Q99104

EV
Gene name
Myo5a (Dilute)
Protein name
Unconventional myosin-Va
Names
Dilute myosin heavy chain, non-muscle
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17918
EC number
Protein Class
MYOSIN (PTHR13140)

Descriptions

Myosin Va (MyoVa) is a protein that functions as a dimer for processive walking on actin filaments. Autoinhibition of MyoVa involves the motor domain (MD) and the globular tail domain (GTD), with the motor adopting a closed, autoinhibited state that is inactive for ATPase activity. This state prevents the unnecessary consumption of ATP and uncontrolled movement when not transporting cargo. MyoVa exists in several states, including closed, half-closed, transition, and open states. The closed state of MyoVa can be changed to a half-closed state when the d-strand temporarily dissociates from the GTD, resulting in the dynamic confirmation of the short side in the triangular-shaped structure, which is called the closed state. In the presence of both a GTBM-containing protein and Rab11a, the half-closed conformation undergoes a significant motion of both the MD and the lever arm (LA), resulting in the disassembly of the hinge structure, which is referred to as a transition state. Finally, the unstable transition conformation quickly shifts to the open conformation, allowing the GTPs to tightly associate with cargo and the MDs to hydrolyze ATP for the walking process. Notably, a single cargo binding of either a GTBM-binding protein or Rab11a is insufficient to effectively activate MyoVa.

Autoinhibitory domains (AIDs)

1-765 (Motor domain, MD) EV

Target domain

1444-1828 (Globular tail domain, GTD)

Relief mechanism

Ligand binding, Partner binding

Assay

Structural analysis, Mutagenesis experiment, Peptide inhibitor test

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q99104

Entry ID Method Resolution Chain Position Source
2IX7 X-ray 250 A C 763-820 PDB
3WB8 X-ray 250 A A/B/C/D/E/F/G/H 1469-1853 PDB
4KP3 X-ray 240 A A/B 1469-1853 PDB
4ZLK X-ray 250 A A 1-791 PDB
6KU0 X-ray 160 A A/C 1469-1853 PDB
7YV9 EM 478 A A/H/X/Y 1-1853 PDB
AF-Q99104-F1 Predicted AlphaFoldDB

71 variants for Q99104

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3400398719 5 E>D No EVA
rs3400590765 6 L>P No EVA
rs3389056291 54 P>L No EVA
rs3389052952 57 G>C No EVA
rs3389058128 68 L>F No EVA
rs3389062330 79 Y>C No EVA
rs3389059015 124 I>F No EVA
rs3389051285 193 E>K No EVA
rs3389066326 194 E>D No EVA
rs3389066372 204 E>D No EVA
rs3389025279 211 T>P No EVA
rs3389038624 215 D>E No EVA
rs3389045626 216 N>K No EVA
rs3389066954 217 S>N No EVA
rs3389058164 242 Y>* No EVA
rs3389066328 266 C>Y No EVA
rs3389003502 296 I>K No EVA
rs3389038640 326 F>S No EVA
rs3389066342 349 T>A No EVA
rs3389038569 354 H>L No EVA
rs3389066398 365 G>D No EVA
rs3389061176 367 D>G No EVA
rs3389045617 387 Y>F No EVA
rs3389058962 387 Y>N No EVA
rs3389034760 402 A>V No EVA
rs3400592085 425 S>A No EVA
rs3389051236 430 H>Q No EVA
rs3389045624 452 F>I No EVA
rs3389052951 486 L>R No EVA
rs3389062310 517 K>E No EVA
rs3389056496 522 T>K No EVA
rs3389059026 525 Q>P No EVA
rs3389059008 545 N>D No EVA
rs3389051313 624 P>H No EVA
rs3389058130 635 V>L No EVA
rs3389038633 636 G>* No EVA
rs3389003466 642 S>F No EVA
rs3389045612 703 Y>* No EVA
rs3389051254 726 T>M No EVA
rs3389066930 727 C>S No EVA
rs3389062296 749 F>L No EVA
rs3389025305 761 L>S No EVA
rs3389066368 771 I>T No EVA
rs3389038574 794 I>T No EVA
rs32943601 831 R>H No EVA
rs3389066940 835 K>* No EVA
rs32943603 837 R>K No EVA
rs3389066352 840 A>G No EVA
rs3389052902 849 R>* No EVA
rs32945517 864 Y>H No EVA
rs223730650 1050 K>R No EVA
rs3389062340 1115 S>Y No EVA
rs3389066949 1139 R>I No EVA
rs32949227 1261 V>M No EVA
rs3389045661 1291 D>N No EVA
rs3389059040 1291 D>V No EVA
rs3389058100 1321 L>F No EVA
rs3400427643 1363 Q>L No EVA
rs3400485867 1365 P>L No EVA
rs238248014 1403 R>W No EVA
rs3389045632 1427 L>V No EVA
rs3400399455 1492 E>D* No EVA
rs3389038612 1512 F>Y No EVA
rs3389066354 1587 C>W No EVA
rs3400266896 1597 R>Q No EVA
rs3389059003 1599 V>E No EVA
rs3389056277 1602 D>H No EVA
rs3389056541 1608 Y>D No EVA
rs3389025277 1691 F>L No EVA
rs3400485885 1814 Q>* No EVA
rs3399816555 1826 T>S No EVA

No associated diseases with Q99104

11 regional properties for Q99104

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 765 - 787 IPR000048-1
binding_site IQ motif, EF-hand binding site 788 - 810 IPR000048-2
binding_site IQ motif, EF-hand binding site 813 - 835 IPR000048-3
binding_site IQ motif, EF-hand binding site 836 - 858 IPR000048-4
binding_site IQ motif, EF-hand binding site 861 - 883 IPR000048-5
binding_site IQ motif, EF-hand binding site 884 - 906 IPR000048-6
domain Myosin head, motor domain 63 - 764 IPR001609
domain Dilute domain 1532 - 1808 IPR002710
domain Myosin, N-terminal, SH3-like 8 - 60 IPR004009
domain Class V myosin, motor domain 83 - 751 IPR036103
domain Myosin 5a, cargo-binding domain 1479 - 1853 IPR037988

Functions

Description
EC Number
Subcellular Localization
PANTHER Family PTHR13140 MYOSIN
PANTHER Subfamily PTHR13140:SF273 UNCONVENTIONAL MYOSIN-VA
PANTHER Protein Class actin binding motor protein
PANTHER Pathway Category Nicotinic acetylcholine receptor signaling pathway
Myosin

28 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
actomyosin Any complex of actin, myosin, and accessory proteins.
actomyosin, myosin complex part The myosin part of any complex of actin, myosin, and accessory proteins.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
filopodium tip The end of a filopodium distal to the body of the cell.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
insulin-responsive compartment A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
intermediate filament A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
postsynapse The part of a synapse that is part of the post-synaptic cell.
postsynaptic actin cytoskeleton The actin cytoskeleton that is part of a postsynapse.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
smooth endoplasmic reticulum The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
unconventional myosin complex A portmanteau term for myosins other than myosin II.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

16 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein binding Binding to a protein or protein complex using energy from ATP hydrolysis.
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent protein binding Binding to a protein or protein complex in the presence of calcium.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
cytoskeletal motor activity Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
disordered domain specific binding Binding to a disordered domain of a protein.
identical protein binding Binding to an identical protein or proteins.
microfilament motor activity A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein-containing complex binding Binding to a macromolecular complex.
small GTPase binding Binding to a small monomeric GTPase.
SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
syntaxin-1 binding Binding to a syntaxin-1 SNAP receptor.

39 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
actin filament-based movement Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
axo-dendritic protein transport The directed movement of proteins along microtubules in neuron projections.
cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
developmental pigmentation The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
dopamine metabolic process The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
endoplasmic reticulum localization Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell.
establishment of endoplasmic reticulum localization to postsynapse The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
hair follicle maturation A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state.
insulin secretion The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
locomotion involved in locomotory behavior Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons.
macroautophagy The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
melanin biosynthetic process The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups
melanin metabolic process The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups
melanocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
melanosome localization Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.
melanosome transport The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
negative regulation of dopamine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.
negative regulation of synaptic transmission, glutamatergic Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
pigmentation The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
positive regulation of cellular response to insulin stimulus Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of vascular associated smooth muscle cell migration Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.
post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
reactive gliosis A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.
regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis.
regulation of postsynaptic cytosolic calcium ion concentration Any process that regulates the concentration of calcium in the postsynaptic cytosol.
secretory granule localization Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27991 MYH10 Myosin-10 Bos taurus (Bovine) SS
Q02440 MYO5A Unconventional myosin-Va Gallus gallus (Chicken) SS
Q5U651 RASIP1 Ras-interacting protein 1 Homo sapiens (Human) PR
B0I1T2 MYO1G Unconventional myosin-Ig Homo sapiens (Human) PR
P35580 MYH10 Myosin-10 Homo sapiens (Human) SS
Q9NQX4 MYO5C Unconventional myosin-Vc Homo sapiens (Human) SS
Q9ULV0 MYO5B Unconventional myosin-Vb Homo sapiens (Human) SS
Q9Y4I1 MYO5A Unconventional myosin-Va Homo sapiens (Human) SS
Q3U0S6 Rasip1 Ras-interacting protein 1 Mus musculus (Mouse) PR
Q61879 Myh10 Myosin-10 Mus musculus (Mouse) SS
E9Q634 Myo1e Unconventional myosin-Ie Mus musculus (Mouse) PR
P21271 Myo5b Unconventional myosin-Vb Mus musculus (Mouse) SS
Q64331 Myo6 Unconventional myosin-VI Mus musculus (Mouse) SS
P70569 Myo5b Unconventional myosin-Vb Rattus norvegicus (Rat) SS
Q9JLT0 Myh10 Myosin-10 Rattus norvegicus (Rat) SS
Q9QYF3 Myo5a Unconventional myosin-Va Rattus norvegicus (Rat) SS
Q9M2K0 XI-J Myosin-16 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAASELYTKF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY RLDPKTGELP
70 80 90 100 110 120
HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG
130 140 150 160 170 180
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF
190 200 210 220 230 240
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR
250 260 270 280 290 300
TYLLEKSRVV FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADSFHYTKQ GGSPMIEGVD
310 320 330 340 350 360
DAKEMAHTRQ ACTLLGISES YQMGIFRILA GILHLGNVGF ASRDSDSCTI PPKHEPLTIF
370 380 390 400 410 420
CDLMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR DALAKHIYAK LFNWIVDHVN
430 440 450 460 470 480
QALHSAVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE
490 500 510 520 530 540
QIPWTLIDFY DNQPCINLIE SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK
550 560 570 580 590 600
PRMSNKAFII KHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS
610 620 630 640 650 660
PTSATSSGRT PLTRVPVKPT KGRPGQTAKE HKKTVGHQFR NSLHLLMETL NATTPHYVRC
670 680 690 700 710 720
IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR WTYQEFFSRY RVLMKQKDVL
730 740 750 760 770 780
GDRKQTCKNV LEKLILDKDK YQFGKTKIFF RAGQVAYLEK LRADKLRAAC IRIQKTIRGW
790 800 810 820 830 840
LLRKRYLCMQ RAAITVQRYV RGYQARCYAK FLRRTKAATT IQKYWRMYVV RRRYKIRRAA
850 860 870 880 890 900
TIVIQSYLRG YLTRNRYRKI LREYKAVIIQ KRVRGWLART HYKRTMKAIV YLQCCFRRMM
910 920 930 940 950 960
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLMEKL TNLEGVYNSE
970 980 990 1000 1010 1020
TEKLRNDVER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE QTRSEKKSIE ERADKYKQET
1030 1040 1050 1060 1070 1080
DQLVSNLKEE NTLLKQEKET LNHRIVEQAK EMTETMERKL VEETKQLELD LNDERLRYQN
1090 1100 1110 1120 1130 1140
LLNEFSRLEE RYDDLKEEMT LMLNVPKPGH KRTDSTHSSN ESEYTFSSEF AETEDIAPRT
1150 1160 1170 1180 1190 1200
EEPIEKKVPL DMSLFLKLQK RVTELEQEKQ LMQDELDRKE EQVFRSKAKE EERPQIRGAE
1210 1220 1230 1240 1250 1260
LEYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVTAP GAPAYRVLME QLTSVSEELD
1270 1280 1290 1300 1310 1320
VRKEEVLILR SQLVSQKEAI QPKDDKNTMT DSTILLEDVQ KMKDKGEIAQ AYIGLKETNR
1330 1340 1350 1360 1370 1380
LLESQLQSQK RSHENEAEAL RGEIQSLKEE NNRQQQLLAQ NLQLPPEARI EASLQHEITR
1390 1400 1410 1420 1430 1440
LTNENLYFEE LYADDPKKYQ SYRISLYKRM IDLMEQLEKQ DKTVRKLKKQ LKVFAKKIGE
1450 1460 1470 1480 1490 1500
LEVGQMENIS PGQIIDEPIR PVNIPRKEKD FQGMLEYKRE DEQKLVKNLI LELKPRGVAV
1510 1520 1530 1540 1550 1560
NLIPGLPAYI LFMCVRHADY LNDDQKVRSL LTSTINSIKK VLKKRGDDFE TVSFWLSNTC
1570 1580 1590 1600 1610 1620
RFLHCLKQYS GEEGFMKHNT SRQNEHCLTN FDLAEYRQVL SDLAIQIYQQ LVRVLENILQ
1630 1640 1650 1660 1670 1680
PMIVSGMLEH ETIQGVSGVK PTGLRKRTSS IADEGTYTLD SILRQLNSFH SVMCQHGMDP
1690 1700 1710 1720 1730 1740
ELIKQVVKQM FYIVGAITLN NLLLRKDMCS WSKGMQIRYN VSQLEEWLRD KNLMNSGAKE
1750 1760 1770 1780 1790 1800
TLEPLIQAAQ LLQVKKKTDD DAEAICSMCN ALTTAQIVKV LNLYTPVNEF EERVSVSFIR
1810 1820 1830 1840 1850
TIQMRLRDRK DSPQLLMDAK HIFPVTFPFN PSSLALETIQ IPASLGLGFI ARV