Q99NB5

SS
Gene name
Gsdmc
Protein name
Gasdermin-C
Names
Gasdermin-C1, Melanoma-derived leucine zipper-containing extranuclear factor, mMLZE
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:83492
EC number
Protein Class

Descriptions

Gasdermin proteins are a pore-forming protein causing membrane permeabilization and pyroptosis, and functions downstream of the inflammatory caspases. The C-terminal gasdermin domain may adopt an intramolecular complex with the N-terminal domain, which may inhibit the activation of the N-terminal gasdermin domain as observed in GSDMD.

Autoinhibitory domains (AIDs)

273-442 (C-terminal gasdermin domain) SS

Target domain

4-236 (N-terminal gasdermin domain)

Relief mechanism

Cleavage

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99NB5

Entry ID Method Resolution Chain Position Source
AF-Q99NB5-F1 Predicted AlphaFoldDB

21 variants for Q99NB5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs241132220 45 R>W No Ensembl
rs234411402 225 T>P No Ensembl
rs244348016 229 T>A No Ensembl
rs582241870 237 M>K No Ensembl
rs220398911 237 M>V No Ensembl
rs255789279 238 R>T No Ensembl
rs237205535 250 D>E No Ensembl
rs31088459 257 S>L No Ensembl
rs578921518 261 D>Y No Ensembl
rs31088457 263 D>V No Ensembl
rs587207889 267 T>R No Ensembl
rs580254039 269 K>Q No Ensembl
rs587331295 272 T>A No Ensembl
rs31087027 296 D>G No Ensembl
rs1135250728 313 D>E No Ensembl
rs1132975992 313 D>N No Ensembl
rs31087025 320 K>N No Ensembl
rs251197998 342 R>Q No Ensembl
rs31085239 376 L>R No Ensembl
rs242146774 385 H>Y No Ensembl
rs586241413 468 A>G No Ensembl

No associated diseases with Q99NB5

2 regional properties for Q99NB5

Type Name Position InterPro Accession
domain Gasdermin, pore forming domain 4 - 236 IPR040460
domain Gasdermin, PUB domain 273 - 441 IPR041263

Functions

Description
EC Number
Subcellular Localization
  • [Gasdermin-C]: Cytoplasm, cytosol
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

2 GO annotations of biological process

Name Definition
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
pyroptosis A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57764 GSDMD Gasdermin-D Homo sapiens (Human) EV
Q96QA5 GSDMA Gasdermin-A Homo sapiens (Human) SS
Q9BYG8 GSDMC Gasdermin-C Homo sapiens (Human) SS
Q8TAX9 GSDMB Gasdermin-B Homo sapiens (Human) EV
Q8CB12 Gsdmc3 Gasdermin-C3 Mus musculus (Mouse) SS
Q2KHK6 Gsdmc2 Gasdermin-C2 Mus musculus (Mouse) SS
Q3TR54 Gsdmc4 Gasdermin-C4 Mus musculus (Mouse) SS
Q5Y4Y6 Gsdma3 Gasdermin-A3 Mus musculus (Mouse) EV
Q9D8T2 Gsdmd Gasdermin-D Mus musculus (Mouse) SS
Q9EST1 Gsdma Gasdermin-A Mus musculus (Mouse) SS
Q32M21 Gsdma2 Gasdermin-A2 Mus musculus (Mouse) SS
P85967 Gsdmc Gasdermin-C Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSYTFDWLSK DVVKKLQGRD LRPVKCLSDA TKFCLFNILQ ETSSRLALKT EYIPVGFTLL
70 80 90 100 110 120
HLLEPNIPVP EPEVSAPIPL KHTISQKLKA DLDVETIAGG EAGFVKSCGY DIEVQSKSIP
130 140 150 160 170 180
NPKLESLQNR KLLDQLPTFM KTCWKDGKNL YVVTEAYEVT KDTVLEGTSN SKFAIKGIIN
190 200 210 220 230 240
QLVKVGGSGQ WQTEKTDSIP IQKGSVLAYK KQQLVIEDNT CVILTSANTK KKMTFPMRFV
250 260 270 280 290 300
GMSGHLRYQD LVIETGSWIN DIDPIGTIKE PTHLDFMCLQ NEVSEQTRLL AELSKDVQEV
310 320 330 340 350 360
VFSSFLHMLC DRDVLYDLMK MLELNQLGHM DGPGGKILDE LRKDSSLSWI NLKDLILYLL
370 380 390 400 410 420
QALMVLSDTQ LCLLALSVEM RLLPHQVELV KSILQPNFKY PWNIPFTLQP QLLAPLQGEG
430 440 450 460
LAITYELLEE CGLKMELNNP RSTWDLEAKM PLSALYGSLS FLQQLSEA