AiPD: Autoinhibited Protein Database

Q9BTV5

Gene name	FSD1 (GLFND, MIR1, VLP27)
Protein name	Fibronectin type III and SPRY domain-containing protein 1
Names	MID1-related protein 1, Microtubule-associated protein GLFND
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79187
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

278-353 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

278-353 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9BTV5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BTV5-F1	Predicted				AlphaFoldDB

416 variants for Q9BTV5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA403424416 rs1254406229	5	R>G		No	ClinGen TOPMed
CA403424873 rs1294055489	10	K>N		No	ClinGen TOPMed
rs1332301511 CA403424884	11	I>F		No	ClinGen gnomAD
rs759497212 CA403424900	11	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1044557733 CA304493549	12	I>F		No	ClinGen Ensembl
rs767521847 CA9094679	12	I>M		No	ClinGen ExAC
rs1443573497 CA403424929	13	K>R		No	ClinGen gnomAD
TCGA novel	13	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	16	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403424963 rs1237043905	16	A>T		No	ClinGen gnomAD
rs76548334 CA304493580	17	V>G		No	ClinGen gnomAD
CA403424992 rs1346760970	18	K>R		No	ClinGen gnomAD
rs1208034684 CA403424999	19	N>H		No	ClinGen TOPMed gnomAD
rs907359822 CA304493595	21	E>D		No	ClinGen Ensembl
rs763638807 CA9094682	22	I>L		No	ClinGen ExAC gnomAD
rs146014708 CA9094684	24	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs753531486 CA9094683	24	S>T		No	ClinGen ExAC TOPMed gnomAD
rs750822840 CA9094686	26	I>M		No	ClinGen ExAC gnomAD
rs1016229141 CA304493629	27	Y>C		No	ClinGen gnomAD
CA304493634 rs961644548	28	S>T		No	ClinGen Ensembl
CA9094687 rs138205709	32	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA304493658 rs995934243	34	L>P		No	ClinGen Ensembl
rs149600547 CA304493640	34	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9094690 rs768849275	35	N>S		No	ClinGen ExAC gnomAD
rs768849275 CA403425246	35	N>T		No	ClinGen ExAC gnomAD
rs202092717 CA9094693	36	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA9094692 rs200096369	36	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771967101	38	A>=	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA9094713 rs148301348	38	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1476440773 CA403425382	39	N>S		No	ClinGen gnomAD
COSM178903 CA403425405 rs1189253379	40	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs774018118 CA304493842	40	S>P		No	ClinGen Ensembl
CA9094716 rs760615368	41	A>V		No	ClinGen ExAC TOPMed gnomAD
CA403425438 rs35696506 CA304493885	42	K>N		No	ClinGen TOPMed
rs1599532302 CA403425450	43	V>G		No	ClinGen Ensembl
CA9094718 rs776056358 CA403425445	43	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	44	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761326213 CA9094719	44	Q>R		No	ClinGen ExAC gnomAD
rs1414934397 CA403426091	48	E>D		No	ClinGen TOPMed gnomAD
CA9094720 rs557470446	48	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA403426140 rs1338684308	52	Q>*		No	ClinGen gnomAD
CA403426154 rs1292829693	52	Q>H		No	ClinGen Ensembl
rs1037181774 CA304493906	54	L>F		No	ClinGen Ensembl
rs772916715 CA403426208	56	S>C		No	ClinGen ExAC TOPMed gnomAD
CA9094721 rs772916715	56	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1310841454 CA403426204	56	S>T		No	ClinGen gnomAD
rs1351594215 CA403426231	57	L>R		No	ClinGen gnomAD
TCGA novel	58	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	59	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9094723 rs766813006	60	E>K		No	ClinGen ExAC gnomAD
rs369508403 CA304493941	63	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA304493944 rs369508403	63	E>Q		No	ClinGen TOPMed
CA9094725 rs755471437	64	G>S		No	ClinGen ExAC gnomAD
rs957531738 CA304493962	66	L>F		No	ClinGen TOPMed
TCGA novel	66	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364750115 CA403426405	67	M>I		No	ClinGen gnomAD
CA403426395 rs1326835929	67	M>T		No	ClinGen TOPMed
CA403426387 rs1184340445	67	M>V		No	ClinGen gnomAD
CA403426498 rs1599532372	72	D>A		No	ClinGen Ensembl
rs778134777 CA9094729	73	R>C		No	ClinGen ExAC TOPMed gnomAD
CA403426513 rs778134777	73	R>G		No	ClinGen ExAC TOPMed gnomAD
rs749563211 CA9094730	73	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757445672 CA9094731	74	A>P		No	ClinGen ExAC gnomAD
rs779862147 CA9094732	74	A>V		No	ClinGen ExAC gnomAD
rs913409257 CA304493985	75	S>R		No	ClinGen TOPMed
CA9094733 rs746789026	76	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746789026 CA403426549	76	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1334936086 CA403426551	76	R>H		No	ClinGen TOPMed gnomAD
CA9094736 rs747653444	78	Y>C		No	ClinGen ExAC gnomAD
rs1255492937 CA403426583	79	E>Q		No	ClinGen gnomAD
CA9094739 rs762615924	81	Q>H		No	ClinGen ExAC gnomAD
CA304494018 rs953987519	81	Q>K		No	ClinGen Ensembl
CA403426777 rs1340385438	82	N>I		No	ClinGen gnomAD
rs761225638 CA9094765	82	N>K		No	ClinGen ExAC gnomAD
CA403426797 rs35484545	83	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9094767 rs149694101	88	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1486655771 CA403426886	89	R>P		No	ClinGen TOPMed gnomAD
rs1486655771 CA403426890	89	R>Q		No	ClinGen TOPMed gnomAD
CA9094769 rs145440493	89	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs929498681 CA304494866	90	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	92	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9094775 rs777581184	92	E>G		No	ClinGen ExAC gnomAD
rs1162453617 CA403426978	94	S>A		No	ClinGen gnomAD
rs1455546642 CA403426989	95	E>K		No	ClinGen TOPMed gnomAD
rs1405598717 CA403427041	97	L>R		No	ClinGen TOPMed
rs1398306216 CA403427069	100	T>A		No	ClinGen gnomAD
rs745564160 CA9094779	100	T>I		No	ClinGen ExAC gnomAD
rs200771550 CA304494908	102	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200771550 CA9094780	102	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403427115 rs1461810903	103	Q>P		No	ClinGen TOPMed
rs1228058949 CA403427124	104	T>A		No	ClinGen gnomAD
rs1373932578 CA403427131	104	T>S		No	ClinGen TOPMed
rs1599533403 CA403427177	107	A>G		No	ClinGen Ensembl
CA403427195 rs1226498652	108	M>I		No	ClinGen TOPMed gnomAD
CA403427183 CA403427178 rs1311033602	108	M>L		No	ClinGen TOPMed gnomAD
rs775931258 CA9094781	109	D>G		No	ClinGen ExAC TOPMed gnomAD
rs536740542 CA9094783	111	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9094784 rs777076572	114	P>T		No	ClinGen ExAC gnomAD
rs1212458362 CA403427317	115	Q>R		No	ClinGen gnomAD
rs957032809 CA403428124	116	A>D		No	ClinGen TOPMed
CA403428122 rs1568379003	116	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs957032809 CA304496958	116	A>V		No	ClinGen TOPMed
rs770366923 CA9094804	118	K>E		No	ClinGen ExAC gnomAD
rs1414043282 CA403428138	119	Q>K		No	ClinGen gnomAD
TCGA novel	120	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291660717 CA403428188	124	V>M		No	ClinGen TOPMed
rs776233464 CA9094829	126	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9094828 rs767810155	126	M>V		No	ClinGen ExAC gnomAD
CA9094830 rs145281893	127	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA9094831 rs371390445	127	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs771659397 CA403428212	128	P>A		No	ClinGen ExAC TOPMed gnomAD
CA9094832 rs771659397	128	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1360599399 CA403428220	129	A>V		No	ClinGen gnomAD
rs543807342 CA304497197	131	R>Q		No	ClinGen gnomAD
CA9094836 rs754522407	136	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9094837 rs780907933	136	A>V	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	138	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9094839 rs756565561	138	V>G		No	ClinGen ExAC TOPMed gnomAD
CA9094841 CA403428291 rs778217458	140	D>E		No	ClinGen ExAC gnomAD
CA403428294 rs1486958659	141	N>Y		No	ClinGen gnomAD
CA403428304 rs1234591688	142	M>T		No	ClinGen TOPMed
CA403428319 rs1307398370	144	H>Y		No	ClinGen gnomAD
CA403428339 rs1337050819	146	M>I		No	ClinGen TOPMed
CA304497231 rs766976177 CA403428341	147	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
TCGA novel	148	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369302746 CA9094844	150	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9094845 rs200331149	150	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403428370 rs1295841563	151	Q>L		No	ClinGen gnomAD
CA304497268 rs375518070	152	E>G		No	ClinGen ESP TOPMed
CA9094848 COSM212040 rs369691691	153	R>Q	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA9094847 rs141559654	153	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9094849 rs769765150	154	Q>*		No	ClinGen ExAC gnomAD
CA9094853 rs750973778	160	K>M		No	ClinGen ExAC gnomAD
rs1240970655 CA403428424	160	K>Q		No	ClinGen TOPMed gnomAD
rs374375166 CA9094854	163	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1239467593 CA403428452	164	V>L		No	ClinGen gnomAD
rs940483157 CA304498387	165	P>S		No	ClinGen TOPMed
rs781619574 CA9094890	166	S>G		No	ClinGen ExAC gnomAD
COSM3378762 CA9094892 rs763813323	167	A>T	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA403428608 rs1279457468	167	A>V		No	ClinGen gnomAD
TCGA novel	168	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774130281 CA9094893	168	P>T		No	ClinGen ExAC gnomAD
CA9094895 rs771934110	169	V>M		No	ClinGen ExAC gnomAD
CA9094898 rs763733889	171	D>A		No	ClinGen ExAC gnomAD
rs760189878 CA9094897	171	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA403428723 rs1194297235	178	A>S		No	ClinGen gnomAD
CA9094900 rs762144186	178	A>V		No	ClinGen ExAC gnomAD
rs765588543 CA9094902	182	V>M		No	ClinGen ExAC gnomAD
rs1305229916 CA403428782	183	T>N		No	ClinGen TOPMed gnomAD
rs758878355 CA9094904	185	V>A		No	ClinGen ExAC gnomAD
rs766812292 CA9094905	186	W>L		No	ClinGen ExAC TOPMed gnomAD
CA9094906 rs142307969	187	R>C		No	ClinGen ESP ExAC gnomAD
rs545061368 CA9094907	187	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA9094908 rs781531917	188	M>V		No	ClinGen ExAC TOPMed gnomAD
rs748425183 CA9094910	189	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9094909 rs748425183	189	P>R		No	ClinGen ExAC TOPMed gnomAD
rs893307833 CA304498539	190	D>H		No	ClinGen TOPMed gnomAD
rs893307833 CA403428842	190	D>Y		No	ClinGen TOPMed gnomAD
CA9094912 rs745655176	191	E>A		No	ClinGen ExAC gnomAD
rs371172774 CA304498550	191	E>D		No	ClinGen ESP TOPMed
TCGA novel	191	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377698035 CA304498566	192	D>G		No	ClinGen ExAC TOPMed gnomAD
rs771985733 CA9094913	192	D>N		No	ClinGen ExAC TOPMed gnomAD
CA9094914 rs377698035	192	D>V		No	ClinGen ExAC TOPMed gnomAD
rs904886538 CA304498608	193	S>R		No	ClinGen Ensembl
CA9094915 rs373678270	196	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA403428882 rs1488967606	196	D>Y		No	ClinGen gnomAD
rs1003192870 CA304498621	197	H>R		No	ClinGen TOPMed gnomAD
rs199532115 CA9094916	198	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs199532115 CA304498623	198	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1414231164 COSM439680 CA403428902	199	V>M	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs773570628 CA304498662	201	E>A		No	ClinGen ExAC TOPMed gnomAD
rs773570628 CA9094920	201	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1298919110 CA403428929	203	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1421541017 CA403428927	203	R>W		No	ClinGen TOPMed gnomAD
rs752149632 CA403428933	204	R>L		No	ClinGen ExAC TOPMed gnomAD
rs752149632 CA403428934	204	R>P		No	ClinGen ExAC TOPMed gnomAD
rs752149632 CA9094923 COSM1393211	204	R>Q	salivary_gland large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs367820799 CA9094921	204	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs759662733 CA9094924	207	F>C		No	ClinGen ExAC gnomAD
rs371650125 CA9094927	208	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	208	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752854838 CA9094926	208	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA403428965 rs1355445198	209	G>D		No	ClinGen gnomAD
CA9094929 rs45575337	210	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9094928 rs777869339	210	P>S		No	ClinGen ExAC gnomAD
CA403428977 rs1246666593	211	P>L		No	ClinGen TOPMed
rs1212142403 CA403428974	211	P>S		No	ClinGen gnomAD
CA304498732 rs376221601	212	R>C	Variant assessed as Somatic; 4.787e-05 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs746900909 CA9094932	212	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1269446410 CA403428983	213	L>V		No	ClinGen TOPMed
rs1162654443 CA403428993	214	K>M		No	ClinGen gnomAD
CA403428996 rs1599536304	215	E>K		No	ClinGen Ensembl
rs1207758397 CA403429009 CA403429010	216	D>E		No	ClinGen TOPMed
rs768611736 CA9094934	216	D>G		No	ClinGen ExAC gnomAD
CA9094935 rs372436661	217	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	217	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1159272414 CA403429020	218	P>S		No	ClinGen gnomAD
rs769476755 CA9094937	219	W>C		No	ClinGen ExAC gnomAD
rs747629351 CA9094936	219	W>G		No	ClinGen ExAC gnomAD
CA403429044 rs1599536329	221	V>G		No	ClinGen Ensembl
CA304498747 rs961982251	221	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1393600479 CA403429052	223	E>K		No	ClinGen TOPMed gnomAD
CA403429053 rs1393600479	223	E>Q		No	ClinGen TOPMed gnomAD
rs763343056 CA9094939	224	G>R		No	ClinGen ExAC gnomAD
rs1366089854 CA403429068	225	I>N		No	ClinGen TOPMed
rs140484251 CA9094941	226	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9094940 rs138693742	226	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9094942 rs760076432	227	Q>E		No	ClinGen ExAC gnomAD
rs201618674 CA304498768	229	E>G		No	ClinGen 1000Genomes TOPMed gnomAD
rs35139245 CA9094944 VAR_038385	232	L>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1247350239 CA403411334	236	K>R		No	ClinGen gnomAD
TCGA novel	238	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9094959 rs201282091	238	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs889719785 CA403411396 CA304459440	239	M>I		No	ClinGen TOPMed
CA403411375 rs1568381088	239	M>V		No	ClinGen Ensembl
rs933034327 CA304459445	242	M>I		No	ClinGen TOPMed gnomAD
rs759990460 CA9094960	242	M>L		No	ClinGen ExAC TOPMed gnomAD
CA9094962 rs775926694	242	M>R		No	ClinGen ExAC gnomAD
rs759990460 CA9094961	242	M>V		No	ClinGen ExAC TOPMed gnomAD
CA9094963 rs760787936	243	N>K		No	ClinGen ExAC TOPMed gnomAD
CA9094965 rs138471666	245	R>C		No	ClinGen ESP ExAC gnomAD
rs765462502 CA9094967	245	R>H		No	ClinGen ExAC gnomAD
CA9094966 rs138471666	245	R>S		No	ClinGen ESP ExAC gnomAD
CA403411519 rs142344050	246	V>A		No	ClinGen TOPMed
COSM109055 CA304459452 rs142344050	246	V>G	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
CA403411532 rs1277179127	248	A>T		No	ClinGen TOPMed
COSM712637 rs751344796 CA9094968	249	C>Y	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA403411617 rs1289847050	253	V>L		No	ClinGen TOPMed gnomAD
CA9094969 rs754838513	254	A>G		No	ClinGen ExAC gnomAD
TCGA novel	256	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9094970 rs767414804	257	F>L		No	ClinGen ExAC gnomAD
CA304459457 rs889054088	257	F>L		No	ClinGen TOPMed
rs1373251136 CA403411706	259	E>G		No	ClinGen TOPMed
rs1336153843 CA403411694	259	E>Q		No	ClinGen TOPMed gnomAD
CA304459462 rs766063741	260	P>L		No	ClinGen TOPMed
rs777105230 CA403411759	264	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs777105230 CA9094973	264	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs748832233 CA9094974	266	P>L		No	ClinGen ExAC gnomAD
rs144315014	267	A>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA403411896 rs1473357211	268	F>L		No	ClinGen TOPMed
rs745470689 CA9094996	269	M>V		No	ClinGen ExAC gnomAD
rs1380368426 CA403411941	271	R>C		No	ClinGen TOPMed gnomAD
COSM1207601 CA304459722 rs189542513	271	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9094997 rs189542513	271	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs867142811 CA304459728	274	A>V		No	ClinGen Ensembl
rs1292162682 CA403412064	275	S>T		No	ClinGen gnomAD
CA403412103 rs1404295957	277	S>C		No	ClinGen gnomAD
rs1414784311 CA403412108	278	H>Y		No	ClinGen gnomAD
CA9094999 rs747414361	279	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA403412164 rs1311823800	282	R>Q		No	ClinGen TOPMed gnomAD
CA9095002 rs777263812	282	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1228512899 CA403412212	285	D>V		No	ClinGen TOPMed
CA403412254 COSM1325300 rs1434011951	288	V>M	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA9095006 rs771186500	289	E>Q		No	ClinGen ExAC gnomAD
rs1328977409 CA403412293	290	W>R		No	ClinGen gnomAD
rs376149637 CA403412331	291	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	291	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760574679 CA9095008	292	A>S		No	ClinGen ExAC TOPMed gnomAD
rs760574679 CA403412338	292	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9095009 rs763931891	293	M>V		No	ClinGen ExAC gnomAD
rs369265705 CA9095011	295	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM997480 rs1438490434 CA403412406	296	K>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs764801761 CA9095012	297	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1387264849 CA403412444	298	Q>R		No	ClinGen TOPMed
rs758068920 CA9095014	300	I>M		No	ClinGen ExAC TOPMed gnomAD
rs749958049 CA9095013	300	I>V		No	ClinGen ExAC gnomAD
COSM342898 CA9095015 rs779815364	303	R>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs937890368 CA304459764	303	R>H		No	ClinGen TOPMed gnomAD
rs141187177 CA9095017	304	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA9095018 rs150751084	307	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs748601764 CA9095019	307	G>V		No	ClinGen ExAC gnomAD
rs111498394 COSM1680526 CA304459777	308	K>E	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1333279548 CA403412663	309	G>R		No	ClinGen gnomAD
rs777760593 CA9095021	310	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9095020 rs770312605	310	R>W		No	ClinGen ExAC TOPMed gnomAD
rs139108551 CA9095022	311	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs888718985 CA304459794	312	A>P		No	ClinGen gnomAD
rs1469478051 CA403412729	312	A>V		No	ClinGen TOPMed gnomAD
rs1599540884 CA403412734	313	S>A		No	ClinGen Ensembl
CA403412740 rs1297693493	314	P>A		No	ClinGen TOPMed
CA403413338 rs1489234966	321	G>D		No	ClinGen gnomAD
rs756552563 CA9095040	321	G>R		No	ClinGen ExAC gnomAD
CA304459966 rs867183423	322	T>A		No	ClinGen Ensembl
rs1260763948 CA403413347	323	P>A		No	ClinGen gnomAD
rs1242840070 CA403413422	329	P>L		No	ClinGen TOPMed
rs1426558933 CA403413417	329	P>S		No	ClinGen gnomAD
rs778307267 CA304459971	330	S>*		No	ClinGen ExAC gnomAD
CA9095041 COSM459947 rs778307267	330	S>L	cervix [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA9095042 rs749364630	332	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs373140133 CA9095044	333	G>A		No	ClinGen ESP ExAC gnomAD
CA9095043 rs771080365	333	G>R		No	ClinGen ExAC TOPMed gnomAD
rs991859124 COSM1750852 CA304459985	335	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9095045 rs376322971	335	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs772189489 CA9095046	337	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs776511823 CA9095047 COSM1393219	337	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA9095048 rs748015968	340	A>T		No	ClinGen ExAC TOPMed gnomAD
rs769851306 CA9095049	340	A>V		No	ClinGen ExAC TOPMed gnomAD
rs773324581 CA9095050	343	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs554540689 CA9095051	344	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1178944503 CA403414623	349	T>M		No	ClinGen gnomAD
rs1302146772 CA403414633	350	L>V		No	ClinGen TOPMed
CA403414692 rs1044214861	351	I>M		No	ClinGen TOPMed gnomAD
CA403414718 rs767149220	352	D>E		No	ClinGen ExAC TOPMed gnomAD
rs759023466 CA9095074	352	D>N		No	ClinGen ExAC TOPMed gnomAD
rs182090774 CA403414730	353	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9095077 rs761003361	353	G>D		No	ClinGen ExAC TOPMed gnomAD
CA9095076 rs182090774	353	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA304461597 rs1029701698	354	G>R		No	ClinGen TOPMed gnomAD
rs573182650 CA304461601	355	E>D		No	ClinGen 1000Genomes
TCGA novel	355	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754185016 CA9095079	356	H>R		No	ClinGen ExAC TOPMed gnomAD
CA9095081 rs765722428	359	E>Q		No	ClinGen ExAC gnomAD
CA9095083 rs758593665	360	V>A		No	ClinGen ExAC gnomAD
rs144527122 CA9095082	360	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9095084 rs539005775	361	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1232364286 CA403414990	361	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs145547298 CA403415008	362	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440598118 CA403415005	362	Y>C		No	ClinGen gnomAD
rs1440598118 CA403415006	362	Y>F		No	ClinGen gnomAD
rs1479738701 CA403414997	362	Y>H		No	ClinGen gnomAD
CA9095087 rs148882494	363	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs148882494 CA304461629 COSM1393229	363	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs148882494 CA9095086	363	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9095089 rs558999778	364	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403415044 rs558999778	364	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9095088 rs558999778	364	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745349961 CA9095091	368	A>V		No	ClinGen ExAC TOPMed gnomAD
CA403415130 rs867424541	370	G>A		No	ClinGen gnomAD
rs867424541 CA304461658	370	G>D		No	ClinGen gnomAD
CA403415122 rs1352226823	370	G>S		No	ClinGen TOPMed gnomAD
rs762344071 CA9095097	371	V>M		No	ClinGen ExAC gnomAD
rs1279877532 CA403415158 COSM3404302	372	G>S	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs766530976 CA9095101	373	V>M		No	ClinGen ExAC TOPMed gnomAD
rs893064222 CA304461677	376	R>H		No	ClinGen TOPMed gnomAD
rs751698287 CA403415239	377	S>G		No	ClinGen ExAC gnomAD
TCGA novel	377	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403415245 rs1223903995	377	S>N		No	ClinGen TOPMed gnomAD
rs751698287 CA9095102	377	S>R		No	ClinGen ExAC gnomAD
CA304461681 rs914661813	382	E>K		No	ClinGen TOPMed gnomAD
CA403415297 rs914661813	382	E>Q		No	ClinGen TOPMed gnomAD
rs755189864 CA9095103	384	L>R		No	ClinGen ExAC gnomAD
CA403415348 rs1265788109	386	K>N		No	ClinGen gnomAD
rs370463498 CA9095104	388	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA9095105 rs753659338	389	A>T		No	ClinGen ExAC gnomAD
TCGA novel	394	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778886532 CA304461695	395	V>F		No	ClinGen ExAC TOPMed gnomAD
rs778886532 CA9095107 COSM1207602	395	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9095109 rs772027664	397	N>Y		No	ClinGen ExAC gnomAD
CA403415517 rs1429833086	400	Q>R		No	ClinGen gnomAD
CA403415534 rs1599544229	401	V>G		No	ClinGen Ensembl
CA9095111 rs746580293	402	S>T		No	ClinGen ExAC gnomAD
rs768350624 CA9095112	403	F>S		No	ClinGen ExAC TOPMed gnomAD
rs770007894 CA9095115 COSM291132	408	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	408	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140631506 CA9095116	409	N>K		No	ClinGen ESP ExAC
rs1313203954 CA403415623	409	N>S		No	ClinGen TOPMed
rs1220864730 CA403415631	410	K>R		No	ClinGen TOPMed gnomAD
CA9095117 rs763491624	413	V>L		No	ClinGen ExAC gnomAD
CA9095120 rs759753782	415	D>G		No	ClinGen ExAC gnomAD
rs368026425 CA304461732	416	A>T		No	ClinGen ESP TOPMed gnomAD
rs1160363606 CA403415672	417	P>S		No	ClinGen TOPMed gnomAD
rs1315973843 CA403415680	418	V>G		No	ClinGen gnomAD
CA9095124 rs200879429	418	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403415686 rs1476509238	419	P>L		No	ClinGen TOPMed
rs1029732884 CA304461743	420	D>E		No	ClinGen TOPMed
rs1454776561 CA403415687	420	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	421	C>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	422	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs954253820 CA304461746	423	G>D		No	ClinGen TOPMed gnomAD
CA403415722 rs1211456304	425	H>R		No	ClinGen TOPMed
rs780033085 CA9095127	426	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	428	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9095128 rs746492451	429	H>Y		No	ClinGen ExAC gnomAD
CA403415774 rs1204862497	430	Q>R		No	ClinGen gnomAD
rs1468420671 CA403415830	431	G>D		No	ClinGen gnomAD
CA403415848 rs1397266367	432	L>P		No	ClinGen TOPMed gnomAD
CA403415859 rs1250487208	433	L>V		No	ClinGen TOPMed
rs746323027 CA9095157	435	F>V		No	ClinGen ExAC gnomAD
CA9095158 rs772639106	437	N>D		No	ClinGen ExAC
rs775374693 CA9095159	438	A>V		No	ClinGen ExAC
rs373115179 CA9095160	439	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9095161 rs200289353	439	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1283023394 CA403415959	440	T>P		No	ClinGen gnomAD
rs762043518 CA9095164	441	K>R		No	ClinGen ExAC TOPMed gnomAD
rs762043518 CA9095163	441	K>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	442	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751357114 CA9095165	442	Q>R		No	ClinGen ExAC gnomAD
CA304461871 rs374849278	445	H>Q		No	ClinGen ESP TOPMed
rs1338118456 CA403416064	446	T>I		No	ClinGen gnomAD
rs754810488 CA9095166	448	K>E		No	ClinGen ExAC gnomAD
rs1407251943 CA403416097	450	R>G		No	ClinGen TOPMed
TCGA novel	451	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1266505367 CA403416118	452	T>I		No	ClinGen gnomAD
CA403416132 rs1167689086	453	Q>H		No	ClinGen TOPMed
CA403416128 rs1568383276	453	Q>R		No	ClinGen Ensembl
TCGA novel	457	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403416205 rs1171259499	458	A>S		No	ClinGen TOPMed
CA9095169 rs375153495	460	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780303964 CA9095197	461	V>L		No	ClinGen ExAC gnomAD
rs1160558353 CA403416424	465	S>R		No	ClinGen TOPMed gnomAD
rs972502868 CA304461937	466	F>L		No	ClinGen gnomAD
rs747507912 CA9095198	467	Q>H		No	ClinGen ExAC gnomAD
CA403416506 rs1206471417	468	V>M		No	ClinGen gnomAD
rs138218709 CA9095199	469	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403416709 rs1224238105	479	R>C		No	ClinGen TOPMed gnomAD
rs889496647 CA304461945	479	R>H		No	ClinGen gnomAD
rs759232762 CA9095204	484	R>*		No	ClinGen ExAC TOPMed gnomAD
rs771854680 CA403416876	484	R>L		No	ClinGen ExAC TOPMed gnomAD
rs771854680 CA9095205	484	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	485	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9095206 rs775182024	487	A>T		No	ClinGen ExAC TOPMed gnomAD
CA403416982 rs1235802389	489	S>G		No	ClinGen gnomAD
CA9095207 rs760625894	490	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1178260404 CA403417035	491	S>Y		No	ClinGen gnomAD
CA403417085 rs1471793487	493	T>I		No	ClinGen gnomAD

No associated diseases with Q9BTV5

2 regional properties for Q9BTV5

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	89 - 110	IPR001611-1
repeat	Leucine-rich repeat	114 - 135	IPR001611-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Cytoplasm Cleavage furrow	Cell-cycle-dependent association with the centrosome Colocalizes with a subpopulation of microtubules Does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cleavage furrow	The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

6 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cytoplasmic microtubule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
regulation of cell division	Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of mitotic spindle organization	Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

46 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9G4	TRIM10	Tripartite motif-containing protein 10	Bos taurus (Bovine)	PR
Q2T9Z0	TRIM17	E3 ubiquitin-protein ligase TRIM17	Bos taurus (Bovine)	PR
E1BJS7	TRIM71	E3 ubiquitin-protein ligase TRIM71	Bos taurus (Bovine)	PR
Q7YRV4	TRIM21	E3 ubiquitin-protein ligase TRIM21	Bos taurus (Bovine)	PR
Q1PRL4	TRIM71	E3 ubiquitin-protein ligase TRIM71	Gallus gallus (Chicken)	PR
Q7YR32	TRIM10	Tripartite motif-containing protein 10	Pan troglodytes (Chimpanzee)	PR
O15553	MEFV	Pyrin	Homo sapiens (Human)	SS
Q9H2S5	RNF39	RING finger protein 39	Homo sapiens (Human)	PR
P19474	TRIM21	E3 ubiquitin-protein ligase TRIM21	Homo sapiens (Human)	PR
P29590	PML	Protein PML	Homo sapiens (Human)	PR
Q9C029	TRIM7	E3 ubiquitin-protein ligase TRIM7	Homo sapiens (Human)	PR
Q86UV6	TRIM74	Tripartite motif-containing protein 74	Homo sapiens (Human)	PR
Q9UPQ4	TRIM35	E3 ubiquitin-protein ligase TRIM35	Homo sapiens (Human)	PR
Q6ZMU5	TRIM72	Tripartite motif-containing protein 72	Homo sapiens (Human)	PR
Q86UV7	TRIM73	Tripartite motif-containing protein 73	Homo sapiens (Human)	PR
Q8N9V2	TRIML1	Probable E3 ubiquitin-protein ligase TRIML1	Homo sapiens (Human)	PR
Q86XT4	TRIM50	E3 ubiquitin-protein ligase TRIM50	Homo sapiens (Human)	PR
Q5EBN2	TRIM61	Putative tripartite motif-containing protein 61	Homo sapiens (Human)	PR
Q9BZY9	TRIM31	E3 ubiquitin-protein ligase TRIM31	Homo sapiens (Human)	PR
Q2Q1W2	TRIM71	E3 ubiquitin-protein ligase TRIM71	Homo sapiens (Human)	PR
Q9BXM9	FSD1L	FSD1-like protein	Homo sapiens (Human)	PR
Q9NQ86	TRIM36	E3 ubiquitin-protein ligase TRIM36	Homo sapiens (Human)	PR
Q9UJV3	MID2	Probable E3 ubiquitin-protein ligase MID2	Homo sapiens (Human)	PR
Q9WUH5	Trim10	Tripartite motif-containing protein 10	Mus musculus (Mouse)	PR
Q8BZT2	Sh3rf2	E3 ubiquitin-protein ligase SH3RF2	Mus musculus (Mouse)	PR
Q7TPM3	Trim17	E3 ubiquitin-protein ligase TRIM17	Mus musculus (Mouse)	PR
Q1XH17	Trim72	Tripartite motif-containing protein 72	Mus musculus (Mouse)	PR
Q60953	Pml	Protein PML	Mus musculus (Mouse)	PR
Q9JJ26	Mefv	Pyrin	Mus musculus (Mouse)	SS
Q99PQ1	Trim12a	Tripartite motif-containing protein 12A	Mus musculus (Mouse)	PR
Q61510	Trim25	E3 ubiquitin/ISG15 ligase TRIM25	Mus musculus (Mouse)	PR
Q810I2	Trim50	E3 ubiquitin-protein ligase TRIM50	Mus musculus (Mouse)	PR
Q1PSW8	Trim71	E3 ubiquitin-protein ligase TRIM71	Mus musculus (Mouse)	PR
Q3TL54	Trim43a	Tripartite motif-containing protein 43A	Mus musculus (Mouse)	PR
P86449	Trim43c	Tripartite motif-containing protein 43C	Mus musculus (Mouse)	PR
O77666	TRIM26	Tripartite motif-containing protein 26	Sus scrofa (Pig)	PR
O19085	TRIM10	Tripartite motif-containing protein 10	Sus scrofa (Pig)	PR
Q865W2	TRIM50	E3 ubiquitin-protein ligase TRIM50	Sus scrofa (Pig)	PR
Q920M2	Rnf39	RING finger protein 39	Rattus norvegicus (Rat)	PR
Q9JJ25	Mefv	Pyrin	Rattus norvegicus (Rat)	SS
A0JPQ4	Trim72	Tripartite motif-containing protein 72	Rattus norvegicus (Rat)	PR
Q810I1	Trim50	E3 ubiquitin-protein ligase TRIM50	Rattus norvegicus (Rat)	PR
D3ZVM4	Trim71	E3 ubiquitin-protein ligase TRIM71	Rattus norvegicus (Rat)	PR
F6QEU4	trim71	E3 ubiquitin-protein ligase TRIM71	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q640S6	trim72	Tripartite motif-containing protein 72	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
E7FAM5	trim71	E3 ubiquitin-protein ligase TRIM71	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEEQREALRK	IIKTLAVKNE	EIQSFIYSLK	QMLLNVEANS	AKVQEDLEAE	FQSLFSLLEE
70	80	90	100	110	120
LKEGMLMKIK	QDRASRTYEL	QNQLAACTRA	LESSEELLET	ANQTLQAMDS	EDFPQAAKQI
130	140	150	160	170	180
KDGVTMAPAF	RLSLKAKVSD	NMSHLMVDFA	QERQMLQALK	FLPVPSAPVI	DLAESLVADN
190	200	210	220	230	240
CVTLVWRMPD	EDSKIDHYVL	EYRRTNFEGP	PRLKEDQPWM	VIEGIRQTEY	TLTGLKFDMK
250	260	270	280	290	300
YMNFRVKACN	KAVAGEFSEP	VTLETPAFMF	RLDASTSHQN	LRVDDLSVEW	DAMGGKVQDI
310	320	330	340	350	360
KAREKDGKGR	TASPINSPAR	GTPSPKRMPS	GRGGRDRFTA	ESYTVLGDTL	IDGGEHYWEV
370	380	390	400	410	420
RYEPDSKAFG	VGVAYRSLGR	FEQLGKTAAS	WCLHVNNWLQ	VSFTAKHANK	VKVLDAPVPD
430	440	450	460	470	480
CLGVHCDFHQ	GLLSFYNART	KQVLHTFKTR	FTQPLLPAFT	VWCGSFQVTT	GLQVPSAVRC
490
LQKRGSATSS	SNTSLT