Q99JP0

SS
Gene name
Map4k3
Protein name
Mitogen-activated protein kinase kinase kinase kinase 3
Names
EC 2.7.11.1 , Germinal center kinase-related protein kinase , GLK , MAPK/ERK kinase kinase kinase 3 , MEK kinase kinase 3 , MEKKK 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:225028
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

524-753 (Leucine-rich domains) SS

Target domain

16-273 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

153-176 (Activation loop from InterPro)

Target domain

16-273 (Protein kinase domain)

Relief mechanism

Assay

153-176 (Activation loop from InterPro)

Target domain

16-273 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q99JP0

Entry ID Method Resolution Chain Position Source
AF-Q99JP0-F1 Predicted AlphaFoldDB

36 variants for Q99JP0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389485267 37 N>I No EVA
rs3389393927 43 A>S No EVA
rs3411385481 52 G>R No EVA
rs3408113477 233 P>T No EVA
rs3389429917 239 K>R No EVA
rs3389494785 266 K>R No EVA
rs3389429929 340 P>S No EVA
rs3389483146 383 H>Q No EVA
rs3389478605 393 K>R No EVA
rs3389482149 394 S>G No EVA
rs3389440101 424 H>D No EVA
rs3389482138 499 Q>L No EVA
rs3389440073 521 S>P No EVA
rs3389462115 526 K>N No EVA
rs50571501 528 V>I No EVA
rs3389485255 534 N>S No EVA
rs3389440108 540 P>H No EVA
rs3389494834 552 F>L No EVA
rs3389489704 567 N>H No EVA
rs3389482977 660 F>I No EVA
rs3389498929 668 E>A No EVA
rs3389482060 669 T>I No EVA
rs3389429931 687 Y>* No EVA
rs3389489679 701 W>R No EVA
rs3389477321 705 M>T No EVA
rs3389392386 711 I>V No EVA
rs3389482077 723 R>W No EVA
rs3389462133 744 R>I No EVA
rs3389448524 750 Q>* No EVA
rs3389429960 764 S>P No EVA
rs3389482925 781 Q>H No EVA
rs3389482075 803 R>G No EVA
rs3389482075 803 R>W No EVA
rs3389429989 828 D>N No EVA
rs3389482113 839 Q>* No EVA
rs3389494806 859 F>Y No EVA

No associated diseases with Q99JP0

3 regional properties for Q99JP0

Type Name Position InterPro Accession
domain Protein kinase domain 16 - 273 IPR000719
domain Citron homology (CNH) domain 556 - 874 IPR001180
binding_site Protein kinase, ATP binding site 22 - 45 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens (Human) PR
Q12851 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens (Human) EV
Q92918 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens (Human) EV
Q8IVH8 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens (Human) SS
P70218 Map4k1 Mitogen-activated protein kinase kinase kinase kinase 1 Mus musculus (Mouse) PR
Q61161 Map4k2 Mitogen-activated protein kinase kinase kinase kinase 2 Mus musculus (Mouse) SS
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
Q6P9R2 Oxsr1 Serine/threonine-protein kinase OSR1 Mus musculus (Mouse) PR
Q9Z1W9 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus (Mouse) PR
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q8BPM2 Map4k5 Mitogen-activated protein kinase kinase kinase kinase 5 Mus musculus (Mouse) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ
70 80 90 100 110 120
EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET
130 140 150 160 170 180
LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP
190 200 210 220 230 240
EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKL
250 260 270 280 290 300
KWSNSFHHFV KMALTKNPKK RPNAEKLLQH PFVTQPLTRS LAIELLDKVN NPDHSTYHDF
310 320 330 340 350 360
DDDDPEPLVA VPHRIPSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH ELPDSDGFFD
370 380 390 400 410 420
SSEEIYYTAR SNLDLQLEYG QGHQSHCFLG GNKSLLKSVE EELHQRGHVA HLEDDEGDDD
430 440 450 460 470 480
DSKHSTMKAK VPPPLPPKPK SIFIPQDTHS AEDGNQGTIK RCPSSGSPAK PSHVPPRPPP
490 500 510 520 530 540
PRLPPQKPAV LGNGVNSFQL NGERDGSLYQ QQSEQRGTNL SRKEKKDVPK PISNGLPPTP
550 560 570 580 590 600
KVHMGACFSK VFNGCPLKIH CATSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF
610 620 630 640 650 660
PRRCTWLYVM NNCLLSVSGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK LPDRILPRKF
670 680 690 700 710 720
AVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALQTSIVLLE WVEPMQKFML IKHIEFPMPC
730 740 750 760 770 780
PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ VVRFETVNPN STSSWFTESD APQTSVTHVT
790 800 810 820 830 840
QLERDTILVC LDCCIKIVNL QGRLKSSRKL SSELTFDFQI ESIVCLQDSV LAFWKHGMQG
850 860 870 880 890
RSFRSNEVTQ EISDNTRIFR LLGSDRVVVL ESRPTDNPTA NSNLYILAGH ENSY