Q99MY8
SS
Gene name |
Ash1l |
Protein name |
Histone-lysine N-methyltransferase ASH1L |
Names |
EC 2.1.1.359 , EC 2.1.1.367 , ASH1-like protein , Absent small and homeotic disks protein 1 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192195 |
EC number |
2.1.1.359: Methyltransferases |
Protein Class |
|
Descriptions
ASH1L (absent, small, or homeotic-like 1) is a histone methyltransferase (HMTase) involved in gene activation. Its autoinhibitory loop in the post-SET subdomain blocks the access of histone substrate to the active site in the catalytic SET domain. There is another loop in the SET-I subdomain. The SET-I region forms key contacts with histone substrates, indicating that it likely functions in determining substrate specificity among different HMTases. The mutations within the SET-I loop decreases ASH1L enzyme activity. ASH1L also contains three C-terminal chromatic-interacting domains (bromodomain, plant homeodomain, and bromo-associated homology domain), which recognize post-translational modifications on native nucleosomes and facilitate catalytic activity of the SET domain via substrate recruitment.
Autoinhibitory domains (AIDs)
Target domain |
2135-2257 (SET domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Rogawski DS et al. (2015) "Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase", Biochemistry, 54, 5401-13
- Lee Y et al. (2019) "Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop", Structure (London, England : 1993), 27, 846-852.e3
Autoinhibited structure
Activated structure
0 structures for Q99MY8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
154 variants for Q99MY8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388622330 | 13 | S>A | No | EVA | |
| rs3388632399 | 32 | A>G | No | EVA | |
| rs238260170 | 37 | A>V | No | EVA | |
| rs3388638196 | 46 | E>D | No | EVA | |
| rs30953299 | 51 | R>W | No | EVA | |
| rs3388629336 | 116 | K>R | No | EVA | |
| rs3393108355 | 162 | I>F | No | EVA | |
| rs252286250 | 163 | H>Y | No | EVA | |
| rs3388637390 | 220 | Q>P | No | EVA | |
| rs3388641533 | 238 | L>F | No | EVA | |
| rs3388641594 | 259 | S>F | No | EVA | |
| rs3388630062 | 263 | I>L | No | EVA | |
| rs3388641563 | 267 | D>N | No | EVA | |
| rs3388630057 | 267 | D>V | No | EVA | |
| rs3388640145 | 316 | N>K | No | EVA | |
| rs3388637896 | 330 | G>E | No | EVA | |
| rs3388637406 | 332 | L>Q | No | EVA | |
| rs3388643923 | 338 | K>* | No | EVA | |
| rs3388637868 | 368 | K>I | No | EVA | |
| rs3388637826 | 372 | K>R | No | EVA | |
| rs3388635349 | 382 | A>T | No | EVA | |
| rs3388641560 | 386 | T>M | No | EVA | |
| rs3388637369 | 387 | K>E | No | EVA | |
| rs219178774 | 445 | N>H | No | EVA | |
| rs234459045 | 447 | D>E | No | EVA | |
| rs3411224993 | 450 | E>D | No | EVA | |
| rs3388637889 | 455 | L>P | No | EVA | |
| rs3388641538 | 470 | R>W | No | EVA | |
| rs3388622331 | 493 | M>V | No | EVA | |
| rs3388642143 | 543 | K>N | No | EVA | |
| rs32918722 | 547 | S>N | No | EVA | |
| rs32919385 | 566 | V>I | No | EVA | |
| rs3388643862 | 572 | E>A | No | EVA | |
| rs3388638119 | 576 | Q>H | No | EVA | |
| rs3388637841 | 620 | S>I | No | EVA | |
| rs3388630049 | 633 | N>I | No | EVA | |
| rs32919388 | 637 | N>S | No | EVA | |
| rs3388641547 | 642 | I>N | No | EVA | |
| rs3393255659 | 690 | D>N | No | EVA | |
| rs3388643917 | 712 | K>I | No | EVA | |
| rs3388637886 | 718 | W>* | No | EVA | |
| rs3388641586 | 718 | W>R | No | EVA | |
| rs3388641569 | 741 | F>L | No | EVA | |
| rs232673272 | 742 | K>N | No | EVA | |
| rs252204590 | 756 | A>V | No | EVA | |
| rs3388629990 | 790 | L>P | No | EVA | |
| rs3388637431 | 791 | L>* | No | EVA | |
| rs3388637833 | 796 | K>R | No | EVA | |
| rs3388632334 | 797 | P>T | No | EVA | |
| rs3388622374 | 838 | E>K | No | EVA | |
| rs230887703 | 844 | T>S | No | EVA | |
| rs3393364257 | 847 | I>M | No | EVA | |
| rs3388629317 | 880 | S>T | No | EVA | |
| rs3388629358 | 887 | K>Q | No | EVA | |
| rs3541550374 | 895 | M>V | No | EVA | |
| rs3393328439 | 916 | S>R | No | EVA | |
| rs3388637389 | 985 | N>I | No | EVA | |
| rs3388642183 | 985 | N>K | No | EVA | |
| rs3388643180 | 1011 | K>I | No | EVA | |
| rs3388622301 | 1016 | L>I | No | EVA | |
| rs3388643927 | 1047 | K>R | No | EVA | |
| rs3388642110 | 1048 | R>S | No | EVA | |
| rs3388630082 | 1059 | G>R | No | EVA | |
| rs3388645223 | 1062 | S>F | No | EVA | |
| rs3388642119 | 1125 | F>S | No | EVA | |
| rs3388641603 | 1133 | Y>F | No | EVA | |
| rs3393108385 | 1135 | H>P | No | EVA | |
| rs3393255634 | 1136 | V>A | No | EVA | |
| rs3393364275 | 1138 | S>Y | No | EVA | |
| rs3393348932 | 1139 | R>* | No | EVA | |
| rs3393289734 | 1139 | R>K | No | EVA | |
| rs3388642169 | 1168 | S>F | No | EVA | |
| rs3393331143 | 1197 | S>N | No | EVA | |
| rs3393364036 | 1198 | D>A | No | EVA | |
| rs3393120609 | 1199 | S>T | No | EVA | |
| rs3393289718 | 1200 | G>V | No | EVA | |
| rs3393348868 | 1201 | I>T | No | EVA | |
| rs3388641578 | 1206 | N>I | No | EVA | |
| rs3388637875 | 1259 | S>N | No | EVA | |
| rs3388642168 | 1293 | I>K | No | EVA | |
| rs3388642159 | 1303 | H>P | No | EVA | |
| rs3388643889 | 1305 | S>N | No | EVA | |
| rs3388637355 | 1315 | P>S | No | EVA | |
| rs3388629344 | 1327 | T>A | No | EVA | |
| rs3388635772 | 1331 | F>C | No | EVA | |
| rs3388640064 | 1356 | E>D | No | EVA | |
| rs3388640107 | 1391 | A>S | No | EVA | |
| rs226549855 | 1619 | S>G | No | EVA | |
| rs244849700 | 1653 | A>S | No | EVA | |
| rs32915864 | 1668 | S>F | No | EVA | |
| rs32920697 | 1697 | P>S | No | EVA | |
| rs30453465 | 1706 | S>C | No | EVA | |
| rs3388629343 | 1716 | Q>H | No | EVA | |
| rs13461590 | 1729 | K>* | No | EVA | |
| rs3388635722 | 1764 | V>M | No | EVA | |
| rs3388640076 | 1769 | N>K | No | EVA | |
| rs3388645215 | 1772 | C>Y | No | EVA | |
| rs262392582 | 1773 | S>N | No | EVA | |
| rs223579216 | 1782 | S>L | No | EVA | |
| rs3388643872 | 1839 | N>D | No | EVA | |
| rs32921395 | 1870 | S>N | No | EVA | |
| rs3393432360 | 1871 | P>L | No | EVA | |
| rs265363860 | 1902 | T>N | No | EVA | |
| rs229529869 | 1909 | V>L | No | EVA | |
| rs3388635749 | 1932 | E>A | No | EVA | |
| rs3388643853 | 2057 | K>E | No | EVA | |
| rs3388635393 | 2080 | G>S | No | EVA | |
| rs3388635307 | 2087 | N>I | No | EVA | |
| rs3388634762 | 2091 | P>Q | No | EVA | |
| rs3388637415 | 2092 | D>E | No | EVA | |
| rs258175779 | 2092 | D>H | No | EVA | |
| rs3388629383 | 2111 | E>V | No | EVA | |
| rs3388635768 | 2162 | I>V | No | EVA | |
| rs3393320238 | 2177 | R>S | No | EVA | |
| rs3388638162 | 2245 | E>D | No | EVA | |
| rs3388634818 | 2258 | E>D | No | EVA | |
| rs3388629387 | 2264 | K>T | No | EVA | |
| rs3388629995 | 2283 | G>* | No | EVA | |
| rs3388634760 | 2289 | G>D | No | EVA | |
| rs3541593748 | 2289 | G>S | No | EVA | |
| rs32920628 | 2303 | K>E | No | EVA | |
| rs3388629391 | 2318 | H>R | No | EVA | |
| rs3388638121 | 2328 | N>K | No | EVA | |
| rs3388645228 | 2336 | Q>H | No | EVA | |
| rs3388634773 | 2362 | E>G | No | EVA | |
| rs3388635778 | 2406 | S>Y | No | EVA | |
| rs3393291312 | 2408 | L>R | No | EVA | |
| rs3393257171 | 2408 | L>V | No | EVA | |
| rs3393257159 | 2410 | T>R | No | EVA | |
| rs3393206799 | 2411 | A>T | No | EVA | |
| rs3388643924 | 2412 | R>S | No | EVA | |
| rs3388641588 | 2414 | V>I | No | EVA | |
| rs3388635348 | 2425 | N>S | No | EVA | |
| rs3388634796 | 2426 | L>M | No | EVA | |
| rs3388629393 | 2444 | G>V | No | EVA | |
| rs32920878 | 2455 | T>A | No | EVA | |
| rs3388635319 | 2484 | T>I | No | EVA | |
| rs3388635319 | 2484 | T>S | No | EVA | |
| rs3388640147 | 2495 | K>R | No | EVA | |
| rs3388629334 | 2508 | F>S | No | EVA | |
| rs3413106497 | 2533 | Y>N | No | EVA | |
| rs3393374093 | 2546 | I>M | No | EVA | |
| rs3388637877 | 2546 | I>V | No | EVA | |
| rs3388622304 | 2577 | C>R | No | EVA | |
| rs3388638177 | 2579 | C>Y | No | EVA | |
| rs3388640096 | 2587 | L>I | No | EVA | |
| rs3388640093 | 2600 | C>R | No | EVA | |
| rs3388622338 | 2601 | D>A | No | EVA | |
| rs3388637873 | 2627 | P>S | No | EVA | |
| rs3388638141 | 2725 | F>L | No | EVA | |
| rs3393121244 | 2745 | V>F | No | EVA | |
| rs3388638176 | 2781 | H>Y | No | EVA | |
| rs3388640101 | 2825 | N>S | No | EVA | |
| rs864265889 | 2833 | S>P | No | EVA |
No associated diseases with Q99MY8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.359 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| histone H3K36 trimethyltransferase activity | Catalysis of the reaction |
| histone H3K4 methyltransferase activity | Catalysis of the reaction |
| histone H3K9 methyltransferase activity | Catalysis of the reaction |
| histone H3K9 monomethyltransferase activity | Catalysis of the reaction |
| histone H3K9me2 methyltransferase activity | Catalysis of the reaction |
| metal ion binding | Binding to a metal ion. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| decidualization | The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. |
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| negative regulation of acute inflammatory response | Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of MAPK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| sebaceous gland development | The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. |
| single fertilization | The union of male and female gametes to form a zygote. |
| skeletal system development | The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). |
| tarsal gland development | The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
| uterine gland development | The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure. |
| uterus morphogenesis | The process in which anatomical structures of the uterus are generated and organized. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPRNTAMLG | LGSDSEGFSR | KSPSTINPGT | LASKREAEIE | GATEEEDPRK | RNRERGTEAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEDGSTDAQQ | QFSVKETNFS | EGNLKLKIGL | QAKRTKKPPK | NLENYVCRPA | IKTTIKHSRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALKSGKMTDE | KNEHCPSKWD | SSKLFKKAGD | ATAIDCQAEE | SIHLHSQGES | NPLSKKLSPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HSQMADYISA | APSLVGSRDP | DIKDRALLNG | GTSVTEKLAQ | LIATCPPSKS | SKAKPKKLGT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GTTVGLVSKD | LIRKPGVGSI | AGIIHKDLIK | KPALSTAVGL | VTKDPGKKPM | FNAAVGLINK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSVKKLGTGT | TAVFINKDLG | KKPGAITTVG | LLSKESGKKL | GIGIVPGLVN | KESGKKLGLG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVVGLVNKEL | GKKLSSTVGL | VAKDVTKKIV | ASSAMGLVNK | DIGKKLLNCP | MAGQLGSKDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LNLKSEALLP | TQEQLKASCS | ANISNHDSQE | LPESLKDSAT | GKAFEKSVMR | HSKESMLEKF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SVRKEITNLE | KEMFNEGTCI | QQDNFSSSER | GAFETSKHEK | QPPVYCTSPD | FQIGGASDAS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TAKSPFSAVG | ESNLPSSSPT | VSVNPVTRSP | PEASSQLVPN | PLLLNSTAEQ | MEEISESIGK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SQFTAESTHL | NVGHRSLGHS | LSIECKGIDK | ELNESKNTHL | DIPRISSSLG | KKPSLTSDSG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IHAITPSVVN | FTSLFSNKPF | LKLGAVTAPD | KHCQVAESLS | SSFQSKPLKK | RKGRKPRWTK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVARSTCRSP | KGLDLERSEL | FKNVSCSSLS | NSSEPAKFMK | TIGASSFVDH | DFLKRRLPKL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SKSSAPSLAL | LTDSEKPSHK | SFITHKLSSS | MCVTSDLLSD | IYKPKRGRPK | SKEMPQLEGP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PKRTLKIPAS | KVFSLQSKEE | QEPPILQPEI | EIPSFKQSLS | VSPFPKKRGR | PKRQMRSPVK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MKPPVLSVAP | FVATESPSKL | ESESENHRSS | SDFFESEDQL | QDTDDLDDSH | RQSVCSMSDL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EMEPDKKISK | RNNGQLMKTI | IRKINKMKTL | KRKKLLNQIL | SSSVESSNKG | KVQSKLHNTV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SSLAATFGSK | LGQQINVSKK | GTIYIGKRRG | RKPKTVLNGL | LSGSPASLAV | LEQTAQQAAG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SALGQILPPL | LPSPASSSEI | LPSPICSQSS | GTSGGQSPVS | SDAGFVEPSS | VPYLHVHSRQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GSMIQTLAMK | KASKGRRRLS | PPTLLPNSPS | HLSELTSLKE | ATPSPVSESH | SDETIPSDSG |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| IGTDNNSTSD | RAEKFCGQKK | RRHSFEHISL | IPPETSTVLN | SLKEKHKHKC | KRRSHDYLSY |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| DKMKRQKRKR | KKKYPQLRNR | QDPDFIAELE | ELISRLSEIR | ITHRSHHFIP | RDLLPTIFRI |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| NFNSFYTHPS | FPLDPLHYIR | KPDLKKKRGR | PPKMREAMAE | MPFMHSLSFP | LSSTGFYPSY |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| GMPYSPSPLT | AAPIGLGYYG | RYPPTLYPPP | PSPSFTTPLP | PPSYMHAGHL | LLNPTKYHKK |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| KHKLLRQEAF | LTTSRTPLLS | MSTYPSVPPE | MAYGWMVEHK | HRHRHKHREH | RSEQPQVSMD |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| SGSSRSVLES | LKRYRFGKDT | VGDRYKHKEK | HRCHMSCPHL | SPSKNLINRE | EQWVSREPSE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| SSSLALGLQT | PLQIDCSESS | PSLSLGGFTP | NSEPASSDEH | MNLFTSAIGS | CRVSNPNSSC |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| RKKLTDSPGL | FPVQDTALNR | PHRKEPLPSS | ERAIQSLAGS | QSASDKPSQR | SSESTNCSPT |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| RKRSSSESTS | STVNGVPSRS | PRLVASMDDS | VDSLLQRIVH | HDEQESMEKN | GDASITTVSA |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| PPSSSPGHSY | SKERALGKSD | SLLVPAVPND | SCSNIPLLSE | KSASRCSPHH | IKRSVVEAMQ |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| RQARKMCNYD | KILATKKNLD | HVNKILKAKK | LQRQARTGNN | FVKRRPGRPR | KCPLQAVVSM |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| QAFQAAQFVS | PELNEGEDMS | LHLSPDTVTD | VIEAVVQSVN | LTSEHKKGVK | RKNWLLEEQT |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| RKKQKTVPEE | EEQENNKSFI | ETPVEIPSPL | ETPAEPSEPE | NTLQPVLALI | PREKKAPRPP |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| KKKYQRAGLY | SDVYKTIDPK | SRLIQLKKEK | LEYTPGEHEY | GLFPAPIHVG | KYLRQKRIDF |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| QLPYDILWQW | KHNQLYKKPD | VPLYKKIRSN | VYVDVKPLSG | YEATTCNCKK | PDDDTRKGCG |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| DDCLNRMIFA | ECSPNTCPCG | EQCCNQRIQR | HEWVQCLERF | RAEEKGWGIR | TKEPLKAGQF |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| IIEYLGEVVS | EQEFRNRMIE | QYHNHSDHYC | LNLDSGMVID | SYRMGNEARF | INHSCDPNCE |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| MQKWSVNGVY | RIGLYALKDM | PAGTELTYDY | NFHSFNVEKQ | QLCKCGFEKC | RGIIGGKSQR |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| MNGLPSHKGS | QSSSTHRKSA | RAKEKRKSKH | KLKKRKGHPS | EEPSENINTP | TRLTPQLQMK |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| PMSNRERNFV | LKHHVFLVRN | WEKIHQKQEE | VKHTRDIHSA | SLYTRWNGLC | RDDGNIKSDV |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| FMTQFSALQT | ARSVRTRRLA | AAEENLEVAR | AARLAQIFKE | ICDGIISYRD | SSQQTLAAPL |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| LNLPPKKKNA | DYYEKISDPL | DLSTIEKQIL | IGYYKTVEAF | DADMLKVFRN | AEKYYGRKSP |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| IGRDVCRLRK | AYYSARHEAS | AQIDEIVGET | ASEADSSETS | VSEKESGHEK | DDDVIRCICG |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| LYKDEGLMIQ | CDKCMVWQHC | DCMGVNTDVE | HYLCEQCDPR | PVDREVPMIP | RPHYAQPGCV |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| YFICLLRDDL | LLRQGDCVYL | MRDSRRTPDG | HPVRQSYRLL | SHINRDKLDI | FRIEKLWKNE |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| KEERFAFGHH | YFRPHETHHS | PSRRFYHNEL | FRVPLYEIIP | LEAVVGTCCV | LDLYTYCKGR |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| PKGIKEQDVY | ICDYRLDKSA | HLFYKIHRNR | YPVCTKPYAF | DHFPKKLTPK | RDFSPHYVPD |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| NYKRNGGRSS | WKSERSKPPL | KDLGQEDDAL | PLIEEVLASQ | EQAAREVPSP | EEPDQERATG |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| DIGDAEKKPE | ESSQEAQLAS | TPEERRHSQR | ERLNQILLNL | LEKIPGKNAI | DVTYLLEEGS |
| 2950 | |||||
| GRKLRRRTLF | IPENSFRK |