Q99543

PR
Gene name
DNAJC2 (MPHOSPH11, MPP11, ZRF1)
Protein name
DnaJ homolog subfamily C member 2
Names
M-phase phosphoprotein 11, Zuotin-related factor 1
Species
Homo sapiens (Human)
KEGG Pathway
hsa:27000
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q99543

Entry ID Method Resolution Chain Position Source
2M2E NMR - A 551-621 PDB
6CGH NMR - A 346-432 PDB
AF-Q99543-F1 Predicted AlphaFoldDB

102 variants for Q99543

Variant ID(s) Position Change Description Diseaes Association Provenance
CA4418869
rs760661476
 2 L>V No ClinGen
ExAC
gnomAD
rs767811968
CA4418867
 3 L>F No ClinGen
ExAC
gnomAD
CA368760638
rs1429421555
 4 L>P No ClinGen
gnomAD
rs774875696
CA4418865
 5 P>R No ClinGen
ExAC
gnomAD
rs771360860
CA4418864
 6 S>R No ClinGen
ExAC
gnomAD
CA4418863
rs749814974
 7 A>P No ClinGen
ExAC
TOPMed
gnomAD
CA368760584
rs1218669354
 7 A>V No ClinGen
TOPMed
rs1250150418
CA368760543
 10 G>S No ClinGen
gnomAD
CA368760501
rs1252654735
 11 R>L No ClinGen
TOPMed
gnomAD
rs1252654735
CA368760504
 11 R>P No ClinGen
TOPMed
gnomAD
rs1252654735
CA368760508
 11 R>Q No ClinGen
TOPMed
gnomAD
CA4418860
rs779577435
 12 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA4418859
rs779577435
 12 G>S No ClinGen
ExAC
TOPMed
gnomAD
CA4418858
rs554340864
 12 G>V No ClinGen
1000Genomes
ExAC
gnomAD
CA4418856
rs778685606
 15 I>V No ClinGen
ExAC
gnomAD
CA368760384
rs1348548920
 16 T>I No ClinGen
gnomAD
rs1410181415
CA368760320
 19 L>V No ClinGen
gnomAD
rs763919535
CA4418852
 20 T>I No ClinGen
ExAC
TOPMed
gnomAD
rs752618958
CA4418832
 24 T>A No ClinGen
ExAC
TOPMed
CA4418831
rs781423813
 24 T>I No ClinGen
ExAC
gnomAD
rs1232231580
CA368759899
 25 L>P No ClinGen
gnomAD
rs766686369
CA4418829
 27 Q>H No ClinGen
ExAC
TOPMed
gnomAD
rs61741449
CA4418830
 27 Q>R No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs763414785
CA4418827
 28 V>A No ClinGen
ExAC
gnomAD
rs1443206854
CA368759882
 28 V>I No ClinGen
gnomAD
TCGA novel 32 G>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA368759854
rs1230296331
 32 G>E No ClinGen
gnomAD
rs1250026084
CA368759856
 32 G>R No ClinGen
TOPMed
rs750775297
CA4418826
 38 F>L No ClinGen
ExAC
TOPMed
gnomAD
CA4418825
rs765580389
 39 V>L No ClinGen
ExAC
gnomAD
CA368759801
rs1171241210
 40 K>E No ClinGen
gnomAD
rs1020172308
CA163911399
 40 K>N No ClinGen
Ensembl
CA163911390
rs189317813
 42 R>K Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
1000Genomes
NCI-TCGA
CA4418823
rs777121043
 43 N>S No ClinGen
ExAC
TOPMed
gnomAD
CA368759763
rs1447270288
 45 N>S No ClinGen
gnomAD
rs1246953093
CA368759752
 47 S>P No ClinGen
gnomAD
rs759028587
CA4418821
 50 F>S No ClinGen
ExAC
gnomAD
CA4418820
rs774036170
 53 L>M No ClinGen
ExAC
gnomAD
rs770525647
CA4418819
 54 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA163911319
rs1043934977
 55 D>Y No ClinGen
Ensembl
rs1480076442
CA368759683
 56 K>N No ClinGen
TOPMed
CA4418818
rs185110980
 58 E>Q No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel
CA368759621
rs1236837651
 61 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA4418816
rs769562609
 61 E>K No ClinGen
ExAC
TOPMed
gnomAD
rs1431544382
CA368759556
 67 E>K No ClinGen
gnomAD
CA4418815
rs748099271
 69 Q>K No ClinGen
ExAC
TOPMed
gnomAD
rs116050414
CA4418814
 70 L>M No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs755157321
CA4418813
 71 E>G No ClinGen
ExAC
gnomAD
CA368759422
rs1389145502
 78 T>I No ClinGen
gnomAD
CA368759396
rs1366653530
 80 D>E No ClinGen
gnomAD
CA4418810
rs758562509
COSM383510
 80 D>H lung [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs750591003
CA4418809
 82 K>R No ClinGen
ExAC
TOPMed
gnomAD
rs1586112017
CA368758318
 91 A>T No ClinGen
Ensembl
CA4418788
rs780001663
 92 V>I No ClinGen
ExAC
gnomAD
CA4418787
rs758499604
 93 L>I No ClinGen
ExAC
TOPMed
gnomAD
rs746131814
CA4418786
 94 G>A No ClinGen
ExAC
gnomAD
CA368758198
rs1350196214
 95 L>V No ClinGen
gnomAD
rs779171668
CA4418785
 97 H>Y No ClinGen
ExAC
gnomAD
rs200720512
CA163908281
 98 V>E No ClinGen
1000Genomes
CA163908272
rs757599400
 101 K>R No ClinGen
ExAC
gnomAD
CA4418784
rs757599400
 101 K>T No ClinGen
ExAC
gnomAD
rs1347720855
CA368757927
 104 Q>H No ClinGen
gnomAD
rs1322356997
CA368757920
 105 R>G No ClinGen
gnomAD
CA4418783
rs536146023
 105 R>K No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA368757886
rs536146023
 105 R>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA368757835
rs1156777048
 106 Q>H No ClinGen
TOPMed
gnomAD
rs1396639043
CA368757867
 106 Q>K No ClinGen
gnomAD
CA368757764
rs1177646991
 109 A>E No ClinGen
gnomAD
rs764388747
CA4418782
 111 H>N No ClinGen
ExAC
gnomAD
TCGA novel 162 P>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1044150804 180 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs768898513 183 T>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 203 D>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 226 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 233 E>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 238 A>missing Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 282 K>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1419301731 292 E>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs1211418461 303 R>W Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 422 I>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs751498127 427 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs973724298 432 R>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1228594083 434 R>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs776862127 434 R>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 439 N>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 457 D>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 465 A>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 466 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 468 L>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 472 G>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 484 M>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 515 D>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 516 D>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 518 N>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 522 F>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs369245611 538 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 562 L>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 573 T>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 580 I>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1487632536 583 A>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs1354991103 595 R>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 618 R>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA

No associated diseases with Q99543

7 regional properties for Q99543

Type Name Position InterPro Accession
domain SANT/Myb domain 450 - 509 IPR001005-1
domain SANT/Myb domain 546 - 602 IPR001005-2
domain DnaJ domain 87 - 161 IPR001623
domain SANT domain 549 - 604 IPR017884
domain Myb domain 553 - 604 IPR017930
conserved_site DnaJ domain, conserved site 138 - 157 IPR018253
domain Ribosome-associated complex head domain 339 - 427 IPR032003

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
ribosome binding Binding to a ribosome.
RNA binding Binding to an RNA molecule or a portion thereof.
ubiquitin modification-dependent histone binding Binding to a histone protein in which a residue has been modified by ubiquitination.

7 GO annotations of biological process

Name Definition
'de novo' cotranslational protein folding The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
negative regulation of DNA biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of cellular response to heat Any process that modulates the frequency, rate or extent of cellular response to heat.
regulation of translational fidelity Any process that modulates the ability of the translational apparatus to interpret the genetic code.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32527 ZUO1 Zuotin Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
P54103 Dnajc2 DnaJ homolog subfamily C member 2 Mus musculus (Mouse) PR
Q7TQ20 Dnajc2 DnaJ homolog subfamily C member 2 Rattus norvegicus (Rat) PR
P34454 F54F2.9 Uncharacterized protein F54F2.9 Caenorhabditis elegans PR
F4KGY6 RVE1 Protein REVEILLE 1 Arabidopsis thaliana (Mouse-ear cress) PR
F4K5X6 RVE2 Protein REVEILLE 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NWJ4 dnajc2 DnaJ homolog subfamily C member 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF QELEDKKELS
70 80 90 100 110 120
EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY KATQRQIKAA HKAMVLKHHP
130 140 150 160 170 180
DKRKAAGEPI KEGDNDYFTC ITKAYEMLSD PVKRRAFNSV DPTFDNSVPS KSEAKDNFFE
190 200 210 220 230 240
VFTPVFERNS RWSNKKNVPK LGDMNSSFED VDIFYSFWYN FDSWREFSYL DEEEKEKAEC
250 260 270 280 290 300
RDERRWIEKQ NRATRAQRKK EEMNRIRTLV DNAYSCDPRI KKFKEEEKAK KEAEKKAKAE
310 320 330 340 350 360
AKRKEQEAKE KQRQAELEAA RLAKEKEEEE VRQQALLAKK EKDIQKKAIK KERQKLRNSC
370 380 390 400 410 420
KTWNHFSDNE AERVKMMEEV EKLCDRLELA SLQCLNETLT SCTKEVGKAA LEKQIEEINE
430 440 450 460 470 480
QIRKEKEEAE ARMRQASKNT EKSTGGGGNG SKNWSEDDLQ LLIKAVNLFP AGTNSRWEVI
490 500 510 520 530 540
ANYMNIHSSS GVKRTAKDVI GKAKSLQKLD PHQKDDINKK AFDKFKKEHG VVPQADNATP
550 560 570 580 590 600
SERFEGPYTD FTPWTTEEQK LLEQALKTYP VNTPERWEKI AEAVPGRTKK DCMKRYKELV
610 620
EMVKAKKAAQ EQVLNASRAK K