Q99KF0

PR
Gene name
Card14 (Bimp2)
Protein name
Caspase recruitment domain-containing protein 14
Names
Bcl10-interacting MAGUK protein 2, Bimp2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:170720
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

241-315 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99KF0

Entry ID Method Resolution Chain Position Source
AF-Q99KF0-F1 Predicted AlphaFoldDB

58 variants for Q99KF0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389211842 136 Q>H No EVA
rs3389192475 170 L>Q No EVA
rs3389231379 193 K>T No EVA
rs3389227781 198 M>K No EVA
rs3389227794 206 S>R No EVA
rs3389231457 216 A>V No EVA
rs230388027 217 T>I No EVA
rs3389227728 217 T>S No EVA
rs3389220135 234 Q>H No EVA
rs3389211832 251 L>M No EVA
rs226429103 260 Q>E No EVA
rs3389158072 321 Q>H No EVA
rs3389238529 332 Q>K No EVA
rs3389223474 372 Q>H No EVA
rs3402943188 396 V>L No EVA
rs3389227779 403 L>Q No EVA
rs3389220104 421 R>M No EVA
rs3401608478 426 R>P No EVA
rs3402989048 427 G>R No EVA
rs3389223460 436 A>D No EVA
rs3402852599 456 W>* No EVA
rs219301895 456 W>R No EVA
rs3402878677 464 S>N No EVA
rs3402624680 467 Q>L No EVA
rs3389192483 531 L>P No EVA
rs3389196588 537 S>C No EVA
rs45732555 549 E>K No EVA
rs27045776 570 A>V No EVA
rs3389226253 574 D>G No EVA
rs3389217595 588 T>I No EVA
rs3389223452 596 T>I No EVA
rs3402624719 616 D>G No EVA
rs3389227741 620 T>I No EVA
rs3389221469 663 Q>* No EVA
rs3389221469 663 Q>K No EVA
rs3389221500 673 G>W No EVA
rs236897544 686 R>K No EVA
rs3389192493 724 K>I No EVA
rs3389220083 730 T>I No EVA
rs3402223537 751 R>W No EVA
rs251475914 762 P>S No EVA
rs3389226209 768 I>T No EVA
rs3389238581 787 Q>L No EVA
rs3389220155 801 F>I No EVA
rs3389220085 803 S>L No EVA
rs1135307932 859 E>K No EVA
rs3389226186 878 D>N No EVA
rs3389227701 886 A>D No EVA
rs3389223127 886 A>T No EVA
rs3389196603 903 L>Q No EVA
rs3389192487 912 M>T No EVA
rs3389238589 948 V>L No EVA
rs3389238586 965 S>N No EVA
rs3402460261 980 C>* No EVA
rs3389223115 986 A>V No EVA
rs3389231421 994 W>* No EVA
rs3389238528 995 T>I No EVA
rs3389223117 998 P>T No EVA

No associated diseases with Q99KF0

1 regional properties for Q99KF0

Type Name Position InterPro Accession
domain ZipA, C-terminal FtsZ-binding domain 216 - 346 IPR007449

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
aggresome An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
CARD domain binding Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.

5 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
tumor necrosis factor-mediated signaling pathway The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
Q9BXL7 CARD11 Caspase recruitment domain-containing protein 11 Homo sapiens (Human) EV
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q811D0 Dlg1 Disks large homolog 1 Mus musculus (Mouse) SS
P70175 Dlg3 Disks large homolog 3 Mus musculus (Mouse) SS
Q91XM9 Dlg2 Disks large homolog 2 Mus musculus (Mouse) SS
Q8CIS0 Card11 Caspase recruitment domain-containing protein 11 Mus musculus (Mouse) SS
A2AIV8 Card9 Caspase recruitment domain-containing protein 9 Mus musculus (Mouse) EV
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH5 dlg1l Discs large homolog 1-like protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAELCRMDST LTALDEEMLW DMLESHRCRI VQSICPSRLT PYLRQAKVLG QLDEEEILHS
70 80 90 100 110 120
SRFTNSAMRV GHLLDLLKAR GKNGAIAFLE SLKFHNPDVY TLVTGLQSDI DFSTFSGLME
130 140 150 160 170 180
TSKLTECLAG AISSLQEELA QEKAQKEVLL RRCQQLKERL GLAEAHAEGL RQLEVDHSRM
190 200 210 220 230 240
KREVSTHFHE VLKLKDEMLN LSLHYSNALR EKELAATRCH SLQEELYLVK QELQRASLVS
250 260 270 280 290 300
SCERESRERS LKMASNLEPQ GEELNRLKEE NEKLRSMTFS LVEKDILEQS LDEARESKQE
310 320 330 340 350 360
LVDRIHSLRE RAVAAERQQK QYWEEKEQTL LQFRKTQVDC ELYKEKMTML QGQVAELQKE
370 380 390 400 410 420
RDQAYTARDR AQMEISQRLV EKDALRRRVF ELTEQVCELR TQLRRLQAEA PGGPKQEAGA
430 440 450 460 470 480
RELCLRGKQR LVRMHAVCPP DDSDCSLLSS TESRLWWDLN STSSREQMDS FRSSSPMPPS
490 500 510 520 530 540
QQSLYKRVAE DFLEDPESLS FPEVLEMRLQ GATVDDTDTD LEFEMIDGAD LSQTEDSLQG
550 560 570 580 590 600
SSRSLNVSES SVPVRRRPAR KILSQVTVLA FQGDALLEQI GVIGGNLTGI FIHRVTPGSA
610 620 630 640 650 660
ADEMALRPGT QIMMVDYKPT KPSLRATLEN TTLEQAVGLL RRVNGSCYLS VKINTEGYKN
670 680 690 700 710 720
LIQDLDAKVV TSGDSFYIRV NLAMQRGGDG ELQTHCNDIL HVTDTMFQGR SCWHAHHVNP
730 740 750 760 770 780
YTMKDMEPGT IPNYSQAQQQ LLALIQDMTQ RCTVPRKPPG GPQKLVRIVS VDKAAVSPLT
790 800 810 820 830 840
SSFDQSQWDS GKEEGGPSVC FWSESCFTLA PYTLVHPHRP ARPRPVLFVP RLVGRILGKK
850 860 870 880 890 900
LCLLQGFKQC SAEYLSQEEY ATWSQRGDII QEGESIGDHH WITRHAVESL MNMSTHALLD
910 920 930 940 950 960
VRLDSVRVLH RMDMFPIIIH VSVNEKTAKK LRKGLHRLGS SEEQFLEVAR QEEGELDRVP
970 980 990
CLYSSLAPDS WSDLDSLLSC VRLAIADEQK KVVWTESPC