AiPD: Autoinhibited Protein Database

Q96RR4

Gene name	CAMKK2 (CAMKKB, KIAA0787)
Protein name	Calcium/calmodulin-dependent protein kinase kinase 2
Names	CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10645
EC number	2.7.11.17: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-176 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

92-176 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

329-352 (Activation loop from InterPro)

Target domain	165-446 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

25 structures for Q96RR4

Entry ID	Method	Resolution	Chain	Position	Source
2ZV2	X-ray	240 A	A	158-448	PDB
5UY6	X-ray	170 A	A	161-449	PDB
5UYJ	X-ray	160 A	A	161-449	PDB
5VT1	X-ray	190 A	A	161-449	PDB
5YV8	X-ray	193 A	A	158-448	PDB
5YV9	X-ray	253 A	A	158-448	PDB
5YVA	X-ray	257 A	A	158-448	PDB
5YVB	X-ray	202 A	A	158-448	PDB
5YVC	X-ray	202 A	A	158-448	PDB
6BKU	X-ray	200 A	A	162-449	PDB
6BLE	X-ray	190 A	A	161-449	PDB
6BQL	X-ray	200 A	A	161-449	PDB
6BQP	X-ray	195 A	A	161-449	PDB
6BQQ	X-ray	180 A	A	161-449	PDB
6BRC	X-ray	220 A	A/B	161-449	PDB
6CMJ	X-ray	240 A	A/B	149-465	PDB
6EF5	X-ray	244 A	Q/S	508-514	PDB
6EWW	X-ray	268 A	E/F/G/H	97-104	PDB
6FEL	X-ray	284 A	E/F/G/H	508-515	PDB
6Y3O	X-ray	150 A	P	97-104	PDB
6Y4K	X-ray	300 A	E/F	97-104	PDB
6Y6B	X-ray	308 A	C/D	97-104	PDB
6Y8A	X-ray	150 A	P	508-515	PDB
8TUC	X-ray	150 A	A	161-449	PDB
AF-Q96RR4-F1	Predicted				AlphaFoldDB

462 variants for Q96RR4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1328220999 CA386946986	2	S>L		No	ClinGen gnomAD
CA386946959 rs1303678199	4	C>R		No	ClinGen gnomAD
CA244555044 rs536363342	9	P>S		No	ClinGen 1000Genomes
VAR_032788 rs28360477 CA6834970	10	S>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs781250016 CA6834969	10	S>R		No	ClinGen ExAC TOPMed gnomAD
CA6834971 rs145827495	10	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6834968 rs747254221	13	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6834966 rs550638648	13	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA6834967 rs747254221	13	R>W		No	ClinGen ExAC TOPMed gnomAD
rs758658098 CA6834965	14	A>T		No	ClinGen ExAC gnomAD
rs867881072 CA244554983	14	A>V		No	ClinGen Ensembl
COSM1188629 CA6834963 COSM1188628 rs779276966	15	A>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1244767346 CA386946758	15	A>V		No	ClinGen TOPMed
rs757852554 CA6834961	16	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386946755 rs757852554	16	P>T		No	ClinGen ExAC gnomAD
CA6834958 rs747697513	17	Q>P		No	ClinGen ExAC TOPMed
rs747697513 CA6834957	17	Q>R		No	ClinGen ExAC TOPMed
CA386946712 rs1279204211	18	D>H		No	ClinGen TOPMed gnomAD
CA386946714 rs1279204211	18	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	20	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6834954 rs199883814	22	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6834952 rs201000982	23	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6834949 rs776642531	25	S>G		No	ClinGen ExAC TOPMed gnomAD
rs768699149 CA6834948	26	S>G		No	ClinGen ExAC gnomAD
rs1156431686 CA386946552	26	S>I		No	ClinGen gnomAD
CA386946548 rs1478831102	27	S>G		No	ClinGen gnomAD
CA6834947 rs747129806	27	S>N		No	ClinGen ExAC gnomAD
CA386946499 rs1566109307	29	E>G		No	ClinGen Ensembl
CA244554885 rs201539661	29	E>K		No	ClinGen ESP TOPMed gnomAD
rs200615415 CA244554858	30	S>I		No	ClinGen TOPMed gnomAD
CA244554882 rs200615415	30	S>N		No	ClinGen TOPMed gnomAD
CA386946468 rs1395733290	30	S>R		No	ClinGen TOPMed
rs772398441 CA6834945	31	Q>*		No	ClinGen ExAC gnomAD
CA6834943 rs528343390	33	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1447927152 CA386946416	33	P>S		No	ClinGen gnomAD
rs757803183 CA6834942	34	C>R		No	ClinGen ExAC gnomAD
CA6834941 rs560937960	34	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386946382 rs1360059984	35	E>K		No	ClinGen gnomAD
rs778476145 CA6834940	36	A>V		No	ClinGen ExAC gnomAD
rs575267981 CA6834938	38	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6834939 rs140975842	38	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765887717 CA6834937	39	G>D		No	ClinGen ExAC gnomAD
rs1325611722 CA386946283	41	S>L		No	ClinGen gnomAD
CA6834936 rs146298458	44	S>N		No	ClinGen ESP ExAC TOPMed
CA6834934 rs765037782	48	G>A		No	ClinGen ExAC gnomAD
COSM936009 CA244554814 COSM1152478 rs199792967	49	M>V	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA244554813 rs771744764	51	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs761645109 CA6834933	53	I>T		No	ClinGen ExAC gnomAD
CA6834932 rs776517605	55	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6834931 rs201430481	57	E>K		No	ClinGen ExAC gnomAD
CA6834929 rs775654283	58	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1462791558 CA386945868	59	E>K		No	ClinGen TOPMed gnomAD
CA6834928 rs141381524	60	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA244554752 rs202061927	61	G>D		No	ClinGen TOPMed
CA386945827 rs202061927	61	G>V		No	ClinGen TOPMed
CA244554743 rs1019995309	62	C>S		No	ClinGen gnomAD
CA6834926 rs200031197	63	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386945766 rs1215069614	65	D>A		No	ClinGen gnomAD
CA6834924 rs201270246	65	D>E		No	ClinGen ExAC TOPMed gnomAD
CA386945765 rs1215069614	65	D>G		No	ClinGen gnomAD
CA6834925 rs771403751	65	D>H		No	ClinGen ExAC gnomAD
rs746435585 CA6834921 COSM1359449 COSM1359448	67	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs202102327 CA6834920	69	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6834917 rs199801387	70	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201146989 CA6834918	70	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386945646 rs1593431765	71	D>A		No	ClinGen Ensembl
CA6834915 rs201878323	72	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs374616967 CA6834916	72	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA386945608 rs1419461541	73	P>S		No	ClinGen gnomAD
CA6834912 rs775392999	77	D>N		No	ClinGen ExAC TOPMed gnomAD
CA244554659 rs750476683	81	V>I		No	ClinGen TOPMed gnomAD
rs767661175 CA6834911	82	P>L		No	ClinGen ExAC gnomAD
rs759588177 CA6834910	84	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1248158748 CA386945481	85	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs3817190 CA386945485	85	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6834908 VAR_020532 rs3817190	85	T>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA386945467 rs1593431259	86	S>F		No	ClinGen Ensembl
rs1314165045 CA386945475	86	S>P		No	ClinGen gnomAD
COSM1578920 COSM1578919 rs200654946 CA6834906	87	G>R	meninges [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA6834905 rs770155843	87	G>V		No	ClinGen ExAC
rs745434921 CA6834901	91	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6834902 rs200162363	91	R>W		No	ClinGen ExAC TOPMed gnomAD
rs756917855 CA6834899	93	H>Y		No	ClinGen ExAC gnomAD
rs1566107499 CA386945366	94	L>F		No	ClinGen Ensembl
rs374592351 CA6834898	95	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA386945347 rs1249796508	96	G>S		No	ClinGen TOPMed gnomAD
CA6834896 rs200801054 COSM430532 COSM1476247	97	R>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6834895 rs199530456	97	R>H	Variant assessed as Somatic; 4.838e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6834894 rs199530456	97	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA244554591 rs948517475	99	L>V		No	ClinGen Ensembl
CA386945290 rs1229531741	101	L>P		No	ClinGen TOPMed
CA386945269 rs1307277623	104	R>L		No	ClinGen gnomAD
CA386945270 rs1307277623	104	R>Q		No	ClinGen gnomAD
CA6834891 rs200809684	104	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs763294715 CA6834890	107	G>C		No	ClinGen ExAC gnomAD
CA6834889 rs773659763	108	G>R		No	ClinGen ExAC gnomAD
CA244554572 rs1054122378	109	L>P		No	ClinGen gnomAD
CA6834888 rs770170374	110	A>G		No	ClinGen ExAC gnomAD
rs201551966 CA6834886	112	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386945201 rs1456729602	113	G>D		No	ClinGen gnomAD
CA244554545 rs374425048	115	L>P		No	ClinGen gnomAD
CA6834885 rs374969030	116	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1409825228 CA386945167	117	M>V		No	ClinGen TOPMed gnomAD
rs115336463 CA244554527	118	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6834883 rs202226737	119	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs201478248 CA6834881	120	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA244554518 rs966324914	120	R>H		No	ClinGen Ensembl
CA386945088 rs35403710	123	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs35403710 CA6834880 VAR_040610	123	C>Y		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs199839826 CA6834879	124	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386945067 rs1264419857	125	S>Y		No	ClinGen gnomAD
VAR_040611	127	P>L	a lung neuroendocrine carcinoma sample; somatic mutation [UniProt]	No	UniProt
CA386945037 rs1283194877	128	Y>*		No	ClinGen gnomAD
CA386945025 rs1385659023	129	S>L		No	ClinGen gnomAD
rs1459116696 CA386945019	130	P>H		No	ClinGen TOPMed
rs1459116696 CA386945016	130	P>L		No	ClinGen TOPMed
CA386945023 rs1364485817	130	P>S		No	ClinGen gnomAD
rs766586427 CA6834874	131	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763171097 CA6834873	132	S>I		No	ClinGen ExAC gnomAD
CA386945005 rs1386765465	132	S>R		No	ClinGen gnomAD
rs765441955 CA6834871	134	P>L		No	ClinGen ExAC gnomAD
TCGA novel	134	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386944967 rs1430275816	135	Q>*		No	ClinGen gnomAD
CA386944971 rs1430275816	135	Q>K		No	ClinGen gnomAD
rs201145728 CA6834868	137	S>L		No	ClinGen ExAC gnomAD
CA244554430 rs1003140498	137	S>P		No	ClinGen Ensembl
CA244554422 rs199839786	138	P>S		No	ClinGen gnomAD
rs1203974346 CA386944928	139	R>Q		No	ClinGen gnomAD
CA6834866 rs202048546	139	R>W	Variant assessed as Somatic; 5.878e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6834865 rs770406690	141	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1323793521 CA386944914	141	P>S		No	ClinGen TOPMed
rs777479538 CA6834863	142	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6834864 rs201263450	142	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775765201 CA6834861	143	R>Q		No	ClinGen ExAC TOPMed
rs35798271 CA386944897	143	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6834859 rs201753522	144	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	148	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780177185 CA6834856	150	H>Y		No	ClinGen ExAC gnomAD
CA6834854 rs201742753	151	V>I		No	ClinGen ExAC gnomAD
CA6834853 rs184189303	152	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386944756 rs1566106026	154	T>A		No	ClinGen Ensembl
CA6834851 rs377581818	154	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6834852 rs377581818	154	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA386944728 rs1253406385	156	M>I		No	ClinGen gnomAD
CA386944739 rs1460637963	156	M>V		No	ClinGen gnomAD
rs200404512 CA244552453	158	D>G		No	ClinGen TOPMed gnomAD
CA386944085 COSM3416554 COSM3416555 rs1407871256	159	C>G	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA6834838 rs758423314	164	Q>R		No	ClinGen ExAC gnomAD
rs1159931088 CA386943854	170	E>A		No	ClinGen gnomAD
CA386943863 rs1593411562	170	E>K		No	ClinGen Ensembl
rs757452308 CA6834835	171	I>T		No	ClinGen ExAC gnomAD
CA6834823 rs768480475	174	G>V		No	ClinGen ExAC gnomAD
TCGA novel	176	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244551599 COSM1199475 rs935552545 COSM1199474	179	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1566095148 CA386943292	180	K>Q		No	ClinGen Ensembl
rs1207121718 COSM20494 VAR_040612 CA386943255	182	A>T	large_intestine a colorectal adenocarcinoma sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt dbSNP gnomAD
CA6834822 rs746740827	183	Y>C		No	ClinGen ExAC gnomAD
rs765340589 CA244551558	184	N>D		No	ClinGen Ensembl
rs1593404609 CA386943121	189	T>I		No	ClinGen Ensembl
rs775428439 CA6834821	190	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs763773184 CA6834805	192	A>T		No	ClinGen ExAC gnomAD
TCGA novel	192	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386942937 rs1297142890	193	M>T		No	ClinGen TOPMed
CA386942901 rs1305210574	195	V>A		No	ClinGen TOPMed
CA6834804 rs760434064	195	V>M		No	ClinGen ExAC gnomAD
TCGA novel	199	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199874688 CA244551050	200	K>T		No	ClinGen Ensembl
rs1430991729 CA386942808	203	R>Q		No	ClinGen gnomAD
CA6834802 rs771971632	203	R>W		No	ClinGen ExAC gnomAD
rs759417993 CA6834801	205	A>S		No	ClinGen ExAC gnomAD
CA244551044 rs1030343452	206	G>A		No	ClinGen TOPMed
rs200886794 CA6834799	209	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs762984197 CA6834781 COSM3416552 COSM3416553	210	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773178395 CA6834780	210	R>H	Variant assessed as Somatic; 4.792e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1490451948 CA386941695	212	P>L		No	ClinGen gnomAD
rs748291040 CA6834778	214	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1593374277 CA386941659	216	T>A		No	ClinGen Ensembl
CA6834777 rs781377596	216	T>I		No	ClinGen ExAC gnomAD
CA386941651 rs1284296009	217	R>W		No	ClinGen TOPMed gnomAD
TCGA novel	218	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200150673 CA386941595	222	G>D		No	ClinGen TOPMed gnomAD
rs200150673 CA244548837	222	G>V		No	ClinGen TOPMed gnomAD
CA6834775 rs747269519	223	C>Y		No	ClinGen ExAC gnomAD
rs780498713 CA6834774	227	R>K		No	ClinGen ExAC gnomAD
TCGA novel	227	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779603792 CA6834771	230	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	234	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1586235 rs1159933592 COSM936007 CA386941389	236	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6834770 rs755682639	237	I>N		No	ClinGen ExAC gnomAD
CA244548803 rs374169294	244	D>G		No	ClinGen ESP gnomAD
CA244548780 rs771674497	246	P>S		No	ClinGen TOPMed
rs767021876 CA244548775	247	N>I		No	ClinGen ExAC TOPMed gnomAD
rs767021876 CA6834768	247	N>S		No	ClinGen ExAC TOPMed gnomAD
rs200059037 CA244548771	249	V>M		No	ClinGen Ensembl
rs1170585723 CA386941087	253	E>D		No	ClinGen TOPMed
rs1367292658 CA386970697	259	N>S		No	ClinGen gnomAD
CA386970659 rs1366156021	262	H>R		No	ClinGen gnomAD
CA6834725 rs753777675	262	H>Y		No	ClinGen ExAC gnomAD
rs1473818454 CA386970624	265	M>T		No	ClinGen gnomAD
rs951504520 CA244597509	265	M>V		No	ClinGen gnomAD
CA6834703 rs777698092	266	V>A		No	ClinGen ExAC gnomAD
TCGA novel	267	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386969930 rs1399397707	271	N>D		No	ClinGen gnomAD
rs759727042 CA386969926	271	N>I		No	ClinGen ExAC TOPMed gnomAD
rs751804866 CA6834698	271	N>K		No	ClinGen ExAC TOPMed gnomAD
rs759727042 CA6834699	271	N>S		No	ClinGen ExAC TOPMed gnomAD
CA386969922 rs1161270986	272	Q>*		No	ClinGen TOPMed
CA386969883 rs1283117666	274	P>S		No	ClinGen gnomAD
rs1354124033 COSM1586236 COSM936006 CA386969873	275	V>M	Variant assessed as Somatic; 4.646e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs371428001 CA244593714	276	M>T		No	ClinGen Ensembl
CA6834673 rs202190716	278	V>E		No	ClinGen 1000Genomes ExAC gnomAD
CA244593712 rs1016081976	278	V>M		No	ClinGen TOPMed gnomAD
rs1370401604 CA386969827	279	P>S		No	ClinGen gnomAD
rs1407341397 CA386969816	280	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1407341397 CA386969818	280	T>N		No	ClinGen gnomAD
CA386969821 rs1593329133	280	T>P		No	ClinGen Ensembl
CA6834669 rs144335101	285	S>P		No	ClinGen ESP ExAC
CA6834667 rs748010012	286	E>K		No	ClinGen ExAC gnomAD
CA244593673 rs752145128	289	A>G		No	ClinGen ExAC gnomAD
rs752145128 CA6834666	289	A>V		No	ClinGen ExAC gnomAD
CA6834665 rs754983449	290	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6834664 rs747039247	290	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1223251103 CA386969696	291	F>L		No	ClinGen gnomAD
CA244593657 rs200803906	293	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1593328807 CA386969666	294	Q>K		No	ClinGen Ensembl
CA386969659 rs1256087090	294	Q>R		No	ClinGen TOPMed
CA386969642 rs1483990259	295	D>V		No	ClinGen TOPMed
CA6834662 rs758547025	296	L>V		No	ClinGen ExAC gnomAD
CA386969623 rs139606987	297	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765553865 CA6834660	299	G>A		No	ClinGen ExAC gnomAD
CA386969576 rs1411013049	301	E>D		No	ClinGen gnomAD
rs1262075225 CA386969579	301	E>G		No	ClinGen gnomAD
CA6834635 rs192796956	307	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386968739 rs1566054000	308	I>F		No	ClinGen Ensembl
rs1566054000 CA386968740	308	I>V		No	ClinGen Ensembl
CA6834634 rs749966784	310	H>Y		No	ClinGen ExAC gnomAD
rs1307905721 CA386968684	311	R>C		No	ClinGen TOPMed
CA244592254 rs199889163	311	R>H		No	ClinGen Ensembl
CA386968652 rs1367628829	313	I>V		No	ClinGen gnomAD
CA6834633 rs764751426	317	N>S		No	ClinGen ExAC gnomAD
CA386968549 rs1566053853	318	L>I		No	ClinGen Ensembl
rs1309944455 CA386968534	319	L>V		No	ClinGen TOPMed
CA386968502 rs1466529785	321	G>R		No	ClinGen gnomAD
rs1566053769 CA386968484	322	E>Q		No	ClinGen Ensembl
rs1358308493 CA386968446	323	D>E		No	ClinGen gnomAD
rs149343557 CA244592222	328	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6834630 rs768551666	329	A>S		No	ClinGen ExAC TOPMed gnomAD
COSM1586237 COSM936005 CA386968346 rs768551666	329	A>T	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6834628 rs775286615	335	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6834626 rs567964739	338	K>T		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	338	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386968209 rs1184060674	339	G>D		No	ClinGen gnomAD
CA6834625 rs779072460	340	S>N		No	ClinGen ExAC
CA6834623 rs749479203	342	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6834622 rs778015051	342	A>V		No	ClinGen ExAC gnomAD
CA386968144 rs1441968844	345	S>F		No	ClinGen TOPMed
rs749863437 CA6834617	346	N>K		No	ClinGen ExAC gnomAD
CA386968133 rs1194134776	346	N>S		No	ClinGen TOPMed
CA386968124 rs1593311136	347	T>P		No	ClinGen Ensembl
rs149707360 CA6834615	348	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs149707360 CA6834616	348	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1396496439 COSM328679 CA386968101	350	T>M	Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA386968106 rs1593311063	350	T>P		No	ClinGen Ensembl
CA6834613 rs763906764	352	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386968051 rs1167545698	355	A>V		No	ClinGen gnomAD
CA6834611 rs775368084	357	E>K		No	ClinGen ExAC TOPMed gnomAD
rs771856117 CA6834610	358	S>L		No	ClinGen ExAC TOPMed gnomAD
CA386967994 rs1303873351	361	E>A		No	ClinGen TOPMed
TCGA novel	361	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6834607 rs202103661	361	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6834606 rs150578614	362	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA386967989 rs1174774660	362	T>S		No	ClinGen Ensembl
rs1132780 CA6834605 VAR_020533	363	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs770005277 CA6834604	363	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770005277 CA386967976	363	R>L		No	ClinGen ExAC TOPMed gnomAD
rs748416243 CA6834603	364	K>R		No	ClinGen ExAC TOPMed gnomAD
CA386967971 rs748416243	364	K>T		No	ClinGen ExAC TOPMed gnomAD
rs755340866 CA6834601	365	I>V		No	ClinGen ExAC gnomAD
rs1291358851 CA386967951	366	F>Y		No	ClinGen gnomAD
rs780765704 CA6834599	367	S>F		No	ClinGen ExAC TOPMed gnomAD
CA244591648 rs201880301	375	A>T		No	ClinGen Ensembl
CA386967803 rs1379774278	376	M>V		No	ClinGen gnomAD
CA386967719 rs1465444503	386	G>D		No	ClinGen gnomAD
rs769333324 CA6834561	389	P>L		No	ClinGen ExAC gnomAD
rs779609974 CA6834562	389	P>T		No	ClinGen ExAC
CA386967167 rs1267930874	391	M>L		No	ClinGen TOPMed gnomAD
CA6834559 rs780828018	393	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6834557 rs200976364	394	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs754596011 CA6834558	394	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1205871215 CA386967131	396	M>K		No	ClinGen gnomAD
rs1419365528 CA386967134	396	M>V		No	ClinGen TOPMed
rs1170183544 CA386967104	399	H>Q		No	ClinGen Ensembl
CA6834556 rs540716908	400	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6834555 rs540716908	400	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386967094 rs1170690274	401	K>E		No	ClinGen gnomAD
CA386967071 rs1418849004	404	S>G		No	ClinGen gnomAD
CA244589749 rs983855142	407	L>V		No	ClinGen gnomAD
CA386967038 rs1593294299	409	F>I		No	ClinGen Ensembl
CA6834554 rs750349984	409	F>L		No	ClinGen ExAC gnomAD
CA386967022 rs1593294236	411	D>A		No	ClinGen Ensembl
rs765156471 CA6834553	411	D>H		No	ClinGen ExAC TOPMed gnomAD
CA6834552 rs147402468	412	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs142766604 CA6834524	414	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA6834523 rs746592299	415	I>T		No	ClinGen ExAC gnomAD
CA6834522 rs138706708	418	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1459757320 CA386966952	419	L>M		No	ClinGen gnomAD
rs1159826368 CA386966924	421	D>E		No	ClinGen gnomAD
rs200160633 CA6834520	424	T>A		No	ClinGen ExAC TOPMed gnomAD
rs778606038 CA6834519	425	R>C		No	ClinGen ExAC TOPMed gnomAD
rs201318802 CA6834518	425	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777824731 CA6834516	426	M>I		No	ClinGen ExAC gnomAD
CA386966876 rs1457107356	426	M>L		No	ClinGen TOPMed
rs199903262 CA244589514	430	N>K		No	ClinGen Ensembl
rs756258369 CA6834515	430	N>Y		No	ClinGen ExAC
CA386966806 rs1465910940	431	P>A		No	ClinGen gnomAD
CA386966807 rs1465910940	431	P>T		No	ClinGen gnomAD
CA6834513 rs143035233	432	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6834512 rs755271634	433	S>L		No	ClinGen ExAC TOPMed gnomAD
CA244589420 rs866315012	433	S>V		No	ClinGen Ensembl
CA6834511 rs751909766	435	I>V		No	ClinGen ExAC gnomAD
CA6834509 rs199783878	436	V>M		No	ClinGen ExAC TOPMed gnomAD
rs201551718 CA6834507	438	P>L		No	ClinGen ExAC TOPMed gnomAD
rs201551718 CA244589374	438	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1465364364 CA386966709	440	I>V		No	ClinGen TOPMed
rs929612914 CA244589348	441	K>R		No	ClinGen TOPMed gnomAD
rs377572588 CA6834480	442	L>V		No	ClinGen ESP ExAC gnomAD
rs199837469 CA6834478	443	H>L		No	ClinGen ExAC TOPMed gnomAD
CA386966618 rs199837469	443	H>P		No	ClinGen ExAC TOPMed gnomAD
rs762593990 CA6834479	443	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA6834477 rs202232880	444	P>L		No	ClinGen ExAC gnomAD
rs1219582970 CA386966594	445	W>C		No	ClinGen TOPMed
rs201016179 CA244588421	446	V>I		No	ClinGen Ensembl
rs1251900123 CA386966567	448	R>K		No	ClinGen gnomAD
CA6834475 rs781339939	449	H>R		No	ClinGen ExAC gnomAD
CA386966532 rs1209363170	451	A>T		No	ClinGen TOPMed
CA6834474 rs768616526	451	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200053670 CA244588396	453	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6834472 rs200053670	453	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs565357862 CA6834473 COSM227101	453	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6834469 rs546491056	455	P>L		No	ClinGen ExAC gnomAD
CA6834467 rs567776497	456	S>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	457	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386966453 rs1167669086	458	D>H		No	ClinGen gnomAD
CA386966439 rs1427750562	459	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA386966418 rs1475836092	460	N>K		No	ClinGen gnomAD
rs751093762 CA6834464	461	C>S		No	ClinGen ExAC gnomAD
CA6834463 rs200503109	462	T>M		No	ClinGen ExAC gnomAD
CA244588362 rs1009556571	462	T>P		No	ClinGen Ensembl
CA386966395 rs200503109	462	T>R		No	ClinGen ExAC gnomAD
rs769686708 CA6834460	470	E>*		No	ClinGen ExAC TOPMed gnomAD
CA386966251 rs1421000257	472	E>*		No	ClinGen TOPMed
CA386966132 rs1275152562	478	I>V		No	ClinGen gnomAD
rs776647930 CA6834458	480	S>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6834456 rs747012116	484	V>M		No	ClinGen ExAC TOPMed gnomAD
rs764988160 CA6834441	487	V>L		No	ClinGen ExAC gnomAD
rs764988160 CA386964456	487	V>M		No	ClinGen ExAC gnomAD
rs1451826262 CA386964345 COSM202432	492	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs34129994 CA6834440 VAR_040613	492	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs369888217 CA6834439	494	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6834438 rs763899089	494	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA244581982 rs113036883	496	F>C		No	ClinGen Ensembl
CA386964155 rs1251240622	497	G>E		No	ClinGen gnomAD
TCGA novel	498	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1447513942 CA386964117	499	P>S		No	ClinGen gnomAD
rs114204054 CA386964056	500	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1349865642 CA386964011	502	G>S		No	ClinGen gnomAD
TCGA novel	502	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs56277702 CA244581968	503	S>R		No	ClinGen TOPMed
rs371330172 CA6834434	504	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs536416352 CA6834435	504	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778228293 CA6834430	505	R>Q		No	ClinGen ExAC gnomAD
CA6834431 rs199796954	505	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1327544155 CA386963912	506	E>K		No	ClinGen gnomAD
CA6834429 rs756471943	506	E>V		No	ClinGen ExAC gnomAD
TCGA novel	507	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1377699388 CA386963898	507	E>Q		No	ClinGen gnomAD
rs201470961 CA6834428	508	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs568977744 CA6834427	508	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA386963829 rs1475813808	510	L>P		No	ClinGen gnomAD
CA6834425 rs757917913	512	A>V		No	ClinGen ExAC TOPMed gnomAD
rs544274688 CA244581900	517	L>V		No	ClinGen Ensembl
CA6834422 rs150968495	518	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867021883 CA244581430	523	R>M		No	ClinGen Ensembl
rs201257798 CA6834405	524	E>D		No	ClinGen ExAC TOPMed gnomAD
CA6834404 rs753516280	525	C>W		No	ClinGen ExAC gnomAD
CA244581416 rs200127209	525	C>Y		No	ClinGen gnomAD
CA6834403 rs777356978	526	E>G		No	ClinGen ExAC gnomAD
CA6834401 rs752446616	529	S>P		No	ClinGen ExAC gnomAD
rs1213672301 CA386963348	530	E>A		No	ClinGen gnomAD
rs767392357 CA6834400	531	L>F		No	ClinGen ExAC gnomAD
rs754760801 CA6834361	535	R>G		No	ClinGen ExAC gnomAD
CA6834360 rs746809158	537	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA244577630 rs766855208	537	R>L		No	ClinGen ExAC gnomAD
CA6834359 rs766855208	537	R>Q		No	ClinGen ExAC gnomAD
rs1477782377 CA386961950	540	P>A		No	ClinGen gnomAD
rs758302519 CA6834358	540	P>L		No	ClinGen ExAC TOPMed gnomAD
CA244577595 rs1038964813	541	P>A		No	ClinGen TOPMed gnomAD
rs1198997575 CA386961901	542	G>R		No	ClinGen gnomAD
rs1481629572 CA386961839	543	H>Q		No	ClinGen gnomAD
CA6834356 rs765213855	544	R>*		No	ClinGen ExAC gnomAD
CA6834357 rs765213855	544	R>G		No	ClinGen ExAC gnomAD
rs754109860 CA6834354	545	P>R		No	ClinGen ExAC gnomAD
rs764417771 CA6834353	546	A>T		No	ClinGen ExAC gnomAD
rs1310112012 CA386961758	547	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6834350 rs377581001	548	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs774966869 CA386961726	548	R>H		No	ClinGen ExAC gnomAD
rs774966869 CA6834348	548	R>L		No	ClinGen ExAC gnomAD
rs774981105	548	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377581001 CA6834349	548	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1051450715 CA386961711	549	G>R		No	ClinGen TOPMed gnomAD
rs1051450715 CA244577466	549	G>W		No	ClinGen TOPMed gnomAD
rs1462274102 CA386961670	550	G>E		No	ClinGen TOPMed gnomAD
rs1462274102 CA386961652	550	G>V		No	ClinGen TOPMed gnomAD
rs776196438 CA6834344	557	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1326533211 CA386961347	559	S>I		No	ClinGen TOPMed gnomAD
rs1251265448 CA386961322	560	P>H		No	ClinGen TOPMed gnomAD
CA386961338 rs1421110149	560	P>T		No	ClinGen gnomAD
rs1254786622 CA386961286	561	C>*		No	ClinGen TOPMed gnomAD
rs1218687088 CA386961273	562	V>L		No	ClinGen TOPMed
rs1593246123 CA386961150	564	S>I		No	ClinGen Ensembl
CA6834340 rs758266407	564	S>R		No	ClinGen ExAC TOPMed gnomAD
CA386961098 rs1484898087	565	C>W		No	ClinGen TOPMed
CA6834339 rs144382983	567	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201361901 CA244577406	568	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757219573 CA6834337	568	P>L		No	ClinGen ExAC gnomAD
rs201361901 CA6834338	568	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6834332 rs753007936	569	A>G		No	ClinGen ExAC gnomAD
TCGA novel	569	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140624198 CA6834335	569	A>T		No	ClinGen ESP ExAC
rs753007936 CA6834333	569	A>V		No	ClinGen ExAC gnomAD
CA244577362 rs866150487	571	G>D		No	ClinGen TOPMed gnomAD
rs200750895 CA6834329	571	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs866150487 CA386960970	571	G>V		No	ClinGen TOPMed gnomAD
CA386960961 rs766910933	572	S>C		No	ClinGen ExAC gnomAD
CA6834328 rs766910933	572	S>F		No	ClinGen ExAC gnomAD
rs776152407 CA6834326	573	P>A		No	ClinGen ExAC gnomAD
TCGA novel	573	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386960937 rs1437886558	574	A>S		No	ClinGen gnomAD
CA386960941 rs1437886558	574	A>T		No	ClinGen gnomAD
CA386960912 rs775271665	575	R>C		No	ClinGen ExAC gnomAD
CA386960897 rs1194145163	575	R>P		No	ClinGen gnomAD
CA6834323 rs775271665	575	R>S		No	ClinGen ExAC gnomAD
CA244577254 rs868609766	576	M>L		No	ClinGen Ensembl
CA6834321 rs200101277	577	H>Y		No	ClinGen ExAC gnomAD
CA6834320 rs202003410	578	P>A		No	ClinGen ExAC gnomAD
CA386960801 rs1486093264	578	P>L		No	ClinGen gnomAD
CA386960805 rs202003410	578	P>S		No	ClinGen ExAC gnomAD
rs749337315 CA6834318	579	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1234530777 CA386960772	580	R>Q		No	ClinGen gnomAD
rs562414798 CA6834316	580	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs752954809 CA6834315	581	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386960741 rs752954809	581	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA386960751 rs1384713240	581	P>S		No	ClinGen TOPMed
rs1566024305 CA386960726	582	E>Q		No	ClinGen Ensembl
rs1242058071 CA386960666	584	A>T		No	ClinGen TOPMed
RCV001091862 rs1888199098	585	M>missing		No	ClinVar dbSNP
rs201638594 CA6834312	585	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6834308 rs763580915	586	E>D		No	ClinGen ExAC TOPMed gnomAD
CA6834309 rs750978029	586	E>G		No	ClinGen ExAC gnomAD
CA6834311 rs766757308	586	E>Q		No	ClinGen ExAC gnomAD
rs750978029 CA6834310	586	E>V		No	ClinGen ExAC gnomAD
rs917895094 CA244577131	588	E>K		No	ClinGen TOPMed gnomAD

No associated diseases with Q96RR4

3 regional properties for Q96RR4

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	165 - 446	IPR000719
active_site	Serine/threonine-protein kinase, active site	308 - 320	IPR008271
binding_site	Protein kinase, ATP binding site	171 - 194	IPR017441

Functions

		Description
EC Number	2.7.11.17	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Cytoplasm Cell projection, neuron projection	Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding	Binding to a calcium ion (Ca2+).
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity	Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

12 GO annotations of biological process

Name	Definition
activation of protein kinase activity	Any process that initiates the activity of an inactive protein kinase.
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
CAMKK-AMPK signaling cascade	The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
cellular response to reactive oxygen species	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
positive regulation of autophagy of mitochondrion	Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of protein kinase activity	Any process that modulates the frequency, rate or extent of protein kinase activity.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8N5S9	CAMKK1	Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (Human)	SS
Q15831	STK11	Serine/threonine-protein kinase STK11	Homo sapiens (Human)	PR
Q8VBY2	Camkk1	Calcium/calmodulin-dependent protein kinase kinase 1	Mus musculus (Mouse)	PR
Q8C078	Camkk2	Calcium/calmodulin-dependent protein kinase kinase 2	Mus musculus (Mouse)	PR
Q5JLQ9	CIPK30	CBL-interacting protein kinase 30	Oryza sativa subsp japonica (Rice)	PR
Q5QNM6	CIPK13	Putative CBL-interacting protein kinase 13	Oryza sativa subsp japonica (Rice)	PR
Q6ERS4	CIPK16	CBL-interacting protein kinase 16	Oryza sativa subsp japonica (Rice)	PR
Q852Q0	OSK3	Serine/threonine protein kinase OSK3	Oryza sativa subsp. japonica (Rice)	SS
O65554	CIPK6	CBL-interacting serine/threonine-protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FJ54	CIPK20	CBL-interacting serine/threonine-protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	PR
O22971	CIPK13	CBL-interacting serine/threonine-protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2V452	CIPK3	CBL-interacting serine/threonine-protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	SS

10	20	30	40	50	60
MSSCVSSQPS	SNRAAPQDEL	GGRGSSSSES	QKPCEALRGL	SSLSIHLGME	SFIVVTECEP
70	80	90	100	110	120
GCAVDLGLAR	DRPLEADGQE	VPLDTSGSQA	RPHLSGRKLS	LQERSQGGLA	AGGSLDMNGR
130	140	150	160	170	180
CICPSLPYSP	VSSPQSSPRL	PRRPTVESHH	VSITGMQDCV	QLNQYTLKDE	IGKGSYGVVK
190	200	210	220	230	240
LAYNENDNTY	YAMKVLSKKK	LIRQAGFPRR	PPPRGTRPAP	GGCIQPRGPI	EQVYQEIAIL
250	260	270	280	290	300
KKLDHPNVVK	LVEVLDDPNE	DHLYMVFELV	NQGPVMEVPT	LKPLSEDQAR	FYFQDLIKGI
310	320	330	340	350	360
EYLHYQKIIH	RDIKPSNLLV	GEDGHIKIAD	FGVSNEFKGS	DALLSNTVGT	PAFMAPESLS
370	380	390	400	410	420
ETRKIFSGKA	LDVWAMGVTL	YCFVFGQCPF	MDERIMCLHS	KIKSQALEFP	DQPDIAEDLK
430	440	450	460	470	480
DLITRMLDKN	PESRIVVPEI	KLHPWVTRHG	AEPLPSEDEN	CTLVEVTEEE	VENSVKHIPS
490	500	510	520	530	540
LATVILVKTM	IRKRSFGNPF	EGSRREERSL	SAPGNLLTKK	PTRECESLSE	LKEARQRRQP
550	560	570	580
PGHRPAPRGG	GGSALVRGSP	CVESCWAPAP	GSPARMHPLR	PEEAMEPE