Q99P58

PR
Gene name
Rab27b
Protein name
Ras-related protein Rab-27B
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:80718
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q99P58

Entry ID Method Resolution Chain Position Source
2IEY X-ray 318 A A/B 1-193 PDB
2IEZ X-ray 280 A A/B/H/I 1-218 PDB
2IF0 X-ray 280 A A/B 1-198 PDB
2ZET X-ray 300 A A/B 1-201 PDB
AF-Q99P58-F1 Predicted AlphaFoldDB

14 variants for Q99P58

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3408769621 2 T>S No EVA
rs3389518060 18 S>T No EVA
rs3389525761 45 D>G No EVA
rs3389488186 52 V>F No EVA
rs3409088863 57 G>S No EVA
rs3389466579 60 G>V No EVA
rs3389509535 70 L>M No EVA
rs3389520427 84 L>H No EVA
rs3389509019 85 T>S No EVA
rs3389488121 123 C>* No EVA
rs3389518045 132 G>D No EVA
rs3408726905 159 Y>D No EVA
rs3389520447 171 E>V No EVA
rs3389418957 175 E>G No EVA

No associated diseases with Q99P58

1 regional properties for Q99P58

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 8 - 176 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Membrane ; Lipid-anchor
  • Late endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
anchored component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
axon cytoplasm Any cytoplasm that is part of a axon.
exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
multivesicular body membrane The lipid bilayer surrounding a multivesicular body.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
secretory granule membrane The lipid bilayer surrounding a secretory granule.
trans-Golgi network transport vesicle A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.
zymogen granule membrane The lipid bilayer surrounding a zymogen granule.

6 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
myosin V binding Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.
protein domain specific binding Binding to a specific domain of a protein.

7 GO annotations of biological process

Name Definition
anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
multivesicular body sorting pathway A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis.
regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis.
synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8HZJ5 RAB27B Ras-related protein Rab-27B Bos taurus (Bovine) PR
Q1HE58 RAB27A Ras-related protein Rab-27A Canis lupus familiaris (Dog) (Canis familiaris) PR
P51159 RAB27A Ras-related protein Rab-27A Homo sapiens (Human) PR
O00194 RAB27B Ras-related protein Rab-27B Homo sapiens (Human) PR
Q9ERI2 Rab27a Ras-related protein Rab-27A Mus musculus (Mouse) PR
Q8CB87 Rab44 Ras-related protein Rab-44 Mus musculus (Mouse) PR
Q8CAM5 Rab36 Ras-related protein Rab-36 Mus musculus (Mouse) PR
Q4LE85 RAB27A Ras-related protein Rab-27A Sus scrofa (Pig) PR
P23640 Rab27a Ras-related protein Rab-27A Rattus norvegicus (Rat) PR
Q99P74 Rab27b Ras-related protein Rab-27B Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR VVYDTQGADG
70 80 90 100 110 120
ASGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD LTSQQSFLNV RNWMSQLQAN
130 140 150 160 170 180
AYCENPDIVL IGNKADLPDQ REVNERQARE LAEKYGIPYF ETSAATGQNV EKSVETLLDL
190 200 210
IMKRMEKCVE KTQVPDTVNG GNSGKLDGEK PAEKKCAC