Q98925

PR
Gene name
IRF2
Protein name
Interferon regulatory factor 2
Names
IRF-2
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396115
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q98925

Entry ID Method Resolution Chain Position Source
AF-Q98925-F1 Predicted AlphaFoldDB

17 variants for Q98925

Variant ID(s) Position Change Description Diseaes Association Provenance
rs736665937 15 Q>H No Ensembl
rs740005681 24 L>R No Ensembl
rs741415055 94 V>G No Ensembl
rs731132877 99 I>K No Ensembl
rs731944144 185 S>G No Ensembl
rs734622828 185 S>R No Ensembl
rs740750079 186 E>G No Ensembl
rs731815247 188 Q>R No Ensembl
rs737891035 202 E>G No Ensembl
rs738916976 280 V>L No Ensembl
rs739555848 282 N>K No Ensembl
rs738109841 286 L>P No Ensembl
rs740182795 289 T>P No Ensembl
rs735355630 297 L>P No Ensembl
rs736678275 306 F>S No Ensembl
rs740035214 309 I>T No Ensembl
rs734438193 332 S>G No Ensembl

No associated diseases with Q98925

2 regional properties for Q98925

Type Name Position InterPro Accession
domain Interferon regulatory factor, DNA-binding domain 1 - 114 IPR001346
conserved_site Interferon regulatory factor, conserved site 26 - 59 IPR019817

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

3 GO annotations of biological process

Name Definition
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90643 IRF3 Interferon regulatory factor 3 Gallus gallus (Chicken) SS
Q90871 IRF8 Interferon regulatory factor 8 Gallus gallus (Chicken) PR
10 20 30 40 50 60
MPVERMRMRP WLEEQINSNT IPGLKWINKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI
70 80 90 100 110 120
HTGKYQSGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLPLSERPSK
130 140 150 160 170 180
KGKKTKSEKD DKFKQIKQEP VESSFGINGL NDVTSDYFLS SSIKNEVDST VNIVVVGQPH
190 200 210 220 230 240
LDGSSEEQVI VANPPDVCQV VEVTTESDEQ PLSMSQLYPL QISPVSSYAE SETTDSVPSD
250 260 270 280 290 300
EENAEGRLHW QKKNIEGKQY LSNLGMRNTS HMLPSMATFV ANKPDLQVTI KEESCPLPYN
310 320 330 340
SSWPPFPDIP LPQVVSTAST SSSRPDRETR ASVIKKTSDI TQSRVKSC