AiPD: Autoinhibited Protein Database

Q99578

Gene name	RIT2 (RIN, ROC2)
Protein name	GTP-binding protein Rit2
Names	Ras-like protein expressed in neurons, Ras-like without CAAX protein 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6014
EC number	3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-48 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q99578

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q99578-F1	Predicted				AlphaFoldDB

174 variants for Q99578

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA299517517 rs772590756	2	E>K		No	ClinGen ExAC gnomAD
CA8945014 rs772590756	2	E>Q		No	ClinGen ExAC gnomAD
rs1161813272 CA402478246	3	V>A		No	ClinGen gnomAD
CA299517516 COSM226807 rs867661849	4	E>K	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1002961408 CA299517515	6	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA402478219 rs1381154303	7	A>G		No	ClinGen gnomAD
rs907330766 CA299517514	7	A>T		No	ClinGen gnomAD
TCGA novel	8	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402478205 rs1417724027	9	C>S		No	ClinGen gnomAD
CA8945013 rs140593847	10	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs140593847 CA8945012	10	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA299517512 rs959230566	11	P>L		No	ClinGen TOPMed gnomAD
CA8945010 rs749608210	11	P>S		No	ClinGen ExAC gnomAD
CA299517511 rs201814254	12	G>D		No	ClinGen 1000Genomes
rs756364776 CA8945008	14	A>S		No	ClinGen ExAC TOPMed gnomAD
rs745967365 CA8945007	14	A>V		No	ClinGen ExAC gnomAD
rs1233900623 CA402478174	15	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8945004 rs752640941	15	S>A		No	ClinGen ExAC gnomAD
rs752640941 CA8945005	15	S>T		No	ClinGen ExAC gnomAD
rs142911081 CA8945003	16	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8945002 rs199603585	17	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	17	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8945001 rs753566491	18	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1401934850 CA402478155	19	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA402478121 rs1598791448	23	V>G		No	ClinGen Ensembl
CA402478126 rs1361352728	23	V>M		No	ClinGen gnomAD
TCGA novel	24	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8945000 rs766054548	25	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8944999 rs760273264	29	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	29	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1177337094 CA402478080	30	G>A		No	ClinGen gnomAD
TCGA novel	30	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765499217	31	V>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA8944996 rs766978653	35	A>S		No	ClinGen ExAC TOPMed
CA8944970 rs143764572	36	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1380040475 CA402478024	37	T>A		No	ClinGen TOPMed
TCGA novel	37	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402478012 rs1338746593	38	M>I		No	ClinGen gnomAD
rs770344980 CA402478008	39	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs770344980 CA8944969	39	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs759963635 CA8944968	39	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs776728832 CA8944967	40	F>L		No	ClinGen ExAC gnomAD
rs1313744392 CA402477989	42	S>R		No	ClinGen gnomAD
rs771120789 CA8944966	43	H>Y		No	ClinGen ExAC gnomAD
rs1404336385 CA402477958	46	P>T		No	ClinGen gnomAD
rs1335325861 CA402477932	49	H>R		No	ClinGen TOPMed
rs1430955035 CA402477914	52	T>A		No	ClinGen TOPMed gnomAD
rs777863748 CA8944964	53	I>V		No	ClinGen ExAC TOPMed gnomAD
CA402476643 rs1328954282	62	R>M		No	ClinGen TOPMed
CA402476636 rs1469467859	63	I>S		No	ClinGen TOPMed gnomAD
CA402476637 rs1469467859	63	I>T		No	ClinGen TOPMed gnomAD
rs748213647 CA8944944	63	I>V		No	ClinGen ExAC gnomAD
rs1280601502 CA402476628	64	D>E		No	ClinGen TOPMed
TCGA novel	64	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402476620 rs1200887243	65	N>K		No	ClinGen gnomAD
rs1452167530 CA402476610	67	P>T		No	ClinGen gnomAD
rs1376207709 CA402476604	68	A>T		No	ClinGen TOPMed
TCGA novel	70	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262882444 CA402476583	71	D>N		No	ClinGen TOPMed
rs1568043990 CA402476572	72	I>N		No	ClinGen Ensembl
rs745671453 CA8944941	75	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1182646862 CA402476542	77	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	78	Q>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201719862 CA299495078	79	A>E		No	ClinGen Ensembl
CA402477344 rs1425850088	79	A>T		No	ClinGen gnomAD
CA402477331 rs1339861578	80	E>D		No	ClinGen TOPMed
rs1475177444 CA402477312	83	A>T		No	ClinGen gnomAD
CA8944913 rs746721549	84	M>I		No	ClinGen ExAC gnomAD
rs868710992 CA299495076	85	R>Q		No	ClinGen TOPMed
TCGA novel	86	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402477278 rs1598716561	87	Q>*		No	ClinGen Ensembl
CA402477267 rs1295593277	88	Y>C		No	ClinGen gnomAD
rs1213491100 CA402477258	89	M>K		No	ClinGen gnomAD
rs1221826475 CA402477262	89	M>L		No	ClinGen TOPMed
CA402477259 rs1213491100	89	M>T		No	ClinGen gnomAD
COSM1388691 CA402477251 rs1359368764	90	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA402477240 rs1285624121	91	G>D		No	ClinGen gnomAD
CA8944911 rs758087210	92	G>E		No	ClinGen ExAC gnomAD
CA402477235 rs1452965453	92	G>R		No	ClinGen gnomAD
CA402477190 rs1334507038	97	I>V		No	ClinGen gnomAD
rs778619263 CA8944909	101	V>I		No	ClinGen ExAC TOPMed gnomAD
rs962872061 COSM1223834 CA299495074	104	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs754435765 CA8944907	104	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs754435765 CA299495073	104	R>L		No	ClinGen ExAC gnomAD
rs754435765 CA402477129	104	R>P		No	ClinGen ExAC gnomAD
CA402477131 rs962872061	104	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1169941643 CA779483041	105	Q>H		No	ClinGen TOPMed
rs1242915978 CA402477100	107	F>L		No	ClinGen gnomAD
COSM393347 rs1182138488 CA402477094	108	Q>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs756516595 CA8944905	113	F>L		No	ClinGen ExAC
CA8944904 rs750689156	115	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1432933021 CA402477037	115	E>G		No	ClinGen TOPMed
rs867935451 CA299495069	115	E>K		No	ClinGen Ensembl
CA402477029 rs1432650081	116	L>P		No	ClinGen TOPMed
rs1334488835 CA402477000	119	Q>H		No	ClinGen gnomAD
CA402476997 rs1203158376	120	V>I		No	ClinGen gnomAD
rs767747736 CA8944903	121	R>C		No	ClinGen ExAC gnomAD
TCGA novel	122	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402476969 rs1282267927	123	T>I		No	ClinGen TOPMed
CA402476956 rs1381670092	124	Y>*		No	ClinGen gnomAD
rs774524808 CA8944901	124	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs267605184 CA299495068 COSM1711220	127	P>S	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs267605184 CA402476936	127	P>T		No	ClinGen gnomAD
TCGA novel	128	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8944898 rs762925413	129	V>A		No	ClinGen ExAC TOPMed gnomAD
CA8944899 rs764225175	129	V>M		No	ClinGen ExAC gnomAD
TCGA novel	131	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA299495067 rs960651232	138	E>*		No	ClinGen Ensembl
CA402476841 rs1352826050	138	E>G		No	ClinGen gnomAD
rs776641218 CA8944897	139	Q>E		No	ClinGen ExAC gnomAD
CA402476832 rs1274638935	139	Q>L		No	ClinGen TOPMed
rs760547840 CA8944895 COSM1611231	141	R>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM1523030 CA402476816 rs1162004248	141	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA402476818 rs1162004248	141	R>L		No	ClinGen TOPMed gnomAD
CA8944894 rs773095164	142	Q>*		No	ClinGen ExAC gnomAD
rs1446142878 CA402477885	143	V>A		No	ClinGen gnomAD
CA8944852 rs763924692	143	V>L		No	ClinGen ExAC gnomAD
CA402477871 rs1452680761	145	T>S		No	ClinGen TOPMed
rs1196354609 CA402477819	151	L>F		No	ClinGen gnomAD
TCGA novel	151	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8944846 rs777127147	154	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8944845 rs771385813	155	Y>N		No	ClinGen ExAC TOPMed gnomAD
COSM3422179 rs199574261 CA8944843	158	G>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA402477754 rs1392527593	160	F>S		No	ClinGen gnomAD
rs754174204	161	E>*	Variant assessed as Somatic; 4.624e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA402477730 rs1426086448	164	A>T		No	ClinGen gnomAD
rs758760009 CA8944841	167	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748387427 CA8944840	168	F>L		No	ClinGen ExAC TOPMed gnomAD
CA402477695 rs1442574006	169	C>Y		No	ClinGen gnomAD
rs939233556 CA299474747	170	I>T		No	ClinGen Ensembl
rs367551216 CA8944839	171	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1182424588 CA402477669	173	A>T		No	ClinGen gnomAD
rs1249827726 CA402477651	175	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA402477628 rs944213504	179	R>G		No	ClinGen TOPMed gnomAD
CA299474744 rs944213504	179	R>W		No	ClinGen TOPMed gnomAD
CA8944837 rs753906491	180	E>*		No	ClinGen ExAC gnomAD
CA8944835 rs757214621 COSM988349	182	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs148544378 CA8944834	182	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1680344 CA299474742 rs148544378	182	R>L	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs757214621 CA8944836	182	R>S		No	ClinGen ExAC gnomAD
rs1354660050 CA402477605	183	K>Q		No	ClinGen gnomAD
rs1281697567 CA402477594	184	K>R		No	ClinGen gnomAD
CA402477587 rs1335690802	185	E>G		No	ClinGen gnomAD
CA402477590 rs1377643588	185	E>K		No	ClinGen Ensembl
CA8944830 rs775014461	187	M>I		No	ClinGen ExAC gnomAD
rs144676190 CA8944831	187	M>T		No	ClinGen ESP ExAC TOPMed
rs1406264401 CA402477575	187	M>V		No	ClinGen gnomAD
CA402477569 rs1164384600	188	P>T		No	ClinGen TOPMed gnomAD
rs1422428322 CA402477539	192	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA402477532 rs1275765276	193	K>E		No	ClinGen TOPMed
CA8944828 rs759077601	193	K>N		No	ClinGen ExAC TOPMed gnomAD
rs776068581 CA8944827 CA299474740	194	K>N		No	ClinGen ExAC TOPMed gnomAD
rs77976328 CA299474739	197	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1443653628 CA402477504	197	R>S		No	ClinGen TOPMed
rs77976328 COSM417843 CA8944825	197	R>T	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1472673491	198	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402477502 rs1180058008	198	K>Q		No	ClinGen gnomAD
rs17851608 CA299474738	200	S>C		No	ClinGen Ensembl
TCGA novel	200	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402477480 rs1269751965	200	S>R		No	ClinGen gnomAD
CA8944823 rs559678016	201	L>M		No	ClinGen ExAC gnomAD
TCGA novel	201	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200268352 CA299474737	203	K>E		No	ClinGen gnomAD
CA8944821 rs531935933	203	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1262780804 CA402477450	205	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs190327842 CA299474736	207	G>C		No	ClinGen 1000Genomes ExAC gnomAD
rs190327842 CA8944819	207	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1345583352 CA402477419	210	K>*		No	ClinGen gnomAD
rs1428795230 CA402477402	212	K>R		No	ClinGen TOPMed
CA299474734 rs746661774	213	R>G		No	ClinGen TOPMed gnomAD
rs1346617687 CA402477389	214	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1290464123 CA402477388	214	E>A		No	ClinGen gnomAD
rs749404972 CA8944816	215	N>D		No	ClinGen ExAC gnomAD
CA402477359 rs1386237332	218	T>R		No	ClinGen TOPMed gnomAD

No associated diseases with Q99578

1 regional properties for Q99578

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	19 - 174	IPR005225

Functions

		Description
EC Number	3.6.5.2	Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus Cell membrane	Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic tree	The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

7 GO annotations of molecular function

Name	Definition
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
G protein activity	A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding	Binding to GDP, guanosine 5'-diphosphate.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
semaphorin receptor binding	Binding to a semaphorin receptor.

14 GO annotations of biological process

Name	Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
chemical synaptic transmission	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
maintenance of protein location in cell	Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of neuron projection development	Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Ras protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
regulation of calcium-mediated signaling	Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
regulation of Cdc42 protein signal transduction	Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction.
regulation of endocytosis	Any process that modulates the frequency, rate or extent of endocytosis.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.

34 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P08642	HRAS	GTPase HRas	Gallus gallus (Chicken)	SS
Q6T310	RASL11A	Ras-like protein family member 11A	Homo sapiens (Human)	PR
Q8IYK8	REM2	GTP-binding protein REM 2	Homo sapiens (Human)	PR
P55040	GEM	GTP-binding protein GEM	Homo sapiens (Human)	PR
Q6IQ22	RAB12	Ras-related protein Rab-12	Homo sapiens (Human)	PR
Q9BU20	CPLANE2	Ciliogenesis and planar polarity effector 2	Homo sapiens (Human)	PR
Q96HU8	DIRAS2	GTP-binding protein Di-Ras2	Homo sapiens (Human)	PR
P62070	RRAS2	Ras-related protein R-Ras2	Homo sapiens (Human)	PR
P11234	RALB	Ras-related protein Ral-B	Homo sapiens (Human)	PR
P11233	RALA	Ras-related protein Ral-A	Homo sapiens (Human)	PR
P01116	KRAS	GTPase KRas	Homo sapiens (Human)	EV
P01112	HRAS	GTPase HRas	Homo sapiens (Human)	SS
Q9JIW9	Ralb	Ras-related protein Ral-B	Mus musculus (Mouse)	PR
Q61411	Hras	GTPase HRas	Mus musculus (Mouse)	SS
P32883	Kras	GTPase KRas	Mus musculus (Mouse)	SS
O08989	Mras	Ras-related protein M-Ras	Mus musculus (Mouse)	PR
Q5PR73	Diras2	GTP-binding protein Di-Ras2	Mus musculus (Mouse)	PR
Q91Z61	Diras1	GTP-binding protein Di-Ras1	Mus musculus (Mouse)	PR
P62071	Rras2	Ras-related protein R-Ras2	Mus musculus (Mouse)	PR
P35283	Rab12	Ras-related protein Rab-12	Mus musculus (Mouse)	PR
Q08AT1	Rasl12	Ras-like protein family member 12	Mus musculus (Mouse)	PR
A2A825	Cplane2	Ciliogenesis and planar polarity effector 2	Mus musculus (Mouse)	PR
P55041	Gem	GTP-binding protein GEM	Mus musculus (Mouse)	PR
Q8VEL9	Rem2	GTP-binding protein REM 2	Mus musculus (Mouse)	PR
P70425	Rit2	GTP-binding protein Rit2	Mus musculus (Mouse)	PR
P36860	Ralb	Ras-related protein Ral-B	Rattus norvegicus (Rat)	PR
P08644	Kras	GTPase KRas	Rattus norvegicus (Rat)	SS
Q9WTY2	Rem2	GTP-binding protein REM 2	Rattus norvegicus (Rat)	PR
P20171	Hras	GTPase HRas	Rattus norvegicus (Rat)	SS
P97538	Mras	Ras-related protein M-Ras	Rattus norvegicus (Rat)	PR
Q5BJQ5	Rit2	GTP-binding protein Rit2	Rattus norvegicus (Rat)	PR
B7ZTR0	cplane2	Ciliogenesis and planar polarity effector 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
P79737	nras	GTPase NRas	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A1DZY4	zgc:110179	Ras-like protein family member 11A-like	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEVENEASCS	PGSASGGSRE	YKVVMLGAGG	VGKSAMTMQF	ISHQFPDYHD	PTIEDAYKTQ
70	80	90	100	110	120
VRIDNEPAYL	DILDTAGQAE	FTAMREQYMR	GGEGFIICYS	VTDRQSFQEA	AKFKELIFQV
130	140	150	160	170	180
RHTYEIPLVL	VGNKIDLEQF	RQVSTEEGLS	LAQEYNCGFF	ETSAALRFCI	DDAFHGLVRE
190	200	210
IRKKESMPSL	MEKKLKRKDS	LWKKLKGSLK	KKRENMT