Q99612
PR
Gene name |
KLF6 (BCD1, COPEB, CPBP, ST12) |
Protein name |
Krueppel-like factor 6 |
Names |
B-cell-derived protein 1, Core promoter element-binding protein, GC-rich sites-binding factor GBF, Proto-oncogene BCD1, Suppressor of tumorigenicity 12 protein, Transcription factor Zf9 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1316 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99612
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99612-F1 | Predicted | AlphaFoldDB |
175 variants for Q99612
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
VAR_065136 rs121909142 CA118893 RCV000008008 |
64 | W>R | Prostate cancer, somatic found in prostate cancer samples; somatic mutation; does not up-regulates CDKN1A in a p53-independent manner and significantly reduces cell proliferation [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
VAR_065137 RCV000008005 CA118887 rs121909139 |
116 | S>P | Prostate cancer, somatic found in prostate cancer samples; somatic mutation; does not up-regulates CDKN1A in a p53-independent manner and significantly reduces cell proliferation [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
RCV000008007 rs121909141 CA118891 VAR_065138 |
123 | A>D | Prostate cancer, somatic found in prostate cancer samples; somatic mutation; does not up-regulates CDKN1A in a p53-independent manner and significantly reduces cell proliferation [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
RCV000008006 CA118889 rs121909140 |
137 | S>* | Prostate cancer, somatic [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
rs121909144 CA210521 RCV000008010 VAR_065139 |
155 | S>R | Gastric cancer found in gastric cancer samples; somatic mutation [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt dbSNP gnomAD |
|
rs121909143 RCV000008009 CA118895 VAR_065140 |
169 | L>P | Prostate cancer, somatic found in prostate cancer samples; somatic mutation; does not up-regulates CDKN1A in a p53-independent manner and significantly reduces cell proliferation [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
| TCGA novel | 5 | P>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1198407776 CA375872991 |
6 | M>L | No |
ClinGen gnomAD |
|
|
rs1253659402 CA375872982 |
6 | M>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1253659402 CA375872985 |
6 | M>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 7 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1355084908 CA375872028 |
11 | Q>R | No |
ClinGen TOPMed |
|
|
rs757278414 CA5388866 |
21 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs780547330 CA5388867 |
21 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5388863 rs762752613 |
29 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA5388862 rs752443335 |
30 | E>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 32 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375870661 rs1229477984 |
36 | C>* | No |
ClinGen gnomAD |
|
| TCGA novel | 48 | C>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776165698 CA5388832 |
49 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
CA5388831 rs770573018 |
50 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1035370294 CA201345807 |
51 | S>A | No |
ClinGen TOPMed |
|
|
CA375870464 rs1321018733 |
52 | A>D | No |
ClinGen gnomAD |
|
|
CA375870475 rs1390532368 |
52 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA201345802 rs981973114 |
54 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
| TCGA novel | 57 | F>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5388830 rs746555690 |
58 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1386659633 CA375870281 |
58 | D>H | No |
ClinGen gnomAD |
|
|
CA375870159 rs1424432923 |
61 | E>A | No |
ClinGen gnomAD |
|
|
rs748060230 CA5388827 |
62 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs758376769 CA5388828 |
62 | D>N | No |
ClinGen ExAC TOPMed |
|
|
CA5388826 rs778831293 |
63 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs778831293 CA375870114 |
63 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA375870057 rs1249031510 |
70 | A>G | No |
ClinGen gnomAD |
|
|
CA375870055 rs1249031510 |
70 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs866307815 CA201345780 |
71 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs866307815 CA375870050 |
71 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA375870052 rs1257403042 |
71 | R>W | No |
ClinGen TOPMed |
|
|
CA375869994 rs1179625032 |
75 | E>V | No |
ClinGen gnomAD |
|
|
CA5388824 COSM41205 COSM3415027 rs753610916 |
78 | E>K | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA201345768 rs991610969 |
81 | I>K | No |
ClinGen Ensembl |
|
|
CA5388821 rs750581486 |
82 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5388822 rs756318202 |
82 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs756318202 CA375869889 |
82 | S>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 85 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5388819 rs141749814 |
86 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375869809 rs1482239005 |
87 | E>D | No |
ClinGen gnomAD |
|
|
rs775004517 CA5388818 |
88 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1203137980 CA375869791 |
90 | L>P | No |
ClinGen gnomAD |
|
|
rs1434006255 CA375869793 |
90 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1564296189 CA375869788 |
91 | I>L | No |
ClinGen Ensembl |
|
|
rs1564296185 CA375869782 |
91 | I>M | No |
ClinGen Ensembl |
|
|
CA5388814 rs763252895 |
92 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA160383 RCV000121325 rs587778436 |
92 | S>R | No |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
|
rs1162850438 CA375869770 |
93 | P>R | No |
ClinGen gnomAD |
|
|
rs1349342383 CA375869773 |
93 | P>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 96 | C>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1269937482 CA375869731 |
98 | N>K | No |
ClinGen gnomAD |
|
|
rs771561652 CA5388810 |
98 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747587726 CA5388809 |
99 | L>V | No |
ClinGen ExAC |
|
|
rs778728731 CA5388808 |
100 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs768589446 CA5388807 |
103 | S>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 104 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 106 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 107 | D>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1329980440 CA375869660 |
109 | S>N | No |
ClinGen gnomAD |
|
|
CA375869636 rs1403721472 |
112 | S>F | No |
ClinGen TOPMed |
|
|
rs779866252 CA5388804 |
113 | S>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 114 | D>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1588344147 CA375869617 |
115 | S>N | No |
ClinGen Ensembl |
|
|
CA201345678 rs111256842 |
117 | E>G | No |
ClinGen Ensembl |
|
|
CA375869607 rs1227606738 |
117 | E>K | No |
ClinGen gnomAD |
|
|
CA5388800 rs757426719 |
119 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA201345673 rs147965199 |
119 | L>P | No |
ClinGen ESP |
|
|
rs947615559 CA375869584 |
120 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA201345671 rs947615559 |
120 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
CA5388798 rs144914426 |
122 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144914426 CA5388799 |
122 | T>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5388795 rs765619505 |
124 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375869548 rs1564296078 |
126 | T>N | No |
ClinGen Ensembl |
|
|
CA5388793 rs533788452 |
128 | D>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5388792 rs533788452 |
128 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1379698490 CA375869532 |
129 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs761334451 CA5388791 |
129 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs371389756 CA5388789 |
130 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1432985435 CA375869530 |
130 | I>V | No |
ClinGen gnomAD |
|
|
CA375869521 rs1313893989 |
131 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
CA375869503 rs1251971839 |
134 | L>V | No |
ClinGen gnomAD |
|
|
rs769716317 CA5388786 |
135 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs184241704 CA5388784 |
136 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA375869472 rs121909140 COSM245311 |
137 | S>L | prostate [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA201345576 rs121909140 |
137 | S>W | No |
ClinGen gnomAD |
|
|
CA375869462 rs1159580959 |
138 | G>A | No |
ClinGen TOPMed |
|
|
CA201345572 rs11252089 |
142 | S>F | No |
ClinGen TOPMed |
|
|
CA375869399 rs11252089 |
142 | S>Y | No |
ClinGen TOPMed |
|
|
rs200767950 CA160385 RCV000121326 |
143 | S>F | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs933440517 CA201345559 |
143 | S>P | No |
ClinGen TOPMed |
|
|
CA5388782 rs777889308 |
145 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA375869364 rs777889308 |
145 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA375869360 rs1405050966 |
146 | S>T | No |
ClinGen gnomAD |
|
|
rs199602374 CA5388781 |
147 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs753240281 CA5388780 |
152 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA375869259 rs1457284828 |
154 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1330721231 CA375869251 |
155 | S>G | No |
ClinGen TOPMed |
|
| TCGA novel | 157 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1039504110 CA201345525 |
160 | Q>H | No |
ClinGen TOPMed |
|
|
CA5388776 rs537666833 |
161 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA201345517 rs537666833 |
161 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA375869073 rs1267743907 |
162 | W>C | No |
ClinGen TOPMed |
|
|
rs943489190 CA201345507 |
162 | W>S | No |
ClinGen TOPMed |
|
|
CA375869070 rs1200996825 |
163 | G>S | No |
ClinGen gnomAD |
|
|
CA201345501 rs375144655 |
164 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5388774 rs375144655 |
164 | C>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs61731927 CA375869026 |
165 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs61731927 CA160387 RCV000121327 RCV000890849 |
165 | V>M | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs769806292 CA5388771 |
166 | P>L | No |
ClinGen ExAC gnomAD |
|
|
RCV000119254 rs142749289 CA156191 |
166 | P>S | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA5388769 rs201647969 COSM1212595 |
167 | G>R | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA375868968 rs1411042502 |
168 | E>K | No |
ClinGen TOPMed |
|
|
rs368266204 CA375868951 |
169 | L>V | No |
ClinGen ESP gnomAD |
|
|
CA5388768 rs148536819 |
171 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1157965962 CA375868886 |
172 | P>S | No |
ClinGen TOPMed gnomAD |
|
| VAR_065141 | 172 | P>T | found in gastric cancer samples; somatic mutation [UniProt] | No | UniProt |
|
rs949283678 CA201345428 |
174 | K>N | No |
ClinGen gnomAD |
|
|
rs777779469 CA5388766 |
175 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs777779469 CA375868828 |
175 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs758505830 CA5388765 |
176 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA375868810 rs758505830 |
176 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs151112485 CA5388764 |
176 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1241031582 CA375868760 |
177 | S>R | No |
ClinGen gnomAD |
|
|
CA5388761 rs754239177 |
178 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779417302 CA5388763 |
178 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs754239177 CA5388762 |
178 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
VAR_065142 rs372338890 CA5388760 |
180 | S>L | found in gastric cancer samples; somatic mutation [UniProt] | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
CA201345378 rs972634245 |
180 | S>P | No |
ClinGen TOPMed |
|
|
CA375868656 rs751230861 |
184 | G>C | No |
ClinGen ExAC gnomAD |
|
|
CA5388758 rs751230861 |
184 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs763596063 CA5388757 |
185 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA375868611 rs1289748441 |
187 | G>E | No |
ClinGen TOPMed |
|
|
rs1381298553 CA375868615 |
187 | G>R | No |
ClinGen gnomAD |
|
|
rs762548312 COSM3790764 CA375868579 COSM3790765 |
190 | D>N | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs762548312 CA5388756 |
190 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1436189659 CA375868554 |
191 | A>V | No |
ClinGen gnomAD |
|
|
rs11544695 CA5388753 |
194 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 194 | D>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs11544695 CA201345341 |
194 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375868508 rs542676563 |
195 | G>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5388751 rs542676563 |
195 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 197 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| VAR_065143 | 198 | R>K | found in gastric cancer samples; somatic mutation [UniProt] | No | UniProt |
|
CA5388747 COSM917997 rs748290439 |
201 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs772132474 CA5388748 |
201 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs111949823 CA375868374 |
205 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 206 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5388743 rs756516743 |
206 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs1380328511 CA375868355 |
208 | R>K | No |
ClinGen TOPMed |
|
| TCGA novel | 208 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5388742 rs750705462 |
208 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA375868352 rs1245944345 |
209 | K>E | No |
ClinGen TOPMed |
|
|
CA5388738 rs764830375 |
222 | R>Q | No |
ClinGen ExAC |
|
|
rs200187706 CA5388737 |
223 | T>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA375872785 rs1360065203 |
233 | S>L | No |
ClinGen gnomAD |
|
|
rs771511975 CA5388691 |
236 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs747407014 CA5388690 |
240 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs773677946 COSM1347736 CA5388689 |
246 | E>K | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 248 | T>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1170260252 CA375872549 |
252 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA5388686 rs779682182 |
258 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs17855372 CA201383018 |
261 | K>* | No |
ClinGen Ensembl |
|
|
rs1490355715 CA375872475 |
263 | S>P | No |
ClinGen gnomAD |
|
| TCGA novel | 268 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 269 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs190182913 CA201382695 |
276 | A>T | No |
ClinGen 1000Genomes |
|
| TCGA novel | 279 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375872333 rs1381754260 |
279 | M>L | No |
ClinGen gnomAD |
2 associated diseases with Q99612
[MIM: 613659]: Gastric cancer (GASC)
A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269|PubMed:15824733}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 176807]: Prostate cancer (PC)
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:11752579}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269|PubMed:15824733}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:11752579}. Note=The disease is caused by variants affecting the gene represented in this entry.
11 regional properties for Q99612
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger C2H2-type | 107 - 134 | IPR013087-1 |
| domain | Zinc finger C2H2-type | 135 - 162 | IPR013087-2 |
| domain | Zinc finger C2H2-type | 163 - 190 | IPR013087-3 |
| domain | Zinc finger C2H2-type | 191 - 218 | IPR013087-4 |
| domain | Zinc finger C2H2-type | 281 - 308 | IPR013087-5 |
| domain | Zinc finger C2H2-type | 309 - 336 | IPR013087-6 |
| domain | Zinc finger C2H2-type | 337 - 359 | IPR013087-7 |
| domain | Zinc finger C2H2-type | 366 - 393 | IPR013087-8 |
| domain | Zinc finger C2H2-type | 446 - 473 | IPR013087-9 |
| domain | Zinc finger C2H2-type | 474 - 501 | IPR013087-10 |
| domain | Zinc finger C2H2-type | 502 - 529 | IPR013087-11 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| metal ion binding | Binding to a metal ion. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell differentiation | The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
177 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08DS3 | OSR1 | Protein odd-skipped-related 1 | Bos taurus (Bovine) | PR |
| Q2VWH6 | FEZF2 | Fez family zinc finger protein 2 | Bos taurus (Bovine) | PR |
| A6QNZ0 | ZSCAN26 | Zinc finger and SCAN domain-containing protein 26 | Bos taurus (Bovine) | PR |
| A7MBI1 | ZFP69 | Zinc finger protein 69 homolog | Bos taurus (Bovine) | PR |
| Q08705 | CTCF | Transcriptional repressor CTCF | Gallus gallus (Chicken) | PR |
| O42409 | GFI1B | Zinc finger protein Gfi-1b | Gallus gallus (Chicken) | PR |
| A2T6W2 | ZNF449 | Zinc finger protein 449 | Pan troglodytes (Chimpanzee) | PR |
| Q9U405 | grau | Transcription factor grauzone | Drosophila melanogaster (Fruit fly) | PR |
| Q7K0S9 | sug | Zinc finger protein GLIS2 homolog | Drosophila melanogaster (Fruit fly) | PR |
| P20385 | Cf2 | Chorion transcription factor Cf2 | Drosophila melanogaster (Fruit fly) | PR |
| Q86P48 | ATbp | AT-rich binding protein | Drosophila melanogaster (Fruit fly) | PR |
| P28698 | MZF1 | Myeloid zinc finger 1 | Homo sapiens (Human) | PR |
| Q9NTW7 | ZFP64 | Zinc finger protein 64 | Homo sapiens (Human) | PR |
| O14978 | ZNF263 | Zinc finger protein 263 | Homo sapiens (Human) | PR |
| O60304 | ZNF500 | Zinc finger protein 500 | Homo sapiens (Human) | PR |
| P08151 | GLI1 | Zinc finger protein GLI1 | Homo sapiens (Human) | PR |
| Q9UFB7 | ZBTB47 | Zinc finger and BTB domain-containing protein 47 | Homo sapiens (Human) | PR |
| Q9UNY5 | ZNF232 | Zinc finger protein 232 | Homo sapiens (Human) | PR |
| Q96SZ4 | ZSCAN10 | Zinc finger and SCAN domain-containing protein 10 | Homo sapiens (Human) | PR |
| P17028 | ZNF24 | Zinc finger protein 24 | Homo sapiens (Human) | PR |
| P25490 | YY1 | Transcriptional repressor protein YY1 | Homo sapiens (Human) | SS |
| O43296 | ZNF264 | Zinc finger protein 264 | Homo sapiens (Human) | PR |
| P49711 | CTCF | Transcriptional repressor CTCF | Homo sapiens (Human) | PR |
| Q9NQX1 | PRDM5 | PR domain zinc finger protein 5 | Homo sapiens (Human) | PR |
| Q9HBE1 | PATZ1 | POZ-, AT hook-, and zinc finger-containing protein 1 | Homo sapiens (Human) | PR |
| Q8TAX0 | OSR1 | Protein odd-skipped-related 1 | Homo sapiens (Human) | PR |
| Q9UL58 | ZNF215 | Zinc finger protein 215 | Homo sapiens (Human) | PR |
| Q8TBJ5 | FEZF2 | Fez family zinc finger protein 2 | Homo sapiens (Human) | PR |
| Q96SR6 | ZNF382 | Zinc finger protein 382 | Homo sapiens (Human) | PR |
| Q96IT1 | ZNF496 | Zinc finger protein 496 | Homo sapiens (Human) | PR |
| Q96N95 | ZNF396 | Zinc finger protein 396 | Homo sapiens (Human) | PR |
| Q9ULJ3 | ZBTB21 | Zinc finger and BTB domain-containing protein 21 | Homo sapiens (Human) | PR |
| Q9H9D4 | ZNF408 | Zinc finger protein 408 | Homo sapiens (Human) | PR |
| Q13127 | REST | RE1-silencing transcription factor | Homo sapiens (Human) | PR |
| Q8IZM8 | ZNF654 | Zinc finger protein 654 | Homo sapiens (Human) | PR |
| Q14526 | HIC1 | Hypermethylated in cancer 1 protein | Homo sapiens (Human) | PR |
| P17022 | ZNF18 | Zinc finger protein 18 | Homo sapiens (Human) | PR |
| Q86XF7 | ZNF575 | Zinc finger protein 575 | Homo sapiens (Human) | PR |
| Q8NAM6 | ZSCAN4 | Zinc finger and SCAN domain-containing protein 4 | Homo sapiens (Human) | PR |
| Q08ER8 | ZNF543 | Zinc finger protein 543 | Homo sapiens (Human) | PR |
| P17029 | ZKSCAN1 | Zinc finger protein with KRAB and SCAN domains 1 | Homo sapiens (Human) | PR |
| Q8N680 | ZBTB2 | Zinc finger and BTB domain-containing protein 2 | Homo sapiens (Human) | PR |
| O95625 | ZBTB11 | Zinc finger and BTB domain-containing protein 11 | Homo sapiens (Human) | PR |
| Q9NPC7 | MYNN | Myoneurin | Homo sapiens (Human) | PR |
| Q96BV0 | ZNF775 | Zinc finger protein 775 | Homo sapiens (Human) | PR |
| Q8NF99 | ZNF397 | Zinc finger protein 397 | Homo sapiens (Human) | PR |
| Q63HK3 | ZKSCAN2 | Zinc finger protein with KRAB and SCAN domains 2 | Homo sapiens (Human) | PR |
| Q5FWF6 | ZNF789 | Zinc finger protein 789 | Homo sapiens (Human) | PR |
| Q15776 | ZKSCAN8 | Zinc finger protein with KRAB and SCAN domains 8 | Homo sapiens (Human) | PR |
| Q53GI3 | ZNF394 | Zinc finger protein 394 | Homo sapiens (Human) | PR |
| O95125 | ZNF202 | Zinc finger protein 202 | Homo sapiens (Human) | PR |
| Q05516 | ZBTB16 | Zinc finger and BTB domain-containing protein 16 | Homo sapiens (Human) | PR |
| Q9H116 | GZF1 | GDNF-inducible zinc finger protein 1 | Homo sapiens (Human) | PR |
| Q8N0Y2 | ZNF444 | Zinc finger protein 444 | Homo sapiens (Human) | PR |
| Q6P9G9 | ZNF449 | Zinc finger protein 449 | Homo sapiens (Human) | PR |
| Q8IW36 | ZNF695 | Zinc finger protein 695 | Homo sapiens (Human) | PR |
| Q5VTD9 | GFI1B | Zinc finger protein Gfi-1b | Homo sapiens (Human) | PR |
| Q6PG37 | ZNF790 | Zinc finger protein 790 | Homo sapiens (Human) | PR |
| Q9NQV6 | PRDM10 | PR domain zinc finger protein 10 | Homo sapiens (Human) | PR |
| Q9Y2D9 | ZNF652 | Zinc finger protein 652 | Homo sapiens (Human) | PR |
| Q5TC79 | ZBTB37 | Zinc finger and BTB domain-containing protein 37 | Homo sapiens (Human) | PR |
| Q9Y4E5 | ZNF451 | E3 SUMO-protein ligase ZNF451 | Homo sapiens (Human) | PR |
| Q8ND82 | ZNF280C | Zinc finger protein 280C | Homo sapiens (Human) | PR |
| Q49AA0 | ZFP69 | Zinc finger protein 69 homolog | Homo sapiens (Human) | PR |
| O43298 | ZBTB43 | Zinc finger and BTB domain-containing protein 43 | Homo sapiens (Human) | PR |
| Q9Y330 | ZBTB12 | Zinc finger and BTB domain-containing protein 12 | Homo sapiens (Human) | PR |
| Q13105 | ZBTB17 | Zinc finger and BTB domain-containing protein 17 | Homo sapiens (Human) | PR |
| P51508 | ZNF81 | Zinc finger protein 81 | Homo sapiens (Human) | PR |
| Q5JNZ3 | ZNF311 | Zinc finger protein 311 | Homo sapiens (Human) | PR |
| Q9BRR0 | ZKSCAN3 | Zinc finger protein with KRAB and SCAN domains 3 | Homo sapiens (Human) | PR |
| Q969J2 | ZKSCAN4 | Zinc finger protein with KRAB and SCAN domains 4 | Homo sapiens (Human) | PR |
| P49910 | ZNF165 | Zinc finger protein 165 | Homo sapiens (Human) | PR |
| P10074 | ZBTB48 | Telomere zinc finger-associated protein | Homo sapiens (Human) | PR |
| P17010 | ZFX | Zinc finger X-chromosomal protein | Homo sapiens (Human) | PR |
| Q9H5H4 | ZNF768 | Zinc finger protein 768 | Homo sapiens (Human) | PR |
| Q6NSZ9 | ZSCAN25 | Zinc finger and SCAN domain-containing protein 25 | Homo sapiens (Human) | PR |
| Q9Y2L8 | ZKSCAN5 | Zinc finger protein with KRAB and SCAN domains 5 | Homo sapiens (Human) | PR |
| Q86UZ6 | ZBTB46 | Zinc finger and BTB domain-containing protein 46 | Homo sapiens (Human) | PR |
| Q9NX65 | ZSCAN32 | Zinc finger and SCAN domain-containing protein 32 | Homo sapiens (Human) | PR |
| O14771 | ZNF213 | Zinc finger protein 213 | Homo sapiens (Human) | PR |
| Q8IWY8 | ZSCAN29 | Zinc finger and SCAN domain-containing protein 29 | Homo sapiens (Human) | PR |
| Q8NCP5 | ZBTB44 | Zinc finger and BTB domain-containing protein 44 | Homo sapiens (Human) | PR |
| P41182 | BCL6 | B-cell lymphoma 6 protein | Homo sapiens (Human) | PR |
| Q9NQX0 | PRDM6 | Putative histone-lysine N-methyltransferase PRDM6 | Homo sapiens (Human) | PR |
| Q9BU19 | ZNF692 | Zinc finger protein 692 | Homo sapiens (Human) | PR |
| Q08AG5 | ZNF844 | Zinc finger protein 844 | Homo sapiens (Human) | PR |
| Q6R2W3 | ZBED9 | SCAN domain-containing protein 3 | Homo sapiens (Human) | PR |
| P98182 | ZNF200 | Zinc finger protein 200 | Homo sapiens (Human) | PR |
| Q9UK11 | ZNF223 | Zinc finger protein 223 | Homo sapiens (Human) | PR |
| O15156 | ZBTB7B | Zinc finger and BTB domain-containing protein 7B | Homo sapiens (Human) | PR |
| Q6ZMS7 | ZNF783 | Zinc finger protein 783 | Homo sapiens (Human) | PR |
| P59923 | ZNF445 | Zinc finger protein 445 | Homo sapiens (Human) | PR |
| Q8N859 | ZNF713 | Zinc finger protein 713 | Homo sapiens (Human) | PR |
| Q8TD17 | ZNF398 | Zinc finger protein 398 | Homo sapiens (Human) | PR |
| P52739 | ZNF131 | Zinc finger protein 131 | Homo sapiens (Human) | PR |
| A6NGD5 | ZSCAN5C | Zinc finger and SCAN domain-containing protein 5C | Homo sapiens (Human) | PR |
| Q7Z398 | ZNF550 | Zinc finger protein 550 | Homo sapiens (Human) | PR |
| Q9Y2K1 | ZBTB1 | Zinc finger and BTB domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q96N20 | ZNF75A | Zinc finger protein 75A | Homo sapiens (Human) | PR |
| A6NJL1 | ZSCAN5B | Zinc finger and SCAN domain-containing protein 5B | Homo sapiens (Human) | PR |
| A1YPR0 | ZBTB7C | Zinc finger and BTB domain-containing protein 7C | Homo sapiens (Human) | PR |
| Q9NWS9 | ZNF446 | Zinc finger protein 446 | Homo sapiens (Human) | PR |
| P24278 | ZBTB25 | Zinc finger and BTB domain-containing protein 25 | Homo sapiens (Human) | PR |
| Q96N38 | ZNF714 | Zinc finger protein 714 | Homo sapiens (Human) | PR |
| Q86YH2 | ZNF280B | Zinc finger protein 280B | Homo sapiens (Human) | PR |
| Q9Y5W3 | KLF2 | Krueppel-like factor 2 | Homo sapiens (Human) | PR |
| Q06889 | EGR3 | Early growth response protein 3 | Homo sapiens (Human) | PR |
| P18146 | EGR1 | Early growth response protein 1 | Homo sapiens (Human) | PR |
| Q05215 | EGR4 | Early growth response protein 4 | Homo sapiens (Human) | PR |
| Q9Y4X4 | KLF12 | Krueppel-like factor 12 | Homo sapiens (Human) | PR |
| O75840 | KLF7 | Krueppel-like factor 7 | Homo sapiens (Human) | PR |
| P57682 | KLF3 | Krueppel-like factor 3 | Homo sapiens (Human) | PR |
| Q61164 | Ctcf | Transcriptional repressor CTCF | Mus musculus (Mouse) | PR |
| Q810A1 | Znf18 | Zinc finger protein 18 | Mus musculus (Mouse) | PR |
| Q8BGS3 | Zkscan1 | Zinc finger protein with KRAB and SCAN domains 1 | Mus musculus (Mouse) | PR |
| Q00899 | Yy1 | Transcriptional repressor protein YY1 | Mus musculus (Mouse) | PR |
| P41183 | Bcl6 | B-cell lymphoma 6 protein homolog | Mus musculus (Mouse) | PR |
| Q9DAI4 | Zbtb43 | Zinc finger and BTB domain-containing protein 43 | Mus musculus (Mouse) | PR |
| O70237 | Gfi1b | Zinc finger protein Gfi-1b | Mus musculus (Mouse) | PR |
| Q99KZ6 | Znf639 | Zinc finger protein 639 | Mus musculus (Mouse) | PR |
| Q9Z1D9 | Znf394 | Zinc finger protein 394 | Mus musculus (Mouse) | PR |
| Q9CXE0 | Prdm5 | PR domain zinc finger protein 5 | Mus musculus (Mouse) | PR |
| P43300 | Egr3 | Early growth response protein 3 | Mus musculus (Mouse) | PR |
| Q9DAU9 | Znf654 | Zinc finger protein 654 | Mus musculus (Mouse) | PR |
| Q9R1Y5 | Hic1 | Hypermethylated in cancer 1 protein | Mus musculus (Mouse) | PR |
| Q8R0T2 | Znf768 | Zinc finger protein 768 | Mus musculus (Mouse) | PR |
| Q9WVG7 | Osr1 | Protein odd-skipped-related 1 | Mus musculus (Mouse) | PR |
| Q8BI73 | Znf775 | Zinc finger protein 775 | Mus musculus (Mouse) | PR |
| Q8VCZ7 | Zbtb7c | Zinc finger and BTB domain-containing protein 7C | Mus musculus (Mouse) | PR |
| Q91VN1 | Znf24 | Zinc finger protein 24 | Mus musculus (Mouse) | PR |
| Q9DB38 | Znf580 | Zinc finger protein 580 | Mus musculus (Mouse) | PR |
| A7KBS4 | Zscan4d | Zinc finger and SCAN domain containing protein 4D | Mus musculus (Mouse) | PR |
| Q91VW9 | Zkscan3 | Zinc finger protein with KRAB and SCAN domains 3 | Mus musculus (Mouse) | PR |
| P10925 | Zfy1 | Zinc finger Y-chromosomal protein 1 | Mus musculus (Mouse) | PR |
| P08046 | Egr1 | Early growth response protein 1 | Mus musculus (Mouse) | PR |
| Q3TTC2 | Yy2 | Transcription factor YY2 | Mus musculus (Mouse) | PR |
| Q3UTQ7 | Prdm10 | PR domain zinc finger protein 10 | Mus musculus (Mouse) | PR |
| Q6P3Y5 | Znf280c | Zinc finger protein 280C | Mus musculus (Mouse) | PR |
| Q9ERU3 | Znf22 | Zinc finger protein 22 | Mus musculus (Mouse) | PR |
| Q8VIG1 | Rest | RE1-silencing transcription factor | Mus musculus (Mouse) | PR |
| Q9Z1D8 | Zkscan5 | Zinc finger protein with KRAB and SCAN domains 5 | Mus musculus (Mouse) | PR |
| Q8BID6 | Zbtb46 | Zinc finger and BTB domain-containing protein 46 | Mus musculus (Mouse) | PR |
| P17012 | Zfx | Zinc finger X-chromosomal protein | Mus musculus (Mouse) | PR |
| Q9WUK6 | Zbtb18 | Zinc finger and BTB domain-containing protein 18 | Mus musculus (Mouse) | PR |
| O35738 | Klf12 | Krueppel-like factor 12 | Mus musculus (Mouse) | PR |
| B2RXC5 | Znf382 | Zinc finger protein 382 | Mus musculus (Mouse) | PR |
| O08900 | Ikzf3 | Zinc finger protein Aiolos | Mus musculus (Mouse) | PR |
| Q5DU09 | Znf652 | Zinc finger protein 652 | Mus musculus (Mouse) | PR |
| Q5RJ54 | Zscan26 | Zinc finger and SCAN domain-containing protein 26 | Mus musculus (Mouse) | PR |
| Q8BLM0 | Klf8 | Krueppel-like factor 8 | Mus musculus (Mouse) | PR |
| Q99JB0 | Klf7 | Krueppel-like factor 7 | Mus musculus (Mouse) | PR |
| Q8R0A2 | Zbtb44 | Zinc finger and BTB domain-containing protein 44 | Mus musculus (Mouse) | PR |
| P20662 | Zfy2 | Zinc finger Y-chromosomal protein 2 | Mus musculus (Mouse) | PR |
| Q80VJ6 | Zscan4c | Zinc finger and SCAN domain containing protein 4C | Mus musculus (Mouse) | PR |
| Q3URS2 | Zscan4f | Zinc finger and SCAN domain containing protein 4F | Mus musculus (Mouse) | PR |
| Q60980 | Klf3 | Krueppel-like factor 3 | Mus musculus (Mouse) | PR |
| Q8K3J5 | Znf131 | Zinc finger protein 131 | Mus musculus (Mouse) | PR |
| O08584 | Klf6 | Krueppel-like factor 6 | Mus musculus (Mouse) | PR |
| Q9Z2K3 | Znf394 | Zinc finger protein 394 | Rattus norvegicus (Rat) | PR |
| Q642B9 | Znf18 | Zinc finger protein 18 | Rattus norvegicus (Rat) | PR |
| B0K011 | Osr1 | Protein odd-skipped-related 1 | Rattus norvegicus (Rat) | PR |
| D3ZUU2 | Gzf1 | GDNF-inducible zinc finger protein 1 | Rattus norvegicus (Rat) | PR |
| B1WBU4 | Zbtb8a | Zinc finger and BTB domain-containing protein 8A | Rattus norvegicus (Rat) | PR |
| Q7TNK3 | Znf24 | Zinc finger protein 24 | Rattus norvegicus (Rat) | PR |
| Q9R1D1 | Ctcf | Transcriptional repressor CTCF | Rattus norvegicus (Rat) | PR |
| P43301 | Egr3 | Early growth response protein 3 | Rattus norvegicus (Rat) | PR |
| P08154 | Egr1 | Early growth response protein 1 | Rattus norvegicus (Rat) | PR |
| A0JPL0 | Znf382 | Zinc finger protein 382 | Rattus norvegicus (Rat) | PR |
| Q4KLI1 | Zkscan1 | Zinc finger protein with KRAB and SCAN domains 1 | Rattus norvegicus (Rat) | PR |
| A1L1J6 | Znf652 | Zinc finger protein 652 | Rattus norvegicus (Rat) | PR |
| O35819 | Klf6 | Krueppel-like factor 6 | Rattus norvegicus (Rat) | PR |
| Q9SHD0 | ZAT4 | Zinc finger protein ZAT4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0P4X6 | zbtb44 | Zinc finger and BTB domain-containing protein 44 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A4II20 | egr1 | Early growth response protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6P882 | zbtb8a.2 | Zinc finger and BTB domain-containing protein 8A.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q567C6 | znf367 | Zinc finger protein 367 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| A7Y7X5 | znf711 | Zinc finger protein 711 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDVLPMCSIF | QELQIVHETG | YFSALPSLEE | YWQQTCLELE | RYLQSEPCYV | SASEIKFDSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDLWTKIILA | REKKEESELK | ISSSPPEDTL | ISPSFCYNLE | TNSLNSDVSS | ESSDSSEELS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PTAKFTSDPI | GEVLVSSGKL | SSSVTSTPPS | SPELSREPSQ | LWGCVPGELP | SPGKVRSGTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKPGDKGNGD | ASPDGRRRVH | RCHFNGCRKV | YTKSSHLKAH | QRTHTGEKPY | RCSWEGCEWR |
| 250 | 260 | 270 | 280 | ||
| FARSDELTRH | FRKHTGAKPF | KCSHCDRCFS | RSDHLALHMK | RHL |