Q99PW8

SS
Gene name
Kif17
Protein name
Kinesin-like protein KIF17
Names
MmKIF17
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:16559
EC number
Protein Class

Descriptions

KIF17 is dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. <br> Two molecular mechanisms contribute to autoinhibition of KIF17. First, the C-terminal tail interferes with microtubule binding. Second, a CC2 segment blocks processive motility.The CC2 and tail segments inhibit KIF17 motility via direct interactions with the motor domain.

Autoinhibitory domains (AIDs)

773-781 (CC2 segment) SS

Target domain

3-343 (Kinesin motor domain)

Relief mechanism

Assay

856-1038 (C-terminal tail) SS

Target domain

3-343 (Kinesin motor domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99PW8

Entry ID Method Resolution Chain Position Source
AF-Q99PW8-F1 Predicted AlphaFoldDB

52 variants for Q99PW8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3542875737 17 K>E No EVA
rs3388719073 132 K>Q No EVA
rs1133240283 153 A>T No EVA
rs3388720860 169 V>M No EVA
rs3388723741 179 V>I No EVA
rs3388715665 184 Q>H No EVA
rs3388725802 221 Y>H No EVA
rs3394984977 243 G>D No EVA
rs3394916397 250 T>P No EVA
rs3394916409 259 E>D No EVA
rs3394960198 261 T>A No EVA
rs3394960194 268 S>P No EVA
rs3388720883 277 L>Q No EVA
rs3388723673 340 R>C No EVA
rs3388713025 344 D>E No EVA
rs261931104 369 G>S No EVA
rs3388725801 473 K>M No EVA
rs3388701442 480 A>T No EVA
rs3388725850 497 A>T No EVA
rs27545790 508 M>V No EVA
rs3394984888 510 P>L No EVA
rs3394860862 511 S>G No EVA
rs3412842861 513 K>R No EVA
rs3388701454 524 E>V No EVA
rs222436108 528 G>V No EVA
rs239518492 530 T>N No EVA
rs258376260 546 E>K No EVA
rs3388725514 555 P>S No EVA
rs3388730213 567 M>R No EVA
rs244599731 568 A>P No EVA
rs27545788 583 G>S No EVA
rs248067906 596 R>H No EVA
rs3388713048 651 S>L No EVA
rs232527801 671 N>I No EVA
rs232527801 671 N>S No EVA
rs213900563 674 L>H No EVA
rs237296878 675 G>R No EVA
rs3388723680 715 Q>K No EVA
rs3388730231 746 D>N No EVA
rs3412964853 766 Q>K No EVA
rs3388701452 778 R>L No EVA
rs3388723755 785 E>Q No EVA
rs3388730300 906 D>H No EVA
rs3388730300 906 D>Y No EVA
rs3542953380 908 I>V No EVA
rs3543111483 910 L>M No EVA
rs3543021498 910 L>P No EVA
rs27545763 933 D>A No EVA
rs3388725590 942 E>D No EVA
rs3394943049 953 D>A No EVA
rs3388720890 958 A>T No EVA
rs3388713071 999 P>S No EVA

No associated diseases with Q99PW8

2 regional properties for Q99PW8

Type Name Position InterPro Accession
domain Kinesin motor domain 3 - 343 IPR001752
conserved_site Kinesin motor domain, conserved site 234 - 245 IPR019821

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell projection, cilium
  • Cell projection, dendrite
  • Localizes to dendrites of pyramidal neurons (PubMed:10846156)
  • Does not localize to the axons or nuclei in cerebral cortex, hippocampus or olfactory bulb (PubMed:10846156)
  • Co-localizes with NR2B-containing vesicles along microtubules (PubMed:10846156)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite cytoplasm All of the contents of a dendrite, excluding the surrounding plasma membrane.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
periciliary membrane compartment A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.
photoreceptor connecting cilium The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
plus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.

9 GO annotations of biological process

Name Definition
anterograde dendritic transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein-containing complex localization A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
spindle elongation The cell cycle process in which the distance is lengthened between poles of the spindle.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9P2E2 KIF17 Kinesin-like protein KIF17 Homo sapiens (Human) EV
Q61768 Kif5b Kinesin-1 heavy chain Mus musculus (Mouse) EV
P28738 Kif5c Kinesin heavy chain isoform 5C Mus musculus (Mouse) SS
P33175 Kif5a Kinesin heavy chain isoform 5A Mus musculus (Mouse) SS
Q7M6Z4 Kif27 Kinesin-like protein KIF27 Mus musculus (Mouse) SS
Q9QXL2 Kif21a Kinesin-like protein KIF21A Mus musculus (Mouse) EV SS
Q9QXL1 Kif21b Kinesin-like protein KIF21B Mus musculus (Mouse) SS
Q9EQW7 Kif13a Kinesin-like protein KIF13A Mus musculus (Mouse) SS
B7ZNG0 Kif7 Kinesin-like protein KIF7 Mus musculus (Mouse) SS
P46864 KIN14M Kinesin-like protein KIN-14M Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASESVKVVV RCRPMNKRER ELSCQSVVTV DSARGQCFIQ NPGAADEPPK QFTFDGAYYI
70 80 90 100 110 120
EHFTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT MQGLPDPPCQ RGIIPRAFEH
130 140 150 160 170 180
VFESVQCAEN TKFLVRASYL EIYNEDVHDL LGADTKQRLE LKEHPEKGVY VKGLSMHTVH
190 200 210 220 230 240
NVAQCERVME TGWKNRAVGY TLMNKDSSRS HSIFTINIEI YAVDERGKDH LRAGKLNLVD
250 260 270 280 290 300
LAGSERQSKT GATGERLKEA TKINLSLSAL GNVISALVDG RCKHIPYRDS KLTRLLQDSL
310 320 330 340 350 360
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIKNKPR INEDPKDALL REYQEEIKRL
370 380 390 400 410 420
KAILAQQMGP GNLSALLSTQ TPPGPVQSEE KLLSPTTVQQ DTEAEKQLIR EEYEERLARL
430 440 450 460 470 480
KADYEAEQES RVRLQEDITA MRNSYDVKLS TLQENLRKEK ETEAILKAEV LCKTEVMSRA
490 500 510 520 530 540
ELASGPEYSP PLQYETAVKP TILSMPDMPP SGKVTKSQAP LAFEEPHGET SRSEFSFESN
550 560 570 580 590 600
ECSTLEDSAT SEAFPGPEEF SNMEFSMAAA LTESRYLPEE YLGGQEAAAS PLEAERYVQE
610 620 630 640 650 660
NEPSLEPLRI LASLQDPFAE VEAKLARLSS TVAMSDSSQT VVPQIPKQPS SADLLEPSDT
670 680 690 700 710 720
KSEADVAVAD NVVLGTEPDV NLRVAEEVVS EAETGVWMES EAQVAHVAQV SEEAQPQPLL
730 740 750 760 770 780
AMVSVRRESV GVEVAVLTEE ELQPVDQQQV LARLQLLEQQ VVGGEQAKNK DLREKHKRRK
790 800 810 820 830 840
RYADERKKQL VAALQNSDED GGDWVLLNVY DSIQEEVRAK SKLLEKMQRK LRAAEVEIKD
850 860 870 880 890 900
LQSEFQLEKI DYLATIRRQE RDSMLFQQLL EQVQPLIRRD CNYSNLEKIR RESSWDEDNG
910 920 930 940 950 960
FWKIPDPIIL KTSLPVVPTG TQNKPARKTS AVDSGEPHMQ EEDRYKLMLS RSDSENIASN
970 980 990 1000 1010 1020
YFRSKRASQI LSTDPMKSLT YHNSPPGLNS SLSNNSALPP TQTPEMPQPR PFRLESLDIP
1030
FSKAKRKKSK NSFGGEPL