Q9BTT0

SS
Gene name
ANP32E
Protein name
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Names
LANP-like protein , LANP-L
Species
Homo sapiens (Human)
KEGG Pathway
hsa:81611
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

121-163 (Autoinhibitory domain) SS

Target domain

1-163 (Leucine-rich region)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q9BTT0

Entry ID Method Resolution Chain Position Source
4CAY X-ray 148 A C 215-240 PDB
4NFT X-ray 261 A E/F 185-232 PDB
AF-Q9BTT0-F1 Predicted AlphaFoldDB

194 variants for Q9BTT0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1369863060 2 E>* No TOPMed
rs782000338 4 K>M No ExAC
gnomAD
TCGA novel 4 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2101802814 7 I>V No Ensembl
rs1649731906 8 N>Y No Ensembl
rs1553843173 9 L>P No gnomAD
rs1649731215 9 L>V No TOPMed
rs782167009 10 E>K No ExAC
gnomAD
rs1649730467 11 L>S No gnomAD
COSM895471 12 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1649729683 14 R>G No TOPMed
rs2101802709 16 P>L No Ensembl
rs782025643 18 E>K No ExAC
gnomAD
rs1233606707 19 V>M No TOPMed
gnomAD
rs1649375215 21 E>D No Ensembl
rs781910592 24 L>R No ExAC
gnomAD
rs1553841835 26 N>D No gnomAD
rs1553841831 27 C>F No gnomAD
rs782794752 31 N>S No ExAC
TOPMed
gnomAD
rs79531555 34 I>T No gnomAD
rs1553841820 35 E>K No gnomAD
rs143204667 39 D>E No 1000Genomes
ExAC
TOPMed
gnomAD
rs782721801 40 T>A No ExAC
gnomAD
TCGA novel 41 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM895470 42 K>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM4021938 43 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs782130323 43 E>K No ExAC
gnomAD
TCGA novel 45 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 47 L>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs781983817 48 S>N No ExAC
gnomAD
rs189085479 53 E>K No 1000Genomes
rs1553841795
COSM2181819
 56 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
gnomAD
COSM423757 59 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1553841785 59 R>W No gnomAD
rs1022216211 61 P>L No Ensembl
rs782233085 62 S>R No ExAC
gnomAD
rs1649367397 65 K>R No TOPMed
rs1553841780 67 R>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs782603651
COSM895468
 67 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
rs1572027097 70 E>K No Ensembl
rs1649281797 71 L>I No Ensembl
TCGA novel 72 S>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1553841468 75 I>V No gnomAD
rs1649280914 76 I>F No Ensembl
COSM4821003 77 S>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2101787523 85 E>G No Ensembl
rs782204447 85 E>Q No ExAC
gnomAD
rs1356164686 87 C>F No TOPMed
rs1214669959 91 T>I No Ensembl
rs1262941375 94 N>S No TOPMed
rs782500643 96 S>T No ExAC
gnomAD
rs587607860 98 N>K No 1000Genomes
ExAC
gnomAD
TCGA novel 98 N>T Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1572026936 99 K>Q No Ensembl
TCGA novel 99 K>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2101787427 100 I>M No Ensembl
COSM2151361 100 I>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1553841439 102 D>E No gnomAD
rs1649277253 102 D>N No gnomAD
TCGA novel 102 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1553841435 104 S>G No gnomAD
rs1649276329 104 S>N No gnomAD
rs782663972 104 S>R No ExAC
gnomAD
rs782453394 105 T>A No ExAC
gnomAD
TCGA novel 106 V>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs781789869 108 A>P No ExAC
gnomAD
rs781789869 108 A>T No ExAC
gnomAD
COSM3984187 114 N>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1553841003 115 L>F No gnomAD
rs1553841000 116 K>T No gnomAD
rs1553840997 117 S>G No TOPMed
gnomAD
TCGA novel 117 S>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2101782555 119 D>N No Ensembl
rs782388606 120 L>R No ExAC
gnomAD
rs1553840986 123 C>* No Ensembl
rs1649136890 123 C>W No TOPMed
COSM4021937 126 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs782234067 126 T>R No ExAC
gnomAD
rs1553840973 127 N>S No gnomAD
rs1553840970 128 L>V No gnomAD
rs782028923 130 D>E No ExAC
TOPMed
gnomAD
rs1553840962 132 R>G No gnomAD
rs868911780 133 E>* No Ensembl
rs782404279 134 S>N No ExAC
TOPMed
gnomAD
rs1440739917 135 I>V No TOPMed
TCGA novel 137 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1383186312 137 E>D No TOPMed
rs1160679621 137 E>Q No TOPMed
rs1400643245 138 L>R No TOPMed
gnomAD
rs782565601 142 I>V No ExAC
gnomAD
rs1649130573 143 T>I No TOPMed
rs1649130573 143 T>R No TOPMed
rs1649130057 144 Y>C No gnomAD
rs1553840937 151 E>K No TOPMed
gnomAD
rs1649128516 152 D>G No TOPMed
rs1553840935 153 N>K No gnomAD
rs782260989 155 A>V No Ensembl
COSM4662105
rs1553840925
 156 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs1553840928 156 P>S No gnomAD
COSM6057930 157 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1649126535 159 E>K No TOPMed
rs587667046 160 E>V No 1000Genomes
ExAC
TOPMed
gnomAD
COSM5353649 161 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs782802339 162 D>E No ExAC
gnomAD
rs1649125673 162 D>V No TOPMed
rs1281081621 163 D>G No gnomAD
rs151007873 164 E>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA
rs1649124791 164 E>K No Ensembl
rs1250286965 165 D>E No TOPMed
gnomAD
rs932917381 165 D>N No TOPMed
gnomAD
COSM4021936 166 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs782628975 167 D>N No ExAC
TOPMed
gnomAD
rs782555226 167 D>V No ExAC
gnomAD
rs1648917095 169 D>E No Ensembl
rs587740119 173 E>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs587740119 173 E>Q No 1000Genomes
ExAC
TOPMed
gnomAD
rs782722374 174 E>G No ExAC
gnomAD
rs782044255 175 E>V No ExAC
TOPMed
gnomAD
rs1648913513 179 G>R No gnomAD
rs375209062 181 P>L No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs782132651 182 E>K No ExAC
gnomAD
rs781991286 183 G>R No ExAC
gnomAD
rs1368657683 184 Y>C No TOPMed
gnomAD
rs1553840205 184 Y>D No gnomAD
rs148947714 187 E>D No 1000Genomes
TOPMed
gnomAD
rs147140632 187 E>K No ESP
ExAC
TOPMed
gnomAD
rs963667965 190 E>G No TOPMed
rs28460085 192 E>D No ExAC
rs28594165 193 E>D No ExAC
gnomAD
rs1572017733 195 D>E No Ensembl
rs1648904300 195 D>G No TOPMed
rs983675670 197 D>N No gnomAD
COSM1472569 199 D>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs782663428 201 D>N No ExAC
TOPMed
gnomAD
rs199559881 202 E>K No 1000Genomes
rs868981144 203 D>N No gnomAD
rs1553840131 205 A>P No gnomAD
rs587648606 206 G>C No 1000Genomes
ExAC
gnomAD
rs1553840119 206 G>D No gnomAD
rs1648899460 207 S>A No Ensembl
rs2101773871 211 E>D No Ensembl
rs1553840111 211 E>G No gnomAD
rs997790854 212 G>A No TOPMed
gnomAD
rs1025377833 212 G>R No Ensembl
rs997790854 212 G>V No TOPMed
gnomAD
rs1553840102 213 E>K No gnomAD
rs1559999159 214 E>D No Ensembl
rs1648896626 215 E>D No TOPMed
gnomAD
rs1553840097 216 V>M No gnomAD
rs781871724 218 L>V No ExAC
COSM1294972 219 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs964993337 220 Y>H No Ensembl
rs782762671 222 M>L No ExAC
gnomAD
rs1163759773 222 M>T No TOPMed
gnomAD
rs1017953863 223 K>E No Ensembl
COSM5477602 224 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM895466 225 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1393020274 226 I>T No TOPMed
gnomAD
rs1648894142 226 I>V No TOPMed
rs141827042 229 E>D No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1553838649 238 E>G No gnomAD
rs2101762616 239 G>R No Ensembl
rs782554691 241 E>K No Ensembl
rs782743734 243 E>K No ExAC
TOPMed
gnomAD
rs1553838635 244 E>K No TOPMed
gnomAD
rs1648573943 245 E>K No TOPMed
gnomAD
rs1648282787 246 E>G No gnomAD
rs782573325 248 G>A No ExAC
gnomAD
TCGA novel 249 G>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs143260001 249 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1553837482 250 L>F No gnomAD
rs1553837482 250 L>I No gnomAD
rs1220619437
COSM1294971
 251 R>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
TOPMed
gnomAD
rs1220619437 251 R>G No TOPMed
gnomAD
rs782221708 251 R>P No ExAC
gnomAD
rs782221708 251 R>Q No ExAC
gnomAD
rs1261119358 253 E>D No TOPMed
gnomAD
rs200309097 255 R>G No 1000Genomes
ExAC
gnomAD
rs782503764 255 R>K No ExAC
gnomAD
rs1486701528 257 R>* No TOPMed
gnomAD
rs997119537 257 R>L No Ensembl
COSM414092 257 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs781881003 261 D>N No ExAC
gnomAD
rs1553837444 262 D>G No gnomAD
rs781837866 262 D>H No ExAC
TOPMed
gnomAD
rs781837866 262 D>N No ExAC
TOPMed
gnomAD
rs781837866 262 D>Y No ExAC
TOPMed
gnomAD
rs782728674 263 G>R No ExAC
gnomAD
rs1185497828 264 E>Q No TOPMed
gnomAD
rs1411944721 266 E>* No TOPMed
rs1411944721 266 E>K No TOPMed
rs781983163 268 D>E No ExAC
gnomAD
rs1553837430 268 D>N No gnomAD
rs1365941937 269 D>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA

No associated diseases with Q9BTT0

2 regional properties for Q9BTT0

Type Name Position InterPro Accession
repeat Leucine-rich repeat 89 - 110 IPR001611-1
repeat Leucine-rich repeat 114 - 135 IPR001611-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Swr1 complex A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.

4 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone chaperone activity Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).
phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a phosphatase.
protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process.

2 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZC6 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Bos taurus (Bovine) SS
P51122 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Bos taurus (Bovine) SS
Q5ZMN0 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Gallus gallus (Chicken) SS
Q5F4A3 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E Gallus gallus (Chicken) SS
Q9V895 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Drosophila melanogaster (Fruit fly) SS
Q92688 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B Homo sapiens (Human) SS
P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Homo sapiens (Human) EV
O43423 ANP32CP Putative uncharacterized protein ANP32CP Homo sapiens (Human) SS
O35381 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Mus musculus (Mouse) SS
Q9EST5 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Mus musculus (Mouse) SS
P57784 Snrpa1 U2 small nuclear ribonucleoprotein A' Mus musculus (Mouse) PR
P97822 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Mus musculus (Mouse) SS
Q9EST6 Anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Rattus norvegicus (Rat) SS
P49911 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Rattus norvegicus (Rat) SS
Q5XIE0 Anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Rattus norvegicus (Rat) SS
Q7Y180 Os03g0668900 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 Oryza sativa subsp. japonica (Rice) SS
Q9SCQ7 At3g50690 Acidic leucine-rich nuclear phosphoprotein 32-related protein Arabidopsis thaliana (Mouse-ear cress) SS
Q6P1U7 anp32b Acidic leucine-rich nuclear phosphoprotein 32 family member B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7ZUP0 anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6NUW5 anp32e Acidic leucine-rich nuclear phosphoprotein 32 family member E Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEMKKKINLE LRNRSPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA NVELSSLARL
70 80 90 100 110 120
PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI KDLSTVEALQ NLKNLKSLDL
130 140 150 160 170 180
FNCEITNLED YRESIFELLQ QITYLDGFDQ EDNEAPDSEE EDDEDGDEDD EEEEENEAGP
190 200 210 220 230 240
PEGYEEEEEE EEEEDEDEDE DEDEAGSELG EGEEEVGLSY LMKEEIQDEE DDDDYVEEGE
250 260
EEEEEEEGGL RGEKRKRDAE DDGEEEDD