Q99LU0
PR
Gene name |
Chmp1b1 (Chmp1b) |
Protein name |
Charged multivesicular body protein 1b-1 |
Names |
Chromatin-modifying protein 1b-1, CHMP1b-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67064 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99LU0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99LU0-F1 | Predicted | AlphaFoldDB |
4 variants for Q99LU0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389524420 | 54 | N>I | No | EVA | |
| rs3389507835 | 137 | S>C | No | EVA | |
| rs3389508168 | 168 | L>V | No | EVA | |
| rs3389516143 | 171 | G>D | No | EVA |
No associated diseases with Q99LU0
No regional properties for Q99LU0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q99LU0 | |||
Functions
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| amphisome membrane | Any membrane that is part of an amphisome. |
| autophagosome membrane | The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| ESCRT III complex | A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission). |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| kinetochore microtubule | Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| membrane coat | Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| multivesicular body | A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| multivesicular body membrane | The lipid bilayer surrounding a multivesicular body. |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| MIT domain binding | Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. |
| protein domain specific binding | Binding to a specific domain of a protein. |
24 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome maturation | Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| endosome transport via multivesicular body sorting pathway | The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. |
| establishment of protein localization | The directed movement of a protein to a specific location. |
| late endosome to lysosome transport | The directed movement of substances from late endosome to lysosome. |
| late endosome to vacuole transport | The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. |
| membrane fission | A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. |
| midbody abscission | The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells. |
| mitotic metaphase plate congression | The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. |
| multivesicular body assembly | The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| multivesicular body sorting pathway | A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. |
| multivesicular body-lysosome fusion | The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. |
| negative regulation of cell death | Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. |
| nuclear membrane reassembly | The reformation of the nuclear membranes following their breakdown in the context of a normal process. |
| nucleus organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. |
| plasma membrane repair | The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of centrosome duplication | Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
| regulation of mitotic spindle assembly | Any process that modulates the frequency, rate or extent of mitotic spindle assembly. |
| ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. |
| vesicle fusion with vacuole | The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. |
| viral budding from plasma membrane | A viral budding that starts with formation of a membrane curvature in the host plasma membrane. |
| viral budding via host ESCRT complex | Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E994 | CHMP1B | Charged multivesicular body protein 1b | Bos taurus (Bovine) | PR |
| Q5ZKX1 | CHMP1B | Charged multivesicular body protein 1b | Gallus gallus (Chicken) | PR |
| Q7LBR1 | CHMP1B | Charged multivesicular body protein 1b | Homo sapiens (Human) | PR |
| Q9CQD4 | Chmp1b2 | Charged multivesicular body protein 1b-2 | Mus musculus (Mouse) | PR |
| Q9CQ10 | Chmp3 | Charged multivesicular body protein 3 | Mus musculus (Mouse) | SS |
| Q9DB34 | Chmp2a | Charged multivesicular body protein 2a | Mus musculus (Mouse) | SS |
| Q84VG1 | CHMP1 | ESCRT-related protein CHMP1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SSM4 | CHMP1B | ESCRT-related protein CHMP1B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LE58 | CHMP1A | ESCRT-related protein CHMP1A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6DF27 | chmp1b | Charged multivesicular body protein 1b | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZVB1 | chmp1b | Charged multivesicular body protein 1b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNMEKHLFN | LKFAAKELNR | SSKKCDKEEK | AEKAKIKKAI | QKGNMEVARI | HAENAIRQKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QGVNFLRMSA | RVDAVAARVQ | TAVTMGKVTK | SMAGVVKSMD | ATLKSMNLEK | ISALMDKFEH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QFETLDVQTQ | QMEDTMSSTT | TLTTPQNQVD | MLLQEMADEA | GLDLNMELPQ | GQTGSVGTSV |
| 190 | |||||
| ASAEQDELSQ | RLARLRDQV |