AiPD: Autoinhibited Protein Database

Q9BYG8

Gene name	GSDMC
Protein name	Gasdermin-C
Names	Melanoma-derived leucine zipper-containing extranuclear factor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:56169
EC number
Protein Class

Descriptions

Gasdermin proteins are a pore-forming protein causing membrane permeabilization and pyroptosis, and functions downstream of the inflammatory caspases. In human Gasdermin-D protein, its C-terminal gasdermin domain adopts an intramolecular complex with the N-terminal domain, which inhibits the activation of the N-terminal gasdermin domain. The N- and C-terminal gasdermin domains of GSDMC can interact with each other, implying a similar autoinhibitory mechanism.

Autoinhibitory domains (AIDs)

313-482 (C-terminal gasdermin domain) SS

Target domain	4-240 (N-terminal gasdermin domain)
Relief mechanism	Cleavage
Assay

AID

313-482 (C-terminal gasdermin domain)

Target domain

4-240 (N-terminal gasdermin domain)

Relief mechanism

Cleavage (Caspases-induced cleavage)

Assay

Accessory elements

No accessory elements

References

Shi J et al. (2015) "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death", Nature, 526, 660-5

Ding J et al. (2016) "Pore-forming activity and structural autoinhibition of the gasdermin family", Nature, 535, 111-6

Autoinhibited structure

Activated structure

1 structures for Q9BYG8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BYG8-F1	Predicted				AlphaFoldDB

471 variants for Q9BYG8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs762258169 CA4876221	2	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1266534046 CA372187782	2	P>R		No	ClinGen TOPMed
CA4876222 rs762258169	2	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1195131557 CA372187773	3	S>A		No	ClinGen TOPMed
CA185370298 rs1013729334	4	M>I		No	ClinGen TOPMed gnomAD
rs115551816 CA4876220	4	M>L		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs149535689 CA4876218	4	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs115551816 CA4876219	4	M>V		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs775958161 CA372187750	5	L>M		No	ClinGen ExAC TOPMed gnomAD
rs775958161 CA4876217	5	L>V		No	ClinGen ExAC TOPMed gnomAD
rs769905738 CA372187729	6	E>*		No	ClinGen ExAC TOPMed gnomAD
CA185370265 rs769905738	6	E>K		No	ClinGen ExAC TOPMed gnomAD
rs769905738 CA4876216	6	E>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1096071 rs369692449 CA4876215	7	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs369692449 CA372187711	7	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876214 rs771002121 COSM1096070	7	R>H	central_nervous_system endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs771002121 CA4876213	7	R>P		No	ClinGen ExAC gnomAD
CA372187713 rs369692449	7	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1386919911 CA372187690	8	I>N		No	ClinGen gnomAD
rs1183981323 CA372187614	13	V>L		No	ClinGen gnomAD
CA185370227 rs138109016	14	K>E		No	ClinGen ESP TOPMed gnomAD
rs138109016 CA372187600	14	K>Q		No	ClinGen ESP TOPMed gnomAD
CA4876212 rs200714543	15	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA372187588 rs1382803314	15	E>K		No	ClinGen gnomAD
rs771977895 CA4876210	16	I>T		No	ClinGen ExAC gnomAD
rs777495083 CA4876211	16	I>V		No	ClinGen ExAC gnomAD
CA372187545 rs1361846237	18	S>G		No	ClinGen TOPMed gnomAD
CA185370200 rs753588428	18	S>N		No	ClinGen Ensembl
rs765627400 CA4876208	21	L>V		No	ClinGen ExAC TOPMed gnomAD
rs368043349 CA4876206	23	P>L		No	ClinGen ESP ExAC gnomAD
rs10090835 VAR_028138 CA4876207	23	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs10090835 CA372187483	23	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1392449481 CA372187474	24	V>L		No	ClinGen gnomAD
CA372187458 rs1386166468	25	K>R		No	ClinGen gnomAD
rs568650364 CA4876205	26	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA4876203 rs750079168	28	L>F		No	ClinGen ExAC gnomAD
CA372187417 rs1407386905	28	L>S		No	ClinGen gnomAD
CA4876202 rs764494837	29	S>N		No	ClinGen ExAC gnomAD
CA4876201 rs138288375	30	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876200 rs753238485	31	T>I		No	ClinGen ExAC gnomAD
CA4876199 rs371192399	33	L>S		No	ClinGen ESP ExAC gnomAD
COSM1736347 rs550446533 CA4876197	34	R>C	central_nervous_system breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs550446533 CA4876198	34	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM604170 CA185370051 rs910419404	34	R>H	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA372187328 rs1175572380	35	Q>P		No	ClinGen gnomAD
CA372187313 rs1218238517	36	F>L		No	ClinGen TOPMed
rs760862584 CA4876195	36	F>L		No	ClinGen ExAC gnomAD
rs1221995002 CA372187296	37	V>I		No	ClinGen gnomAD
CA372187279 rs1563813538	38	I>T		No	ClinGen Ensembl
CA4876194 rs772031336	39	L>V		No	ClinGen ExAC TOPMed
COSM1643503 CA4876192 rs112465762	40	R>*	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs754298748 CA4876191 COSM1096069	40	R>Q	kidney endometrium skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs200005605 CA4876189	42	K>R		No	ClinGen ExAC gnomAD
CA4876188 rs200005605	42	K>T		No	ClinGen ExAC gnomAD
CA4876187 rs755630735	43	K>R		No	ClinGen ExAC gnomAD
rs750087595 CA4876185	44	D>G		No	ClinGen ExAC gnomAD
rs1490410688 CA372187179	45	S>T		No	ClinGen gnomAD
rs1303435675 CA372187171	45	S>Y		No	ClinGen gnomAD
CA4876184 rs140640562	46	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876182 rs115362838	46	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4876183 rs115362838	46	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765739292 CA4876181 COSM3834048	48	S>L	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4876179 rs760029934	51	E>G		No	ClinGen ExAC gnomAD
rs754354297 CA4876178	52	Q>P		No	ClinGen ExAC gnomAD
CA4876175 rs760776030	53	S>C		No	ClinGen ExAC gnomAD
CA4876177 rs368643866	53	S>T		No	ClinGen ESP ExAC gnomAD
CA4876173 rs143364779	54	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876171 rs773117841	54	D>E		No	ClinGen ExAC gnomAD
rs143364779 CA4876172	54	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs35919954 CA4876174 RCV000889701	54	D>N		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4876170 rs768564093	55	Y>C		No	ClinGen ExAC gnomAD
rs961715187 CA185369764	57	P>L		No	ClinGen Ensembl
CA372186998 rs749235759	59	E>A		No	ClinGen ExAC TOPMed gnomAD
CA372187004 rs1380081667	59	E>K		No	ClinGen TOPMed
CA4876169 rs749235759	59	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1242192052 CA372186977	60	F>L		No	ClinGen TOPMed
CA372186981 rs1319926826	60	F>Y		No	ClinGen TOPMed
rs1272397471 CA372186969	61	S>P		No	ClinGen TOPMed gnomAD
rs149214871 CA4876168	62	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs115142760 CA372186940	63	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4876167 rs115142760	63	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1325125520 CA372186866	68	P>L		No	ClinGen gnomAD
rs1181698984 CA372186873	68	P>T		No	ClinGen TOPMed
rs1442125447 CA372186853	69	S>N		No	ClinGen TOPMed
CA372186822 rs559980444	73	L>I		No	ClinGen 1000Genomes ExAC gnomAD
rs745375697 CA4876144	74	E>D		No	ClinGen ExAC gnomAD
CA4876145 rs769715058	74	E>G		No	ClinGen ExAC
CA4876143 rs776192121	76	V>I		No	ClinGen ExAC gnomAD
rs542215717 CA4876142	80	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA372186369 rs1375926726	80	P>S		No	ClinGen gnomAD
rs1200333992 CA372186354	81	F>S		No	ClinGen gnomAD
rs1388773073 CA372186345	82	H>Y		No	ClinGen gnomAD
CA4876139 rs755328553	84	S>N		No	ClinGen ExAC gnomAD
rs1445547755 CA372186298	84	S>R		No	ClinGen gnomAD
rs1345821216 CA372186291	85	D>G		No	ClinGen TOPMed
CA372186283 rs1243105803	86	I>V		No	ClinGen gnomAD
rs141144013 CA4876138	87	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1182234537 CA372186273	87	M>V		No	ClinGen gnomAD
CA4876137 rs756573853	88	I>N		No	ClinGen ExAC gnomAD
CA4876136 rs756573853	88	I>S		No	ClinGen ExAC gnomAD
rs750958886 CA4876135	91	H>D		No	ClinGen ExAC TOPMed gnomAD
CA4876133 rs757383851	93	A>S		No	ClinGen ExAC TOPMed gnomAD
rs937569829 CA185368440	95	M>I		No	ClinGen TOPMed gnomAD
rs79403769 CA4876131	96	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372186123 rs79403769	96	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4876132 rs79403769	96	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA185368397 rs954188634	97	V>L		No	ClinGen TOPMed
CA372186114 rs954188634	97	V>M		No	ClinGen TOPMed
rs762673763 CA372186048	103	V>L		No	ClinGen ExAC TOPMed gnomAD
rs762673763 CA4876130	103	V>M		No	ClinGen ExAC TOPMed gnomAD
CA372186032 rs1197562132	105	V>A		No	ClinGen TOPMed
rs1329612348 CA372186025	106	S>L		No	ClinGen gnomAD
CA372186022 rs1563811969	107	G>W		No	ClinGen Ensembl
CA372186013 rs1202630552	108	E>V		No	ClinGen TOPMed gnomAD
rs113659517 CA372186007	109	A>D		No	ClinGen gnomAD
rs191844570 CA4876126	109	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA185368337 rs113659517	109	A>V		No	ClinGen gnomAD
rs776529955 CA4876124	112	D>E		No	ClinGen ExAC gnomAD
CA4876125 rs759529407	112	D>G		No	ClinGen ExAC gnomAD
rs759529407 CA372185990	112	D>V		No	ClinGen ExAC gnomAD
CA372185975 rs1196809199	114	G>V		No	ClinGen TOPMed gnomAD
rs763298619 CA372185967	115	C>*		No	ClinGen ExAC TOPMed gnomAD
rs544555954 CA4876120	116	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs544555954 CA4876121	116	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA372185950 rs1482417091	117	L>F		No	ClinGen gnomAD
rs373440506 CA4876117 COSM1096066	118	E>K	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA372185932 rs1586615234	119	F>V		No	ClinGen Ensembl
CA372185915 rs1586615215	121	I>S		No	ClinGen Ensembl
CA185368279 rs577510947	122	V>I		No	ClinGen 1000Genomes
rs1403757250 CA372185892	125	P>A		No	ClinGen TOPMed
rs144307746 CA4876116	126	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876115 rs781751895	127	P>A		No	ClinGen ExAC gnomAD
rs1341930421 CA372185880	127	P>R		No	ClinGen TOPMed
rs781751895 CA372185881	127	P>S		No	ClinGen ExAC gnomAD
CA185368243 rs867165355	129	L>V		No	ClinGen TOPMed
CA372185857 rs1280000605	131	D>N		No	ClinGen gnomAD
CA372185836 rs1238462212	133	Q>R		No	ClinGen gnomAD
rs369223774 CA185368231	135	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs369223774 CA4876114	135	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1480457639 CA372184377	136	K>*		No	ClinGen gnomAD
rs1424069164 CA372184362	138	L>W		No	ClinGen gnomAD
rs1223314292 CA372184349	140	P>T		No	ClinGen TOPMed
CA372184344 rs1189052687	141	E>Q		No	ClinGen gnomAD
CA372184257 rs1247711510	147	E>D		No	ClinGen TOPMed
rs114211637 CA4876091	149	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4876089 rs754787261	149	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4876090 rs114211637	149	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_028139 CA4876088 rs16904151 RCV000961895	150	R>K		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4876087 rs766304265	154	N>S		No	ClinGen ExAC TOPMed gnomAD
CA185358664 rs766304265	154	N>T		No	ClinGen ExAC TOPMed gnomAD
rs570433175 CA372184142	156	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148475316 CA4876085	157	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876083 rs761196170	162	V>G		No	ClinGen ExAC gnomAD
rs774076693 CA372184069	163	E>A		No	ClinGen ExAC gnomAD
rs774076693 CA4876082	163	E>G		No	ClinGen ExAC gnomAD
rs1206126466 CA372184051	165	I>F		No	ClinGen gnomAD
rs1045544002 CA185358608	165	I>N		No	ClinGen Ensembl
CA372184026 rs1452758944	166	N>K		No	ClinGen gnomAD
rs763783378 CA4876081	167	N>D		No	ClinGen ExAC gnomAD
rs201826548 CA4876080	167	N>S		No	ClinGen ExAC gnomAD
CA372184007 rs1411296604	168	T>A		No	ClinGen gnomAD
rs1419715780 CA372183996	169	V>M		No	ClinGen gnomAD
CA372183983 rs1323587334	170	L>M		No	ClinGen TOPMed
rs1367326536 CA372183966	171	Y>C		No	ClinGen TOPMed
CA4876078 COSM229115 rs375510820	172	D>N	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1184102986 CA372183913	174	S>T		No	ClinGen gnomAD
rs747603724 CA4876077	177	N>D		No	ClinGen ExAC gnomAD
CA372183867 rs1226724057	177	N>T		No	ClinGen TOPMed gnomAD
rs1235800630 CA372183847	178	I>T		No	ClinGen gnomAD
CA4876076 rs773564089	179	L>F		No	ClinGen ExAC TOPMed gnomAD
rs772222662 CA4876075	182	I>T		No	ClinGen ExAC gnomAD
CA372183781 rs201944967	183	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs201944967 CA4876074	183	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA185358549 rs934581138	185	W>R		No	ClinGen Ensembl
CA372183722 rs1316416759	187	T>A		No	ClinGen gnomAD
CA372183705 rs1395929306	188	Y>C		No	ClinGen gnomAD
rs749507712 CA4876071	189	G>D		No	ClinGen ExAC gnomAD
CA372183693 rs1300580183	189	G>S		No	ClinGen TOPMed gnomAD
rs780217662 CA4876052	191	G>V		No	ClinGen ExAC gnomAD
CA372183305 rs1401985324	192	Q>P		No	ClinGen gnomAD
rs1586594516 CA372183293	193	G>R		No	ClinGen Ensembl
rs755966363 CA4876051	195	G>R		No	ClinGen ExAC
CA4876050 rs73406822	196	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374508236 CA4876049	197	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876048 rs149293328	197	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA185351524 rs374508236	197	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA185351513 rs149293328	197	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs954409907 CA185351507	199	R>G		No	ClinGen TOPMed
rs1209911584 CA372183155	203	K>R		No	ClinGen TOPMed
rs200990251 CA372183141	204	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM3317173 CA4876046 rs200990251	204	A>V	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA372183098 rs1225977236	207	L>R		No	ClinGen gnomAD
rs975555344 CA185351493	209	K>Q		No	ClinGen TOPMed
CA372183058 COSM1187614 rs1347014620	210	G>D	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4876041 rs761111935	211	M>I		No	ClinGen ExAC gnomAD
rs764930991 CA4876042	211	M>V		No	ClinGen ExAC gnomAD
rs1290606624 CA372183022	212	V>A		No	ClinGen gnomAD
rs750683131 CA372183026	212	V>L		No	ClinGen ExAC gnomAD
rs750683131 CA4876040	212	V>M		No	ClinGen ExAC gnomAD
rs1157054387 CA372182898	220	L>R		No	ClinGen gnomAD
CA185351449 rs900292984	222	I>V		No	ClinGen TOPMed
CA372182851 rs1432815651	224	E>K		No	ClinGen TOPMed
CA4876037 rs201872844	225	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4876016 rs752090078	226	A>D		No	ClinGen ExAC gnomAD
rs768762583 CA4876036	226	A>P		No	ClinGen ExAC gnomAD
rs768762583 CA372182815	226	A>T		No	ClinGen ExAC gnomAD
rs1237294987 CA372182110	227	I>M		No	ClinGen TOPMed
rs1346309359 CA372182077	229	I>N		No	ClinGen TOPMed
rs763026962 CA4876014	230	S>L		No	ClinGen ExAC gnomAD
CA372182010 COSM1096064 rs1308814649	231	D>G	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs775614968 CA4876013	231	D>N		No	ClinGen ExAC TOPMed gnomAD
CA185350479 rs933934327	232	D>G		No	ClinGen Ensembl
rs1459099348 CA372181961	233	D>N		No	ClinGen TOPMed
rs949715371 CA185350458	234	E>K		No	ClinGen TOPMed gnomAD
rs949715371 CA372181932	234	E>Q		No	ClinGen TOPMed gnomAD
rs1388675095 CA372181901	235	Q>L		No	ClinGen gnomAD
rs1388675095 CA372181898	235	Q>R		No	ClinGen gnomAD
CA185350450 rs915633900 COSM176724	236	R>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs769904707 CA4876012	237	T>S		No	ClinGen ExAC TOPMed gnomAD
rs759730605 CA4876011	240	D>H		No	ClinGen ExAC gnomAD
CA372180155 rs753181335	243	E>*		No	ClinGen ExAC gnomAD
rs753181335 CA4875994 COSM281572	243	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1486853126 CA372180136	244	I>F		No	ClinGen TOPMed gnomAD
CA372180138 rs1486853126	244	I>V		No	ClinGen TOPMed gnomAD
rs759624672 CA4875992	246	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1478901216 CA372180067	247	M>I		No	ClinGen TOPMed
rs776743103 CA4875991	250	Y>F		No	ClinGen ExAC gnomAD
CA4875990 rs377444902	251	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs138900124 CA4875989	252	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138900124 CA185346791	252	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs115622630 CA185346780	253	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4875988 rs773205428	253	A>S		No	ClinGen ExAC gnomAD
rs115622630 CA4875987	253	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs986247138 CA185346773	254	R>G		No	ClinGen Ensembl
CA4875984 rs768081301	255	S>N		No	ClinGen ExAC gnomAD
CA372179916 rs1392710438	255	S>R		No	ClinGen TOPMed
CA185346761 rs200006561	256	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373684856 CA4875983	256	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1294280324 CA372179885	257	G>R		No	ClinGen gnomAD
rs1343290547 CA372179875	257	G>V		No	ClinGen TOPMed
rs150792538 CA4875980	260	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1362645153 CA372179757	264	T>A		No	ClinGen TOPMed gnomAD
CA372179739 rs1245908403	265	I>F		No	ClinGen gnomAD
CA372179717 rs1196743016	265	I>M		No	ClinGen gnomAD
CA4875975 rs765728176	269	L>H		No	ClinGen ExAC TOPMed gnomAD
CA372179659 rs765728176	269	L>P		No	ClinGen ExAC TOPMed gnomAD
CA4875974 rs141073989	271	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA372179609 rs766559947	272	A>D		No	ClinGen ExAC TOPMed gnomAD
rs753886861 CA4875973	272	A>P		No	ClinGen ExAC TOPMed gnomAD
CA372179612 rs753886861	272	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4875972 rs766559947	272	A>V		No	ClinGen ExAC TOPMed gnomAD
rs773542987 CA4875970	273	S>L		No	ClinGen ExAC gnomAD
rs1433244828 CA372179503	277	M>T		No	ClinGen gnomAD
rs1425647326 CA372179470	278	K>N		No	ClinGen TOPMed gnomAD
CA4875967 rs574276492	279	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373460186 CA185346717	281	P>T		No	ClinGen gnomAD
CA372178641 rs1358255154	283	L>P		No	ClinGen gnomAD
rs368850633 CA4875953	285	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167944979 CA372178618	286	T>A		No	ClinGen gnomAD
CA372178614 rs1447594610	286	T>I		No	ClinGen gnomAD
rs1167944979 CA372178617	286	T>S		No	ClinGen gnomAD
CA4875952 rs780326163	287	Q>R		No	ClinGen ExAC gnomAD
rs1272193294 CA372178590	289	F>L		No	ClinGen TOPMed gnomAD
CA4875951 rs529616613	291	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA372178576 rs529616613	291	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA4875948 rs373573200	292	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373573200 CA4875949	292	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751300382 CA4875947	294	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4875923 rs770331372	298	E>*		No	ClinGen ExAC TOPMed gnomAD
CA4875921 COSM1096062 rs770331372	298	E>K	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs770331372 CA4875922	298	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA4875920 rs760421413	299	Q>E		No	ClinGen ExAC gnomAD
CA185346308 rs142858365	300	V>I		No	ClinGen 1000Genomes
CA4875919 rs772705468	301	H>Y		No	ClinGen ExAC gnomAD
rs201857986 CA185346302	304	P>Q		No	ClinGen Ensembl
CA372178472 rs1359308228	305	V>A		No	ClinGen Ensembl
CA4875894 rs771066017	306	G>E		No	ClinGen ExAC gnomAD
rs369317212 CA4875893	307	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs373058778 CA4875892	308	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1420288016 CA372178442	309	E>Q		No	ClinGen TOPMed
CA185346067 rs369920568	311	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA4875890 rs369920568	311	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs369920568 CA4875889	311	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA372178403 rs997741728	311	P>S		No	ClinGen gnomAD
rs997741728 CA185346083	311	P>T		No	ClinGen gnomAD
CA4875888 rs778726000	312	F>L		No	ClinGen ExAC TOPMed
rs754732316 CA4875886	312	F>L		No	ClinGen ExAC gnomAD
CA185345610 rs959369231	317	K>R		No	ClinGen Ensembl
CA4875861 rs756788046	320	Q>*		No	ClinGen ExAC gnomAD
CA185345606 rs756788046	320	Q>E		No	ClinGen ExAC gnomAD
CA4875860 rs751281101	321	E>D		No	ClinGen ExAC TOPMed gnomAD
rs751281101 CA372178305	321	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1455783624 CA372178303	322	E>K		No	ClinGen TOPMed
rs1159691987 CA372178285	324	F>C		No	ClinGen TOPMed
rs759986457 CA4875858	325	Q>*		No	ClinGen ExAC gnomAD
CA4875855 rs761139010	327	I>M		No	ClinGen ExAC gnomAD
rs766757505 CA4875856	327	I>T		No	ClinGen ExAC gnomAD
CA4875857 rs374611855	327	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA185345572 rs966800345	330	L>V		No	ClinGen gnomAD
CA185345553 rs149922852	331	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149922852 CA4875853	331	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369892614 CA4875852	332	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs774567484 CA4875851	332	Q>R		No	ClinGen ExAC
CA4875849 rs139154539	337	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4875848 rs139154539	337	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA372178207 rs1211927289	337	V>I		No	ClinGen TOPMed gnomAD
CA4875847 rs769609242	338	Q>*		No	ClinGen ExAC gnomAD
CA4875845 rs781227916	339	D>N		No	ClinGen ExAC gnomAD
CA4875846 rs781227916	339	D>Y		No	ClinGen ExAC gnomAD
rs1010063841 CA185345521	340	V>I		No	ClinGen gnomAD
rs756843173 CA4875844	341	M>I		No	ClinGen ExAC TOPMed gnomAD
CA4875843 rs76700535	343	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4875842 rs777421063	344	S>R		No	ClinGen ExAC gnomAD
CA372178154 rs1324441287	345	I>V		No	ClinGen gnomAD
rs1032891525 CA185345490	347	A>D		No	ClinGen Ensembl
rs373501715 CA4875839	348	M>I		No	ClinGen ESP ExAC gnomAD
CA4875840 rs749257738	348	M>T		No	ClinGen ExAC gnomAD
rs1244811507 CA372178137	348	M>V		No	ClinGen TOPMed
rs761056719 CA4875838	349	L>V		No	ClinGen ExAC gnomAD
CA4875833 rs761884305	354	A>P		No	ClinGen ExAC gnomAD
rs761884305 CA372178081	354	A>T		No	ClinGen ExAC gnomAD
rs1466364878 CA372178074	354	A>V		No	ClinGen gnomAD
rs868293824 CA185345453	357	D>N		No	ClinGen Ensembl
CA185345447 rs139994074	359	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4875831 rs139994074	359	M>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372178004 rs1201432668	360	N>K		No	ClinGen gnomAD
CA4875830 rs763132646	360	N>S		No	ClinGen ExAC gnomAD
rs1023788010 CA185345422	360	N>Y		No	ClinGen TOPMed gnomAD
rs759674281 CA4875807	362	L>M		No	ClinGen ExAC gnomAD
CA4875805 rs770829453	364	L>S		No	ClinGen ExAC gnomAD
rs746987965 CA4875804	365	D>E		No	ClinGen ExAC gnomAD
CA372177897 rs1451521911	365	D>V		No	ClinGen TOPMed
CA4875803 rs773248235	366	S>I		No	ClinGen ExAC TOPMed gnomAD
CA372177887 rs773248235	366	S>N		No	ClinGen ExAC TOPMed gnomAD
rs771500874 CA4875802	368	G>D		No	ClinGen ExAC TOPMed gnomAD
CA372177871 rs1182455681	368	G>S		No	ClinGen gnomAD
CA372177847 rs1184826791	370	L>S		No	ClinGen gnomAD
rs1465654652 CA372177849	370	L>V		No	ClinGen TOPMed
CA4875801 rs146298406	371	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1444716047 CA372177831	372	G>D		No	ClinGen TOPMed gnomAD
rs113476200 CA185345133	374	G>D		No	ClinGen Ensembl
rs778432458 COSM604173 CA4875800	374	G>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA372177819 rs1163898067	375	G>S		No	ClinGen TOPMed
CA4875797 rs781584471	376	A>G		No	ClinGen ExAC TOPMed gnomAD
CA4875798 rs748924722	376	A>T		No	ClinGen ExAC TOPMed gnomAD
CA185345119 rs756471596	377	I>T		No	ClinGen TOPMed
CA4875796 rs757586374	377	I>V		No	ClinGen ExAC
CA372177789 rs1319388204	380	K>E		No	ClinGen TOPMed
CA372177772 rs1333727142	382	Q>H		No	ClinGen TOPMed gnomAD
rs750869353 CA185345110	382	Q>K		No	ClinGen Ensembl
CA372177775 rs1205272477	382	Q>P		No	ClinGen gnomAD
rs1289205515 CA372177768	383	Q>K		No	ClinGen gnomAD
rs764604422 CA4875794	384	D>H		No	ClinGen ExAC gnomAD
rs764604422 CA4875793	384	D>Y		No	ClinGen ExAC gnomAD
CA4875792 rs758413625	385	S>*		No	ClinGen ExAC TOPMed gnomAD
CA185345070 rs371390275	386	N>D		No	ClinGen ESP
rs1297609721 CA372177733	388	A>E		No	ClinGen gnomAD
rs765220246 CA4875790	389	W>*		No	ClinGen ExAC gnomAD
rs899351019 CA185345030	389	W>C		No	ClinGen gnomAD
rs762161458 CA4875789	392	P>S		No	ClinGen ExAC gnomAD
rs1286979850 CA372177696	393	K>E		No	ClinGen TOPMed
CA372177679 rs1586572888	394	D>A		No	ClinGen Ensembl
rs766313314 CA4875787	394	D>N		No	ClinGen ExAC gnomAD
CA4875786 rs760827512	398	Y>*		No	ClinGen ExAC gnomAD
rs1175776431 CA372177591	402	A>G		No	ClinGen gnomAD
rs760493267 CA4875785	403	I>V		No	ClinGen ExAC TOPMed gnomAD
CA372177561 rs1435016137	404	M>I		No	ClinGen Ensembl
rs773291879 CA4875784	404	M>R		No	ClinGen ExAC TOPMed gnomAD
CA185344993 rs958243335	404	M>V		No	ClinGen TOPMed
CA4875756 rs748724070	405	V>A		No	ClinGen ExAC gnomAD
rs771975440 CA4875783	405	V>L		No	ClinGen ExAC gnomAD
CA372177475 rs751797551	406	L>P		No	ClinGen gnomAD
CA185344721 rs751797551	406	L>Q		No	ClinGen gnomAD
rs779244141 CA4875755	407	S>C		No	ClinGen ExAC TOPMed gnomAD
CA185344714 rs755118406	408	D>E		No	ClinGen ExAC TOPMed gnomAD
CA185344694 rs374279128	411	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4875752 rs374279128	411	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1484150576 CA372177406	411	H>Y		No	ClinGen TOPMed gnomAD
COSM1454829 CA4875750 rs114264223	412	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs756962115 CA4875748	415	A>D		No	ClinGen ExAC TOPMed gnomAD
rs868342635 CA185344680	416	C>Y		No	ClinGen Ensembl
rs1325904597 CA372177336	417	S>C		No	ClinGen gnomAD
rs1228291009 CA372177340	417	S>T		No	ClinGen gnomAD
CA372177327 rs1187384840	418	M>K		No	ClinGen TOPMed
rs751537547 CA4875747	418	M>V		No	ClinGen ExAC TOPMed gnomAD
CA372177287 rs1367238168	421	R>K		No	ClinGen TOPMed
CA4875746 rs763952862	422	I>T		No	ClinGen ExAC gnomAD
CA372177259 rs1563785298	424	L>F		No	ClinGen Ensembl
rs550680319 CA372177236	426	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs550680319 CA4875744	426	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764706903 CA4875743	428	E>*		No	ClinGen ExAC gnomAD
rs764706903 CA372177209	428	E>Q		No	ClinGen ExAC gnomAD
rs370978892 CA4875741	429	L>P		No	ClinGen ESP ExAC gnomAD
CA4875742 rs759275225	429	L>V		No	ClinGen ExAC gnomAD
rs1437191534 CA372177152	430	V>I		No	ClinGen gnomAD
CA4875720 rs550396087	432	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA4875719 rs532245909	433	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA4875718 rs776098748	434	L>M		No	ClinGen ExAC gnomAD
CA372177109 rs1272850493	436	P>L		No	ClinGen gnomAD
rs1358111388 CA372177112	436	P>S		No	ClinGen TOPMed
rs770014882 CA4875717	437	N>K		No	ClinGen ExAC TOPMed gnomAD
CA4875716 rs569568081	439	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs34385086 CA4875715	440	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1238718560 CA372177083	440	Y>C		No	ClinGen gnomAD
CA372177086 rs1280516391	440	Y>H		No	ClinGen gnomAD
CA4875713 rs149748731	441	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372177077 rs149748731	441	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1047596087 CA185344062	441	P>S		No	ClinGen Ensembl
rs897671513 COSM234247 CA185344052	442	W>*	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs897671513 CA372177072	442	W>L		No	ClinGen gnomAD
CA4875711 rs758152327	443	S>G		No	ClinGen ExAC gnomAD
CA185344026 rs200964859	443	S>N		No	ClinGen gnomAD
CA372177039 rs1158967038	447	T>N		No	ClinGen TOPMed gnomAD
rs562110298 CA185344015	447	T>P		No	ClinGen Ensembl
CA4875709 rs778760906	450	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1195655500 CA372177009	452	L>I		No	ClinGen gnomAD
CA4875707 rs753360215	454	A>T		No	ClinGen ExAC gnomAD
CA372176985 rs765903577	456	L>F		No	ClinGen ExAC gnomAD
CA4875706 rs765903577	456	L>I		No	ClinGen ExAC gnomAD
CA185343999 rs943573369	458	S>G		No	ClinGen TOPMed gnomAD
CA4875705 rs760297354	458	S>N		No	ClinGen ExAC gnomAD
CA185343996 rs926525412	460	G>R		No	ClinGen Ensembl
rs750072260 CA4875704	462	A>T		No	ClinGen ExAC gnomAD
rs1204954355 CA372176943	462	A>V		No	ClinGen gnomAD
rs1483378132 CA372176936	463	I>T		No	ClinGen TOPMed
CA4875702 rs202184744	463	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776155660 CA4875701	464	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4875700 rs770270429	465	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1370837740 CA372176921	465	Y>N		No	ClinGen gnomAD
CA4875698 rs776622434	466	G>A		No	ClinGen ExAC gnomAD
rs369201045 CA4875699	466	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1399955907 CA372176892	467	L>P		No	ClinGen gnomAD
CA372176881 rs1432332922	469	E>Q		No	ClinGen TOPMed
rs1406975028 CA372176862	470	E>D		No	ClinGen gnomAD
CA372176839 rs1175211774	472	G>D		No	ClinGen gnomAD
rs1563784114 CA372176833	473	L>F		No	ClinGen Ensembl
CA4875694 rs771864086	474	R>S		No	ClinGen ExAC gnomAD
rs754932128 CA4875691	475	M>I		No	ClinGen ExAC gnomAD
rs4144738 CA4875692 VAR_028140	475	M>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs747867390 CA4875693	475	M>V		No	ClinGen ExAC gnomAD
CA372176767 rs1391375173	478	D>E		No	ClinGen TOPMed
CA372176772 rs1371701310	478	D>G		No	ClinGen TOPMed
CA4875690 rs753795099	479	N>D		No	ClinGen ExAC gnomAD
rs1586569777 CA372176748	479	N>K		No	ClinGen Ensembl
rs755612165 CA4875688	480	P>S		No	ClinGen ExAC TOPMed gnomAD
rs755612165 CA4875689	480	P>T		No	ClinGen ExAC TOPMed gnomAD
rs750123614 CA4875687	481	R>G		No	ClinGen ExAC TOPMed gnomAD
rs150668828 CA185343917 COSM107630	482	S>L	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs374835768 CA4875685	484	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs919279559 CA372176638	485	D>E		No	ClinGen TOPMed gnomAD
CA4875684 rs753169677	485	D>N		No	ClinGen ExAC gnomAD
rs1231505866 CA372176629	486	V>I		No	ClinGen gnomAD
CA372176537 rs1363439926	490	M>V		No	ClinGen gnomAD
CA4875683 rs115019901	491	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372176499 rs115019901	491	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372176504 rs201817415	491	P>S		No	ClinGen TOPMed gnomAD
CA185343873 rs201817415	491	P>T		No	ClinGen TOPMed gnomAD
CA185343853 rs979564302	492	L>P		No	ClinGen Ensembl
CA372176458 rs1415125488	493	S>F		No	ClinGen TOPMed gnomAD
CA372176464 rs1415125488	493	S>Y		No	ClinGen TOPMed gnomAD
CA4875679 rs770936296	494	A>S		No	ClinGen ExAC gnomAD
CA4875678 rs760686608	494	A>V		No	ClinGen ExAC gnomAD
CA372176374 rs1474564773	498	T>A		No	ClinGen gnomAD
COSM1454828 rs748360610 CA4875675	499	L>P	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4875674 rs778626448	500	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1189148616 CA372176333	500	S>P		No	ClinGen gnomAD
rs1207243167 CA372176232	503	Q>H		No	ClinGen gnomAD
rs749217446 CA4875670	507	E>A		No	ClinGen ExAC TOPMed gnomAD
CA4875671 rs374274478	507	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1166688664 CA372176136	508	A>V		No	ClinGen TOPMed
CA4875669 rs779994855	509	A>E		No	ClinGen ExAC gnomAD

No associated diseases with Q9BYG8

2 regional properties for Q9BYG8

Type	Name	Position	InterPro Accession
domain	Gasdermin, pore forming domain	4 - 240	IPR040460
domain	Gasdermin, PUB domain	314 - 481	IPR041263

Functions

		Description
EC Number
Subcellular Localization	[Gasdermin-C]: Cytoplasm, cytosol ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
phosphatidylinositol-4,5-bisphosphate binding	Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
phosphatidylinositol-4-phosphate binding	Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
phosphatidylserine binding	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

2 GO annotations of biological process

Name	Definition
defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
pyroptosis	A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P57764	GSDMD	Gasdermin-D	Homo sapiens (Human)	EV
Q96QA5	GSDMA	Gasdermin-A	Homo sapiens (Human)	SS
Q8TAX9	GSDMB	Gasdermin-B	Homo sapiens (Human)	EV
Q32M21	Gsdma2	Gasdermin-A2	Mus musculus (Mouse)	SS
Q5Y4Y6	Gsdma3	Gasdermin-A3	Mus musculus (Mouse)	EV
Q8CB12	Gsdmc3	Gasdermin-C3	Mus musculus (Mouse)	SS
Q9D8T2	Gsdmd	Gasdermin-D	Mus musculus (Mouse)	SS
Q9EST1	Gsdma	Gasdermin-A	Mus musculus (Mouse)	SS
Q2KHK6	Gsdmc2	Gasdermin-C2	Mus musculus (Mouse)	SS
Q3TR54	Gsdmc4	Gasdermin-C4	Mus musculus (Mouse)	SS
Q99NB5	Gsdmc	Gasdermin-C	Mus musculus (Mouse)	SS
P85967	Gsdmc	Gasdermin-C	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MPSMLERISK	NLVKEIGSKD	LTPVKYLLSA	TKLRQFVILR	KKKDSRSSFW	EQSDYVPVEF
70	80	90	100	110	120
SLNDILEPSS	SVLETVVTGP	FHFSDIMIQK	HKADMGVNVG	IEVSVSGEAS	VDHGCSLEFQ
130	140	150	160	170	180
IVTIPSPNLE	DFQKRKLLDP	EPSFLKECRR	RGDNLYVVTE	AVELINNTVL	YDSSSVNILG
190	200	210	220	230	240
KIALWITYGK	GQGQGESLRV	KKKALTLQKG	MVMAYKRKQL	VIKEKAILIS	DDDEQRTFQD
250	260	270	280	290	300
EYEISEMVGY	CAARSEGLLP	SFHTISPTLF	NASSNDMKLK	PELFLTQQFL	SGHLPKYEQV
310	320	330	340	350	360
HILPVGRIEE	PFWQNFKHLQ	EEVFQKIKTL	AQLSKDVQDV	MFYSILAMLR	DRGALQDLMN
370	380	390	400	410	420
MLELDSSGHL	DGPGGAILKK	LQQDSNHAWF	NPKDPILYLL	EAIMVLSDFQ	HDLLACSMEK
430	440	450	460	470	480
RILLQQQELV	RSILEPNFRY	PWSIPFTLKP	ELLAPLQSEG	LAITYGLLEE	CGLRMELDNP
490	500
RSTWDVEAKM	PLSALYGTLS	LLQQLAEA