ClinGen ExAC gnomAD
CA10424230 rs782598022	1433	V>L		No	ClinGen ExAC gnomAD
rs782496409 CA10424229	1434	T>S		No	ClinGen ExAC
rs1296662761 CA413341881	1439	F>C		No	ClinGen TOPMed gnomAD
RCV000584908 rs1557150367 CA413341776	1444	A>D		No	ClinGen ClinVar Ensembl dbSNP
CA413341649 rs1392269889	1449	M>V		No	ClinGen TOPMed
CA413341544 rs1312487747	1453	S>F		No	ClinGen TOPMed
rs1010731015 CA329008186	1456	L>F		No	ClinGen TOPMed
rs781896072 CA10424225	1458	K>E		No	ClinGen ExAC gnomAD
rs782704749 CA10424224	1460	R>G		No	ClinGen ExAC gnomAD
rs1557150342 CA413341348	1462	I>R		No	ClinGen gnomAD
CA10424223 rs782060243	1462	I>V		No	ClinGen ExAC gnomAD
CA413341276 rs1248776858	1466	G>E		No	ClinGen TOPMed
CA413341264 rs1293219673	1467	K>E		No	ClinGen TOPMed
CA413341201 rs1603378895	1469	P>L		No	ClinGen Ensembl
CA413341162 rs1557150322	1472	D>G		No	ClinGen gnomAD
CA413341170 rs1340841083	1472	D>H		No	ClinGen TOPMed gnomAD
rs895003487 CA329008118	1476	S>L		No	ClinGen TOPMed gnomAD
CA413341006 rs1557150309	1483	G>R		No	ClinGen gnomAD
rs782135739 CA10424220	1485	S>T		No	ClinGen ExAC TOPMed gnomAD
rs782018207 CA10424219	1488	K>N		No	ClinGen ExAC gnomAD
rs782814352 CA10424218	1490	G>D		No	ClinGen ExAC gnomAD
CA10424217 rs376399429	1491	P>L		No	ClinGen ESP ExAC gnomAD
rs781939588 CA10424216	1492	E>D		No	ClinGen ExAC TOPMed gnomAD
CA413340902 rs1240999666	1493	S>N		No	ClinGen TOPMed
rs782346623 CA10424215	1493	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1055881340 CA329008067	1494	N>S		No	ClinGen Ensembl
rs937375026 CA329008044	1496	C>R		No	ClinGen Ensembl
rs1164114808 CA413340845	1497	L>F		No	ClinGen TOPMed
CA10424212 rs149043219 COSM248353 RCV000910385	1501	E>K	prostate [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10424209 rs782434295	1505	Y>C		No	ClinGen ExAC gnomAD
rs1462661271 CA413340711	1508	T>I		No	ClinGen TOPMed gnomAD
rs144870410 CA329008001	1512	L>F		No	ClinGen ESP gnomAD
CA413340650 rs1569536232	1513	F>L		No	ClinGen Ensembl
rs1557150252 CA413340643	1514	Y>C		No	ClinGen gnomAD
rs1381022082 CA413340628	1515	S>L		No	ClinGen TOPMed gnomAD
rs782495607 CA413340579	1520	M>R		No	ClinGen ExAC TOPMed gnomAD
rs782495607 CA10424206	1520	M>T		No	ClinGen ExAC TOPMed gnomAD
CA413340585 rs1316269346	1520	M>V		No	ClinGen TOPMed
CA413340573 rs1274544232	1521	S>G		No	ClinGen TOPMed
CA413340555 rs1557150236	1522	S>N		No	ClinGen gnomAD
CA10424205 rs781851151	1523	D>N		No	ClinGen ExAC gnomAD
rs1307607722 CA413340524	1524	D>V		No	ClinGen TOPMed gnomAD
rs929982592 CA329007976	1534	K>R		No	ClinGen TOPMed
rs918834673 CA329007974	1535	V>A		No	ClinGen Ensembl
CA413340420 rs1557150216	1538	Q>R		No	ClinGen gnomAD
CA10424204 rs782798378	1543	K>I		No	ClinGen ExAC gnomAD
rs782798378 CA413340384	1543	K>R		No	ClinGen ExAC gnomAD
rs1557149375 CA413339517	1548	V>A		No	ClinGen gnomAD
rs1569536143 CA413339506	1549	V>G		No	ClinGen Ensembl
CA10424200 rs782086003	1553	T>I		No	ClinGen ExAC TOPMed gnomAD
CA413339431 rs1557149363	1555	Q>H		No	ClinGen gnomAD
rs187102838 CA10424197	1561	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10424195 rs150271543	1565	R>C		No	ClinGen ESP ExAC gnomAD
COSM1123338 rs1192392222 CA413339311	1565	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs782179137 CA10424194	1567	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA413339294 rs1557149344	1567	R>W		No	ClinGen gnomAD
rs1194158150 CA413339231	1572	S>I		No	ClinGen TOPMed
rs377009916 CA10424193	1574	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557149318 CA413339192	1576	S>T		No	ClinGen gnomAD
CA413339143 rs1557149314	1580	P>L		No	ClinGen gnomAD
rs201518613 CA10424191	1587	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA10424190 rs782639623	1588	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10424188 rs782290033	1592	F>S		No	ClinGen ExAC gnomAD
CA329006555 rs988114050	1596	L>V		No	ClinGen Ensembl
rs958055900 CA329006553	1597	R>Q		No	ClinGen TOPMed gnomAD
rs782572831 CA10424187	1599	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782454662 CA10424186	1599	R>H		No	ClinGen ExAC TOPMed gnomAD
CA413338948 rs1557149292	1600	P>S		No	ClinGen TOPMed
rs1330942169 CA413338937	1601	Q>R		No	ClinGen TOPMed
rs1557149282 CA413338905	1604	T>A		No	ClinGen gnomAD
rs1557149280 CA413338889	1605	H>R		No	ClinGen gnomAD
CA413338576 rs1557148354	1614	G>E		No	ClinGen gnomAD
CA413338535 rs1557148352	1617	C>*		No	ClinGen gnomAD
CA10424175 rs782368964	1622	L>W		No	ClinGen ExAC TOPMed gnomAD
rs1253641535 CA413334942	1624	N>I		No	ClinGen TOPMed gnomAD
rs1557141813 CA413334938	1624	N>K		No	ClinGen gnomAD
CA413334936 rs1557141809	1625	P>T		No	ClinGen gnomAD
rs1425249218 CA413334925	1626	L>P		No	ClinGen TOPMed gnomAD
rs994592566 CA328993143	1627	C>Y		No	ClinGen Ensembl
CA413334910 rs1557141798	1628	V>M		No	ClinGen gnomAD
CA328993132 rs900353213	1636	Q>E		No	ClinGen Ensembl
rs782698755 CA10424162	1636	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
rs782462161 CA10424159	1643	K>T		No	ClinGen ExAC
rs781819566 CA10424158	1646	F>L		No	ClinGen ExAC gnomAD
rs1422572787 CA413334712	1646	F>Y		No	ClinGen TOPMed
rs1463898930 CA413334643	1652	K>R		No	ClinGen TOPMed gnomAD
CA10424156 rs782116364	1656	D>N		No	ClinGen ExAC gnomAD
rs142607795 CA10424155	1665	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557141766 CA413334505	1666	L>F		No	ClinGen Ensembl
rs1557141762 CA413334502	1666	L>H		No	ClinGen gnomAD
rs782819287 CA10424154	1667	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1302393067 CA413334424	1673	Q>R		No	ClinGen TOPMed
rs1557141752 CA413334397	1675	K>N		No	ClinGen gnomAD
CA10424153 rs782152711	1676	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA10424151 rs782342462	1682	E>A		No	ClinGen ExAC gnomAD
rs782106434 CA10424150	1683	T>A		No	ClinGen ExAC gnomAD
rs782025064 CA10424149	1686	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413334279 rs782025064	1686	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1557141728 CA413334255	1688	K>Q		No	ClinGen gnomAD
rs782605253 CA10424142	1692	N>D		No	ClinGen ExAC gnomAD
CA413340360 rs1459930052	1693	T>S		No	ClinGen TOPMed
rs147722907 CA10424141	1694	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413340358 rs1603369560	1694	P>S		No	ClinGen Ensembl
rs374105382 CA10424139	1696	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA10424138 rs192899527	1696	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413340339 rs1557140935	1697	M>T		No	ClinGen gnomAD
CA10424137 rs781792497	1698	G>C		No	ClinGen ExAC gnomAD
CA413340325 rs1229442170	1699	Y>C		No	ClinGen TOPMed gnomAD
CA413340316 rs1557140917	1700	T>I		No	ClinGen gnomAD
rs1557140907 CA413340305	1702	T>I		No	ClinGen gnomAD
CA10424135 rs781802718	1702	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA328987457 rs947312556	1705	S>F		No	ClinGen Ensembl
rs1557140906 CA413340278	1706	S>F		No	ClinGen gnomAD
CA10424133 rs782781504	1708	S>C		No	ClinGen ExAC gnomAD
rs782139722 CA10424132	1709	Q>P		No	ClinGen ExAC gnomAD
COSM141639 CA413340251 rs1216100438	1711	R>C	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1557140894 CA413340249	1711	R>H		No	ClinGen gnomAD
rs140063797 CA10424131	1713	A>G		No	ClinGen ESP ExAC gnomAD
CA413340235 rs1557140889	1714	V>L		No	ClinGen gnomAD
rs782817875 CA10424130	1715	P>R		No	ClinGen ExAC TOPMed gnomAD
CA328987420 rs151287033	1716	T>N		No	ClinGen ESP
CA10424129 rs782044624	1719	P>S		No	ClinGen ExAC gnomAD
rs1557140872 CA413340190	1721	G>A		No	ClinGen gnomAD
CA413340186 rs1480036312	1722	L>F		No	ClinGen TOPMed gnomAD
CA413340187 rs1480036312	1722	L>V		No	ClinGen TOPMed gnomAD
CA10424127 rs782332392	1723	S>P		No	ClinGen ExAC gnomAD
CA10424125 rs781979498	1724	L>F		No	ClinGen ExAC gnomAD
CA10424124 rs782683979	1725	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413340166 rs1415413427	1726	S>P		No	ClinGen TOPMed
rs1569534710 CA413340158	1727	F>Y		No	ClinGen Ensembl
rs914392824 CA328987409	1728	P>L		No	ClinGen Ensembl
rs1476108519 CA413340151	1728	P>S		No	ClinGen TOPMed
rs1557140839 CA413340140 COSM1123328	1730	P>S	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1603369477 CA413340128	1732	S>P		No	ClinGen Ensembl
rs1165436691 CA413340122	1733	S>P		No	ClinGen TOPMed gnomAD
CA413340096 rs868921968	1736	M>I		No	ClinGen Ensembl
CA10424122 rs782569664	1736	M>R		No	ClinGen ExAC gnomAD
rs782457700 CA10424121	1738	H>P		No	ClinGen ExAC gnomAD
CA413340081 rs782629234	1739	V>F		No	ClinGen ExAC gnomAD
CA10424119 rs782629234	1739	V>I		No	ClinGen ExAC gnomAD
CA413340074 rs1557140812	1740	C>Y		No	ClinGen gnomAD
rs1557140804 CA413340057	1742	Y>C		No	ClinGen gnomAD
rs1372717266 CA413340059	1742	Y>D		No	ClinGen TOPMed
CA10424118 rs782504607	1743	N>D		No	ClinGen ExAC TOPMed gnomAD
CA10424117 COSM1123326 rs781877129	1746	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs782792961 CA10424116	1747	G>R		No	ClinGen ExAC gnomAD
CA10424114 rs199996615	1748	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10424115 rs199996615	1748	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1557140773 CA413340015	1749	G>V		No	ClinGen gnomAD
CA10424112 rs782079394	1750	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA10424111 rs781962583	1754	W>R		No	ClinGen ExAC TOPMed gnomAD
rs782125765 CA10424110	1755	V>A		No	ClinGen ExAC gnomAD
CA10424109 rs782125765	1755	V>G		No	ClinGen ExAC gnomAD
CA413339949 rs1569534687	1760	T>A		No	ClinGen Ensembl
rs1557140752 CA413339926	1763	Q>R		No	ClinGen gnomAD
rs372840598 CA10424107	1765	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA413339916 rs372840598	1765	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA413339907 rs1603369440	1766	V>A		No	ClinGen Ensembl
rs781958016 CA413339891	1769	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10424105 rs781958016	1769	A>T		No	ClinGen ExAC TOPMed gnomAD
CA10424103 COSM457769 rs782247541	1771	S>F	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA413339876 rs782247541	1771	S>Y		No	ClinGen ExAC gnomAD
rs1255090791 CA413339873	1772	G>R		No	ClinGen TOPMed
CA10424100 rs200621254	1777	P>S		No	ClinGen ExAC TOPMed gnomAD
CA413339807 rs1557140718	1781	M>R		No	ClinGen gnomAD
CA413339800 rs1557140712	1782	Q>R		No	ClinGen gnomAD
rs782446596 CA10424098	1783	A>T		No	ClinGen ExAC gnomAD
rs782613910 CA10424096	1785	P>L		No	ClinGen ExAC gnomAD
CA10424097 rs781817419	1785	P>S		No	ClinGen ExAC TOPMed gnomAD
CA413339777 rs375856558	1786	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs375856558 CA10424095	1786	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs781868717 CA10424094	1787	S>A		No	ClinGen ExAC gnomAD
CA10424093 rs782784534	1788	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1430595412 CA413339759	1789	V>A		No	ClinGen TOPMed
rs1392102851 CA413339763	1789	V>M		No	ClinGen TOPMed
rs1557140688 CA413339755	1790	Q>*		No	ClinGen gnomAD
rs1173270244 CA413339745	1791	N>S		No	ClinGen TOPMed
CA10424091 rs201501755	1795	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10424089 rs782102982	1796	P>S		No	ClinGen ExAC gnomAD
rs781991689 CA413339705	1797	P>L		No	ClinGen ExAC gnomAD
rs781991689 CA10424088	1797	P>R		No	ClinGen ExAC gnomAD
rs1557140659 CA413339698	1798	G>D		No	ClinGen gnomAD
rs782398134 CA10424087	1798	G>S		No	ClinGen ExAC gnomAD

No associated diseases with Q9BYP7

3 regional properties for Q9BYP7

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	147 - 405	IPR000719
active_site	Serine/threonine-protein kinase, active site	271 - 283	IPR008271
domain	Serine/threonine-protein kinase OSR1/WNK, CCT domain	426 - 488	IPR024678

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm	Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
bicellular tight junction	An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chloride channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a chloride channel.
potassium channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a potassium channel.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

20 GO annotations of biological process

Name	Definition
cell volume homeostasis	Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
ion homeostasis	Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
maintenance of blood-brain barrier	Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of sodium ion transport	Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
osmosensory signaling pathway	The series of molecular signals initiated in response to osmotic change.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of calcium ion transport	Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of ion transmembrane transporter activity	Any process that activates or increases the activity of an ion transporter.
positive regulation of peptidyl-threonine phosphorylation	Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of potassium ion import across plasma membrane	Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
positive regulation of protein localization to plasma membrane	Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of sodium ion transmembrane transporter activity	Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
positive regulation of sodium ion transport	Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of calcium ion import	Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
regulation of cation transmembrane transport	Any process that modulates the frequency, rate or extent of cation transmembrane transport.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96J92	WNK4	Serine/threonine-protein kinase WNK4	Homo sapiens (Human)	SS
P51957	NEK4	Serine/threonine-protein kinase Nek4	Homo sapiens (Human)	PR
Q9Y3S1	WNK2	Serine/threonine-protein kinase WNK2	Homo sapiens (Human)	SS
Q9UHY1	NRBP1	Nuclear receptor-binding protein	Homo sapiens (Human)	PR
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Homo sapiens (Human)	SS
Q9Y2U5	MAP3K2	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (Human)	PR
Q99759	MAP3K3	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (Human)	PR
P83741	Wnk1	Serine/threonine-protein kinase WNK1	Mus musculus (Mouse)	SS
Q3UH66	Wnk2	Serine/threonine-protein kinase WNK2	Mus musculus (Mouse)	SS
Q80UE6	Wnk4	Serine/threonine-protein kinase WNK4	Mus musculus (Mouse)	SS
Q80XP9	Wnk3	Serine/threonine-protein kinase WNK3	Mus musculus (Mouse)	SS
Q6R2V0	WNK1	Serine/threonine-protein kinase WNK1	Sus scrofa (Pig)	SS
Q9JIH7	Wnk1	Serine/threonine-protein kinase WNK1	Rattus norvegicus (Rat)	EV
Q7TPK6	Wnk4	Serine/threonine-protein kinase WNK4	Rattus norvegicus (Rat)	SS
X5M5N0	wnk-1	Serine/threonine-protein kinase WNK	Caenorhabditis elegans	SS
Q8RXE5	WNK10	Probable serine/threonine-protein kinase WNK10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q944Q0	WNK8	Serine/threonine-protein kinase WNK8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LVL5	WNK4	Probable serine/threonine-protein kinase WNK4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STK6	WNK3	Probable serine/threonine-protein kinase WNK3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LST2	WNK7	Probable serine/threonine-protein kinase WNK7	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MATDSGDPAS	TEDSEKPDGI	SFENRVPQVA	ATLTVEARLK	EKNSTFSASG	ETVERKRFFR
70	80	90	100	110	120
KSVEMTEDDK	VAESSPKDER	IKAAMNIPRV	DKLPSNVLRG	GQEVKYEQCS	KSTSEISKDC
130	140	150	160	170	180
FKEKNEKEME	EEAEMKAVAT	SPSGRFLKFD	IELGRGAFKT	VYKGLDTETW	VEVAWCELQD
190	200	210	220	230	240
RKLTKAEQQR	FKEEAEMLKG	LQHPNIVRFY	DSWESILKGK	KCIVLVTELM	TSGTLKTYLK
250	260	270	280	290	300
RFKVMKPKVL	RSWCRQILKG	LQFLHTRTPP	IIHRDLKCDN	IFITGPTGSV	KIGDLGLATL
310	320	330	340	350	360
MRTSFAKSVI	GTPEFMAPEM	YEEHYDESVD	VYAFGMCMLE	MATSEYPYSE	CQNAAQIYRK
370	380	390	400	410	420
VTSGIKPASF	NKVTDPEVKE	IIEGCIRQNK	SERLSIRDLL	NHAFFAEDTG	LRVELAEEDD
430	440	450	460	470	480
CSNSSLALRL	WVEDPKKLKG	KHKDNEAIEF	SFNLETDTPE	EVAYEMVKSG	FFHESDSKAV
490	500	510	520	530	540
AKSIRDRVTP	IKKTREKKPA	GCLEERRDSQ	CKSMGNVFPQ	PQNTTLPLAP	AQQTGAECEE
550	560	570	580	590	600
TEVDQHVRQQ	LLQRKPQQHC	SSVTGDNLSE	AGAASVIHSD	TSSQPSVAYS	SNQTMGSQMV
610	620	630	640	650	660
SNIPQAEVNV	PGQIYSSQQL	VGHYQQVSGL	QKHSKLTQPQ	ILPLVQGQST	VLPVHVLGPT
670	680	690	700	710	720
VVSQPQVSPL	TVQKVPQIKP	VSQPVGAEQQ	AALLKPDLVR	SLNQDVATTK	ENVSSPDNPS
730	740	750	760	770	780
GNGKQDRIKQ	RRASCPRPEK	GTKFQLTVLQ	VSTSGDNMVE	CQLETHNNKM	VTFKFDVDGD
790	800	810	820	830	840
APEDIADYMV	EDNFVLESEK	EKFVEELRAI	VGQAQEILHV	HFATERATGV	DSITVDSNSS
850	860	870	880	890	900
QTGSSEQVQI	NSTSTQTSNE	SAPQSSPVGR	WRFCINQTIR	NRETQSPPSL	QHSMSAVPGR
910	920	930	940	950	960
HPLPSPKNTS	NKEISRDTLL	TIENNPCHRA	LFTSKSEHKD	VVDGKISECA	SVETKQPAIL
970	980	990	1000	1010	1020
YQVEDNRQIM	APVTNSSSYS	TTSVRAVPAE	CEGLTKQASI	FIPVYPCHQT	ASQADALMSH
1030	1040	1050	1060	1070	1080
PGESTQTSGN	SLTTLAFDQK	PQTLSVQQPA	MDAEFISQEG	ETTVNTEASS	PKTVIPTQTP
1090	1100	1110	1120	1130	1140
GLEPTTLQPT	TVLESDGERP	PKLEFADNRI	KTLDEKLRNL	LYQEHSISSI	YPESQKDTQS
1150	1160	1170	1180	1190	1200
IDSPFSSSAE	DTLSCPVTEV	IAISHCGIKD	SPVQSPNFQQ	TGSKLLSNVA	ASQPANISVF
1210	1220	1230	1240	1250	1260
KRDLNVITSV	PSELCLHEMS	SDASLPGDPE	AYPAAVSSGG	AIHLQTGGGY	FGLSFTCPSL
1270	1280	1290	1300	1310	1320
KNPISKKSWT	RKLKSWAYRL	RQSTSFFKRS	KVRQVETEEM	RSAIAPDPIP	LTRESTADTR
1330	1340	1350	1360	1370	1380
ALNRCKAMSG	SFQRGRFQVI	TIPQQQSAKM	TSFGIEHISV	FSETNHSSEE	AFIKTAKSQL
1390	1400	1410	1420	1430	1440
VEIEPATQNP	KTSFSYEKLQ	ALQETCKENK	GVPKQGDNFL	SFSAACETDV	SSVTPEKEFE
1450	1460	1470	1480	1490	1500
ETSATGSSMQ	SGSELLLKER	EILTAGKQPS	SDSEFSASLA	GSGKSVAKTG	PESNQCLPHH
1510	1520	1530	1540	1550	1560
EEQAYAQTQS	SLFYSPSSPM	SSDDESEIED	EDLKVELQRL	REKHIQEVVN	LQTQQNKELQ
1570	1580	1590	1600	1610	1620
ELYERLRSIK	DSKTQSTEIP	LPPASPRRPR	SFKSKLRSRP	QSLTHVDNGI	VATGKSCLIN
1630	1640	1650	1660	1670	1680
ELENPLCVES	NAASCQQSPA	SKKGMFTDDL	HKLVDDWTKE	AVGNSLIKPS	LNQLKQSQHK
1690	1700	1710	1720	1730	1740
LETENWNKVS	ENTPSTMGYT	STWISSLSQI	RGAVPTSLPQ	GLSLPSFPGP	LSSYGMPHVC
1750	1760	1770	1780	1790
QYNAVAGAGY	PVQWVGISGT	TQQSVVIPAQ	SGGPFQPGMN	MQAFPTSSVQ	NPATIPPGPK