AiPD: Autoinhibited Protein Database

Q9BT23

Gene name	LIMD2
Protein name	LIM domain-containing protein 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:80774
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-62 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9BT23

Entry ID	Method	Resolution	Chain	Position	Source
2LZU	NMR	-	A	33-104	PDB
AF-Q9BT23-F1	Predicted				AlphaFoldDB

126 variants for Q9BT23

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320613037 CA400583270	3	Q>*		No	ClinGen gnomAD
TCGA novel	3	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400582611 rs1365265440	4	A>G		No	ClinGen gnomAD
CA400582601 rs1294873762	5	A>S		No	ClinGen gnomAD
rs919638440 CA292932556	6	G>E		No	ClinGen gnomAD
rs767126463 CA8703026	7	A>T		No	ClinGen ExAC gnomAD
rs751236539 CA8703024	8	A>S		No	ClinGen ExAC TOPMed gnomAD
rs751236539 CA8703025	8	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1381415949 CA400582537	9	Q>H		No	ClinGen gnomAD
CA292932512 rs867751332	10	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs765874844 CA8703023	10	A>V		No	ClinGen ExAC gnomAD
CA400582497 rs1436741164	12	P>H		No	ClinGen TOPMed
rs1436741164 CA400582495	12	P>R		No	ClinGen TOPMed
rs374604238 CA292932469	13	S>F		No	ClinGen ESP TOPMed gnomAD
TCGA novel	13	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8703018 rs200367312	14	H>P		No	ClinGen ExAC TOPMed gnomAD
CA8703017 rs200367312	14	H>R		No	ClinGen ExAC TOPMed gnomAD
CA400582365 rs1318144043	15	D>E		No	ClinGen TOPMed gnomAD
rs1200372802 CA400582373	15	D>G		No	ClinGen gnomAD
rs1255897560 CA400582378	15	D>N		No	ClinGen gnomAD
CA8702991 rs555698558	16	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs555698558 CA8702990	16	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA292932216 rs902621768	18	G>D		No	ClinGen TOPMed gnomAD
CA400582294 rs1391298298	19	G>D		No	ClinGen gnomAD
CA8702988 rs199625729 COSM3783086	19	G>S	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA8702986 COSM1385175 rs367901623	21	S>G	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1466524196 CA400582209	22	S>R		No	ClinGen gnomAD
rs1412284331 CA400582193	23	T>M		No	ClinGen TOPMed
CA400582203 rs1374299910	23	T>S		No	ClinGen TOPMed
rs1473796801 CA400582174	24	V>E		No	ClinGen gnomAD
CA400582186 rs1161687540	24	V>M		No	ClinGen gnomAD
rs1369154756 CA400582126	25	Q>H		No	ClinGen TOPMed gnomAD
CA8702982 COSM1213394 rs778234120	26	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8702981 rs778234120	26	R>L		No	ClinGen ExAC gnomAD
CA8702983 rs758026712	26	R>S		No	ClinGen ExAC gnomAD
CA400582099 rs1236340654	27	S>F		No	ClinGen gnomAD
rs1398181086 CA400581973	29	S>F		No	ClinGen TOPMed gnomAD
CA292932097 rs376733012	30	F>C		No	ClinGen ESP TOPMed gnomAD
CA400581945 rs1276675478	30	F>L		No	ClinGen TOPMed
rs1345885376 CA400581926	31	S>R		No	ClinGen TOPMed
rs778629147 CA8702963	34	A>D		No	ClinGen ExAC TOPMed gnomAD
CA8702964 rs778629147	34	A>V		No	ClinGen ExAC TOPMed gnomAD
CA400581871 rs1424454464	35	Q>*		No	ClinGen gnomAD
rs1598135070 CA400581841	36	V>G		No	ClinGen Ensembl
CA8702962 rs756767360	36	V>M		No	ClinGen ExAC gnomAD
CA400581836 rs1478894400	37	K>E		No	ClinGen gnomAD
CA8702960 rs777825419	38	E>K		No	ClinGen ExAC gnomAD
rs1020705520 CA292932079	39	T>N		No	ClinGen TOPMed
CA8702958 rs767177238	41	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1264683341 CA400581723	41	A>S		No	ClinGen gnomAD
CA8702957 rs767177238	41	A>V		No	ClinGen ExAC TOPMed gnomAD
CA400581708 rs1277130206	42	A>P		No	ClinGen gnomAD
rs1346185053 CA400581648	44	Q>L		No	ClinGen gnomAD
rs1346185053 CA400581651	44	Q>R		No	ClinGen gnomAD
CA8702954 rs750555243	47	V>A		No	ClinGen ExAC TOPMed
rs550246449 CA292932045	48	Y>N		No	ClinGen 1000Genomes gnomAD
CA8702953 rs765499799	49	P>A		No	ClinGen ExAC gnomAD
CA400581489 rs1410101382	51	E>*		No	ClinGen TOPMed gnomAD
CA400581491 rs1410101382	51	E>Q		No	ClinGen TOPMed gnomAD
CA8702952 rs761875853	52	R>L		No	ClinGen ExAC gnomAD
rs200123283 CA8702950	54	V>G		No	ClinGen ExAC gnomAD
rs373935635 CA8702951	54	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8702949 rs761034724	55	A>G		No	ClinGen ExAC
CA400581354 rs1402675150	57	K>R		No	ClinGen TOPMed gnomAD
CA8702946 rs746254704	58	L>R		No	ClinGen ExAC gnomAD
rs1425725647 CA400581311	59	I>V		No	ClinGen TOPMed
CA8702945 rs774145429	60	F>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1193678161 CA400581262	61	H>Y		No	ClinGen gnomAD
rs770751360 CA8702943	62	N>D		No	ClinGen ExAC gnomAD
CA8702942 rs748788832	62	N>S		No	ClinGen ExAC gnomAD
rs1197216211 CA400581094	67	C>R		No	ClinGen gnomAD
TCGA novel	67	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA292931931 rs11541952	68	K>R		No	ClinGen Ensembl
rs777374063 CA8702940	71	H>R		No	ClinGen ExAC gnomAD
rs1163961072 CA400580954	72	T>A		No	ClinGen TOPMed
rs1046562843 CA292931919	72	T>S		No	ClinGen Ensembl
rs755717333 CA400580923 CA400580926	73	K>N		No	ClinGen ExAC gnomAD
CA400580935 rs1388380505	73	K>T		No	ClinGen TOPMed
TCGA novel	74	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400580914 rs1568162569	74	L>F		No	ClinGen Ensembl
rs747970544 CA8702938	74	L>R		No	ClinGen ExAC gnomAD
TCGA novel	75	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773004872 CA8702918	75	S>R		No	ClinGen ExAC gnomAD
TCGA novel	77	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8702916 rs747754379	78	S>G		No	ClinGen ExAC gnomAD
CA292931737 rs796120134	78	S>N		No	ClinGen gnomAD
CA292931725 rs148770418	79	Y>F		No	ClinGen ESP gnomAD
rs1157417212 CA400580734	79	Y>H		No	ClinGen gnomAD
rs982918289 CA292931695	80	A>T		No	ClinGen TOPMed gnomAD
rs1487627264 CA400580663	81	A>V		No	ClinGen gnomAD
TCGA novel	82	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	83	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1222330290 CA400580606	84	G>E		No	ClinGen gnomAD
rs1344161029 CA400580530	87	Y>S		No	ClinGen gnomAD
rs746756767 CA8702913	89	K>Q		No	ClinGen ExAC gnomAD
rs200732428 CA292931681	90	P>S		No	ClinGen Ensembl
CA8702912 rs376579306	91	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA400580377 rs1294928415	93	Q>E		No	ClinGen gnomAD
rs1355733475 CA400580250	98	S>G		No	ClinGen gnomAD
rs756132640 CA400580237 CA8702908	98	S>R		No	ClinGen ExAC gnomAD
CA8702907 rs752864147	99	K>T		No	ClinGen ExAC gnomAD
CA400580199 rs1422029961	100	G>C		No	ClinGen gnomAD
TCGA novel	102	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364950392 CA400580164	102	Y>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs751729738 CA8702905	105	G>W		No	ClinGen ExAC gnomAD
rs1261078575 CA400580057 TCGA novel	106	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA400580020 rs1218971339	108	R>H		No	ClinGen gnomAD
rs1254021064 CA400580008	109	K>R		No	ClinGen TOPMed
rs1008303191 CA400579944	112	K>N		No	ClinGen Ensembl
CA8702904 rs752143532	116	A>T		No	ClinGen ExAC gnomAD
rs766598940 CA292931554	117	H>Q		No	ClinGen Ensembl
rs1406367921 CA400579880	117	H>Y		No	ClinGen gnomAD
CA8702903 rs766786905	119	E>*		No	ClinGen ExAC TOPMed gnomAD
rs763428211 CA8702902	120	V>A		No	ClinGen ExAC TOPMed gnomAD
rs763428211 CA400579822	120	V>E		No	ClinGen ExAC TOPMed gnomAD
rs1188014970 CA400579829	120	V>M		No	ClinGen TOPMed
CA400579817 rs1157128690	121	D>N		No	ClinGen TOPMed
rs529061709 CA8702898	123	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs201424588 CA8702899	123	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768069022 CA400579785	124	T>I		No	ClinGen ExAC gnomAD
CA8702897 rs768069022	124	T>S		No	ClinGen ExAC gnomAD
rs199852029 CA8702896	126	T>A		No	ClinGen ExAC TOPMed gnomAD
rs370859086 CA8702895	126	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8702894 rs771796363	127	A>S		No	ClinGen ExAC gnomAD
CA400579739 rs1223294984	128	A>R		No	ClinGen Ensembl

No associated diseases with Q9BT23

2 regional properties for Q9BT23

Type	Name	Position	InterPro Accession
domain	Zinc finger, LIM-type	38 - 98	IPR001781
domain	LIMD2, LIM domain	40 - 92	IPR044115

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Mainly found in cytoplasm, concentrated in membrane ruffles and in streaks reminiscent of focal adhesion plaques (PubMed:24590809) Also found in nucleus (PubMed:24590809)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
F1MH07	MICAL1	[F-actin]-monooxygenase MICAL1	Bos taurus (Bovine)	SS
Q8TDZ2	MICAL1	[F-actin]-monooxygenase MICAL1	Homo sapiens (Human)	EV
Q9ERG0	Lima1	LIM domain and actin-binding protein 1	Mus musculus (Mouse)	PR
Q8VDP3	Mical1	[F-actin]-monooxygenase MICAL1	Mus musculus (Mouse)	EV
Q8BGB5	Limd2	LIM domain-containing protein 2	Mus musculus (Mouse)	PR
D3ZBP4	Mical1	[F-actin]-monooxygenase MICAL1	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MFQAAGAAQA	TPSHDAKGGG	SSTVQRSKSF	SLRAQVKETC	AACQKTVYPM	ERLVADKLIF
70	80	90	100	110	120
HNSCFCCKHC	HTKLSLGSYA	ALHGEFYCKP	HFQQLFKSKG	NYDEGFGRKQ	HKELWAHKEV

DPGTKTA