Q99ML2

PR
Gene name
Tnk1
Protein name
Non-receptor tyrosine-protein kinase TNK1
Names
Kinase of embryonic stem cells
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:83813
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

457-551 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99ML2

Entry ID Method Resolution Chain Position Source
AF-Q99ML2-F1 Predicted AlphaFoldDB

40 variants for Q99ML2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389166382 2 L>H No EVA
rs3389168870 26 I>N No EVA
rs3389143436 44 E>D No EVA
rs3389175166 57 R>C No EVA
rs3389172676 73 K>M No EVA
rs216576882 117 R>L No EVA
rs3389135324 131 H>Y No EVA
rs3389172700 133 G>A No EVA
rs3389174000 168 E>* No EVA
rs3389184739 192 L>Q No EVA
rs3389166320 194 M>I No EVA
rs13475650 206 A>T No EVA
rs3389143399 282 P>S No EVA
rs3389182190 288 A>T No EVA
rs3389109206 307 W>R No EVA
rs3389143369 355 S>F No EVA
rs3389166311 363 P>Q No EVA
rs3389143461 371 F>L No EVA
rs3389143408 388 C>F No EVA
rs3389184718 399 R>L No EVA
rs3389143442 400 M>T No EVA
rs3389147434 405 P>T No EVA
rs3389170747 406 I>N No EVA
rs241406539 413 L>P No EVA
rs3389175238 459 E>* No EVA
rs3401749580 466 D>E No EVA
rs3402014812 468 D>A No EVA
rs3402464283 468 D>H No EVA
rs3401749571 469 R>* No EVA
rs3389178878 514 S>A No EVA
rs3389166351 522 T>I No EVA
rs26908182 526 P>L No EVA
rs3389182221 527 Q>* No EVA
rs47367273 547 C>Y No EVA
rs3389166406 549 S>P No EVA
rs3389175228 557 K>R No EVA
rs3389178834 561 K>Q No EVA
rs214459041 582 S>F No EVA
rs3389147492 637 S>C No EVA
rs3389170520 645 R>H No EVA

No associated diseases with Q99ML2

6 regional properties for Q99ML2

Type Name Position InterPro Accession
domain Protein kinase domain 116 - 383 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 118 - 375 IPR001245
domain SH3 domain 381 - 441 IPR001452
active_site Tyrosine-protein kinase, active site 241 - 253 IPR008266
binding_site Protein kinase, ATP binding site 122 - 148 IPR017441
domain Tyrosine-protein kinase, catalytic domain 116 - 378 IPR020635

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Membrane
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

6 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of Ras protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

33 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q17R13 TNK2 Activated CDC42 kinase 1 Bos taurus (Bovine) SS
Q07912 TNK2 Activated CDC42 kinase 1 Homo sapiens (Human) EV
Q13470 TNK1 Non-receptor tyrosine-protein kinase TNK1 Homo sapiens (Human) PR
Q05397 PTK2 Focal adhesion kinase 1 Homo sapiens (Human) EV
Q14289 PTK2B Protein-tyrosine kinase 2-beta Homo sapiens (Human) PR
P48025 Syk Tyrosine-protein kinase SYK Mus musculus (Mouse) SS
P43404 Zap70 Tyrosine-protein kinase ZAP-70 Mus musculus (Mouse) SS
Q64434 Ptk6 Protein-tyrosine kinase 6 Mus musculus (Mouse) SS
P14234 Fgr Tyrosine-protein kinase Fgr Mus musculus (Mouse) SS
P25911 Lyn Tyrosine-protein kinase Lyn Mus musculus (Mouse) EV
P39688 Fyn Tyrosine-protein kinase Fyn Mus musculus (Mouse) SS
P05480 Src Proto-oncogene tyrosine-protein kinase Src Mus musculus (Mouse) EV
P06240 Lck Proto-oncogene tyrosine-protein kinase LCK Mus musculus (Mouse) SS
P16277 Blk Tyrosine-protein kinase Blk Mus musculus (Mouse) SS
P08103 Hck Tyrosine-protein kinase HCK Mus musculus (Mouse) SS
Q04736 Yes1 Tyrosine-protein kinase Yes Mus musculus (Mouse) SS
Q922K9 Frk Tyrosine-protein kinase FRK Mus musculus (Mouse) SS
Q03526 Itk Tyrosine-protein kinase ITK/TSK Mus musculus (Mouse) SS
P35991 Btk Tyrosine-protein kinase BTK Mus musculus (Mouse) EV
P24604 Tec Tyrosine-protein kinase Tec Mus musculus (Mouse) SS
P41242 Matk Megakaryocyte-associated tyrosine-protein kinase Mus musculus (Mouse) SS
P41241 Csk Tyrosine-protein kinase CSK Mus musculus (Mouse) EV
Q9QVP9 Ptk2b Protein-tyrosine kinase 2-beta Mus musculus (Mouse) PR
P34152 Ptk2 Focal adhesion kinase 1 Mus musculus (Mouse) SS
O54967 Tnk2 Activated CDC42 kinase 1 Mus musculus (Mouse) SS
P70451 Fer Tyrosine-protein kinase Fer Mus musculus (Mouse) PR
Q6J9G1 Styk1 Tyrosine-protein kinase STYK1 Mus musculus (Mouse) PR
P00520 Abl1 Tyrosine-protein kinase ABL1 Mus musculus (Mouse) EV
Q62270 Srms Tyrosine-protein kinase Srms Mus musculus (Mouse) SS
Q4JIM5 Abl2 Tyrosine-protein kinase ABL2 Mus musculus (Mouse) SS
Q5U2X5 Tnk2 Activated CDC42 kinase 1 Rattus norvegicus (Rat) SS
P70600 Ptk2b Protein-tyrosine kinase 2-beta Rattus norvegicus (Rat) PR
Q95YD4 kin-32 Inactive tyrosine-protein kinase kin-32 Caenorhabditis elegans PR
10 20 30 40 50 60
MLPEASSLWL LRLLRDVQLA QFYRPILEEL NVTRPEHFDF VRPEDLDNIG MGRPAQRRLN
70 80 90 100 110 120
EALKRYRSGV KSKNWVYKIL GGFAPEQKEI PPRSDSPLCF HEPEGGLKCL IPEGAVRRGE
130 140 150 160 170 180
LLGSGCFGVV HRGLWTLPSG QSIPVAVKSL RVGPEGPMGT ELGDFLREVS VMMKLEHPHV
190 200 210 220 230 240
LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLPVA LLCLFLRQLA GAMAYLGSCG
250 260 270 280 290 300
LVHRDLATRN LLLASPRMIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRQGAF
310 320 330 340 350 360
SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEKDR ARLPKPPLCS RALYSLALRC
370 380 390 400 410 420
WAPHPADRPS FSNLEGLLQE AWLSEGRCVR EVTEPGALRM EPGDPITIIE GSLDTATWKG
430 440 450 460 470 480
QNGRTLKVGN FPASAVTLAD LGGSPVTHPA HRGSPAHGEK CRGGTDGDRE KATLQDLPPA
490 500 510 520 530 540
RSHRTKMPLQ RMRGISKSLE SVLSLGPRPT GGGSSPPELR RTRAMPQRLP DLPPRPPDLP
550 560 570 580 590 600
PRPPIICNSS QPTQPHKARP KRESSHNHRT GAPGASKATV PSGGPLSDPE WQRKVVEVEL
610 620 630 640 650 660
SVHGVTYQEC QVALRTTGGD VASAIRNLKV DQLFHLSNRS RADCRRILEH HQWDLSAASR
YILARS