Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q96S21

Entry ID Method Resolution Chain Position Source
AF-Q96S21-F1 Predicted AlphaFoldDB

179 variants for Q96S21

Variant ID(s) Position Change Description Diseaes Association Provenance
CA394066490
rs1160798415
4 Q>H No ClinGen
TOPMed
CA394066485
rs1433230982
4 Q>R No ClinGen
TOPMed
gnomAD
rs775383195
CA7780755
5 G>S No ClinGen
ExAC
TOPMed
gnomAD
rs1365298888
CA394066593
10 S>T No ClinGen
gnomAD
rs145637964
CA276495530
13 Y>F No ClinGen
gnomAD
rs1025699962
CA276495536
14 L>R No ClinGen
TOPMed
gnomAD
CA276495544
rs981413012
17 F>L No ClinGen
TOPMed
gnomAD
rs1218164093
CA394066700
18 L>P No ClinGen
TOPMed
rs765624453
CA7780763
CA394066717
20 V>L No ClinGen
ExAC
gnomAD
rs1219894722
CA394066763
24 D>Y No ClinGen
TOPMed
CA394066798
rs1301128434
29 E>A No ClinGen
TOPMed
CA7780766
rs777544608
31 L>R No ClinGen
ExAC
gnomAD
CA7780765
rs370585823
31 L>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA394066814
rs1422405551
32 E>Q No ClinGen
gnomAD
CA7780767
rs751170210
33 S>T No ClinGen
ExAC
gnomAD
CA394066829
rs1461622851
34 L>V No ClinGen
gnomAD
CA7780771
rs76494279
38 A>T No ClinGen
ExAC
gnomAD
CA7780773
rs749162107
39 A>V No ClinGen
ExAC
gnomAD
rs1322108355
CA394066869
40 E>V No ClinGen
gnomAD
rs771019645
CA7780777
42 P>A No ClinGen
ExAC
gnomAD
CA394066879
rs771019645
42 P>S No ClinGen
ExAC
gnomAD
rs1243070285
CA394066892
44 A>T No ClinGen
gnomAD
CA394066899
rs1184130466
45 Y>H No ClinGen
gnomAD
rs760042619
CA7780779
46 S>G No ClinGen
ExAC
gnomAD
CA394068504
rs1382152924
48 G>E No ClinGen
gnomAD
rs142098590
CA7780816
49 I>M No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs369008599
CA7780817
50 D>N No ClinGen
ESP
ExAC
gnomAD
rs1411364460
CA394068543
51 Y>C No ClinGen
gnomAD
CA276515088
rs146714041
53 T>I No ClinGen
ESP
CA394068597
rs1312638237
56 I>V No ClinGen
TOPMed
CA394068644
rs1333925847
60 G>S No ClinGen
gnomAD
rs760354318
CA7780822
61 R>Q No ClinGen
ExAC
gnomAD
CA7780823
rs765943081
62 R>C No ClinGen
ExAC
TOPMed
gnomAD
CA276515119
rs113743432
62 R>H No ClinGen
gnomAD
rs754957777
CA7780825
CA394068671
63 V>L No ClinGen
ExAC
TOPMed
gnomAD
rs754957777
CA394068669
63 V>M No ClinGen
ExAC
TOPMed
gnomAD
CA394068692
rs765148251
64 K>N No ClinGen
ExAC
TOPMed
gnomAD
CA394068828
rs1231223854
69 D>E No ClinGen
gnomAD
rs1006101164
CA276515728
70 T>A No ClinGen
TOPMed
gnomAD
CA7780857
rs747437679
72 G>V No ClinGen
ExAC
gnomAD
CA394068968
rs1195343299
81 R>G No ClinGen
gnomAD
rs1213297962
CA394043853
91 L>I No ClinGen
TOPMed
gnomAD
rs773870979
CA7780904
99 R>C No ClinGen
ExAC
gnomAD
CA7780905
rs748038180
99 R>H No ClinGen
ExAC
TOPMed
gnomAD
rs1430814944
CA394044069
101 S>A No ClinGen
gnomAD
rs773009600
COSM1735050
CA7780907
106 D>N pancreas [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
COSM1732509
CA394044193
rs1234126973
107 R>C Variant assessed as Somatic; impact. bone [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
TOPMed
CA394044196
rs1353411124
107 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs760615654
CA7780908
109 I>M No ClinGen
ExAC
TOPMed
gnomAD
CA7780910
COSM972449
rs141847125
113 D>N Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA394044626
rs1456590673
115 H>Y No ClinGen
TOPMed
rs1445146734
CA394044718
118 G>R No ClinGen
gnomAD
CA394044799
rs1596418384
121 R>W No ClinGen
Ensembl
CA394044957
rs1295127772
126 N>S No ClinGen
gnomAD
rs766733866
CA7780936
128 L>P No ClinGen
ExAC
TOPMed
gnomAD
CA394045170
rs1257435947
135 Q>* No ClinGen
gnomAD
CA394045217
rs1316180705
136 V>F No ClinGen
gnomAD
CA7780938
rs755321969
136 V>G No ClinGen
ExAC
gnomAD
CA7780939
rs778692638
137 P>L No ClinGen
ExAC
TOPMed
gnomAD
rs778692638
CA394045259
137 P>R No ClinGen
ExAC
TOPMed
gnomAD
rs1475952215
CA394045338
139 E>G No ClinGen
gnomAD
CA7780941
rs757975981
140 Q>H No ClinGen
ExAC
gnomAD
CA276486031
rs368232575
142 R>C No ClinGen
ESP
TOPMed
CA394045514
rs1596418452
COSM1378727
142 R>H large_intestine [Cosmic] No ClinGen
cosmic curated
Ensembl
rs770929145
CA7780944
143 A>G No ClinGen
ExAC
TOPMed
gnomAD
rs746975761
CA7780943
COSM1378728
143 A>T Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs770929145
CA276486042
COSM1519530
143 A>V lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1240083495
CA394045580
144 Y>N No ClinGen
TOPMed
rs774680458
CA7780948
146 E>G No ClinGen
ExAC
gnomAD
rs761887472
CA7780949
147 K>N No ClinGen
ExAC
gnomAD
rs1303903822
CA394045726
148 N>D No ClinGen
TOPMed
CA7780950
rs772222679
150 M>V No ClinGen
ExAC
gnomAD
CA394045844
rs1193159585
151 T>I No ClinGen
TOPMed
CA7780952
rs761182946
155 V>A No ClinGen
ExAC
gnomAD
CA394045984
rs1190688306
157 P>L No ClinGen
TOPMed
gnomAD
CA7780953
rs766928136
160 N>K No ClinGen
ExAC
TOPMed
gnomAD
CA276486078
rs145146569
162 N>K No ClinGen
1000Genomes
ExAC
gnomAD
rs199820805
CA7780955
163 V>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
CA394046179
rs1277866850
164 I>T No ClinGen
gnomAD
TCGA novel 165 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA394046288
rs1262081897
167 F>L No ClinGen
gnomAD
CA7780958
COSM3377929
rs149553764
168 T>M pancreas [Cosmic] No ClinGen
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA394046338
rs1373153766
170 L>P No ClinGen
gnomAD
CA394046380
rs1486990388
172 R>C No ClinGen
TOPMed
rs1410673010
CA394046493
175 L>F No ClinGen
TOPMed
gnomAD
rs1358945782
CA394046521
176 M>I No ClinGen
gnomAD
CA7780963
rs745774805
177 R>W No ClinGen
ExAC
TOPMed
CA394046672
rs1344090586
180 M>T No ClinGen
gnomAD
CA7780966
rs748403129
182 K>R No ClinGen
ExAC
gnomAD
CA394046756
rs1596418581
183 I>M No ClinGen
Ensembl
rs772126157
CA7780967
185 R>K No ClinGen
ExAC
gnomAD
rs138855752
CA7780969
188 R>* No ClinGen
ESP
ExAC
gnomAD
CA394046904
rs1234823780
188 R>Q No ClinGen
gnomAD
rs1022176244
CA276487392
189 V>A No ClinGen
TOPMed
CA276487406
rs1040445841
193 Q>R No ClinGen
gnomAD
CA394048341
rs1596420636
194 D>A No ClinGen
Ensembl
rs1354362718
CA394048363
195 L>V No ClinGen
gnomAD
rs761513789
CA7780996
198 R>Q No ClinGen
ExAC
gnomAD
CA7780995
rs774200663
198 R>W No ClinGen
ExAC
gnomAD
TCGA novel 199 A>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1402993791
CA394048472
199 A>V No ClinGen
TOPMed
CA394048545
rs1178206059
203 C>G No ClinGen
gnomAD
CA276487442
rs1047236492
204 T>I No ClinGen
gnomAD
CA394048559
rs1596420732
204 T>P No ClinGen
Ensembl
rs766292623
CA7781000
205 P>L No ClinGen
ExAC
gnomAD
rs754816141
CA7781002
206 V>M No ClinGen
ExAC
TOPMed
gnomAD
CA394048631
rs887252783
207 H>D No ClinGen
gnomAD
rs1596420774
CA394048637
207 H>P No ClinGen
Ensembl
rs887252783
CA276487450
207 H>Y No ClinGen
gnomAD
rs751811524
CA7781004
209 I>M No ClinGen
ExAC
TOPMed
gnomAD
rs1596420808
CA394048774
210 D>G No ClinGen
Ensembl
rs757405774
CA7781005
210 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA394048842
rs1470757171
211 K>T No ClinGen
TOPMed
gnomAD
CA7781008
rs769916923
216 V>I No ClinGen
ExAC
TOPMed
gnomAD
rs780469810
CA7781009
217 T>A No ClinGen
ExAC
gnomAD
CA7781010
rs142091223
218 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1294052167
CA394048987
219 K>Q No ClinGen
gnomAD
rs1309709264
CA394049073
221 H>Y No ClinGen
gnomAD
rs1038617356
CA276487501
224 S>Y No ClinGen
TOPMed
CA276487521
rs1012886686
230 G>S Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
CA7781014
rs771906342
231 M>L No ClinGen
ExAC
gnomAD
rs942580330
CA276487536
233 A>T No ClinGen
TOPMed
rs1488002534
CA394049434
233 A>V No ClinGen
TOPMed
gnomAD
CA7781017
rs765889616
235 M>T No ClinGen
ExAC
gnomAD
rs1596420975
CA394049513
237 H>P No ClinGen
Ensembl
CA7781019
rs759429407
238 G>R No ClinGen
ExAC
gnomAD
rs759429407
CA7781020
238 G>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA7781021
rs752433198
239 R>C No ClinGen
ExAC
gnomAD
rs759820839
CA276487574
239 R>H No ClinGen
gnomAD
rs1382478653
CA394049646
242 S>P No ClinGen
TOPMed
CA7781022
rs758178772
244 A>T No ClinGen
ExAC
gnomAD
rs975360807
CA394049722
245 S>C No ClinGen
TOPMed
gnomAD
rs975360807
CA276487578
245 S>G No ClinGen
TOPMed
gnomAD
rs866522531
CA276487587
245 S>N No ClinGen
Ensembl
CA276487597
rs931162548
246 G>R No ClinGen
TOPMed
gnomAD
rs370444305
CA7781025
248 G>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 249 G>missing Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
COSM3387545
rs373191568
CA7781028
250 G>S pancreas [Cosmic] No ClinGen
cosmic curated
ESP
ExAC
TOPMed
gnomAD
CA7781031
rs201836577
251 G>D No ClinGen
1000Genomes
ExAC
gnomAD
rs145997805
COSM1222947
CA7781030
251 G>S Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA394049922
rs1596421171
252 S>C No ClinGen
Ensembl
rs1243883695
CA394050015
253 K>N No ClinGen
gnomAD
rs1202019186
CA394050054
254 G>D No ClinGen
TOPMed
rs772787623
CA7781033
255 N>I No ClinGen
ExAC
TOPMed
gnomAD
CA7781032
rs772787623
255 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs1252365326
CA394050095
256 S>G No ClinGen
gnomAD
rs1452332492
CA394050120
257 L>F No ClinGen
gnomAD
CA7781035
rs776140672
258 K>* No ClinGen
ExAC
gnomAD
rs759484476
CA7781036
258 K>M No ClinGen
ExAC
gnomAD
CA7781037
rs765219284
259 R>G No ClinGen
ExAC
gnomAD
CA394050183
rs1346422228
260 S>F No ClinGen
gnomAD
rs1346422228
CA394050178
260 S>Y No ClinGen
gnomAD
CA276487657
rs1057450215
264 R>C No ClinGen
TOPMed
gnomAD
CA7781039
rs762779175
264 R>H No ClinGen
ExAC
TOPMed
gnomAD
CA394050302
rs1567196130
265 P>L No ClinGen
Ensembl
rs763930817
CA394050430
268 S>I No ClinGen
ExAC
TOPMed
rs750636999
CA394050434
268 S>R No ClinGen
ExAC
gnomAD
CA7781041
rs763930817
268 S>T No ClinGen
ExAC
TOPMed
CA276487684
rs200782060
269 P>A No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA394050441
rs1350446944
269 P>L No ClinGen
gnomAD
CA276487692
rs200782060
269 P>S No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA7781043
rs200782060
269 P>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA7781045
rs754026121
270 P>A No ClinGen
ExAC
rs142169601
CA394050468
270 P>H No ClinGen
ESP
ExAC
TOPMed
CA7781046
rs142169601
270 P>R No ClinGen
ESP
ExAC
TOPMed
CA394050457
rs754026121
270 P>T No ClinGen
ExAC
CA394050489
rs150789883
271 Q>* No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7781050
rs150789883
271 Q>E No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs150789883
CA7781049
271 Q>K No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1555457247 271 Q>P Variant assessed as Somatic; 0.0002928 impact. [NCI-TCGA] No NCI-TCGA
rs1245393727
CA394050565
273 C>S No ClinGen
TOPMed
rs1317581608
CA394050611
274 S>L No ClinGen
gnomAD
TCGA novel 274 S>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1467035714
CA394050624
275 R>Q No ClinGen
gnomAD
CA276487709
rs11548187
275 R>W No ClinGen
ExAC
gnomAD
rs776136791
CA7781054
276 S>N No ClinGen
ExAC
gnomAD
rs745451139
CA7781055
277 N>Y No ClinGen
ExAC
CA7781057
rs775459220
279 K>N No ClinGen
ExAC
gnomAD
rs1400937522
CA394050812
282 S>W No ClinGen
gnomAD

No associated diseases with Q96S21

2 regional properties for Q96S21

Type Name Position InterPro Accession
domain SOCS box domain 175 - 228 IPR001496
domain Small GTP-binding protein domain 15 - 157 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P07560 SEC4 Ras-related protein SEC4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2HJI8 RAB8B Ras-related protein Rab-8B Bos taurus (Bovine) PR
A4FV54 RAB8A Ras-related protein Rab-8A Bos taurus (Bovine) PR
Q1RMR4 RAB15 Ras-related protein Rab-15 Bos taurus (Bovine) PR
Q5F470 RAB8A Ras-related protein Rab-8A Gallus gallus (Chicken) PR
P0C0E4 RAB40AL Ras-related protein Rab-40A-like Homo sapiens (Human) PR
Q8WXH6 RAB40A Ras-related protein Rab-40A Homo sapiens (Human) PR
Q12829 RAB40B Ras-related protein Rab-40B Homo sapiens (Human) PR
Q6IQ22 RAB12 Ras-related protein Rab-12 Homo sapiens (Human) PR
Q92930 RAB8B Ras-related protein Rab-8B Homo sapiens (Human) PR
P61006 RAB8A Ras-related protein Rab-8A Homo sapiens (Human) PR
P59190 RAB15 Ras-related protein Rab-15 Homo sapiens (Human) PR
P55258 Rab8a Ras-related protein Rab-8A Mus musculus (Mouse) PR
Q8K386 Rab15 Ras-related protein Rab-15 Mus musculus (Mouse) PR
P61028 Rab8b Ras-related protein Rab-8B Mus musculus (Mouse) PR
P35283 Rab12 Ras-related protein Rab-12 Mus musculus (Mouse) PR
Q9DD03 Rab13 Ras-related protein Rab-13 Mus musculus (Mouse) PR
Q8CB87 Rab44 Ras-related protein Rab-44 Mus musculus (Mouse) PR
Q8VHP8 Rab40b Ras-related protein Rab-40B Mus musculus (Mouse) PR
Q8VHQ4 Rab40c Ras-related protein Rab-40C Mus musculus (Mouse) PR
P35289 Rab15 Ras-related protein Rab-15 Rattus norvegicus (Rat) PR
P35280 Rab8a Ras-related protein Rab-8A Rattus norvegicus (Rat) PR
P70550 Rab8b Ras-related protein Rab-8B Rattus norvegicus (Rat) PR
P35284 Rab12 Ras-related protein Rab-12 Rattus norvegicus (Rat) PR
P35281 Rab10 Ras-related protein Rab-10 Rattus norvegicus (Rat) PR
O24466 RABE1A Ras-related protein RABE1a Arabidopsis thaliana (Mouse-ear cress) PR
Q9SF91 RABE1E Ras-related protein RABE1e Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZD4 RABE1D Ras-related protein RABE1d Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGSQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG
70 80 90 100 110 120
RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP
130 140 150 160 170 180
RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM TFFEVSPLCN FNVIESFTEL SRIVLMRHGM
190 200 210 220 230 240
EKIWRPNRVF SLQDLCCRAI VSCTPVHLID KLPLPVTIKS HLKSFSMANG MNAVMMHGRS
250 260 270 280
YSLASGAGGG GSKGNSLKRS KSIRPPQSPP QNCSRSNCKI S