Q99MJ9
PR
Gene name |
Ddx50 |
Protein name |
ATP-dependent RNA helicase DDX50 |
Names |
DEAD box protein 50, Gu-beta, Nucleolar protein Gu2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:94213 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99MJ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99MJ9-F1 | Predicted | AlphaFoldDB |
20 variants for Q99MJ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389102382 | 77 | G>V | No | EVA | |
| rs3389099197 | 78 | L>V | No | EVA | |
| rs3401501630 | 98 | G>DL* | No | EVA | |
| rs3389114775 | 148 | L>H | No | EVA | |
| rs3389102536 | 154 | V>I | No | EVA | |
| rs3401387642 | 328 | Q>L | No | EVA | |
| rs3400608984 | 335 | K>E | No | EVA | |
| rs3389099198 | 458 | I>N | No | EVA | |
| rs3389102762 | 460 | S>T | No | EVA | |
| rs3389114763 | 490 | Q>L | No | EVA | |
| rs3389091106 | 500 | V>L | No | EVA | |
| rs3389102740 | 504 | A>S | No | EVA | |
| rs3389046425 | 556 | V>M | No | EVA | |
| rs3389099248 | 656 | A>G | No | EVA | |
| rs3389046406 | 675 | Q>E | No | EVA | |
| rs3401288271 | 685 | G>D | No | EVA | |
| rs3401387617 | 687 | S>P | No | EVA | |
| rs3401121729 | 688 | G>E | No | EVA | |
| rs3400607478 | 690 | S>P | No | EVA | |
| rs3389069907 | 694 | S>T | No | EVA |
No associated diseases with Q99MJ9
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2NL08 | DDX55 | ATP-dependent RNA helicase DDX55 | Bos taurus (Bovine) | PR |
| P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | Homo sapiens (Human) | PR |
| Q8NHQ9 | DDX55 | ATP-dependent RNA helicase DDX55 | Homo sapiens (Human) | PR |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q61655 | Ddx19a | ATP-dependent RNA helicase DDX19A | Mus musculus (Mouse) | SS |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| Q5QMN3 | Os01g0197200 | DEAD-box ATP-dependent RNA helicase 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N7W4 | Os01g0911100 | DEAD-box ATP-dependent RNA helicase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q0E2Z7 | Os02g0201900 | DEAD-box ATP-dependent RNA helicase 41 | Oryza sativa subsp japonica (Rice) | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGKLLWGDI | MELEAPLEES | ESQRKERQKS | DRRKSRHHSE | SEERTETREN | GVTDDLDAPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PKKAKMREKL | NGDTKEGLRF | SDEFSPSHKS | RRKDLPNGDV | DEYEKRSKRV | SSSENSHKSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DKAEETLTRE | QKEGAFSNFS | ISEETIKLLK | GRGVTYLFPI | QVKTFGPVYE | GKDLIAQART |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTGKTFSFAI | PLIERLQRNQ | ETIKKSRSPK | VLVLAPTREL | ANQVAKDFKD | ITRKLSVACF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YGGTSYQSQI | NQIRNGIDIL | VGTPGRIKDH | LQSGRLDLSK | LRHVVLDEVD | QMLDLGFAEQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEDIIHESYK | TDSEDNPQTL | LFSATCPQWV | YKVAKKYMKS | RYEQVDLVGK | MTQKAATTVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HLAIQCHWSQ | RPAVIGDVLQ | VYSGSEGRAI | IFCETKKNVT | EMAMNPHIKQ | NAQCLHGDIA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QSQREITLKG | FREGSFKVLV | ATNVAARGLD | IPEVDLVIQS | SPPQDVESYI | HRSGRTGRAG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RTGICVCFYQ | PRERGQLRYV | EQKAGITFKR | VGVPSTMDLV | KSKSMDAIRS | LASVSYAAVD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FFRPSAQRLI | EEKGAVDALA | AALAHISGAS | SFEPRSLITS | DKGFVTMTLE | SPEEIQDVSC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AWKELNRKLS | SNAVSHVTRM | CLLKGNMGVC | FDVPTSESER | LQAEWHDSDW | ILSVPAKLPE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IEEYYDGNTS | SNPRQRSGWS | GGRSGRSGRS | GGRSGGRSGR | QSRQGSRSGS | RQDGRRRSGN |
| 730 | |||||
| RNRSRSGGHK | RNFD |