Q99KH8
Gene name |
Stk24 (Mst3, Stk3) |
Protein name |
Serine/threonine-protein kinase 24 |
Names |
Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:223255 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
161-184 (Activation loop from InterPro)
Target domain |
24-274 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q99KH8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99KH8-F1 | Predicted | AlphaFoldDB |
18 variants for Q99KH8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3406051837 | 15 | N>S | No | EVA | |
| rs3389347596 | 28 | E>* | No | EVA | |
| rs3389320078 | 121 | I>N | No | EVA | |
| rs3389359529 | 144 | D>G | No | EVA | |
| rs3389339307 | 155 | H>N | No | EVA | |
| rs3389311705 | 167 | G>S | No | EVA | |
| rs3389359533 | 175 | K>E | No | EVA | |
| rs3389359607 | 199 | K>N | No | EVA | |
| rs3389345675 | 199 | K>R | No | EVA | |
| rs3389271551 | 206 | G>D | No | EVA | |
| rs3389344054 | 218 | P>S | No | EVA | |
| rs3389350230 | 244 | S>I | No | EVA | |
| rs3389300971 | 259 | P>H | No | EVA | |
| rs3389344014 | 340 | G>R | No | EVA | |
| rs3389347605 | 362 | Q>H | No | EVA | |
| rs3389347553 | 368 | I>F | No | EVA | |
| rs50362944 | 373 | A>V | No | EVA | |
| rs3389320038 | 377 | E>K | No | EVA |
No associated diseases with Q99KH8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. |
| execution phase of apoptosis | A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| intrinsic apoptotic signaling pathway in response to oxidative stress | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| positive regulation of axon regeneration | Any process that activates, maintains or increases the rate of axon regeneration. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of axon regeneration | Any process that modulates the frequency, rate or extent of axon regeneration. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWY6 | STK25 | Serine/threonine-protein kinase 25 | Bos taurus (Bovine) | PR |
| Q5E9L6 | STK4 | Serine/threonine-protein kinase 4 | Bos taurus (Bovine) | SS |
| P41279 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (Human) | EV |
| Q9P289 | STK26 | Serine/threonine-protein kinase 26 | Homo sapiens (Human) | PR |
| O00506 | STK25 | Serine/threonine-protein kinase 25 | Homo sapiens (Human) | PR |
| Q9Y6E0 | STK24 | Serine/threonine-protein kinase 24 | Homo sapiens (Human) | PR |
| Q13188 | STK3 | Serine/threonine-protein kinase 3 | Homo sapiens (Human) | SS |
| Q13043 | STK4 | Serine/threonine-protein kinase 4 | Homo sapiens (Human) | EV |
| Q07174 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Mus musculus (Mouse) | SS |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| O54988 | Slk | STE20-like serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| O55098 | Stk10 | Serine/threonine-protein kinase 10 | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| P70218 | Map4k1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q8BPM2 | Map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Mus musculus (Mouse) | PR |
| Q63562 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Rattus norvegicus (Rat) | SS |
| B0LT89 | Stk24 | Serine/threonine-protein kinase 24 | Rattus norvegicus (Rat) | PR |
| H2L099 | gck-1 | Germinal center kinase 1 | Caenorhabditis elegans | PR |
| Q9NB31 | cst-1 | Serine/threonine-protein kinase cst-1 | Caenorhabditis elegans | PR |
| Q6P3Q4 | stk4 | Serine/threonine-protein kinase 4 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7ZUQ3 | stk3 | Serine/threonine-protein kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHSPVQSGL | PGMQNLKADP | EELFTKLEKI | GKGSFGEVFK | GIDNRTQKVV | AIKIIDLEEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDEIEDIQQE | ITVLSQCDSP | YVTKYYGSYL | KDTKLWIIME | YLGGGSALDL | LEPGPLDEIQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IATILREILK | GLDYLHSEKK | IHRDIKAANV | LLSEHGEVKL | ADFGVAGQLT | DTQIKRNTFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTPFWMAPEV | IKQSAYDSKA | DIWSLGITAI | ELAKGEPPHS | ELHPMKVLFL | IPKNNPPTLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNYSKPLKEF | VEACLNKEPS | FRPTAKELLK | HKFIIRNAKK | TSYLTELIDR | YKRWKAEQSH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EDSSSEDSDV | ETDGQASGGS | DSGDWIFTIR | EKDPKNLENG | TLQLSDLERN | KMKDIPKRPF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQCLSTIISP | LFAELKEKSQ | ACGGNLGSIE | ELRGAIYLAE | EACPGISDTM | VAQLVQRLQR |
| 430 | |||||
| YSLSGGGASA | H |