AiPD: Autoinhibited Protein Database

Q99801

Gene name	NKX3-1
Protein name	Homeobox protein Nkx-3.1
Names	Homeobox protein NK-3 homolog A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4824
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-144 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

8-144 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q99801

Entry ID	Method	Resolution	Chain	Position	Source
2L9R	NMR	-	A	132-189	PDB
AF-Q99801-F1	Predicted				AlphaFoldDB

240 variants for Q99801

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs768668734 CA4677923	3	R>G		No	ClinGen ExAC TOPMed gnomAD
CA370605386 rs1267660944	3	R>S		No	ClinGen gnomAD
rs577623101 CA174001635	4	V>I		No	ClinGen 1000Genomes TOPMed
CA370605374 rs1285897954	5	P>L		No	ClinGen TOPMed
CA370605364 rs1326340072	7	P>A		No	ClinGen TOPMed gnomAD
CA370605360 rs1261836549	7	P>L		No	ClinGen gnomAD
rs1326340072 CA370605363	7	P>S		No	ClinGen TOPMed gnomAD
CA370605365 rs1326340072	7	P>T		No	ClinGen TOPMed gnomAD
CA4677921 rs775772672	8	R>P		No	ClinGen ExAC gnomAD
CA370605352 rs1297199959	9	P>L		No	ClinGen gnomAD
rs745651520 CA4677919	10	G>A		No	ClinGen ExAC gnomAD
CA4677920 CA370605349 rs199879315	10	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA370605344 rs1454142087	11	E>Q		No	ClinGen gnomAD
CA370605322 rs1462253726	14	A>P		No	ClinGen TOPMed gnomAD
CA370605320 rs1374642281	14	A>V		No	ClinGen TOPMed gnomAD
CA370605310 rs1427001113	15	E>D		No	ClinGen gnomAD
rs1247467088 CA370605307	16	G>R		No	ClinGen gnomAD
CA4677914 rs57111114	17	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4677913 rs752189119	18	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1332416473 CA370605274	22	P>A		No	ClinGen TOPMed
CA4677912 rs780877207	22	P>L		No	ClinGen ExAC TOPMed gnomAD
CA370605272 rs780877207	22	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1308934846 CA370605268	23	S>P		No	ClinGen TOPMed
rs1563298304 CA370605252	25	P>Q		No	ClinGen Ensembl
rs962693280 CA174001574	25	P>S		No	ClinGen TOPMed gnomAD
CA4677910 rs751259434	27	T>A		No	ClinGen ExAC gnomAD
CA4677908 rs375526684	27	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375526684 CA4677909	27	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4677905 rs760710802	30	L>F		No	ClinGen ExAC gnomAD
CA370605225 rs1398321563	30	L>R		No	ClinGen gnomAD
rs760710802 CA4677906	30	L>V		No	ClinGen ExAC gnomAD
rs998940798 CA174001557	33	D>H		No	ClinGen Ensembl
rs767654937 CA4677903	36	R>P		No	ClinGen ExAC gnomAD
rs1023751485 CA174001555	36	R>W		No	ClinGen TOPMed
CA4677902 rs759635441	37	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs371246224 CA4677901	38	G>D		No	ClinGen ESP ExAC gnomAD
CA370605171 rs1438951952	39	A>E		No	ClinGen gnomAD
rs770792266 CA4677900	39	A>T		No	ClinGen ExAC TOPMed gnomAD
rs556114777 CA4677899	40	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA370605168 rs1194399427	40	Q>P		No	ClinGen gnomAD
CA370605163 rs1585244174	41	R>G		No	ClinGen Ensembl
rs769902120 CA4677897	41	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769902120 CA4677898	41	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4677895 rs780531112	42	Q>*		No	ClinGen ExAC gnomAD
CA174001528 rs889105602	43	G>C		No	ClinGen TOPMed
CA4677894 rs754523359	43	G>D		No	ClinGen ExAC TOPMed gnomAD
rs746588963 CA370605145	44	G>A		No	ClinGen ExAC gnomAD
CA4677893 rs746588963	44	G>D		No	ClinGen ExAC gnomAD
rs1465585673 CA370605148	44	G>S		No	ClinGen TOPMed
rs377326314 CA4677892	45	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA370605142 rs1337410944	45	R>H		No	ClinGen gnomAD
rs377326314 CA370605144	45	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4677891 rs757610599	46	T>M		No	ClinGen ExAC
CA4677887 rs753277029	47	S>N		No	ClinGen ExAC gnomAD
rs1365972378 CA370605122	48	S>I		No	ClinGen gnomAD
rs767428389 CA4677886	48	S>R		No	ClinGen ExAC gnomAD
CA370605118 rs1426862155	49	Q>*		No	ClinGen gnomAD
CA4677884 rs2228013 VAR_011612	52	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs566595925 CA4677883	53	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766749717 CA4677882	54	P>A		No	ClinGen ExAC gnomAD
rs762820297 CA4677881	54	P>R		No	ClinGen ExAC gnomAD
CA370605074 rs1585244121	55	E>D		No	ClinGen Ensembl
CA4677880 rs747972625 COSM140603	56	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4677879 rs747972625	56	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs747972625 CA4677878	56	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1270136920 CA370605066	57	E>A		No	ClinGen gnomAD
rs1290540018 CA370605065	57	E>D		No	ClinGen gnomAD
CA174001481 rs1036449900	57	E>Q		No	ClinGen Ensembl
rs940861134 CA174001478	58	P>L		No	ClinGen TOPMed gnomAD
rs1259390468 CA370605051	59	E>D		No	ClinGen TOPMed
CA174001473 rs908335165	60	P>A		No	ClinGen TOPMed
CA370605046 rs1224211749	60	P>L		No	ClinGen gnomAD
CA370605049 rs908335165	60	P>S		No	ClinGen TOPMed
CA4677876 rs776156075	62	P>A		No	ClinGen ExAC TOPMed gnomAD
CA4677875 rs768042328	62	P>L		No	ClinGen ExAC gnomAD
rs746600226 CA4677874	63	E>Q		No	ClinGen ExAC gnomAD
rs900158612 CA174001456	64	G>V		No	ClinGen TOPMed gnomAD
CA370605017 rs1345904782	65	G>E		No	ClinGen TOPMed gnomAD
CA370605014 rs55910090	66	R>C		No	ClinGen gnomAD
rs779646488 CA4677870	66	R>H		No	ClinGen ExAC gnomAD
rs55910090 CA174001453	66	R>S		No	ClinGen gnomAD
CA4677869 rs758091147	69	A>S		No	ClinGen ExAC TOPMed gnomAD
CA370604997 rs758091147	69	A>T		No	ClinGen ExAC TOPMed gnomAD
CA174001443 rs930991062	69	A>V		No	ClinGen gnomAD
CA370604992 CA370604993 rs1323149986	70	G>R		No	ClinGen TOPMed gnomAD
rs1401299939 CA370604988	70	G>V		No	ClinGen gnomAD
rs1323149986 CA370604991	70	G>W		No	ClinGen TOPMed gnomAD
CA4677868 rs745540248	71	A>E		No	ClinGen ExAC gnomAD
CA4677865 rs753086212	74	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1477262365 CA370604940	77	S>R		No	ClinGen gnomAD
rs781751508 CA4677864	78	T>A		No	ClinGen ExAC gnomAD
CA174001428 rs959942038	78	T>I		No	ClinGen TOPMed
CA370604932 rs1193469070	79	G>R		No	ClinGen gnomAD
CA4677863 rs755007639	80	P>S		No	ClinGen ExAC gnomAD
rs751739256 CA4677862	83	A>S		No	ClinGen ExAC gnomAD
CA4677859 rs769698076	84	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4677860 rs551706518	84	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA370604893 rs1328246472	86	E>Q		No	ClinGen gnomAD
CA370604878 rs1280668959	88	E>K		No	ClinGen TOPMed
rs761729474 CA4677856	89	T>A		No	ClinGen ExAC gnomAD
rs1340529539 CA370604869	89	T>K		No	ClinGen TOPMed
CA4677854 rs768675345	91	A>G		No	ClinGen ExAC TOPMed gnomAD
CA4677853 rs760076949	92	E>Q		No	ClinGen ExAC gnomAD
CA370604845 rs1021743701	93	T>N		No	ClinGen gnomAD
CA174001396 rs1021743701	93	T>S		No	ClinGen gnomAD
CA370604839 rs1245843205	94	E>D		No	ClinGen gnomAD
rs1011639520 CA174001390	94	E>K		No	ClinGen TOPMed
rs1011639520 CA370604844	94	E>Q		No	ClinGen TOPMed
rs771598336 CA4677851	94	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1563298044 CA370604836	95	P>S		No	ClinGen Ensembl
rs1369160993 CA370604809	97	R>S		No	ClinGen gnomAD
CA4677830 rs748916888	97	R>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	99	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4677829 rs781581537	99	L>W		No	ClinGen ExAC gnomAD
CA370604791 rs1366871497	100	G>E		No	ClinGen gnomAD
CA174000988 rs952034137	100	G>R		No	ClinGen gnomAD
TCGA novel	102	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4677825 rs758551886	104	L>W		No	ClinGen ExAC TOPMed
CA370604761 rs1408537144	105	D>Y		No	ClinGen gnomAD
CA370604754 rs868781535	106	S>A		No	ClinGen TOPMed gnomAD
CA174000968 rs868781535	106	S>P		No	ClinGen TOPMed gnomAD
rs778976303 CA4677823	107	E>D		No	ClinGen ExAC gnomAD
CA4677824 rs147240965	107	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757448285 CA4677822	108	N>H		No	ClinGen ExAC TOPMed gnomAD
CA370604737 rs1490588087	109	T>P		No	ClinGen gnomAD
rs1490588087 CA370604735	109	T>S		No	ClinGen gnomAD
CA4677820 rs763879828 CA4677821	110	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs752617008 CA4677818	113	L>P		No	ClinGen ExAC gnomAD
rs773863000 CA4677815	114	P>R		No	ClinGen ExAC gnomAD
COSM1456178 rs759016206 CA4677816	114	P>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1012659513 CA174000929	115	R>S		No	ClinGen TOPMed
rs1288173962 CA370604698	116	L>F		No	ClinGen gnomAD
rs1346963831 CA370604684	118	Q>R		No	ClinGen gnomAD
rs765838779 CA4677814	119	T>A		No	ClinGen ExAC gnomAD
CA4677813 rs762601609	119	T>I		No	ClinGen ExAC TOPMed gnomAD
rs765838779 CA370604680	119	T>P		No	ClinGen ExAC gnomAD
rs769053755 CA4677811	120	P>H		No	ClinGen ExAC gnomAD
CA4677809 rs776112993	121	K>Q		No	ClinGen ExAC gnomAD
CA4677808 rs139972728	122	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs569305540 CA4677807	123	P>L		No	ClinGen ExAC gnomAD
CA370604653 rs569305540	123	P>Q		No	ClinGen ExAC gnomAD
TCGA novel	124	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370604638 rs1189758651	125	K>M		No	ClinGen gnomAD
rs757285315 CA4677805	125	K>N		No	ClinGen ExAC gnomAD
rs1189758651 CA370604639	125	K>R		No	ClinGen gnomAD
rs749467152 COSM1217402 CA4677804	126	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs749467152 CA370604635	126	R>G		No	ClinGen ExAC TOPMed gnomAD
CA370604634 rs1215218995	126	R>L		No	ClinGen TOPMed
CA370604626 rs1563297569	127	S>F		No	ClinGen Ensembl
rs777912792 CA4677803	128	R>*		No	ClinGen ExAC TOPMed gnomAD
CA370604625 rs777912792	128	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1484337779 CA370604622	128	R>L		No	ClinGen TOPMed
CA370604619 rs1327642172	129	A>T		No	ClinGen gnomAD
rs1184467711 CA370604616	129	A>V		No	ClinGen TOPMed
CA370604610 rs1585243226	130	A>V		No	ClinGen Ensembl
CA4677799 rs754870999	132	S>F		No	ClinGen ExAC TOPMed gnomAD
CA370604600 rs1314320986	132	S>P		No	ClinGen gnomAD
CA4677800 rs754870999	132	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1361995501 CA370604590	133	H>Q		No	ClinGen gnomAD
CA174000884 rs751458014	137	I>M		No	ClinGen ExAC TOPMed gnomAD
rs765858750 CA4677797	138	E>D		No	ClinGen ExAC gnomAD
CA174000878 rs751677679	138	E>K		No	ClinGen TOPMed
CA370604562 rs751677679	138	E>Q		No	ClinGen TOPMed
CA370604559 rs1156261414	138	E>V		No	ClinGen TOPMed
rs532961866 CA4677795	140	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4677794 rs765024916	145	H>R		No	ClinGen ExAC
rs761102947 CA4677793	146	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA4677792 rs775943527	150	S>L		No	ClinGen ExAC gnomAD
rs1470827773 CA370604476	150	S>P		No	ClinGen gnomAD
CA174000855 rs892777834	151	A>T		No	ClinGen Ensembl
rs1222039563 CA370604466	152	P>A		No	ClinGen TOPMed
rs1222039563 CA370604467	152	P>T		No	ClinGen TOPMed
CA4677789 rs774732037	153	E>Q		No	ClinGen ExAC gnomAD
CA4677788 rs771028824	154	R>G		No	ClinGen ExAC gnomAD
CA370604453 rs749394163	154	R>P		No	ClinGen ExAC gnomAD
CA4677787 rs749394163	154	R>Q		No	ClinGen ExAC gnomAD
rs771028824 CA370604454	154	R>W		No	ClinGen ExAC gnomAD
rs748401390 CA4677784	162	K>E		No	ClinGen ExAC gnomAD
CA4677783 rs780899789	162	K>M		No	ClinGen ExAC gnomAD
rs780899789 CA370604402	162	K>R		No	ClinGen ExAC gnomAD
CA4677781 rs751502850	164	T>M		No	ClinGen ExAC gnomAD
CA370604385 rs1299402721	165	E>*		No	ClinGen gnomAD
rs1363904843 CA370604375	166	T>N		No	ClinGen gnomAD
rs147493253 CA370604365 CA4677778	168	V>L		No	ClinGen ESP ExAC gnomAD
CA4677779 rs147493253	168	V>M		No	ClinGen ESP ExAC gnomAD
COSM240892 CA4677776 rs373263457	177	Y>C	lung Variant assessed as Somatic; 0.0 impact. prostate [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1462337389 CA370604292	178	K>E		No	ClinGen gnomAD
rs138864262 CA4677774	178	K>N		No	ClinGen ESP ExAC gnomAD
TCGA novel	179	T>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370604286 rs1170727985	179	T>A		No	ClinGen gnomAD
TCGA novel	181	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370604268 rs1200957711	181	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	182	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA174000815 rs1040221629	182	K>Q		No	ClinGen Ensembl
CA4677772 rs774915727	184	L>P		No	ClinGen ExAC gnomAD
rs1389698201 CA370604251	184	L>V		No	ClinGen gnomAD
rs1254712780 CA370604238	186	S>L		No	ClinGen TOPMed gnomAD
rs748311757 CA4677767	189	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1585243046 CA370604183	194	H>P		No	ClinGen Ensembl
CA370604169 rs1563297408	196	S>Y		No	ClinGen Ensembl
rs746822077 CA370604156	198	P>L		No	ClinGen ExAC TOPMed gnomAD
CA370604155 rs746822077	198	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA4677764 rs746822077	198	P>R		No	ClinGen ExAC TOPMed gnomAD
rs750401928 CA4677761	199	A>D		No	ClinGen ExAC gnomAD
rs1391702603 CA370604154	199	A>T		No	ClinGen gnomAD
rs112216055 CA174000781	201	K>R		No	ClinGen Ensembl
rs778496540 CA4677760	202	E>K		No	ClinGen ExAC gnomAD
rs1369997445 CA370604120	204	A>S		No	ClinGen gnomAD
CA4677757 rs764325622	207	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs753524833 COSM183459 CA4677758	207	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs192773652 CA4677756	209	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145218166 CA4677755	211	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4677754 rs766788281	212	S>F		No	ClinGen ExAC gnomAD
rs769852677 CA4677751	213	V>L		No	ClinGen ExAC gnomAD
CA4677752 rs769852677	213	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4677750 rs761949631	214	Y>C		No	ClinGen ExAC gnomAD
rs776805818 CA4677749	215	N>D		No	ClinGen ExAC TOPMed gnomAD
CA370604055 rs1352061722	215	N>K		No	ClinGen gnomAD
CA4677748 rs768812820	217	Y>H		No	ClinGen ExAC gnomAD
rs1350059133 CA370604019	220	Y>*		No	ClinGen gnomAD
rs539709206 CA4677747	220	Y>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	221	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4677746 rs775112273	222	Y>C		No	ClinGen ExAC gnomAD
rs372830582 CA4677744	224	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4677741 rs760842941	225	C>*		No	ClinGen ExAC TOPMed gnomAD
CA4677742 rs756820704	225	C>F		No	ClinGen ExAC gnomAD
rs779048659 CA4677743	225	C>S		No	ClinGen ExAC TOPMed gnomAD
CA370603989 rs760842941	225	C>W		No	ClinGen ExAC TOPMed gnomAD
CA370603988 rs1279217950	226	V>M		No	ClinGen gnomAD
rs755672206 CA4677739	227	G>D		No	ClinGen ExAC gnomAD
CA370603982 rs1157351931	227	G>S		No	ClinGen gnomAD
CA4677738 rs752426352	231	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1246873542 CA370603952	231	P>T		No	ClinGen gnomAD
CA4677737 rs766593759	233	F>L		No	ClinGen ExAC TOPMed gnomAD
CA370603940 rs766593759	233	F>V		No	ClinGen ExAC TOPMed gnomAD
rs758854103 CA4677736	234	W>L		No	ClinGen ExAC gnomAD
rs966856597 CA174000715	234	W>R		No	ClinGen Ensembl
rs758854103 CA174000710	234	W>S		No	ClinGen ExAC gnomAD
CA370603924 rs1418450504	235	W>L		No	ClinGen TOPMed
CA370603928 rs1168153334	235	W>Q		No	ClinGen TOPMed

No associated diseases with Q99801

4 regional properties for Q99801

Type	Name	Position	InterPro Accession
domain	Homeobox domain	122 - 186	IPR001356
conserved_site	Homeobox, conserved site	157 - 180	IPR017970
domain	Homeobox domain, metazoa	146 - 157	IPR020479-1
domain	Homeobox domain, metazoa	161 - 180	IPR020479-2

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of DNA damage	A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

15 GO annotations of molecular function

Name	Definition
cysteine-type endopeptidase activator activity involved in apoptotic process	Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
histone deacetylase binding	Binding to histone deacetylase.
MADS box domain binding	Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC
nuclear estrogen receptor binding	Binding to a nuclear estrogen receptor.
nuclear receptor activity	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
nucleic acid binding	Binding to a nucleic acid.
protein self-association	Binding to a domain within the same polypeptide.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
transcription regulator inhibitor activity	A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.

46 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
androgen receptor signaling pathway	The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
branching involved in prostate gland morphogenesis	The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
branching morphogenesis of an epithelial tube	The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
cellular response to interleukin-1	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to steroid hormone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
cellular response to tumor necrosis factor	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
dorsal aorta development	The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
epithelial cell proliferation involved in prostate gland development	The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time.
epithelial cell proliferation involved in salivary gland morphogenesis	The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
metanephros development	The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
negative regulation of cell cycle G1/S phase transition	Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of epithelial cell proliferation	Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of epithelial cell proliferation involved in prostate gland development	Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of insulin-like growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
pharyngeal system development	The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
positive regulation of androgen secretion	Any process that activates or increases the frequency, rate or extent of androgen secretion.
positive regulation of apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
positive regulation of cell death	Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
positive regulation of cell division	Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
positive regulation of DNA-binding transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of intrinsic apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of phosphatidylinositol 3-kinase signaling	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of response to DNA damage stimulus	Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein kinase B signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of protein localization	Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to testosterone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
salivary gland development	The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
somitogenesis	The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q90788	NKX-2.5	Homeobox protein Nkx-2.5	Gallus gallus (Chicken)	PR
P52952	NKX2-5	Homeobox protein Nkx-2.5	Homo sapiens (Human)	PR
P42582	Nkx2-5	Homeobox protein Nkx-2.5	Mus musculus (Mouse)	PR
P97503	Nkx3-2	Homeobox protein Nkx-3.2	Mus musculus (Mouse)	PR
P70397	Dlx6	Homeobox protein DLX-6	Mus musculus (Mouse)	PR
Q9FN29	ATHB-52	Homeobox-leucine zipper protein ATHB-52	Arabidopsis thaliana (Mouse-ear cress)	PR
P46603	HAT9	Homeobox-leucine zipper protein HAT9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M276	ATHB-12	Homeobox-leucine zipper protein ATHB-12	Arabidopsis thaliana (Mouse-ear cress)	PR
Q98875	dlx1a	Homeobox protein Dlx1a	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q98878	dlx4b	Homeobox protein Dlx4b	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MLRVPEPRPG	EAKAEGAAPP	TPSKPLTSFL	IQDILRDGAQ	RQGGRTSSQR	QRDPEPEPEP
70	80	90	100	110	120
EPEGGRSRAG	AQNDQLSTGP	RAAPEEAETL	AETEPERHLG	SYLLDSENTS	GALPRLPQTP
130	140	150	160	170	180
KQPQKRSRAA	FSHTQVIELE	RKFSHQKYLS	APERAHLAKN	LKLTETQVKI	WFQNRRYKTK
190	200	210	220	230
RKQLSSELGD	LEKHSSLPAL	KEEAFSRASL	VSVYNSYPYY	PYLYCVGSWS	PAFW