Q96Q40
PR
Gene name |
CDK15 (ALS2CR7, PFTK2) |
Protein name |
Cyclin-dependent kinase 15 |
Names |
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein, Cell division protein kinase 15, Serine/threonine-protein kinase ALS2CR7, Serine/threonine-protein kinase PFTAIRE-2 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:65061 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
241-264 (Activation loop from InterPro)
Target domain |
103-387 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q96Q40
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q96Q40-F1 | Predicted | AlphaFoldDB |
369 variants for Q96Q40
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1259390528 CA350329850 |
2 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1457984844 CA350329854 |
3 | Q>K | No |
ClinGen gnomAD |
|
|
CA350329872 rs1208856499 |
5 | L>P | No |
ClinGen gnomAD |
|
| TCGA novel | 7 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767300371 CA2058786 |
8 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA350329893 rs1172958647 |
8 | K>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2058787 rs750597035 |
8 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA350329895 rs1313351728 |
9 | T>A | No |
ClinGen TOPMed |
|
|
rs749369969 CA2058791 |
11 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2058794 rs748700701 |
12 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779517791 CA2058793 |
12 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1390901532 CA350329920 |
13 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA350329926 rs1326872038 |
14 | C>Y | No |
ClinGen gnomAD |
|
|
rs1413649352 CA350329933 |
15 | S>C | No |
ClinGen TOPMed |
|
|
CA350329942 rs1220995138 |
16 | C>Y | No |
ClinGen gnomAD |
|
|
rs1317925044 CA350329957 |
18 | H>R | No |
ClinGen gnomAD |
|
|
rs772499604 CA2058795 |
18 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs773725256 CA350329968 |
19 | C>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 20 | S>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745523013 CA2058797 |
22 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA350329996 rs775042284 |
24 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2058799 rs775042284 |
24 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762318734 CA2058800 |
25 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs775901921 CA63969408 |
29 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774206560 CA2058802 |
29 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2058801 rs775901921 |
29 | R>W | Variant assessed as Somatic; 8.584e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2058804 rs747573179 |
30 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs971223883 CA63969412 |
32 | Q>H | No |
ClinGen TOPMed |
|
|
CA63969417 rs1003207221 |
33 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA2058807 rs750249147 |
36 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750249147 CA2058806 |
36 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1016630656 CA63969466 |
39 | A>S | No |
ClinGen Ensembl |
|
|
rs1359004229 CA350330095 |
39 | A>V | No |
ClinGen gnomAD |
|
|
CA2058810 rs536756372 |
41 | K>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs779138761 CA2058811 |
41 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs369158011 CA350330139 |
44 | D>E | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 44 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2058835 rs757496592 |
46 | K>E | No |
ClinGen ExAC TOPMed |
|
|
rs569840064 CA2058836 |
46 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2058837 rs748922435 |
47 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1198285571 CA350330164 |
48 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2058838 rs200245595 |
50 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2058840 rs747703696 |
52 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1460359142 CA350330196 |
53 | T>S | No |
ClinGen gnomAD |
|
|
CA350330200 rs1178799533 |
54 | S>* | No |
ClinGen gnomAD |
|
|
CA2058841 rs771636326 |
54 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA2058843 rs746974802 |
58 | R>T | No |
ClinGen ExAC gnomAD |
|
|
rs1330297237 CA350330236 |
59 | G>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA350330242 rs1397738310 |
60 | L>P | No |
ClinGen gnomAD |
|
| TCGA novel | 62 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1005013404 CA63969957 |
63 | A>S | No |
ClinGen TOPMed |
|
|
CA2058844 rs34776344 |
64 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
VAR_042016 CA2058845 rs34776344 |
64 | R>G | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA2058846 rs759835104 |
64 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759835104 CA350330264 |
64 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2058847 rs548746565 |
68 | F>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA350330305 rs1226602687 |
70 | S>N | No |
ClinGen TOPMed |
|
|
CA2058848 rs201632234 |
74 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA350330332 rs1217408740 |
74 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs1218144710 CA350330364 |
78 | D>V | No |
ClinGen gnomAD |
|
|
CA2058851 rs764238297 |
79 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764238297 CA2058852 |
79 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1459313210 CA350330393 |
82 | E>G | No |
ClinGen gnomAD |
|
|
rs757836967 CA2058853 |
84 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1559110715 CA350330409 |
84 | D>V | No |
ClinGen Ensembl |
|
|
CA2058854 rs767765738 |
87 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA350330436 rs1574839147 |
88 | G>V | No |
ClinGen Ensembl |
|
|
CA2058855 rs750823228 |
91 | W>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 92 | R>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| VAR_042017 | 93 | K>E | a renal clear cell carcinoma sample; somatic mutation [UniProt] | No | UniProt |
|
rs1559110879 CA350330490 |
94 | S>N | No |
ClinGen Ensembl |
|
|
CA63970155 rs997863043 |
96 | P>A | No |
ClinGen Ensembl |
|
|
CA2058883 rs769653908 |
99 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA2058884 rs780051899 |
100 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA63970199 rs955385484 |
102 | S>F | No |
ClinGen Ensembl |
|
|
rs768959454 CA2058886 |
102 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA2058887 rs138441846 |
103 | Y>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA350330576 rs1215121253 |
107 | E>D | No |
ClinGen gnomAD |
|
|
rs761901115 CA2058889 |
110 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761901115 CA350330594 |
110 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772172729 CA2058890 |
111 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2058891 rs772172729 |
111 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761187271 CA350330604 |
112 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA2058892 rs761187271 |
112 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1236379760 CA350330603 |
112 | G>S | No |
ClinGen gnomAD |
|
|
CA350330614 rs1418823906 |
114 | Y>F | No |
ClinGen gnomAD |
|
|
rs766721567 CA2058893 |
114 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2058895 rs149189465 |
115 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350330630 rs1401190918 |
117 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA350330632 rs1401190918 |
117 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA350330652 rs1246886614 |
120 | G>R | No |
ClinGen TOPMed |
|
|
rs1357281663 CA350330657 |
120 | G>V | No |
ClinGen TOPMed |
|
|
CA350330659 rs1333673579 |
121 | I>V | No |
ClinGen gnomAD |
|
|
rs1336667433 CA350330713 |
126 | G>E | No |
ClinGen gnomAD |
|
|
rs527598721 CA63973113 |
127 | Q>* | No |
ClinGen Ensembl |
|
|
VAR_042018 rs56135556 CA2058918 |
127 | Q>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs941976314 CA63973118 |
128 | L>P | No |
ClinGen gnomAD |
|
|
rs1273544586 CA350330722 |
128 | L>V | No |
ClinGen gnomAD |
|
|
CA350330726 rs1173346860 |
129 | V>M | No |
ClinGen TOPMed |
|
|
CA350330734 rs1455786661 |
130 | A>P | No |
ClinGen TOPMed |
|
|
rs749992898 CA2058920 |
133 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA2058921 rs565829983 |
135 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs780089190 CA2058922 |
138 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA2058923 rs753748222 |
141 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA2058924 rs139496477 |
142 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2058926 rs748390519 COSM356930 |
143 | P>S | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1478949554 CA350330826 |
144 | F>L | No |
ClinGen gnomAD |
|
|
CA2058927 rs758687247 |
147 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368163684 CA2058928 |
147 | I>T | No |
ClinGen ESP ExAC gnomAD |
|
|
COSM476758 CA2058929 rs767930884 |
148 | R>* | kidney [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA2058930 rs370446004 |
148 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA350330863 rs1397696820 |
150 | A>P | No |
ClinGen gnomAD |
|
|
rs772931373 CA2058955 |
151 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 151 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs149717877 CA63979608 |
152 | L>H | No |
ClinGen ESP |
|
|
CA2058957 rs757611284 |
152 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1311561065 CA350331743 |
153 | L>P | No |
ClinGen gnomAD |
|
|
CA350331749 rs1223173559 |
154 | K>R | No |
ClinGen gnomAD |
|
|
CA2058959 rs148470814 |
157 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2058960 rs139500243 |
158 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2058962 rs758152470 |
159 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs763883378 CA2058963 |
160 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757484525 CA2058965 |
163 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs144339303 CA2058967 |
164 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144339303 CA2058966 |
164 | L>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780384158 CA2058969 |
165 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs756240601 CA2058968 |
165 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350331828 rs1290189748 |
167 | I>V | No |
ClinGen gnomAD |
|
|
rs201611168 CA2058970 |
170 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA350331866 rs1310076004 |
172 | E>G | No |
ClinGen gnomAD |
|
|
rs1384763997 CA350331870 |
173 | T>A | No |
ClinGen gnomAD |
|
|
rs1302097834 CA350331873 |
173 | T>K | No |
ClinGen TOPMed |
|
|
rs779480760 CA350331893 COSM3798514 |
176 | F>L | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs199511628 CA350331896 |
177 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199511628 CA2058973 |
177 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2058976 rs372570537 |
181 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs767348456 CA2059001 |
182 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA2059000 rs761474386 |
182 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs199869929 CA2059002 |
183 | T>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2059003 rs761014003 |
183 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs766563923 CA2059004 |
184 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs191446880 CA2059005 |
185 | L>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA63980116 rs1041576494 |
185 | L>P | No |
ClinGen TOPMed |
|
|
rs890208304 CA63980118 |
188 | Y>C | No |
ClinGen TOPMed |
|
|
rs765790847 CA2059007 CA63980139 |
189 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs755520069 CA63980120 |
189 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1385004995 CA350331986 |
189 | M>T | No |
ClinGen gnomAD |
|
|
CA2059006 rs755520069 |
189 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350331999 rs1324299118 |
191 | Q>R | No |
ClinGen gnomAD |
|
|
CA350332007 rs753282798 |
192 | H>L | No |
ClinGen ExAC gnomAD |
|
|
rs753282798 CA2059008 |
192 | H>P | No |
ClinGen ExAC gnomAD |
|
|
CA350332006 rs753282798 |
192 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs778216084 CA2059010 |
193 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1415880447 CA350332011 |
193 | P>S | No |
ClinGen TOPMed |
|
|
CA350332016 rs1205720099 |
194 | G>R | No |
ClinGen gnomAD |
|
|
CA2059012 rs745500022 |
195 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1179844780 CA350332041 |
198 | P>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
| TCGA novel | 198 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755801738 CA2059013 |
199 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2059014 rs373766977 |
200 | N>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373766977 CA2059015 |
200 | N>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350332068 rs1463306383 |
202 | R>I | No |
ClinGen TOPMed |
|
|
CA63980172 rs748169761 |
202 | R>S | No |
ClinGen Ensembl |
|
|
CA350332609 rs1419007633 |
203 | L>V | No |
ClinGen gnomAD |
|
|
CA2059038 rs772862888 |
205 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs115873067 CA2059042 |
210 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2059041 rs115873067 |
210 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs137880666 CA2059040 |
210 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1250795141 CA350332865 |
211 | G>A | No |
ClinGen gnomAD |
|
|
CA2059044 rs775709227 |
211 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763343769 CA350332875 |
213 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs763343769 CA2059045 |
213 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA350332904 rs1216105983 |
217 | H>R | No |
ClinGen gnomAD |
|
|
CA350332911 rs1236577698 |
218 | Q>P | No |
ClinGen gnomAD |
|
|
CA350332923 rs142697496 |
219 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350332918 rs1230984459 |
219 | H>Y | No |
ClinGen TOPMed |
|
|
rs1385628938 CA350332927 |
220 | V>A | No |
ClinGen gnomAD |
|
|
rs767881343 CA350332925 |
220 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767881343 CA2059049 |
220 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350332937 rs1234294106 |
222 | H>Y | No |
ClinGen TOPMed |
|
|
rs1030353473 CA63986919 |
223 | R>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
| TCGA novel | 225 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1192078063 CA350332995 |
230 | L>S | No |
ClinGen TOPMed gnomAD |
|
|
rs778256691 CA2059052 |
231 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs777726730 CA2059056 |
232 | I>N | No |
ClinGen ExAC gnomAD |
|
|
rs777726730 CA2059055 |
232 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA63986947 rs773075862 |
233 | S>G | No |
ClinGen TOPMed |
|
|
CA350333028 rs1454781903 |
235 | L>R | No |
ClinGen gnomAD |
|
|
CA350333029 rs1431388342 COSM1737430 |
236 | G>R | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs770796387 CA2059057 |
237 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2059058 rs781193371 |
238 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA350333060 rs1351989133 |
241 | A>T | No |
ClinGen gnomAD |
|
|
CA63986965 rs370176322 |
242 | D>H | No |
ClinGen ESP TOPMed |
|
| TCGA novel | 244 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350333081 rs1223903290 |
244 | G>S | No |
ClinGen gnomAD |
|
|
CA2059083 rs772617356 |
246 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs142416956 CA350333259 |
247 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142416956 CA2059085 |
247 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2059084 rs145253830 |
247 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350333276 rs1361391523 |
248 | A>V | No |
ClinGen TOPMed |
|
|
CA350333283 rs1200197383 |
249 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1200197383 CA350333281 |
249 | K>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs956671327 CA63987983 |
250 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
rs201045225 CA63987978 |
250 | S>T | No |
ClinGen Ensembl |
|
|
CA2059087 rs775154649 |
252 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs762575378 CA2059088 |
253 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1397574344 CA350333366 |
254 | Q>R | No |
ClinGen gnomAD |
|
|
CA2059090 rs34851370 VAR_042019 |
255 | T>I | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs34851370 CA2059091 |
255 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1416051616 CA350333399 |
256 | Y>C | No |
ClinGen Ensembl |
|
|
rs977546470 CA63988000 |
257 | S>T | No |
ClinGen Ensembl |
|
|
rs756847196 CA2059094 |
258 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA2059095 rs767519586 |
260 | V>F | No |
ClinGen ExAC gnomAD |
|
|
CA2059097 COSM719742 rs755877050 |
261 | V>L | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
COSM74102 CA2059098 rs755877050 |
261 | V>M | ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA350333487 rs1574876393 |
262 | T>P | No |
ClinGen Ensembl |
|
|
TCGA novel rs1224713115 CA350333539 |
264 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen gnomAD |
|
CA2059101 rs191987869 |
266 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs138476978 COSM1404545 CA2059099 |
266 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA63988049 rs866522241 |
267 | P>T | No |
ClinGen Ensembl |
|
| TCGA novel | 269 | D>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs748178452 CA2059102 |
270 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA2059103 rs772170627 |
275 | T>S | No |
ClinGen ExAC gnomAD |
|
|
COSM614 CA350333648 VAR_042020 rs1490814436 |
276 | E>D | breast a breast infiltrating ductal carcinoma sample; somatic mutation [Cosmic, UniProt] | No |
ClinGen cosmic curated UniProt TOPMed dbSNP gnomAD |
|
rs773644696 CA2059104 |
276 | E>G | No |
ClinGen ExAC |
|
|
CA2059105 rs747486064 |
277 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs61383268 CA63988108 |
279 | S>F | No |
ClinGen Ensembl |
|
|
rs578060023 CA2059107 |
279 | S>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs201420169 CA2059108 |
280 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2059109 rs763892276 |
281 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774174305 CA2059110 |
282 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA63988143 rs1050810677 |
283 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA63988159 rs866609774 |
284 | W>* | No |
ClinGen Ensembl |
|
|
rs200379340 CA2059133 |
284 | W>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350333772 rs1303238674 |
284 | W>R | No |
ClinGen gnomAD |
|
|
rs760638025 CA2059134 |
285 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766177958 CA2059135 |
285 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350392523 rs1574896451 |
286 | A>T | No |
ClinGen Ensembl |
|
|
CA2059136 rs757899266 |
288 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1017727754 CA64493510 |
289 | I>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 290 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2059137 rs187005870 |
292 | E>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1429753554 CA350392674 |
295 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2059139 rs752903564 |
297 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs143327698 CA64493511 |
298 | P>S | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA2059140 rs758689434 |
300 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1268413699 CA350393300 |
301 | P>L | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 301 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777880215 CA2059141 |
303 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1470160703 CA350393343 |
305 | N>H | No |
ClinGen gnomAD |
|
|
CA2059143 COSM3838311 rs757384628 |
305 | N>S | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA2059145 rs143486430 |
306 | I>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350393364 rs143486430 |
306 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350393401 rs1344912578 |
309 | Q>* | No |
ClinGen gnomAD |
|
|
rs1334212514 CA350393408 |
309 | Q>H | No |
ClinGen gnomAD |
|
| TCGA novel | 311 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2059147 rs780630778 |
314 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350393486 rs1231737320 |
315 | E>* | No |
ClinGen gnomAD |
|
|
CA2059172 rs746688089 |
316 | V>A | No |
ClinGen ExAC |
|
|
CA2059171 rs199639155 |
316 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs776273369 CA2059174 |
320 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA2059176 rs1363462142 |
322 | E>G | No |
ClinGen TOPMed |
|
|
CA2059178 rs769775034 |
324 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA2059179 rs775432947 |
324 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA64494279 rs367719089 |
325 | W>C | No |
ClinGen Ensembl |
|
|
COSM1200546 CA2059181 rs763959488 |
326 | P>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1395650456 CA350393584 |
328 | V>A | No |
ClinGen TOPMed |
|
|
CA2059184 rs550695496 |
333 | N>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1451626749 CA350393622 |
334 | Y>C | No |
ClinGen gnomAD |
|
|
CA64494280 rs1033625521 |
334 | Y>H | No |
ClinGen Ensembl |
|
|
CA2059185 rs371256915 |
335 | N>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2059186 rs371256915 |
335 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 337 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2059246 rs751966765 |
338 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs370819607 CA2059245 |
338 | W>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs201605804 CA2059249 |
342 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA350393682 rs1299543287 |
342 | P>T | No |
ClinGen gnomAD |
|
|
rs549338953 CA64496081 |
343 | T>A | No |
ClinGen Ensembl |
|
|
CA2059250 rs375122798 |
343 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350393691 rs1411204752 |
344 | P>T | No |
ClinGen TOPMed |
|
|
CA64496082 rs370382391 |
345 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA gnomAD |
|
CA350393699 rs571966218 |
345 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2059253 rs571966218 |
345 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs777690518 CA2059255 |
346 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA64496083 rs1002530733 |
346 | S>R | No |
ClinGen Ensembl |
|
|
rs1195860899 CA350393735 |
351 | W>* | No |
ClinGen gnomAD |
|
|
rs1035442017 CA64496084 |
351 | W>* | No |
ClinGen gnomAD |
|
|
CA350393738 rs1035442017 |
351 | W>C | No |
ClinGen gnomAD |
|
|
rs757153144 CA2059257 |
352 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 352 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1169458052 CA350393764 |
353 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
CA2059295 rs139951366 |
355 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350393781 rs762488718 CA350393780 |
356 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1364986256 CA350393786 |
357 | V>G | No |
ClinGen gnomAD |
|
|
CA2059297 rs763714093 |
359 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA350393807 rs1382075589 |
361 | E>K | No |
ClinGen gnomAD |
|
|
CA64496904 rs200366047 |
362 | D>H | No |
ClinGen gnomAD |
|
|
CA350393815 rs200366047 |
362 | D>N | No |
ClinGen gnomAD |
|
|
rs767334097 CA2059300 |
363 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs369311448 CA2059303 |
365 | S>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1248143640 CA350393838 |
366 | Q>* | No |
ClinGen gnomAD |
|
|
rs1257570669 CA350393847 |
367 | M>L | No |
ClinGen TOPMed |
|
|
rs1488594759 CA350393858 |
368 | L>R | No |
ClinGen gnomAD |
|
|
rs754083630 CA2059304 |
370 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755029586 CA2059305 |
371 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA2059306 rs779004408 |
374 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350393896 rs779004408 |
374 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM442121 CA2059307 rs145205966 |
375 | R>C | breast [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA2059308 rs189350681 |
375 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs189350681 CA350393901 |
375 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA64496905 rs61995877 |
376 | V>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2059311 rs61995877 |
376 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2059310 rs61995877 |
376 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1401135209 CA350393913 |
378 | A>D | No |
ClinGen TOPMed |
|
|
CA2059314 rs144726331 |
378 | A>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2059313 rs144726331 |
378 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 379 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1372429754 CA350393936 |
381 | A>G | No |
ClinGen gnomAD |
|
|
CA2059315 rs201179449 |
383 | V>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1156560901 CA350393954 |
384 | H>R | No |
ClinGen TOPMed |
|
|
rs975234784 CA64496906 |
385 | D>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 385 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2059317 rs767293718 |
388 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350393980 rs767293718 |
388 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1291395821 CA350393987 |
389 | A>T | No |
ClinGen gnomAD |
|
|
rs1321952810 CA350393994 |
390 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA350394008 rs1449136461 |
392 | S>C | No |
ClinGen TOPMed |
|
| TCGA novel | 392 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs760340387 CA2059319 |
393 | Q>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 395 | Y>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1266046958 CA350394023 |
395 | Y>H | No |
ClinGen gnomAD |
|
|
rs754028788 CA2059321 |
397 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA350394042 rs1242526154 |
397 | L>P | No |
ClinGen gnomAD |
|
|
CA350394039 rs754028788 |
397 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA350394056 rs755260494 |
399 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1471769325 CA350394050 |
399 | D>H | No |
ClinGen gnomAD |
|
|
CA350394093 rs1343015733 |
400 | E>G | No |
ClinGen gnomAD |
|
|
rs1574948377 CA350394099 |
401 | E>* | No |
ClinGen Ensembl |
|
|
rs370638439 CA2059362 |
401 | E>A | No |
ClinGen ESP ExAC gnomAD |
|
|
CA350394103 rs1265606022 |
401 | E>D | No |
ClinGen gnomAD |
|
| TCGA novel | 402 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350394105 rs1453537815 |
402 | S>P | No |
ClinGen gnomAD |
|
|
rs1559154287 CA350394112 |
403 | L>S | No |
ClinGen Ensembl |
|
|
rs776552584 CA2059363 |
403 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1241837323 CA350394117 |
404 | F>L | No |
ClinGen gnomAD |
|
|
rs759284385 CA2059364 |
405 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA2059366 rs542650426 |
406 | V>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1559154303 CA539005352 |
406 | V>P | No |
ClinGen Ensembl |
|
|
CA350394144 rs1251202502 |
408 | G>R | No |
ClinGen TOPMed |
|
|
CA2059367 rs113623048 |
410 | R>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350394160 rs1314357119 |
410 | R>S | No |
ClinGen TOPMed |
|
|
rs1429884522 CA350394175 |
413 | P>A | No |
ClinGen gnomAD |
|
|
rs142602589 CA2059368 |
414 | E>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs764072704 CA2059369 |
415 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA2059370 rs751603570 |
418 | L>H | No |
ClinGen ExAC gnomAD |
|
|
CA350394211 rs1388215631 |
418 | L>I | No |
ClinGen gnomAD |
|
|
rs757420709 CA2059371 |
419 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750991365 CA64498063 |
421 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750991365 CA2059374 |
421 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200263338 CA2059376 |
423 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201587988 CA64498064 |
425 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
rs113092152 CA64498065 |
426 | H>Q | No |
ClinGen Ensembl |
|
|
CA2059377 rs747751660 |
426 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1210612705 CA350394272 |
427 | H>Q | No |
ClinGen gnomAD |
|
|
CA2059378 rs375313939 |
428 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1351202760 CA350394277 |
428 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2059380 rs746460384 |
430 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA350394330 rs1479911782 |
435 | W>* | No |
ClinGen TOPMed |
|
| TCGA novel | 436 | W>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with Q96Q40
4 regional properties for Q96Q40
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin binding | Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of transcription involved in G1/S transition of mitotic cell cycle | Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00526 | CDK3 | Cyclin-dependent kinase 3 | Homo sapiens (Human) | PR |
| Q15131 | CDK10 | Cyclin-dependent kinase 10 | Homo sapiens (Human) | PR |
| Q9UQ88 | CDK11A | Cyclin-dependent kinase 11A | Homo sapiens (Human) | PR |
| O94921 | CDK14 | Cyclin-dependent kinase 14 | Homo sapiens (Human) | PR |
| Q00537 | CDK17 | Cyclin-dependent kinase 17 | Homo sapiens (Human) | PR |
| P49336 | CDK8 | Cyclin-dependent kinase 8 | Homo sapiens (Human) | PR |
| Q9BWU1 | CDK19 | Cyclin-dependent kinase 19 | Homo sapiens (Human) | PR |
| P50750 | CDK9 | Cyclin-dependent kinase 9 | Homo sapiens (Human) | PR |
| Q5MAI5 | CDKL4 | Cyclin-dependent kinase-like 4 | Homo sapiens (Human) | PR |
| Q00532 | CDKL1 | Cyclin-dependent kinase-like 1 | Homo sapiens (Human) | PR |
| Q92772 | CDKL2 | Cyclin-dependent kinase-like 2 | Homo sapiens (Human) | PR |
| Q8IZL9 | CDK20 | Cyclin-dependent kinase 20 | Homo sapiens (Human) | PR |
| P21127 | CDK11B | Cyclin-dependent kinase 11B | Homo sapiens (Human) | PR |
| O35495 | Cdk14 | Cyclin-dependent kinase 14 | Mus musculus (Mouse) | PR |
| Q8K0D0 | Cdk17 | Cyclin-dependent kinase 17 | Mus musculus (Mouse) | PR |
| O35831 | Cdk17 | Cyclin-dependent kinase 17 | Rattus norvegicus (Rat) | PR |
| Q5Z754 | CDKF-1 | Cyclin-dependent kinase F-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9S713 | STN7 | Serine/threonine-protein kinase STN7, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A4IIW7 | cdk14 | Cyclin-dependent kinase 14 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q1RLU9 | cdk15 | Cyclin-dependent kinase 15 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGQELCAKTV | QPGCSCYHCS | EGGEAHSCRR | SQPETTEAAF | KLTDLKEASC | SMTSFHPRGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QAARAQKFKS | KRPRSNSDCF | QEEDLRQGFQ | WRKSLPFGAA | SSYLNLEKLG | EGSYATVYKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISRINGQLVA | LKVISMNAEE | GVPFTAIREA | SLLKGLKHAN | IVLLHDIIHT | KETLTFVFEY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MHTDLAQYMS | QHPGGLHPHN | VRLFMFQLLR | GLAYIHHQHV | LHRDLKPQNL | LISHLGELKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADFGLARAKS | IPSQTYSSEV | VTLWYRPPDA | LLGATEYSSE | LDIWGAGCIF | IEMFQGQPLF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGVSNILEQL | EKIWEVLGVP | TEDTWPGVSK | LPNYNPEWFP | LPTPRSLHVV | WNRLGRVPEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDLASQMLKG | FPRDRVSAQE | ALVHDYFSAL | PSQLYQLPDE | ESLFTVSGVR | LKPEMCDLLA |
| 430 | |||||
| SYQKGHHPAQ | FSKCW |