Q99JZ0

SS
Gene name
Sdcbp2
Protein name
Syntenin-2
Names
Syndecan-binding protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:228765
EC number
Protein Class

Descriptions

SDCBP (Syntenin-1) is a multifunctional adapter protein that regulates TGFB1-mediated SMAD2/3 activation, TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. The 100 amino acid long N-terminal domain (NTD) works as an autoinhibitory region, which restricts the membrane targeting by flanking to PDZ tandem. The deletion of the first 102 amino acids confers a strong plasma membrane enrichment. The region between amino acids 56 and 59 is highly conserved among systenin-1 proteins. In particular, phosphorylation of Tyr56 may regulate the plasma membrane binding of syntenin-1 by modulating the interaction strength between the internal peptide stretch and PDZ1-PDZ2.

Autoinhibitory domains (AIDs)

2-96 (N-terminal domain) SS

Target domain

97-269 (PDZ tandem)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99JZ0

Entry ID Method Resolution Chain Position Source
AF-Q99JZ0-F1 Predicted AlphaFoldDB

21 variants for Q99JZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3540816438 15 Q>R No EVA
rs264397646 26 T>M No EVA
rs27387956 29 T>I No EVA
rs3388603241 31 P>T No EVA
rs3540816535 34 M>K No EVA
rs3388597782 70 I>F No EVA
rs27387943 73 S>G No EVA
rs3540816319 83 P>L No EVA
rs3388590771 93 N>I No EVA
rs3388594866 111 L>M No EVA
rs3388597103 118 K>* No EVA
rs3388600906 136 Q>E No EVA
rs3388592371 142 S>T No EVA
rs3388594825 143 L>H No EVA
rs3388597106 150 D>N No EVA
rs3388597684 154 Q>L No EVA
rs246797381 171 V>A No EVA
rs229353726 184 I>V No EVA
rs3388597805 247 K>M No EVA
rs3388601432 261 L>P No EVA
rs3388590669 275 R>S No EVA

No associated diseases with Q99JZ0

2 regional properties for Q99JZ0

Type Name Position InterPro Accession
domain PDZ domain 108 - 188 IPR001478-1
domain PDZ domain 191 - 267 IPR001478-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Cell membrane
  • Nucleus speckle
  • Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments
  • Colocalizes with TM4SF1 in the apical region of the cell
  • Predominantly targeted to nuclear PIP2 pools
  • Shuttles between several subcellular compartments
  • PIP2 plays an important role in the distribution of SDCBP2
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.

1 GO annotations of biological process

Name Definition
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H190 SDCBP2 Syntenin-2 Homo sapiens (Human) SS
O00560 SDCBP Syntenin-1 Homo sapiens (Human) EV
B2RUJ5 Apba1 Amyloid-beta A4 precursor protein-binding family A member 1 Mus musculus (Mouse) SS
P98084 Apba2 Amyloid-beta A4 precursor protein-binding family A member 2 Mus musculus (Mouse) SS
O08992 Sdcbp Syntenin-1 Mus musculus (Mouse) SS
Q4KLN0 Sdcbp2 Syntenin-2 Rattus norvegicus (Rat) SS
Q9JI92 Sdcbp Syntenin-1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSVLYPSLED LKVGQVIQAQ GRASPTMPTL PAPMASAPPL SELYPNLAEL ESYMGLSLSS
70 80 90 100 110 120
QEVQKNLTQI PDSDNMVVTS PGPGQVVAPV SGNNLGILRA EIKPGVREIH LCKDERGKTG
130 140 150 160 170 180
LRLQAVDKGL FVQLVQANTP ASLVGLRFGD QILQIDGCDC AGWNTHKAHK VLKKASAEKI
190 200 210 220 230 240
VMVIRDRPFQ RTVTMHKDSS GQVGFSIKKG KIVSVVKGSS AARNGLLTNH YVCEVNGQNV
250 260 270 280 290
IGLKDKKVTE ILTTAGDVIT LTIIPTVIYE HMIKRLSPLL LHHTMDHSIP DT