AiPD: Autoinhibited Protein Database

Q99759

Gene name	MAP3K3 (MAPKKK3, MEKK3)
Protein name	Mitogen-activated protein kinase kinase kinase 3
Names	MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4215
EC number	2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-385 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

91-385 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

506-532 (Activation loop from InterPro)

Target domain	362-622 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for Q99759

Entry ID	Method	Resolution	Chain	Position	Source
2C60	X-ray	125 A	A	37-124	PDB
2JRH	NMR	-	A	42-126	PDB
2O2V	X-ray	183 A	B	37-124	PDB
2PPH	NMR	-	A	42-126	PDB
4Y5O	X-ray	235 A	B	1-124	PDB
4YL6	X-ray	210 A	B	1-22	PDB
AF-Q99759-F1	Predicted				AlphaFoldDB

421 variants for Q99759

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs551562207 CA8702286 COSM982645	3	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	8	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400559459 rs1235611832	8	N>S		No	ClinGen TOPMed gnomAD
CA400559535 rs992562802	11	M>L		No	ClinGen gnomAD
CA8702289 rs773357327	11	M>T		No	ClinGen ExAC gnomAD
CA292929928 rs992562802	11	M>V		No	ClinGen gnomAD
CA400559641 rs1204202373	15	V>E		No	ClinGen gnomAD
rs1208634089 CA400559623	15	V>M		No	ClinGen TOPMed
CA8702292 rs774406091	20	N>K		No	ClinGen ExAC gnomAD
rs1366845047 CA400559765	21	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs957760333 CA292929969	22	R>C		No	ClinGen TOPMed gnomAD
CA8702293 rs760586639	22	R>H		No	ClinGen ExAC gnomAD
rs1421945598 CA400559783	23	H>Y		No	ClinGen gnomAD
CA292930007 rs868728863	24	R>Q		No	ClinGen gnomAD
CA8702294 rs199910953	24	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8702295 rs753831759	27	G>A		No	ClinGen ExAC gnomAD
CA400559837 rs1376444271	27	G>R		No	ClinGen gnomAD
CA8702296 rs145910072	28	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs983615858 COSM3932693 COSM1750224 CA292930040	32	K>E	urinary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
rs764760347 CA400559903	33	N>S		No	ClinGen ExAC gnomAD
rs764760347 CA8702298	33	N>T		No	ClinGen ExAC gnomAD
rs1277835026 CA400559961	36	T>A		No	ClinGen TOPMed
CA400560012 rs1598061463	37	G>V		No	ClinGen Ensembl
rs1023242624 CA292930048	38	H>R		No	ClinGen TOPMed
TCGA novel	39	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400563453 rs1365121364	43	S>N		No	ClinGen TOPMed
rs1352675048 CA400563470	44	D>A		No	ClinGen TOPMed
CA8702369 rs372206804	44	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs372206804 CA292939775	44	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA292939776 rs1001024067 COSM1750225 COSM3932694	45	V>I	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs747235726 CA8702370	48	K>M		No	ClinGen ExAC gnomAD
CA400564277 rs1230878267	50	E>D		No	ClinGen gnomAD
TCGA novel	50	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1273003221 CA400564288	51	H>R		No	ClinGen gnomAD
rs149314666 CA8702373 COSM97948	53	G>R	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA8702375 rs184639184	55	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA8702376 rs745762268	55	R>K		No	ClinGen ExAC TOPMed gnomAD
CA400564358 rs1261733963	56	R>*		No	ClinGen gnomAD
rs532359502 CA8702403	58	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8702404 rs531230584	59	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs761117004 CA8702406	61	S>C		No	ClinGen ExAC TOPMed gnomAD
rs761117004 CA400566184	61	S>G		No	ClinGen ExAC TOPMed gnomAD
rs766920130 CA400566226	62	R>P		No	ClinGen ExAC gnomAD
rs766920130 CA8702407	62	R>Q		No	ClinGen ExAC gnomAD
rs1477555164 CA400566217	62	R>W		No	ClinGen gnomAD
CA400566384 rs1568132839	70	E>G		No	ClinGen Ensembl
rs991373817 CA292943949	71	H>Y		No	ClinGen Ensembl
CA292943951 rs764495536	72	K>R		No	ClinGen gnomAD
COSM1214419 CA8702409 rs755109399	75	T>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1447424546 CA400566564	79	Q>K		No	ClinGen TOPMed
CA400566612 rs919542124	81	L>F		No	ClinGen TOPMed
rs919542124 CA292943972	81	L>V		No	ClinGen TOPMed
rs756320615 CA8702412	85	Y>N		No	ClinGen ExAC gnomAD
rs1352881305 CA400566729	86	M>R		No	ClinGen TOPMed gnomAD
CA292943983 rs949924451	86	M>V		No	ClinGen gnomAD
rs1227087534 CA400566756	87	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8702413 rs778598069	88	N>D		No	ClinGen ExAC gnomAD
CA8702414 rs750283630	88	N>S		No	ClinGen ExAC gnomAD
rs751544538 CA8702435	93	L>Q		No	ClinGen ExAC gnomAD
CA8702436 rs754924253	95	K>R		No	ClinGen ExAC gnomAD
rs1169442799 CA400568978	96	N>S		No	ClinGen gnomAD
CA400569006 rs1273730100	97	Q>R		No	ClinGen gnomAD
CA400569040 rs1568135703	98	D>E		No	ClinGen Ensembl
rs1392458792 CA400569017	98	D>H		No	ClinGen gnomAD
CA400569021 rs1392458792	98	D>N		No	ClinGen gnomAD
rs780588217 CA8702437	99	D>A		No	ClinGen ExAC gnomAD
TCGA novel	100	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747742093 CA8702438	103	A>V		No	ClinGen ExAC gnomAD
rs769154360 CA8702439	104	I>T		No	ClinGen ExAC gnomAD
CA292948033 rs1051842818	105	D>E		No	ClinGen Ensembl
CA8702440 rs777548849	105	D>G		No	ClinGen ExAC gnomAD
CA400569191 rs1416587975	105	D>H		No	ClinGen TOPMed gnomAD
rs748881884 CA8702441	108	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1366117704 CA400569323	110	S>R		No	ClinGen gnomAD
TCGA novel	112	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1299321265 CA400569375	112	S>N		No	ClinGen gnomAD
CA8702442 rs148711373	113	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374735208 CA8702443	116	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1404085613 CA400569555	117	R>K		No	ClinGen TOPMed
rs1280706133 CA400569581 CA400569576	118	I>L		No	ClinGen gnomAD
rs760060741 CA8702444	118	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1441881728 CA400569645	120	L>Q		No	ClinGen gnomAD
rs1250156409 CA400569720	122	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA400569786 rs1197113816	124	D>V		No	ClinGen gnomAD
rs1447823821 CA400569881	127	H>P		No	ClinGen gnomAD
rs1041649176 CA292906934	128	N>H		No	ClinGen TOPMed gnomAD
rs1208335913 CA400560378	128	N>S		No	ClinGen gnomAD
CA400560397 rs1278640447	129	S>G		No	ClinGen TOPMed
TCGA novel	129	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268561080 CA400560401	129	S>N		No	ClinGen gnomAD
CA400560394 rs1278640447	129	S>R		No	ClinGen TOPMed
rs755708063 CA8702457	131	S>F		No	ClinGen ExAC gnomAD
rs141438505 CA8702459	133	H>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141438505 CA8702460	133	H>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141438505 CA8702458	133	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8702461 rs778517747	134	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	138	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	138	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1162103729 CA400560739	139	Q>K		No	ClinGen TOPMed
CA400560748 rs1474680011	139	Q>P		No	ClinGen TOPMed
rs776126405 CA8702464	140	V>M		No	ClinGen ExAC gnomAD
rs568640776 CA292906991	141	R>Q		No	ClinGen gnomAD
rs761104061 CA8702465	141	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8702466 rs768781864	142	I>L		No	ClinGen ExAC gnomAD
CA8702467 rs374801462	143	K>E		No	ClinGen ESP ExAC gnomAD
rs35028835 CA292907019	144	A>G		No	ClinGen Ensembl
rs1195812994 CA400560820	144	A>T		No	ClinGen TOPMed
rs1427164192 CA400560859	146	Q>P		No	ClinGen TOPMed
CA8702469 rs139576613	148	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA292907042 rs139576613	148	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1290352112 CA400560921	148	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	149	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	150	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773535213 CA8702470	151	I>V		No	ClinGen ExAC gnomAD
CA8702472 rs201709115	152	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8702471 rs759442484	152	N>Y		No	ClinGen ExAC gnomAD
rs1489562470 CA400561017	154	I>T		No	ClinGen gnomAD
rs752685930 CA400561058	157	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8702476 rs763617586	157	P>H		No	ClinGen ExAC gnomAD
CA8702475 rs763617586	157	P>L		No	ClinGen ExAC gnomAD
rs752685930 CA8702474	157	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8702473 rs752685930	157	P>T		No	ClinGen ExAC TOPMed gnomAD
CA292907116 rs1022609171	158	P>L		No	ClinGen gnomAD
rs1022609171 CA400561063	158	P>R		No	ClinGen gnomAD
rs745509910 CA8702479	158	P>S		No	ClinGen ExAC gnomAD
rs1369849994 CA400561065	159	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1208446998	159	E>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1455997663 CA400561092	160	P>H		No	ClinGen gnomAD
CA292907147 rs768845358	161	R>G		No	ClinGen ExAC gnomAD
CA400561106 rs1370920864	161	R>T		No	ClinGen gnomAD
rs1306078389 CA400561141	163	R>S		No	ClinGen gnomAD
CA400561220 rs367914417	164	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA292907174 rs928510869	165	L>R		No	ClinGen gnomAD
CA8702485 rs748275986	166	S>F		No	ClinGen ExAC gnomAD
rs554729342 CA8702500	170	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs755335974 CA8702502	171	N>K		No	ClinGen ExAC TOPMed gnomAD
CA8702503 rs374807460	172	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs770006698 CA8702504	172	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8702505 rs777960277	175	S>N		No	ClinGen ExAC gnomAD
rs749547349 CA8702506 COSM1385173	178	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA400564848 rs1248289487	179	P>S		No	ClinGen gnomAD
CA400564896 rs1186452717	181	Y>C		No	ClinGen gnomAD
CA400564910 rs1280412757	182	V>I		No	ClinGen gnomAD
CA400564971 rs774603132	185	R>L		No	ClinGen ExAC gnomAD
CA8702508 rs774603132	185	R>Q		No	ClinGen ExAC gnomAD
CA400564989 rs1598113098	187	Q>E		No	ClinGen Ensembl
rs745343360 CA292917150	187	Q>R		No	ClinGen Ensembl
rs1057241127 CA292917153	189	I>F		No	ClinGen Ensembl
rs1336098078 CA400565084	192	Q>H		No	ClinGen gnomAD
CA400565126 rs1598113143	194	S>A		No	ClinGen Ensembl
CA292917158 rs866349133	197	S>N		No	ClinGen Ensembl
TCGA novel	203	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs547108714 CA8702511	208	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1310911007 CA400565498	209	S>G		No	ClinGen gnomAD
rs1209421331 CA400565516	210	E>K		No	ClinGen gnomAD
rs749850994 CA8702514	211	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA8702529 rs542260882	213	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1321884842 CA400565990	216	P>L		No	ClinGen gnomAD
TCGA novel	221	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778266515 CA292919466	223	S>T		No	ClinGen Ensembl
rs1490181764 CA400566045	224	L>F		No	ClinGen gnomAD
rs748109392 CA8702531	225	S>P		No	ClinGen ExAC gnomAD
CA400566058 rs1252675599	227	S>G		No	ClinGen gnomAD
rs1252675599 CA400566057	227	S>R		No	ClinGen gnomAD
rs1028106301 CA292919493	232	D>N		No	ClinGen Ensembl
rs1407549847 CA400566140	233	R>T		No	ClinGen gnomAD
CA400566179 rs1314599907	235	A>G		No	ClinGen TOPMed
rs747980360 CA400567211	241	R>L		No	ClinGen ExAC TOPMed gnomAD
rs747980360 CA8702550	241	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8702549 rs201427854	241	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1327667606 COSM982649 CA400567265	244	R>*	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs769629755 CA8702551	244	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1214307160 CA400567305	246	S>Y		No	ClinGen gnomAD
rs1282098667 CA400567323	247	R>C		No	ClinGen TOPMed gnomAD
rs1282098667 CA400567319	247	R>G		No	ClinGen TOPMed gnomAD
rs773083246 CA8702552	247	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	247	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770352176 CA8702554	252	P>S		No	ClinGen ExAC TOPMed gnomAD
rs773871394 CA400567462	253	D>E		No	ClinGen ExAC TOPMed gnomAD
CA400567466 rs1195146315	254	N>D		No	ClinGen gnomAD
rs1272441798 CA400567481	255	R>K		No	ClinGen TOPMed gnomAD
rs1272441798 CA400567482	255	R>T		No	ClinGen TOPMed gnomAD
rs759095415 CA8702556	256	Q>E		No	ClinGen ExAC gnomAD
CA8702558 rs775275166	257	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8702557 rs767317282	257	E>G		No	ClinGen ExAC gnomAD
CA400567504 rs767317282	257	E>V		No	ClinGen ExAC gnomAD
CA8702559 rs761176612	258	Y>C		No	ClinGen ExAC gnomAD
rs200364244 CA8702571	260	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1382490890 CA400567545	260	D>N		No	ClinGen TOPMed
CA292921694 rs200364244	260	D>V		No	ClinGen 1000Genomes ExAC gnomAD
CA400567636 rs146112270	261	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA8702573 rs371194292	261	R>Q		No	ClinGen ESP ExAC gnomAD
rs146112270 CA8702572	261	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs901924145 CA292921717	262	E>A		No	ClinGen Ensembl
rs771693753 CA8702574	266	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8702576 rs760333977	268	K>R		No	ClinGen ExAC TOPMed gnomAD
rs139920227 CA400567847	270	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs139920227 CA400567843	270	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs139920227 CA8702577	270	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8702578 rs777002011	271	K>R		No	ClinGen ExAC gnomAD
rs1598122037 CA400567954	275	Y>S		No	ClinGen Ensembl
rs763081777 CA8702582	277	R>Q		No	ClinGen ExAC gnomAD
CA400567991 rs1173724169 COSM245573	277	R>W	Variant assessed as Somatic; 0.0 impact. prostate haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA400568006 rs1457492910	278	R>C		No	ClinGen TOPMed gnomAD
rs368873892 CA8702583 COSM982651	278	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs368873892 CA400568016	278	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1050901169 CA292921816	280	H>N		No	ClinGen TOPMed
RCV000885411 rs36109904 CA8702585 VAR_040685	281	V>M		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs370717303 CA8702586	283	V>A		No	ClinGen ESP ExAC gnomAD
CA400568115 rs1323902778	283	V>M		No	ClinGen gnomAD
CA8702588 rs753706365	284	H>Y		No	ClinGen ExAC gnomAD
CA8702589 rs756997078	286	K>E		No	ClinGen ExAC gnomAD
rs1011855480 CA292921846	286	K>R		No	ClinGen TOPMed
CA292921862 rs1023626299	288	Y>H		No	ClinGen Ensembl
CA8702609 rs750413982	292	R>G		No	ClinGen ExAC gnomAD
rs1187774612 CA400569294	292	R>S		No	ClinGen gnomAD
TCGA novel	293	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1422533446 CA400569357	295	F>L		No	ClinGen gnomAD
rs149846705 CA8702611	297	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA8702613 COSM1189535 rs754446404	299	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8702612 rs370207376 COSM982657	299	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs747700437 CA8702615	300	R>C		No	ClinGen ExAC TOPMed gnomAD
rs199571831 CA8702616	300	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199571831 CA400569501	300	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA400569655 rs1598123051	307	T>P		No	ClinGen Ensembl
rs773528129 CA8702617	308	L>P		No	ClinGen ExAC TOPMed gnomAD
rs749817590 CA8702618	309	V>L		No	ClinGen ExAC gnomAD
rs771477615 CA8702619	311	S>P		No	ClinGen ExAC gnomAD
rs1249153560 CA400569776	313	R>C		No	ClinGen TOPMed gnomAD
rs994733913 CA292922413	313	R>H		No	ClinGen TOPMed gnomAD
rs994733913 CA400569798	313	R>L		No	ClinGen TOPMed gnomAD
rs1026101631 CA292922422	316	S>N		No	ClinGen Ensembl
CA400569970 CA8702623 rs775783118	320	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8702622 rs767436855	320	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA400569998 rs1465923230	322	M>T		No	ClinGen TOPMed gnomAD
rs372390229 CA8702624	322	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1451311071 CA400570021	323	G>D		No	ClinGen gnomAD
rs1390549871 CA400570007	323	G>S		No	ClinGen gnomAD
rs34042309 VAR_037275 CA292922480	325	A>G		No	ClinGen UniProt dbSNP gnomAD
rs34042309 CA400570051	325	A>V		No	ClinGen gnomAD
rs1054395177 CA292922490	326	V>M		No	ClinGen TOPMed
rs964350175 CA292922491	328	Y>H		No	ClinGen TOPMed
CA8702625 rs765143147	330	D>E		No	ClinGen ExAC gnomAD
rs915797254 CA292922516	331	P>H		No	ClinGen TOPMed
rs750289116 CA400570107	331	P>S		No	ClinGen ExAC TOPMed gnomAD
rs750289116 CA8702626	331	P>T		No	ClinGen ExAC TOPMed gnomAD
CA8702628 rs766496256	332	R>C	Variant assessed as Somatic; 4.656e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA292922534 rs372179093	332	R>H		No	ClinGen TOPMed
rs869233786	332	R>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751441762 CA400570121	334	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8702629 rs751441762	334	R>G		No	ClinGen ExAC TOPMed gnomAD
rs754533496 CA8702630	334	R>H		No	ClinGen ExAC gnomAD
rs747867118 CA8702632	336	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8702631 rs780502633	336	R>W		No	ClinGen ExAC TOPMed gnomAD
rs755715664 CA8702633	337	S>N		No	ClinGen ExAC TOPMed gnomAD
rs201458544 CA8702634	338	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771271392 CA8702636	339	D>N		No	ClinGen ExAC gnomAD
rs1202619222 CA400570198	340	S>G		No	ClinGen TOPMed gnomAD
rs907003390 CA292922609	341	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1184509514 CA400570236	342	N>D		No	ClinGen gnomAD
rs1336289198 CA400570247	342	N>S		No	ClinGen gnomAD
CA400570272 rs1244157374	344	L>V		No	ClinGen TOPMed
CA8702639 rs746292640	348	E>Q		No	ClinGen ExAC gnomAD
CA400570361 rs1176968473	349	R>K		No	ClinGen gnomAD
TCGA novel	350	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8702640 rs772222539	350	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1598123413 CA400570425	353	T>S		No	ClinGen Ensembl
CA8702658 rs546447902	357	S>I		No	ClinGen 1000Genomes ExAC gnomAD
rs747155850 CA8702659	357	S>R		No	ClinGen ExAC
CA292923097 rs997234056	361	N>S		No	ClinGen gnomAD
rs1283341292 CA400570672	363	R>C		No	ClinGen gnomAD
CA8702660 rs768847997	363	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA400570687 rs764375472	364	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8702662 rs764375472	364	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs777009629 CA8702661	364	R>W		No	ClinGen ExAC TOPMed gnomAD
CA400570715 rs1568155526	366	K>R		No	ClinGen Ensembl
rs148821588 CA8702663	367	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1598124280 CA400570776	370	Q>R		No	ClinGen Ensembl
TCGA novel	371	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	371	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8702665 rs759352927	372	A>G		No	ClinGen ExAC gnomAD
rs1470540654 CA400570834	374	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA400570852 rs1175671702	375	R>G		No	ClinGen gnomAD
CA400570865 rs1407480712	375	R>S		No	ClinGen TOPMed gnomAD
CA400570881 rs1598124343	376	V>G		No	ClinGen Ensembl
rs1165798317 CA400570891	377	Y>C		No	ClinGen gnomAD
CA292923151 rs901861960	382	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs763526019 CA8702669	384	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756808678 CA8702671 COSM1385174	386	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA400571049 rs1379366668	386	R>H		No	ClinGen gnomAD
CA400571047 rs1379366668	386	R>L		No	ClinGen gnomAD
rs1568155631 CA400571070	388	L>F		No	ClinGen Ensembl
rs1247901635 CA400571087	389	A>V		No	ClinGen gnomAD
CA8702673 rs375031748	392	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1417521726 CA400571134	393	V>I		No	ClinGen TOPMed
rs201376513 CA8702675	397	P>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	398	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768864371 CA8702677	399	S>G		No	ClinGen ExAC
rs1232535625 CA400571227	400	P>A		No	ClinGen gnomAD
rs769961099 CA8702680	402	T>I		No	ClinGen ExAC gnomAD
rs1453992625 CA400571919	411	C>R		No	ClinGen gnomAD
rs1400087576 CA400571942	412	E>G		No	ClinGen gnomAD
CA400571932 rs1382486715	412	E>K		No	ClinGen gnomAD
CA400571984 rs1347255762	414	Q>H		No	ClinGen gnomAD
TCGA novel	417	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400572058 rs1281446200	419	L>S		No	ClinGen gnomAD
rs777869698 CA8702716	420	Q>E		No	ClinGen ExAC gnomAD
CA400572073 rs1281681903	420	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8702717 rs749494387	421	H>N		No	ClinGen ExAC gnomAD
rs746868574 CA8702720	423	R>C		No	ClinGen ExAC TOPMed gnomAD
CA400572134 rs1219703682 COSM982661	423	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1267542104 CA400572142	424	I>V		No	ClinGen TOPMed gnomAD
rs776560365 CA8702722	425	V>L		No	ClinGen ExAC gnomAD
CA8702723 rs776560365	425	V>M		No	ClinGen ExAC gnomAD
CA400572223 rs1369913003	428	Y>C		No	ClinGen TOPMed
CA400572238 rs1434017021	429	G>C		No	ClinGen TOPMed
CA292923742 rs1006020517	429	G>D		No	ClinGen gnomAD
TCGA novel	429	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8702726 rs762349103	432	R>Q		No	ClinGen ExAC gnomAD
rs1390067438 CA400572338	433	D>E		No	ClinGen gnomAD
CA8702727 rs766174733	433	D>G		No	ClinGen ExAC TOPMed gnomAD
rs368232481 CA8702728	434	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs368232481 CA8702729	434	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs371837391 CA8702730	434	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA292923812 VAR_037276 rs9910858	435	A>G		No	ClinGen UniProt Ensembl dbSNP
rs376092350 CA8702732	435	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA400572396 rs1311300884	436	E>K		No	ClinGen Ensembl
rs1316165392 CA400572440	437	K>N		No	ClinGen TOPMed gnomAD
CA400572432 rs1367378410	437	K>R		No	ClinGen gnomAD
rs61737830 CA8702734	438	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	439	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8702735 rs757320092	439	L>V		No	ClinGen ExAC gnomAD
rs1480692639 CA400572492	441	I>V		No	ClinGen gnomAD
CA400572537 rs1488340717	443	M>V		No	ClinGen TOPMed
CA8702736 rs779162078	446	M>I		No	ClinGen ExAC gnomAD
rs1477623445 CA400572853	451	V>L		No	ClinGen TOPMed
CA400572887 rs1209246033	453	D>N		No	ClinGen gnomAD
CA8702765 rs147563538	464	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA8702768 rs761154998	465	V>L		No	ClinGen ExAC TOPMed gnomAD
rs761154998 CA8702767	465	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1346123153 CA400573186	466	T>I		No	ClinGen gnomAD
rs577384322 CA8702769	467	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	471	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1405033518 CA400573292	473	I>T		No	ClinGen TOPMed gnomAD
CA8702773 rs762993883	477	M>I		No	ClinGen ExAC gnomAD
CA8702774 rs182553269	478	S>F		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	479	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA292924301 rs367720019	482	S>G		No	ClinGen Ensembl
TCGA novel	482	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776940651 CA8702777	484	M>I		No	ClinGen ExAC gnomAD
CA8702776 rs755952221	484	M>T		No	ClinGen ExAC gnomAD
rs1329731681 CA400573469	484	M>V		No	ClinGen TOPMed
CA8702778 rs369531094	485	I>T		No	ClinGen ESP ExAC gnomAD
CA8702780 rs77866388	488	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs757306885 CA8702779	488	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	510	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400574285 rs1355988216	512	K>R		No	ClinGen gnomAD
CA292924673 rs992780814	513	R>C		No	ClinGen TOPMed gnomAD
rs746700251 CA8702804	515	Q>R		No	ClinGen ExAC gnomAD
rs1215446675 CA400574392	516	T>M		No	ClinGen TOPMed
CA292924724 rs1009976119	519	M>I		No	ClinGen Ensembl
CA8702806 rs144796639	519	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA400574576 rs1226725135	520	S>L		No	ClinGen TOPMed
CA8702809 rs773722519	522	T>M		No	ClinGen ExAC gnomAD
rs771075974 CA8702811	523	G>C		No	ClinGen ExAC gnomAD
rs200968266 CA8702812	524	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368376876 CA8702813	525	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs368376876 CA400574726	525	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs772489241 CA8702814	525	R>H		No	ClinGen ExAC TOPMed gnomAD
CA400574751 rs772489241	525	R>L		No	ClinGen ExAC TOPMed gnomAD
rs761709890 CA8702816	527	V>I		No	ClinGen ExAC gnomAD
CA8702818 rs750413926	530	T>K		No	ClinGen ExAC TOPMed gnomAD
CA400574918 rs750413926	530	T>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	533	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762747364 CA8702819	540	S>C		No	ClinGen ExAC gnomAD
rs202160737 CA292924790	541	G>S		No	ClinGen 1000Genomes
rs1470835367 CA400575209	542	E>K		No	ClinGen TOPMed gnomAD
CA8702821 rs751073898	544	Y>C		No	ClinGen ExAC gnomAD
CA292924796 rs1001042867	544	Y>H		No	ClinGen Ensembl
TCGA novel	545	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754509552 CA8702822	547	K>R		No	ClinGen ExAC gnomAD
CA292925947 rs750420240	554	G>A		No	ClinGen Ensembl
rs759061216 CA8702841	556	T>S		No	ClinGen ExAC gnomAD
rs150374712 CA8702843	557	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA400576693 rs1487590679	562	T>A		No	ClinGen gnomAD
CA400576734 rs1568158365 CA400576735	564	K>N		No	ClinGen Ensembl
TCGA novel	566	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1598128991 CA400576897	573	M>R		No	ClinGen Ensembl
rs1598129009 CA400576941	575	A>G		No	ClinGen Ensembl
rs757626698 CA8702848	575	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1298185299 CA400576953	576	I>V		No	ClinGen TOPMed
CA400577001 rs1160019670	578	K>R		No	ClinGen gnomAD
rs1598129032 CA400577052	581	T>P		No	ClinGen Ensembl
CA8702849 rs779301433	583	P>L		No	ClinGen ExAC gnomAD
CA8702850 rs779301433	583	P>R		No	ClinGen ExAC gnomAD
CA8702851 rs772305243	585	N>S		No	ClinGen ExAC TOPMed gnomAD
rs889483840 CA292926006	587	Q>H		No	ClinGen TOPMed gnomAD
rs747061434 CA8702853	587	Q>R		No	ClinGen ExAC gnomAD
CA400577283 rs1328686600	591	H>R		No	ClinGen TOPMed
CA400577301 rs1435697933	592	I>M		No	ClinGen TOPMed
rs769042361 CA8702854	595	H>D		No	ClinGen ExAC gnomAD
rs1330673530 CA400577335	595	H>R		No	ClinGen TOPMed gnomAD
rs776910307 CA8702855	596	G>S		No	ClinGen ExAC gnomAD
rs1352214077 COSM175771 CA400577358	597	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1311899564 COSM48529 CA400577356	597	R>W	lung large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA400577366 rs1240017475	598	D>H		No	ClinGen TOPMed gnomAD
rs549447984 CA8702856	602	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs770706062 CA8702857	602	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770706062 CA400577420	602	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8702858 rs774161042	603	I>V		No	ClinGen ExAC gnomAD
TCGA novel	604	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400577454 rs1266240817	605	V>M		No	ClinGen gnomAD
rs61737831 CA8702859	608	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA400577505 rs61737831	608	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA8702860 COSM1196206 rs201464511	608	R>H	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs775019440 CA8702861	609	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1445489020 CA400577599	613	A>T		No	ClinGen gnomAD
CA8702863 rs200161650	622	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs142840047 CA8702864	624	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1333837448 CA400577861	625	M>I		No	ClinGen gnomAD
rs957850875 CA292926058	625	M>T		No	ClinGen TOPMed gnomAD

No associated diseases with Q99759

4 regional properties for Q99759

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	261 - 422	IPR001650
domain	DEAD/DEAH box helicase domain	70 - 235	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	64 - 265	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	45 - 73	IPR014014

Functions

		Description
EC Number	2.7.11.25	Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity	Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
metal ion binding	Binding to a metal ion.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

9 GO annotations of biological process

Name	Definition
blood vessel development	The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
negative regulation of cellular senescence	Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
positive regulation of cell migration involved in sprouting angiogenesis	Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
positive regulation of cell proliferation in bone marrow	A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of p38MAPK cascade	Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P51957	NEK4	Serine/threonine-protein kinase Nek4	Homo sapiens (Human)	PR
Q9Y3S1	WNK2	Serine/threonine-protein kinase WNK2	Homo sapiens (Human)	SS
Q9UHY1	NRBP1	Nuclear receptor-binding protein	Homo sapiens (Human)	PR
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Homo sapiens (Human)	SS
Q9BYP7	WNK3	Serine/threonine-protein kinase WNK3	Homo sapiens (Human)	SS
Q9Y2U5	MAP3K2	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (Human)	PR
Q61083	Map3k2	Mitogen-activated protein kinase kinase kinase 2	Mus musculus (Mouse)	PR
Q61084	Map3k3	Mitogen-activated protein kinase kinase kinase 3	Mus musculus (Mouse)	PR
O22042	ANP3	Mitogen-activated protein kinase kinase kinase 3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MDEQEALNSI	MNDLVALQMN	RRHRMPGYET	MKNKDTGHSN	RQSDVRIKFE	HNGERRIIAF
70	80	90	100	110	120
SRPVKYEDVE	HKVTTVFGQP	LDLHYMNNEL	SILLKNQDDL	DKAIDILDRS	SSMKSLRILL
130	140	150	160	170	180
LSQDRNHNSS	SPHSGVSRQV	RIKASQSAGD	INTIYQPPEP	RSRHLSVSSQ	NPGRSSPPPG
190	200	210	220	230	240
YVPERQQHIA	RQGSYTSINS	EGEFIPETSE	QCMLDPLSSA	ENSLSGSCQS	LDRSADSPSF
250	260	270	280	290	300
RKSRMSRAQS	FPDNRQEYSD	RETQLYDKGV	KGGTYPRRYH	VSVHHKDYSD	GRRTFPRIRR
310	320	330	340	350	360
HQGNLFTLVP	SSRSLSTNGE	NMGLAVQYLD	PRGRLRSADS	ENALSVQERN	VPTKSPSAPI
370	380	390	400	410	420
NWRRGKLLGQ	GAFGRVYLCY	DVDTGRELAS	KQVQFDPDSP	ETSKEVSALE	CEIQLLKNLQ
430	440	450	460	470	480
HERIVQYYGC	LRDRAEKTLT	IFMEYMPGGS	VKDQLKAYGA	LTESVTRKYT	RQILEGMSYL
490	500	510	520	530	540
HSNMIVHRDI	KGANILRDSA	GNVKLGDFGA	SKRLQTICMS	GTGMRSVTGT	PYWMSPEVIS
550	560	570	580	590	600
GEGYGRKADV	WSLGCTVVEM	LTEKPPWAEY	EAMAAIFKIA	TQPTNPQLPS	HISEHGRDFL
610	620
RRIFVEARQR	PSAEELLTHH	FAQLMY