Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q98878

Entry ID Method Resolution Chain Position Source
AF-Q98878-F1 Predicted AlphaFoldDB

No variants for Q98878

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q98878

No associated diseases with Q98878

5 regional properties for Q98878

Type Name Position InterPro Accession
conserved_site Helix-turn-helix motif 158 - 183 IPR000047
domain Homeobox domain 127 - 191 IPR001356
conserved_site Homeobox, conserved site 162 - 185 IPR017970
domain Homeobox domain, metazoa 151 - 162 IPR020479-1
domain Homeobox domain, metazoa 166 - 185 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

15 GO annotations of biological process

Name Definition
auditory receptor cell fate specification The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
camera-type eye development The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
embryonic viscerocranium morphogenesis The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
endocrine system development Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.
inner ear receptor cell development The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
lens fiber cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
olfactory placode formation The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
otic placode formation The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.
otic vesicle formation The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.
otic vesicle morphogenesis The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
trigeminal nerve development The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50577 DLX5 Homeobox protein DLX-5 Gallus gallus (Chicken) PR
O60479 DLX3 Homeobox protein DLX-3 Homo sapiens (Human) PR
P56179 DLX6 Homeobox protein DLX-6 Homo sapiens (Human) PR
Q99801 NKX3-1 Homeobox protein Nkx-3.1 Homo sapiens (Human) PR
P70396 Dlx5 Homeobox protein DLX-5 Mus musculus (Mouse) PR
Q64205 Dlx3 Homeobox protein DLX-3 Mus musculus (Mouse) PR
P70397 Dlx6 Homeobox protein DLX-6 Mus musculus (Mouse) PR
P50575 Dlx5 Homeobox protein DLX-5 Rattus norvegicus (Rat) PR
Q9FN29 ATHB-52 Homeobox-leucine zipper protein ATHB-52 Arabidopsis thaliana (Mouse-ear cress) PR
P46603 HAT9 Homeobox-leucine zipper protein HAT9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M276 ATHB-12 Homeobox-leucine zipper protein ATHB-12 Arabidopsis thaliana (Mouse-ear cress) PR
Q98875 dlx1a Homeobox protein Dlx1a Danio rerio (Zebrafish) (Brachydanio rerio) PR
P50574 dlx2a Homeobox protein Dlx2a Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q01702 dlx3b Homeobox protein Dlx3b Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMSMSFMSDT LNSSDPSKSA FLEFGHGLAS NQQHLSGFAH NIYPVHGLHS GGHLQHDAPY
70 80 90 100 110 120
PSSAPHYSRP LGYAYPGPVS AAAPGAYMPY QPNNHSGALA HTRAENTNHE KPAVIENGEI
130 140 150 160 170 180
RLNGKGKKIR KPRTIYSSVQ LQALHQRFQQ TQYLALPERA DLAAKLGLTQ TQVKIWFQNK
190 200 210 220 230 240
RSKYKKIMKH GSSGPEGELL HTSSSSPCSP GLSQLWEVSM ANKVPPMHPS SYMNNYGHWY
250
PPHHQDPVPR PQMM